Why not support Unix/Linux? Java, Perl or Python are also elegant and powerfull and freely avaible. Linux can be as easy as windows, with a very good GUI too, its just a matter of time to Linux become the choice in most molecular biology labs. And, Linux is much more stable and reliable than windows, if you are doing a research, you d ont want a blue screen error message when are saving a special sequence or analysis results or reset your computer after each run of a local BLAST search to free memory.

If there is people coding bioperl, there is people coding biopython. That is real redundance.

Bioperl and Biopython have different approaches. Read the documentation :-)