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    BACKGROUND

    The NYU Metabolomics Core Resource Laboratory is a new facility designed to offer cutting edge and custom metabolomics services to the Langone Medical Center campus. The core specializes in mass-spectrometry based metabolomics, offering both global untargeted and targeted methods for metabolite identification and quantification. The Bioinformatician will work on the continuing development of advanced software tools to analyze global LCMS data which makes complex metabolomic information useful to investigators. The Bioinformatician will also aid in the analysis of specific projects and datasets, working closely with other staff and clients of the NYU Metabolomics Core Resource Laboratory. All staff in the core will continue to develop their scientific knowledge through active participation in meetings, conferences, and relevant training. The Bioinformatician will report to the Director of the NYU Metabolomics Core Resource Laboratory. The successful candidate will have expertise in Perl, with prior experience in the development of high-performance software for omics.

    RESPONSIBILITIES

    Development of novel algorithms for metabolomics data analysis and application of

    REQUIREMENTS

    Ph.D. in a Life Sciences field, specializing in bioinformatics, expertise with Perl and R

    PREFERENCES

    Experience with PHP, and past development of high performance bioinformatic software

    LOCALE

    New York, NY

    HOW TO APPLY

    Please submit application through www.indeed.com (employers.indeed.com/j#jo[...]368f9)

    DEADLINE

    Rolling

    BACKGROUND

    A Bioinformaticist/Research Programmer position is available immediately at the University of North Carolina, Chapel Hill. The successful applicant will join a team of academic researchers working in the area of high-throughput genomics, and will play a key role in ongoing NIH sponsored research on expression quantitative trait loci (eTL) analysis that is being carried out as part of the Genotype-Tissue Expression (GTEx) consortium. The primary focus of the position is the development, testing, and maintenance of publicly available statistical software, and underlying methodology, for use by researchers in genomics and biomedicine.

    We have a strong research group involving two PIs, graduate students and post-docs, that is actively working and publishing in genomics, bioinformatics, and biostatistics. While our emphasis is on eQTL analysis, group members are also working in the areas of toxicology, data mining, and machine learning. The successful applicant will be integral member of the research group, and will have the opportunity to play a leading role in methodological and software development, and be a co-author on group publications.

    RESPONSIBILITIES & REQUIREMENTS

    • Assisting in development and testing of new software, primarily in R, in conjunction with other members of the research group
    • Maintaining and updating existing software packages
    • Handling high throughput data from a variety of genomics platforms
    • Masters or Doctoral degree in a discipline related to computer science, statistics, or genetics
    Technical Skills:
    Required: High-level of programming capability and experience
    Desirable: some basic knowledge of statistics, genetics, and computational biology

    LOCALE

    Chapel Hill, NC

    COMPENSATION

    Dependent on skills and experience

    HOW TO APPLY

    For more details and how to apply: unc.peopleadmin.com/postings/111125

    All applications must be received through the UNC application system.

    DEADLINE

    Open until filled

    BACKGROUND

    The London Institute of Medical Sciences (LMS) at Hammersmith Hospital is the third directly funded MRC research institute and enjoys close links with its partners at Imperial College and at the Imperial College Healthcare NHS Trust. The LMS research focuses on strengthening the basic science underpinning our understanding of human diseases and the translation of such high quality research into a clinical setting.

    RESPONSIBILITIES

    The post provides a unique opportunity to work both with leading edge experimental and bioinformatics techniques across the diversity of research topics within the LMS and in establishing the bioinformatics infrastructure necessary to maintain high quality computational proteomics research within the institute. For more information, please visit www.lms.mrc.ac.uk.

    REQUIREMENTS

    We are seeking a skilled and highly motivated Bioinformatician to work within the LMS's Bioinformatics Team and alongside the LMS proteomics facility. An in depth knowledge of biology and bioinformatics is required. Experience in high throughput proteomics analysis, using/writing R/Bioconductor packages, bioinformatics programming (Python, Java, C++) and web programming would be highly desired.

