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    Events: Computational Bridge to Experiments Workshop
    Submitted by Iddo Friedberg; posted on Wednesday, June 09, 2010


    DATE: September 15, 2010
    LOCALE: Lake Arrowhead, California

    Announcing the first COMBREX Workshop for Computational and Experimental Determination of Protein Function. COMBREX (Computational Bridge to Experiments) is a new NIH funded effort that aims to increase the pace of experimental determination of the function of large and high priority gene families in bacterial genomes.

    Central to this effort would be the creation of a community web-based database that will allow computational and experimental scientists to communicate easily and assist experimentalists in identifying high-priority genes with high-quality computational predictions. Experimentalists will be able to submit bids (proposals) to validate individual predictions, and if successful, will receive modest funding from COMBREX to perform the validation.

    The morning session will provide an overview of COMBREX, including both the experimental and computational challenges, related talks, and a description of topics to be discussed by breakout groups. These groups will convene in the afternoon to discuss the topics and prepare a short summary, for presentation to the entire workshop after dinner.


    Topics to be discussed by the breakout groups will roughly divide into the following areas: (1) whole genome annotation, (2) assessment of computational predictions, (3) use of structure to predict function, and (4) infrastructure for function annotation. General topics to be discussed include:

    1. How to prioritize predictions?
    2. How to evaluate experimental bids?
    3. How to handle non-enzymatic proteins?
    4. How best to handle predictions/phenotypes from high-throughput experimentation?

    A key desired outcome of the workshop is the identification of opportunities and catalysis collaborations between computational and experimental biologists.


    We hope you will be able to join us for this event. You can register at:[...].html


    Co-chairs: Martin Steffen, Boston University, steffen 'at' bu 'dot' edu
    Iddo Friedberg, Miami University, i.friedberg 'at' muohio 'dot' edu


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