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BACKGROUND

A central goal of cancer research is the development of methods to predict vulnerabilities of individual tumors based upon their molecular features. To this end, the Broad Institute is undertaking an interdisciplinary approach using genetic and chemical disruption of genes and pathways in hundreds of well-annotated model systems of cancer, and creating high-throughput datasets of tumor vulnerabilities. To enhance the seamless integration of data and analyses derived from different types of molecular perturbation, we are undertaking the computational challenge of merging these datasets into a central, easily accessible database.

RESPONSIBILITIES

Overall Responsibilities:
This individual will work to develop this database and associated Web-based tools that enable computational and experimental biologists to integrate and analyze data from various high-throughput biology projects, including small-molecule, RNAi, and genomic variation data in cancer-related cell lines. Specific work will focus on the development of an integrated data model and associated means to query the integrated data in a robust, easy to use and stable manner. We envision that a working database, object-relational mapping, and initial query tools will comprise the main work products for the first 12-18 months. An important goal for that term will be to provide for easy maintenance of the database by computational biologists in the future. An overarching responsibility of this individual will be to work closely members of the Cancer Program and Chemical Biology Program communities to help to set and execute a longer term vision for data integration at the interface of these disciplines.

Characteristic Duties:

Develop and implement a finalized schema from an existing information model
Integrate data across formats and sources by robust synchronization with existing transactional systems
Work with researchers to specify, design, and implement database-driven Web applications that serve as a front-end to retrieval and analysis tools
Design and implement interfaces to back-end analysis tools
Enable computational scientists to build sophisticated queries and tools by creating materialized views and object-relational maps facilitating rapid prototyping of new analyses
Work with technical writers to document functionality

REQUIREMENTS

Bachelor's or Masters in Computer Science, Engineering, Statistics, Physics, or any quantitative discipline
Experience with at least one modern language (2+ desirable)
Expertise in server- and client-side web development required
Knowledge of relational databases (e.g. Oracle) and SQL required
Bioinformatics Analyst (3+ years experience) or Senior Bioinformatics Analyst (6+ years experience) with biological datasets and/or exposure to an analytic field such as bioinformatics, computational biology, machine learning, or statistics required
Application integration experience (e.g. web services, messaging) a plus
Data warehousing experience a plus
Familiarity with genomic databases or prior experience interacting with such databases helpful
Sensitivity to end-user needs, reflected in design of user interface and application workflow
Excellent written and verbal communications skills
Self-starter with excellent problem-solving, organizational, and people skills
Adaptable to rapidly-changing and high-demand environments

LOCALE

Cambridge, MA

HOW TO APPLY

Please visit http://www.broadinstitute.org/careers/career-center and search for job 774

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