    TERMS

    3 Year fixed term

    LOCALE

    Hammersmith Hospital
    London, UK

    COMPENSATION

    £34,988 to £37,801 pa inclusive

    HOW TO APPLY

    For full details of this post and to complete an online application, visit mrc.tal.net/vx/l[...]en-GB and upload your CV, names and contacts of two scientific references along with a brief cover letter describing research interests and motivation for the position. Please quote reference number LMS-481.

    Applications which do not provide a cover letter will not be considered.

    DEADLINE

    28 March 2017

    DESCRIPTION

    A consortium of universities and research institutes in Vienna (Austria) recently received a large grant aimed at making JAK-STAT signaling the most comprehensively characterized signaling pathway. To lead integrative analysis of various high-throughput data types, we are recruiting two bioinformatics postdocs with an interest in systems biology, functional genomics/epigenomics, prote-omics, or pathway modeling.

    Our group is part of the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences in Vienna. We com-bine a strong background in computational biology and bioinformatic methods development with a high-throughput laboratory, which allows us to validate computational predictions experimentally. We work closely with physicians at the Vienna General Hospital and the Medical University of Vienna, seeking to translate bioinformatic discoveries into novel diagnostic and therapeutic approaches.

    The Project (www.jak-stat.at):
    The JAK-STAT signaling pathway is central to cellular homeostasis and development, and it controls inflammation, infection and can-cer. The Viennese JAK-STAT community recently attracted funding from the Austrian Science Fund for a Special Research Programme (SFB) on JAK-STAT signaling, chromatin remodeling, and disease. This new project consortium builds upon long-standing collaborations and provides a productive, tightly interconnected network for interdisciplinary investigation of the complexities of mammalian gene regulation. It is hosted by the University of Veterinary Medicine Vienna (www.vetmeduni.ac.at; Richard Moriggl, Mathias Müller, Ve-ronika Sexl) and involves CeMM, Austrian Academy of Sciences (www.cemm.at; Christoph Bock), MFPL, University of Vienna (www.mfpl.ac.at; Thomas Decker) and the Medical University of Vienna (www.meduniwien.ac.at; Sylvia Knapp). The consortium will investigate principles that underlie switches in transcription directed by the chromatin landscape and 3D structure, such as those that occur in normal and aberrant development, in the reaction to infection, and in carcinogenesis. Consortium members have expertise in areas as comprising immunity, inflammation, hematopoietic malignancies, pharmacogenomics, epigenetics, bioinformatics, `disease-tailored' mouse models, and genome editing. The consortium's mission is to pave the way for novel therapeutic possibilities, especially with regard to personalized medicine.

    The Candidate(s):
    We are looking for highly motivated and academically outstanding candidates who want to advance their scientific career in the field of bioinformatics and computational systems biology. A strong candidate may have a background in the computational sciences (bioin-formatics, statistics, physics, engineering, etc.) and some prior experience with collaborative research in high-throughput biology. In the same way, we are considering applicants with a background in medicine or in biology (e.g., functional genomics, chemical biology, human genetics, molecular medicine, etc.) who have strong quantitative skills and a keen interest in pursuing systems medicine pro-jects. The successful candidates will have the opportunity to pursue bioinformatic methods development and lead consortium-wide analyses at the cutting edge of molecular systems biology. They will be trained by the entire consortium and associated faculty, em-powering them to make major contributions to future of pathway-driven personalized medicine. The available computational re-sources, massive-scale datasets, and bioinformatic mentoring will give them the freedom to explore new approach to computational systems biology. Postdoc salaries will follow the guidelines of the Austrian Science Fund (www.fwf.ac.at/en/r[...]costs).

