Basic Information
Gene ID 4205 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name MEF2A; MEF2
Full Name Myocyte-specific enhancer factor 2A
Organism Homo sapiens [9606]

Cross Reference
UniProt Q02078 UniGene Hs.268675
PDB 3P57 OMIM 608320
KEGG hsa:4205 UCSC uc010urw.2

Protein Interactions
DIP DIP-40711N
IntAct Q02078
MINT MINT-104848
STRING 9606.ENSP00000346389

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000453095 Pfam PF00319 IPR002100 10 59 8.30e-22 Transcription factor, MADS-box
ENSP00000453095 Pfam PF12347 IPR022102 95 152 1.30e-05 Holliday junction regulator protein family C-terminal
ENSP00000453095 PRINTS PR00404 IPR002100 23 38 1.40e-25 Transcription factor, MADS-box
ENSP00000453095 PRINTS PR00404 IPR002100 3 23 1.40e-25 Transcription factor, MADS-box
ENSP00000453095 PRINTS PR00404 IPR002100 38 59 1.40e-25 Transcription factor, MADS-box
ENSP00000453095 ProSitePatterns PS00350 IPR002100 3 57 - Transcription factor, MADS-box
ENSP00000453095 ProSiteProfiles PS50066 IPR002100 1 61 0.00e-00 Transcription factor, MADS-box
ENSP00000453095 SMART SM00432 IPR002100 1 60 1.60e-39 Transcription factor, MADS-box
ENSP00000453095 SUPERFAMILY SSF55455 IPR002100 2 89 0.00e-00 Transcription factor, MADS-box

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000453095 PF00319 4.8e-22 SRF-TF SRF-type transcription factor (DNA-binding and dimerisation domain)
ENSP00000453095 PF12347 3.5e-06 HJURP_C Holliday junction regulator protein family C-terminal repeat

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000453095 GO:0000122 biological_process negative regulation of transcription from RNA polymerase II promoter
ENSP00000453095 GO:0000165 biological_process MAPK cascade
ENSP00000453095 GO:0006351 biological_process transcription, DNA-templated
ENSP00000453095 GO:0006915 biological_process apoptotic process
ENSP00000453095 GO:0045944 biological_process positive regulation of transcription from RNA polymerase II promoter
ENSP00000453095 GO:0071277 biological_process cellular response to calcium ion
ENSP00000453095 GO:0005634 cellular_component nucleus
ENSP00000453095 GO:0000977 molecular_function RNA polymerase II regulatory region sequence-specific DNA binding
ENSP00000453095 GO:0000981 molecular_function sequence-specific DNA binding RNA polymerase II transcription factor activity
ENSP00000453095 GO:0003677 molecular_function DNA binding
ENSP00000453095 GO:0003682 molecular_function chromatin binding
ENSP00000453095 GO:0046983 molecular_function protein dimerization activity

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9258 Ornithorhynchus anatinus 100076657 6087 Hydra magnipapillata 100204453
10224 Saccoglossus kowalevskii 100313657 400682 Amphimedon queenslandica 100636842
30195 Bombus terrestris 100649884 132113 Bombus impatiens 100745731
7463 Apis florea 100871942 143995 Megachile rotundata 100877544
9597 Pan paniscus 100989820 9555 Papio anubis 101002825
39432 Saimiri boliviensis 101041298 31033 Takifugu rubripes 101063649
9685 Felis catus 101098464 7897 Latimeria chalumnae 102348604
13735 Pelodiscus sinensis 102454317 10090 Mus musculus 17258
6239 Caenorhabditis elegans 172732 7227 Drosophila melanogaster 36032
7460 Apis mellifera 413946 9796 Equus caballus 100050068
7029 Acyrthosiphon pisum 100572713 10029 Cricetulus griseus 100754401
34638 Metaseiulus occidentalis 100902919 9913 Bos taurus ENSBTAG00000020701
30608 Microcebus murinus ENSMICG00000008255 9669 Mustela putorius furo ENSMPUG00000010826
7668 Strongylocentrotus purpuratus 591326 7070 Tribolium castaneum 660448
28377 Anolis carolinensis ENSACAG00000000488 9646 Ailuropoda melanoleuca ENSAMEG00000003398
9615 Canis familiaris ENSCAFG00000010775 9358 Choloepus hoffmanni ENSCHOG00000010767
7719 Ciona intestinalis ENSCING00000000628 9483 Callithrix jacchus ENSCJAG00000005848
10141 Cavia porcellus ENSCPOG00000008716 51511 Ciona savignyi ENSCSAVG00000003571
7955 Danio rerio ENSDARG00000057527 9361 Dasypus novemcinctus ENSDNOG00000018848
10020 Dipodomys ordii ENSDORG00000015216 9365 Erinaceus europaeus ENSEEUG00000015651
9371 Echinops telfairi ENSETEG00000018987 69293 Gasterosteus aculeatus ENSGACG00000013182
9031 Gallus gallus ENSGALG00000007100 9595 Gorilla gorilla ENSGGOG00000013064
8049 Gadus morhua ENSGMOG00000015431 9785 Loxodonta africana ENSLAFG00000004656
9315 Macropus eugenii ENSMEUG00000013873 9103 Meleagris gallopavo ENSMGAG00000009283
59463 Myotis lucifugus ENSMLUG00000016420 9544 Macaca mulatta ENSMMUG00000018122
13616 Monodelphis domestica ENSMODG00000020223 61853 Nomascus leucogenys ENSNLEG00000012609
9986 Oryctolagus cuniculus ENSOCUG00000010966 30611 Otolemur garnettii ENSOGAG00000008728
8128 Oreochromis niloticus ENSONIG00000015126 9978 Ochotona princeps ENSOPRG00000014581
8090 Oryzias latipes ENSORLG00000008489 9813 Procavia capensis ENSPCAG00000013783
9601 Pongo abelii ENSPPYG00000006816 9598 Pan troglodytes ENSPTRG00000007496
132908 Pteropus vampyrus ENSPVAG00000014423 10116 Rattus norvegicus ENSRNOG00000033134
42254 Sorex araneus ENSSARG00000009233 9305 Sarcophilus harrisii ENSSHAG00000016994
9823 Sus scrofa ENSSSCG00000004815 43179 Ictidomys tridecemlineatus ENSSTOG00000028856
37347 Tupaia belangeri ENSTBEG00000006420 59729 Taeniopygia guttata ENSTGUG00000008733
99883 Tetraodon nigroviridis ENSTNIG00000019231 9478 Tarsius syrichta ENSTSYG00000001620
9739 Tursiops truncatus ENSTTRG00000015831 30538 Vicugna pacos ENSVPAG00000011436
8364 Xenopus tropicalis ENSXETG00000018788 8083 Xiphophorus maculatus ENSXMAG00000003697

Paralogs
4207 ENSG00000064489