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    Opportunity: Postdoctoral Fellow in Single Cell Genomics (#81231) @ Wellcome Trust Sanger Institute--Hinxton, Cambridge, UK
    Submitted by Sam Bowker; posted on Friday, June 22, 2012


    The Wellcome Trust Sanger Institute is a world leader in genomic research, with an expanding scientific programme dedicated to understanding gene function in health & disease.

    The Sanger Institute is currently seeking a highly talented postdoctoral fellow with strong laboratory and analytical skills to drive a new programme in Single Cell Genomics headed jointly by two new Associate Faculty members, Thierry Voet and Chris Ponting. The successful applicant would play a prominent role in developing new approaches to understand DNA and RNA sequence differences among single cells.

    The ability to accurately interpret (simultaneously) DNA- and RNA-sequence from single cells will revolutionise our understanding of somatic genomic variation, cell type differences, developmental processes, the degree of stochasticity of transcript levels amongst cells of the same type, DNA-mutation rates and mechanisms, genetic mosaicism and disease/phenotype aetiology.
    The 2 year position offers scope for the development of methods for whole-genome amplification and sequencing library preparation from small amounts of input DNA and RNA. The postholder will be required to participate in, and develop, the computational analysis of sequencing data generated by this project. The successful candidate will also have the challenge and opportunities afforded by being in a world-class research institution, in groups led by experts in reproductive genomics and computational genomics.


    Essential Skills:
    • A PhD in Genomics, Genetics, (Computational) Biology (or similar), and a passion for problem solving
    • Proven cell culture and molecular biology skills are an essential requirement, including: DNA- and RNA-extraction methods, amplification protocols, Molecular cloning, vector construction, sequencing protocols.
    • Understanding and experience in analysing large datasets using at least one statistical package (e.g. R/SPLUS, SAS) and programming experience (e.g. Perl, Python, C++, Java).
    • Excellent written and spoken English are essential
    • Must be able to effectively communicate with collaborators and occasionally present oral communication to large groups
    • Proven independent working style, technical problem solving, data analysis and generation of novel ideas.


    Ideal Skills:
    • Extensive programming experience and computational analysis of next generation sequence data.
    • Experience in cell culture, DNA- and RNA-seq protocols
    • Experience in supervising and training other laboratory personnel in specialized techniques and presenting results at scientific conferences [posters and talks].


    As a world leader in human genomics, genome informatics, and whole genome DNA sequencing, the Wellcome Trust Sanger Institute (WTSI) is now focusing large-scale genotyping, DNA sequencing, and mathematical analysis on illuminating the biology of different cell types. The postholder will develop protocols for simultaneous genome and transcriptome sequence analysis of one human / mouse cell. Thus far, no such protocol is available off-the-shelf. He/she will be a main driver in genomics projects in the fields of cancer-, neuro- and developmental genetics carried out at the Institute that involve single-cell analyses.


    Postdoctoral Fellows are typically in their first or second postdoctoral position as part of a period of early career research training. The post is a two year fixed-term contract.


    Salary range GBP 28,563 to GBP 35,795 per annum depending on experience

    Successful applicant(s) who have submitted their PhD thesis and are awaiting their PhD award to be confirmed will be placed on a transitional pay point, currently GBP 26364 per annum. On confirmation applicants will be moved on to the pay scale above.

    The Institute has excellent purpose built facilities on the Genome Campus, Hinxton on the outskirts of Cambridge. We offer a comprehensive range of benefits including a final salary pension scheme and excellent on-site facilities. Further details can be found on our website


    To submit your CV and apply for this job please go to to register and apply.


    Interviews are planned to take place on 15 and 16 August 2012
    The closing date for applications is 20 July 2012

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