Basic Information
Gene ID 2309 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name FOXO3; FKHRL1, FOXO3A
Full Name Forkhead box protein O3
Organism Homo sapiens [9606]

Cross Reference
UniProt O43524 UniGene Hs.220950
PDB 2UZK OMIM 602681
KEGG hsa:2309 UCSC uc003psk.2

Protein Interactions
DIP DIP-29723N
IntAct O43524
MINT MINT-89098
STRING 9606.ENSP00000339527

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000339527 Gene3D G3DSA:1.10.10.10 IPR011991 150 238 6.60e-43 Winged helix-turn-helix DNA-binding domain
ENSP00000339527 Pfam PF00250 IPR001766 160 241 4.70e-21 Transcription factor, fork head
ENSP00000339527 PRINTS PR00053 IPR001766 157 170 3.20e-11 Transcription factor, fork head
ENSP00000339527 PRINTS PR00053 IPR001766 178 195 3.20e-11 Transcription factor, fork head
ENSP00000339527 PRINTS PR00053 IPR001766 206 223 3.20e-11 Transcription factor, fork head
ENSP00000339527 ProSitePatterns PS00658 IPR018122 206 212 - Transcription factor, fork head, conserved site
ENSP00000339527 ProSiteProfiles PS50039 IPR001766 157 251 0.00e-00 Transcription factor, fork head
ENSP00000339527 SMART SM00339 IPR001766 155 245 4.30e-48 Transcription factor, fork head

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000339527 PF00250 2.7e-21 Fork_head Fork head domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000339527 GO:0006351 biological_process transcription, DNA-templated
ENSP00000339527 GO:0006915 biological_process apoptotic process
ENSP00000339527 GO:0006974 biological_process cellular response to DNA damage stimulus
ENSP00000339527 GO:0008286 biological_process insulin receptor signaling pathway
ENSP00000339527 GO:0045893 biological_process positive regulation of transcription, DNA-templated
ENSP00000339527 GO:0045944 biological_process positive regulation of transcription from RNA polymerase II promoter
ENSP00000339527 GO:0005634 cellular_component nucleus
ENSP00000339527 GO:0005737 cellular_component cytoplasm
ENSP00000339527 GO:0005829 cellular_component cytosol
ENSP00000339527 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSP00000339527 GO:0043565 molecular_function sequence-specific DNA binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
7425 Nasonia vitripennis 100118797 10224 Saccoglossus kowalevskii 100303473
10029 Cricetulus griseus 100770315 143995 Megachile rotundata 100882630
7897 Latimeria chalumnae 102359675 6087 Hydra magnipapillata 100202184
8090 Oryzias latipes 100301621 9601 Pongo abelii 100460676
400682 Amphimedon queenslandica 100635906 30195 Bombus terrestris 100643217
8128 Oreochromis niloticus 100700657 132113 Bombus impatiens 100745007
7463 Apis florea 100867766 34638 Metaseiulus occidentalis 100899828
30611 Otolemur garnettii 100948347 9597 Pan paniscus 100976373
9555 Papio anubis 101022550 39432 Saimiri boliviensis 101039948
31033 Takifugu rubripes 101072269 9669 Mustela putorius furo 101684130
43179 Ictidomys tridecemlineatus 101957921 8083 Xiphophorus maculatus 102217263
59463 Myotis lucifugus 102440021 7227 Drosophila melanogaster 41709
9598 Pan troglodytes 462921 10090 Mus musculus 56484
7668 Strongylocentrotus purpuratus 585334 7070 Tribolium castaneum 664090
7460 Apis mellifera 727091 28377 Anolis carolinensis ENSACAG00000016628
9646 Ailuropoda melanoleuca ENSAMEG00000008158 9913 Bos taurus ENSBTAG00000044105
7719 Ciona intestinalis ENSCING00000023214 9483 Callithrix jacchus ENSCJAG00000017816
51511 Ciona savignyi ENSCSAVG00000008339 7955 Danio rerio ENSDARG00000042904
10020 Dipodomys ordii ENSDORG00000013871 9796 Equus caballus ENSECAG00000015262
9365 Erinaceus europaeus ENSEEUG00000014132 69293 Gasterosteus aculeatus ENSGACG00000008910
9031 Gallus gallus ENSGALG00000015297 9595 Gorilla gorilla ENSGGOG00000003517
9785 Loxodonta africana ENSLAFG00000028324 9315 Macropus eugenii ENSMEUG00000014523
9103 Meleagris gallopavo ENSMGAG00000002173 9544 Macaca mulatta ENSMMUG00000029632
13616 Monodelphis domestica ENSMODG00000017333 61853 Nomascus leucogenys ENSNLEG00000001131
9258 Ornithorhynchus anatinus ENSOANG00000000768 9986 Oryctolagus cuniculus ENSOCUG00000010471
9813 Procavia capensis ENSPCAG00000008041 13735 Pelodiscus sinensis ENSPSIG00000007776
132908 Pteropus vampyrus ENSPVAG00000001137 42254 Sorex araneus ENSSARG00000005586
9305 Sarcophilus harrisii ENSSHAG00000018299 9823 Sus scrofa ENSSSCG00000004387
37347 Tupaia belangeri ENSTBEG00000012196 99883 Tetraodon nigroviridis ENSTNIG00000019314
9478 Tarsius syrichta ENSTSYG00000006122 30538 Vicugna pacos ENSVPAG00000000815
8364 Xenopus tropicalis ENSXETG00000012944 10116 Rattus norvegicus 294515
9615 Canis familiaris 481954 10141 Cavia porcellus ENSCPOG00000021906
9361 Dasypus novemcinctus ENSDNOG00000005257 9371 Echinops telfairi ENSETEG00000004130
9685 Felis catus ENSFCAG00000030227 8049 Gadus morhua ENSGMOG00000012748
30608 Microcebus murinus ENSMICG00000014311 9978 Ochotona princeps ENSOPRG00000008735
59729 Taeniopygia guttata ENSTGUG00000012135 9739 Tursiops truncatus ENSTTRG00000017232