    The Principal Investigator (scholar.google.com/cita[...]AAAAJ):
    Christoph Bock is a principal investigator at CeMM. He is also a guest professor at the Medical University of Vienna's Department for Laboratory Medicine, scientific coordinator of the Biomedical Sequencing Facility at CeMM, and an adjunct group leader for bioinfor-matics at the Max Planck Institute for Informatics. Christoph Bock obtained his PhD summa cum laude from Saarland University and the Max Planck Institute for Informatics in 2008, followed by three years of postdoctoral research at the Broad Institute of MIT and Har-vard, where he contributed to the NIH Roadmap Epigenomics project. He has been a principal investigator of BLUEPRINT (in the Inter-national Human Epigenome Consortium), and he co-initiated and is project leader of Genom Austria, a scientific and educational citizen science project that is the Austrian partner in the International Network of Personal Genome Projects. He has received several major research awards, including the Max Planck Society's Otto Hahn Medal (2009), a New Frontier Group grant by the Austrian Academy of Sciences (2015-2020), an ERC Starting Grant (2016-2021), and the Overton Prize of the International Society of Computational Biology (2017).

    The Institute (www.cemm.at):
    CeMM is an international research institute of the Austrian Academy of Sciences and a founding member of EU-LIFE. It has an outstand-ing track record of top-notch science (last five years: >10 papers in Nature/Cell/Science/NEJM, >25 papers in Nature/Cell sister jour-nals) and medical translation. With about hundred researchers, CeMM provides a truly collaborative and personal environment, while maintaining critical mass and all relevant technologies. Research at CeMM focuses on cancer, inflammation, and immune disorders. CeMM is located at the center of one of the largest medical campuses in Europe, within walking distance of Vienna's historical city center. A study by "The Scientist" placed CeMM among the top-5 best places to work in academia world-wide (the-scientist.com/2012[...]-2012). Vienna is frequently ranked the world's best city to live. It is a Unit-ed Nations city with a large English-speaking community. The official language at CeMM is English, and more than 40 different nation-alities are represented at the institute.

    HOW TO APPLY

    Please apply online cemm.at/care[...]ions/ with cover letter, CV, academic transcripts, and contact details of three referees. Applications will be reviewed on a rolling basis. Any application received by 31 March 2017 will be considered. Start dates are very flexible.

    DESCRIPTION

    The University of Sheffield and its associated Medical School and hospitals is ranked as one of the nation's top biomedical research institutions in patient care, research, and education. We seek an experienced computational biologist with Core services experience to become its Director and grow a Bioinformatics Core team.

    The Sheffield Bioinformatics Core (SBC) is dedicated to providing outstanding consultation to our researchers in need of informatics solutions and consulting support and provision of infrastructure for data management and analysis pipelines for commonly used omics. Led by you, it will comprise a multi-disciplinary team of senior and junior analysts, who will work with researchers across the University of Sheffield, its Medical School and the Sheffield Hospital Trusts community.

    The team will provide a comprehensive portfolio of infrastructure, data analysis, training and development. The Core will be part of the Bioinformatics Hub at the University of Sheffield. The Hub is committed to leading the development of computational biology and bioinformatics and its application to discoveries made by data analytics, enabled by open collaboration, highly integrated team science, and professional bioinformatics services for our researchers. It is made up of a team of academic staff who both research and teach bioinformatics and who liaise with the University Research Software Engineering team who deliver scientific software support to facilitate the teaching of data.

    This is a unique opportunity to participate in world-class research. As part of the SBC, you will be working directly with researchers on projects ranging from the interpretation of single cell transcriptomics, the interpretation of sequencing of patient genomes, to plant bioinformatics studies. You will work with centres, programmes and institutes across the University. This is a great opportunity to build and drive a cohesive, interactive team of experienced bioinformaticians.

    HOW TO APPLY

    Please see bit.ly/2lJyjhC for details, application and salary.

    BACKGROUND

    The Quantitative Biomedical Research Center (QBRC) is newly established at UT Southwestern Medical Center (UTSW). It aims to foster collaborations involving quantitative methods and technologies in any aspect of biomedical research, particularly for understanding disease etiologies and developing treatment and prevention strategies. Currently, the center has seven faculty members, several staff members, postdocs and student research assistants. We are actively recruiting new members (Postdoctoral Fellow, Data Scientist or Computational Biologist) to join this new and dynamic group.

