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    Opportunity: PhD positions in genome-scale proteomics, imaging-based screening & cancer biology @ DTU -- Lyngby, Denmark
    Submitted by Signatur AS; posted on Wednesday, December 05, 2012


    The Cellular Signal Integration Group (C-SIG),, is a network biology research group located at the Department of Systems Biology at the Technical University of Denmark (DTU). Our department represents one of the largest network biology centers in academia and has a highly multi-disciplinary profile. In our lab, we explore biological systems by both generating high-throughput data and developing and deploying algorithms aimed at predicting cell behavior with accuracy similar to that of weather or aircraft models. A major focus is on studying cellular signal processing and decision-making during cancer progression.


    Two PhD positions are available in the Linding Lab. Prof Dr Linding is a world-leading network biologist whose laboratory is interested in the mechanisms by whi¬ch cells use signaling networks to respond and adapt to changes in their environment. We are seeking highly motivated, bright researchers to join our highly dynamic, productive and stimulating lab.

    In these positions, the successful applicants will work in a fast-paced dynamic environment, performing large-scale integrative studies to advance research into biological and complex systems in order to develop a new understanding of evolution and therapies for human diseases.

    We are seeking experienced and motivated PhD students to work on projects related to our recent studies on phosphorylation networks and network medicine(Creixell et al. 20012 Nature Biotechnology, Erler & Linding Cell 2012, Bakal, Linding et al. Science 2008, Tan et al. Science 2009 and Tan et al. Science 2011 and Jørgensen et al. Science 2009).The projects involve different combinations of RNAi screening, mass-spectrometry, NGS/genomics and large-scale cell culturing. By combining computational modelling with genomics, quantitative phospho-proteomics and high-throughput imaging we aim to perform global modeling of biological systems and to systematically investigate dysregulation of signaling networks in cancer.


    Candidates should hold a MSc degree in systems biology, molecular biology, computer science, physics or chemistry or another relevant field, and have experience in cell biology. Experience in large-scale/systems studies is desirable. Experience in mammalian tissue culture, cell imaging, genomics, signal transduction, bioinformatics, programming, mass-spectrometry and quantitative proteomics or phospho-proteomics is a distinct advantage. Experience with LINUX and HPC technical computing is an advantage.

    The candidate must be keen to generate, analyze and computationally handle large-scale quantitative data to reach a deeper understanding of biological question at hand. Applicants should be able to work independently and to plan and carry out complicated tasks, while also being part of a large and dynamic group. Good communication skills in English, both written and spoken are required


    The period of employment is 3 years.

    The scholarships for the PhD degree are subject to academic approval, and the candidates will be enrolled in one of the general degree programmes of DTU. For information about the general requirements for enrollment and the general planning of the scholarship studies, please see the DTU PhD Guide ([...].aspx).

    The C-SIG lab is part of the Center for Biological Sequence Analysis (CBS) at the Technical University of Denmark (DTU). CBS represents one of the largest systems and computational biology centers in academia and has a highly multi-disciplinary profile. DTU strives for academic excellence, collegial respect and freedom tempered by responsibility. DTU is a leading technical university in Europe and ranks with the best universities in the world. We offer a highly attractive training environment and the opportunity to take part in a frontier research program combating cancer.


    The salary and appointment terms are consistent with the current rules for PhD degree students.


    Apply at

    Applications must be submitted as one pdf file containing all materials to be given consideration. To apply, please open the link "Apply online," fill in the online application form, and attach all your materials in English in one pdf file. The file must include:
    • A letter motivating the application (cover letter, max 1 page)
    • Curriculum vitae
    • Grade transcripts and BSc/MSc diploma
    • Excel sheet with translation of grades to the Danish grading system (see guidelines and excel spreadsheet here:[...]k.xls)
    Please do not include reprints of already published papers in your application. The material that should be given consideration in the assessment must be attached.

    Candidates may apply prior to obtaining their master's degree, but cannot begin before having received it.

    Further information may be obtained from Prof Rune Linding, +45 2365 1941 or linding[at] or from center administrator Dorthe Kjærsgaard, + 45 4525 2480 or dorthek[at]

    You can read more about Rune Linding's Research Group at


    By 31 January 2013

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