Basic Information
Gene ID 41709
Gene Name foxo; Afx; CG3143
Full Name Forkhead box protein O
Organism Drosophila melanogaster [7227]

Cross Reference
UniProt Q95V55 UniGene Dm.3957
PDB NULL OMIM NULL
KEGG dme:Dmel_CG3143 UCSC CG3143-RB

Protein Interactions
DIP NULL
IntAct Q95V55
MINT MINT-831229
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
FBpp0089344 Gene3D G3DSA:1.10.10.10 IPR011991 87 176 1.90e-44 Winged helix-turn-helix DNA-binding domain
FBpp0089344 Pfam PF00250 IPR001766 98 180 5.00e-22 Transcription factor, fork head
FBpp0089344 PRINTS PR00053 IPR001766 116 133 7.20e-12 Transcription factor, fork head
FBpp0089344 PRINTS PR00053 IPR001766 144 161 7.20e-12 Transcription factor, fork head
FBpp0089344 PRINTS PR00053 IPR001766 95 108 7.20e-12 Transcription factor, fork head
FBpp0089344 ProSitePatterns PS00658 IPR018122 144 150 - Transcription factor, fork head, conserved site
FBpp0089344 ProSiteProfiles PS50039 IPR001766 95 201 0.00e-00 Transcription factor, fork head
FBpp0089344 SMART SM00339 IPR001766 93 182 3.20e-44 Transcription factor, fork head

Pfam Annotation
Protein Pfam ID E.value Name Description
FBpp0089344 PF00250 5e-22 Fork_head Fork head domain

Gene Ontology Annotation
Protein Entry Name Space Description
FBpp0089344 GO:0006351 biological_process transcription, DNA-templated
FBpp0089344 GO:0006355 biological_process regulation of transcription, DNA-templated
FBpp0089344 GO:0007049 biological_process cell cycle
FBpp0089344 GO:0007275 biological_process multicellular organismal development
FBpp0089344 GO:0008285 biological_process negative regulation of cell proliferation
FBpp0089344 GO:0010259 biological_process multicellular organismal aging
FBpp0089344 GO:0019216 biological_process regulation of lipid metabolic process
FBpp0089344 GO:0030154 biological_process cell differentiation
FBpp0089344 GO:0030308 biological_process negative regulation of cell growth
FBpp0089344 GO:0040008 biological_process regulation of growth
FBpp0089344 GO:0042593 biological_process glucose homeostasis
FBpp0089344 GO:0046627 biological_process negative regulation of insulin receptor signaling pathway
FBpp0089344 GO:0005634 cellular_component nucleus
FBpp0089344 GO:0005737 cellular_component cytoplasm
FBpp0089344 GO:0003677 molecular_function DNA binding
FBpp0089344 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
FBpp0089344 GO:0043565 molecular_function sequence-specific DNA binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
7029 Acyrthosiphon pisum 100168097 10224 Saccoglossus kowalevskii 100303473
132113 Bombus impatiens 100745007 10029 Cricetulus griseus 100756577
143995 Megachile rotundata 100882630 39432 Saimiri boliviensis 101039948
31033 Takifugu rubripes 101072519 9595 Gorilla gorilla 101151399
9669 Mustela putorius furo 101684130 8083 Xiphophorus maculatus 102225439
9606 Homo sapiens 2309 7425 Nasonia vitripennis 100123890
6087 Hydra magnipapillata 100202184 8090 Oryzias latipes 100301620
9601 Pongo abelii 100460676 400682 Amphimedon queenslandica 100635906
30195 Bombus terrestris 100643217 7463 Apis florea 100867766
34638 Metaseiulus occidentalis 100899828 30611 Otolemur garnettii 100948347
9597 Pan paniscus 100996020 9555 Papio anubis 101017109
9598 Pan troglodytes 467352 10090 Mus musculus 56484
7668 Strongylocentrotus purpuratus 585334 10116 Rattus norvegicus 84482
28377 Anolis carolinensis ENSACAG00000016628 9646 Ailuropoda melanoleuca ENSAMEG00000011714
9913 Bos taurus ENSBTAG00000044105 7719 Ciona intestinalis ENSCING00000023214
9483 Callithrix jacchus ENSCJAG00000017816 51511 Ciona savignyi ENSCSAVG00000008339
10020 Dipodomys ordii ENSDORG00000013871 9796 Equus caballus ENSECAG00000015262
9365 Erinaceus europaeus ENSEEUG00000014132 9685 Felis catus ENSFCAG00000024925
69293 Gasterosteus aculeatus ENSGACG00000017029 9031 Gallus gallus ENSGALG00000017034
8049 Gadus morhua ENSGMOG00000005771 7897 Latimeria chalumnae ENSLACG00000009595
9785 Loxodonta africana ENSLAFG00000028324 9103 Meleagris gallopavo ENSMGAG00000002173
13616 Monodelphis domestica ENSMODG00000017333 61853 Nomascus leucogenys ENSNLEG00000001131
9986 Oryctolagus cuniculus ENSOCUG00000010471 8128 Oreochromis niloticus ENSONIG00000016186
9813 Procavia capensis ENSPCAG00000005483 13735 Pelodiscus sinensis ENSPSIG00000007776
9305 Sarcophilus harrisii ENSSHAG00000003662 9823 Sus scrofa ENSSSCG00000009370
43179 Ictidomys tridecemlineatus ENSSTOG00000009697 37347 Tupaia belangeri ENSTBEG00000011894
59729 Taeniopygia guttata ENSTGUG00000012008 9478 Tarsius syrichta ENSTSYG00000006122
30538 Vicugna pacos ENSVPAG00000000815 9615 Canis familiaris 481954
7955 Danio rerio 567969 7070 Tribolium castaneum 664090
7460 Apis mellifera 727091 10141 Cavia porcellus ENSCPOG00000021906
9361 Dasypus novemcinctus ENSDNOG00000005257 9371 Echinops telfairi ENSETEG00000004130
9315 Macropus eugenii ENSMEUG00000012979 30608 Microcebus murinus ENSMICG00000014311
59463 Myotis lucifugus ENSMLUG00000029037 9544 Macaca mulatta ENSMMUG00000032429
9258 Ornithorhynchus anatinus ENSOANG00000015514 9978 Ochotona princeps ENSOPRG00000008735
132908 Pteropus vampyrus ENSPVAG00000012042 42254 Sorex araneus ENSSARG00000008583
99883 Tetraodon nigroviridis ENSTNIG00000011758 9739 Tursiops truncatus ENSTTRG00000017232
8364 Xenopus tropicalis ENSXETG00000012944