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BACKGROUND

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch's pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer with minimal side effects. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation's first and largest cancer prevention research program, as well as the clinical coordinating center of the Women's Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

The Genetics and Epidemiology of Colorectal Cancer (GECCO) is an NCI funded consortium of international collaborators that aims to identify genetic susceptibility loci associated with colorectal cancer risk, and to investigate interactions between genetic and environmental risk factors. We are utilizing a custom panel design to run high coverage targeted sequencing on ~4,000 colorectal tumor samples to better determine CRC tumor subtypes (including point mutations, copy number alternations (CNA), and microsatellite instability status (MSI)). We will utilize this subtype information in analyses to better characterize and identify novel associations with germline DNA and epidemiologic risk factors. Additionally, there will be opportunities for several other analyses unrelated to grant aims (e.g., relating tumor data to clinical outcomes, etc.).

RESPONSIBILITIES

The candidate will work with coordinating center staff, the PI, and the sequencing lab (Ontario Institute for Cancer Research, OICR) to assess performance of the panel design, assist with data quality control analyses, call CNA and MSI status, run CNA analyses, and assist with other types of analyses (e.g., point mutation calling, definition of appropriate pathways for pathway driven analyses, etc.). S/he will also take the lead working with available TCGA data to incorporate into our planned tumor marker analyses, as well as other types of analyses within the consortium (e.g., GWAS, eQTL, etc.).

Additionally, the candidate will help manage and analyze datasets, provide programming support, and contribute to manuscript preparation, as required. S/he should be able to install and configure the appropriate hardware and software for analyses, maintain user interface programs and software tools to manage and analyze data sets, and maintain current knowledge of publicly available data and associated software tools. The candidate will perform other responsibilities, as required.

REQUIREMENTS

To be considered, the successful candidate must have:

A graduate degree in bioinformatics, biostatistics, or a scientific field such as biology, genetics, or chemistry
Experience analyzing tumor sequencing data and solid training in biostatistics and bioinformatics
Previous experience working with large datasets and high performance computing environments

The successful candidate will be well-organized, detail-oriented, and have excellent oral and written communication skills.

PREFERENCES

Advanced computer skills, strong familiarity with publicly available data (such as TCGA, ENCODE, and RoadMap), and experience using associated software/tools is highly preferred.

LOCALE

Seattle, WA

COMPENSATION

DOE

HOW TO APPLY

Please visit http://www.fredhutch.org/en/careers.html

Please apply with a cover letter summarizing previous work experience and suitability for this position.

Discussion forums: Opportunity: System Analyst/Programmer II (Bioinformatics Scientist) @ Fred Hutchinson Cancer Research Center -- Seattle, WA (US)

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