Dear deying, I can see that you are probably an expert in bioinformatics. But, it is apparent you are not one in software technology. There is nothing wrong in you considering a C# based bioinformatics tool/toolset. But, the reasons you provide are wrong and plain misleading. That, my friend is very irresponsible. Any software in Perl and Java can be easily executed on windows platfrom. Runtime environments - JVM for Java and Perl interpreter for Perl are easily available for windows. Also, if enduser usability was the a concern, one expects that you have a look at Mac systems too. Nevertheless, just say you are looking a C# and .Net just because you would like to explore the possibility. I request you to refrain from making statements which hurt your credibility. Take care.