[Next-Generation Sequencing Book]
  • [Photo] Linda Tolosano • March 10, 2010

    BACKGROUND

    At Pfizer BioTherapeutics Division, Applied Quantitative Genotherapeutics (AQG) group, we are dedicated to developing and implementing investigative approaches focused on evaluating potential drug candidates and identifying new targets in preclinical models of disease. We use the latest scientific knowledge and apply novel approaches to discover new ways of treating disease. We encourage cooperation and support a high level of scientific freedom to find the best answers to biological questions. Located in South San Francisco, AQG provides the feel of a small start-up company with the resources of a large pharmaceutical company in the heart of the biotech capital of the world.

    RESPONSIBILITIES

    We are seeking to hire a computational expert to develop software and algorithms for emerging DNA sequencing technologies with revolutionary applications. The incumbent will collaborate with fellow group members to solve challenging algorithmic problems and develop analysis techniques for large, complex data sets; rapidly design and prototype algorithms for new data and problems; implement and optimize successful algorithms; interact and collaborate with laboratory colleagues to improve data quality and participate in experimental design.

    Duties:
    • Developing infrastructure for high throughput sequence analysis and oligonucleotide design
    • Integration of public domain genomic databases with proprietary data
    • Analysis and annotation of human genome variation associated with disease or adverse drug effects
    • Implementation of Laboratory Information Management Systems (LIMS)
    • Development and automation of workflows for bioinformatics processes, using Perl, Python and shell scripting
    • Using grid environment (e.g. LSF, xgrid, Sun Grid Engine) to distribute and manage large compute jobs
    • Developing components for analyses and visualization of sequence data

    REQUIREMENTS

    • BS/MS in computational or life sciences (biologist/chemist with computational sciences training/experience or computational scientist with experience in biology/chemistry) with 5+ years relevant experience; or PhD with 1-2 years experience
    • Proven expertise in the development and/or implementation of algorithms to distill, analyze and interpret complex datasets, particularly those associated with pharmacogenomics, pharmacogenetics and biomarker discovery
    • Experience with genomic database mining and bioinformatics systems
    • Computer science skills: object oriented Perl, C or C++, SQL, MySQL, strong dynamic web skills, SVN experience, advanced Linux (Unix), MediaWiki exposure a plus
    • Working knowledge of genomic technologies, e.g. DNA sequencing, SNP genotyping, gene expression profiling
    • Background in biological sciences: genetics (population variation, gene structure, genomics), gene annotation, sequence analysis algorithms, pattern recognition. Background in immunology a plus
    • Social skills: enthusiastic self starter, effective communicator and team contributor, can take pride in his/her work
    TERMS: Full time

    LOCALE: South San Francisco, CA

    SALARY & COMPENSATION

    Salary commensurate with background and experience. Full benefits.

    HOW TO APPLY

    Please submit resumes to http://www.pfizer.com.

Discussion forums: Opportunity: BIOINFORMATICS Scientist @ Pfizer BioTherapeutics Division--South San Francisco, CA (US)

Expanded view | Monitor forum | Save place

Start a new thread:

You have to be logged in to post a reply.

© 1998-2025 Scilico, LLC. All rights reserved.