[Next-Generation Sequencing Book]
  • [Photo] Per Stenberg • September 20, 2010

    BACKGROUND

    In all higher organisms chromatin is the physiological template of the genetic information. Gene expression in animals and plants is an intricate interplay between transcription factors and a plethora of factors that targets and modifies the three dimensional structure of chromatin. Thanks to the rapid evolution of genome wide mapping techniques we now have access to vast amounts of data regarding transcription, transcription factors, chromatin modifications and remodelers. The problem is to make sense of all these data in order to understand how correct gene regulation is achieved in a eukaryotic cell as well as to establish links between chromatin and expression. We also need to understand how all the proteins that interact with chromatin are targeted to their sites of action. By developing bioinformatics approaches and combining those with genetics approaches and genome mapping of chromatin factors we hope to contribute to the understanding of the complex networks that control gene regulation in higher organisms.

    RESPONSIBILITIES

    Development and use of bioinformatics tools in the study of targeting and regulation of chromatin associated factors in eukaryotes (mainly flies and humans). The work will be in close contact with leading researchers in experimental biology and the successful applicant is expected to take an active part in planning, analysis, evaluating and publishing of scientific projects.

    REQUIREMENTS

    • PhD degree in an appropriate area
    • Proficiency in both written and spoken English
    • Experience of working with genomics data and bioinformatics
    • Programming experience (preferably Perl and Java)

    PREFERENCES

    • Experience of analysing next-generation sequencing data
    • Expertise in statistics and statistical genetics
    • Theoretical knowledge of genetics, epigenetics and molecular biology
    • Experience of machine learning algorithms

    TERMS

    The position is for one year with possible extension one additional year.

    LOCALE

    The position is at the Department of Molecular Biology and within the Computational Life Science Cluster (CLiC) at Umeå University, Sweden

    COMPENSATION

    20 000 SEK tax free stipend/month (approximately 2170 EUR/month)

    HOW TO APPLY

    Send your application and questions to Dr. Per Stenberg (Per.Stenberg{at}molbiol.umu.se). Only electronic applications will be considered. The application should include:
    • Personal letter describing your fulfilment of the required and desired qualifications listed above
    • CV and list of publications
    • Relevant publications in pdf-format
    • Copies of important certificates
    • One to two reference names with contact details

    DEADLINE

    The position will be open during fall 2010 or until a suitable person is found.

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