[Next-Generation Sequencing Book]
  • [Photo] Richard Edwards • May 10, 2011
    You are invited to apply for the post of Postdoctoral Research Fellow to work closely with Dr Richard Edwards on a BBSRC-funded project to develop and apply computational tools for the prediction of protein motifs that mediate protein-protein interactions (PPI).

    BACKGROUND

    Many protein-protein interactions are mediated by Short Linear Motifs (SLiMs): short stretches of proteins (5-15 amino acids long), of which only a few positions are critical to function. These motifs are vital for biological processes of fundamental importance, such as signalling pathways and targeting proteins to the correct part of a cell. The primary objective of this project is to integrate a number of leading computational techniques to predict novel SLiMs and, in so doing, add crucial detail to protein-protein interaction networks. This will generate a valuable resource of potential SLiMs, including defined occurrences and interactions. Further information at http://www.southampton.ac.uk/~re1u06/index.html.

    RESPONSIBILITIES

    The project will use a number of computational and sequence analysis techniques. Project aims are well established and the candidate will be expected to spend the vast majority of their time on research activities relating to this project. There are no teaching duties attached to the position but there will be opportunities to develop undergraduate and/or postgraduate teaching experience.

    REQUIREMENTS

    • Basic programming skills are essential.
    • Experience with database design, HPC and web programming are highly desirable.
    • You will be required to develop a thorough knowledge of SLiM-mediated protein-protein interactions and should therefore be comfortable with biological literature, biochemistry, molecular evolution and structural biology.
    • Please note that the project is 100% computational.

    PREFERENCES

    • A background in either computer science or biology, with a (submitted) PhD in a relevant subject area, is essential.
    • Previous research experience (PhD or Postdoctoral) in computational biology is highly desirable.
    • Candidates with a computer science background must demonstrate an interest and aptitude for molecular biology.
    • Similarly, candidates with a biology background must demonstrate an interest and aptitude for computer programming.
    • Project management skills and independent research experience are desirable.
    • You should be an enthusiastic researcher, a good teamworker and an excellent communicator.

    TERMS

    The position is full-time and available immediately for a period of three years. Start date is flexible but the successful candidate must be in post by September 2011.

    LOCALE

    University of Southampton, UK. School of Biological Sciences.

    COMPENSATION

    GBP 27,428 - GBP 33,734 per annum pro rata

    HOW TO APPLY

    Apply online at https://jobs.soton.ac.uk - Ref 5441-11-F. Informal enquiries to r.edwards[at]soton.ac.uk are encouraged. Please quote reference number 5441-11-F on all correspondence.

    DEADLINE

    16 May 2011

Discussion forums: Opportunity: 3 Year BBSRC Post-Doctoral Research Fellow - PPI & Mol Evol (#5441-11-F) @ U Southampton, UK

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