    RESPONSIBILITIES

    The new member will work on one or more of several interesting topics. For postdocs, the projects include developing novel method for analysis and integration of tumor imaging and high-dimensional -omics data, developing prediction models for patients clinical outcomes. For Computational Biologists and Bioinformaticians, the projects include bioinformatics analysis of genomics and genetics data and statistical analysis of clinical and biological data. For Programmer, the projects include software, website and database development.

    At UTSW, there are great opportunities for postdocs to collaborate with outstanding biomedical investigators and work on exciting research projects. UT Southwestern provides a dynamic, collaborative, and integrative research and training environment with state-of-the-art facilities.

    REQUIREMENTS

    Candidates should have a doctoral degree in computer sciences, biomedical engineering, bioinformatics, biostatistics, electrical engineering, physics or a related field.

    LOCALE

    Dallas, Texas

    HOW TO APPLY

    Email application to Dr. Guanghua Xiao (Guanghua.Xiao[at]UTSouthwestern.edu)

    DEADLINE

    Until filled

    POLICY

    UT Southwestern Western Medical Center is an Affirmative Action/Equal Opportunity Employer. Women, minorities, veterans and individuals with disabilities are encouraged to apply.

    BACKGROUND

    The Wellcome Trust Sanger Institute conducts cutting edge genomic research and the focus of our group is to develop new methods and models that will further our understanding of gene expression and gene regulation. We are looking for a dynamic and motivated Postdoctoral Fellow to join the Hemberg Faculty Team and undertake research into neurobiology and bioinformatics. The successful candidate will be expected to contribute to the formulation and submission of research publications and research proposals as well as help manage and direct this complex and challenging project, as opportunities allow.

    RESPONSIBILITIES

    The primary goal of this position is to be involved in the Open Targets funded study of human neuronal cultures derived from patients with familial Alzheimer's disease (AD) mutations using single-cell RNA-seq (scRNA-seq). The main goal is to characterize and compare different cell-types for mutants and controls to identify the pathways that result in early onset AD. This will require using established pipelines and software for analysing scRNA-seq data, as well as developing novel methods for identifying differentially expressed genes and inferring gene regulatory networks. The project is a collaboration with the Livesey and Teichmann labs, and an important aspect of this role will be to interact with members of those groups for the analysis and interpretation of the data.

    REQUIREMENTS

    • PhD (or equivalent) in Mathematics, Physics or Computer Science
    • Ability to independently solve complex scientific/technical problems and manage scientific projects
    • Excellent communication skills
    • Self-motivation and diligence
    • Ability to work with an international group of scientists
    • Good publication track record

    PREFERENCES

    • Advanced bioinformatics skills in NGS data analysis
    • Good understanding of genomics and molecular biology
    • Strong programming skills
    • Experience with single-cell genomics

    TERMS

    Fixed Term contract.

    LOCALE

    Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1RQ

    COMPENSATION

    Salary £31,115 to £39,004 plus excellent benefits.

    HOW TO APPLY

    Click on the link: jobs.sanger.ac.uk/wd/p[...]04977

    DEADLINE

    Closing date for applications: 23rd March 2017 , however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline

    POLICY

    Please include a covering letter and CV with your application.

    BACKGROUND

    Living DNA is seeking a highly motivated individual to join our company in a hands on manner. The key task is developing, managing, and programming scalable bioinformatics pipelines to infer human ancestry and health-related information from SNP data.

    The position would suit both a new graduate, someone within industry as well as someone who has recently finished a PhD or Post Doc position.

    RESPONSIBILITIES

    You will work closely with leading academic partners and our internal bioinformatics team to evolve algorithms that have been developed to calculate genetic ancestry, relationships and traits. Part of these methods and processes are unique and highly specialised offering a unique picture on individuals' genetic history. Both for ancestry and health trait determination, the position will also involve identification, selection and implementation of public and proprietary methods, as well as mining of genetic data.

    This is a commercial position where you will be responsible for the day-to-day running of the various pipelines, database and data management, as well as programming and development of new features.

    REQUIREMENTS

    Candidate: An individual with a relevant PHD or those with MA and relevant industry experience.

    A candidate with skills in interfacing and project management who has 2+ years working experience would be great a great fit.

    Experience needed:
    • Scripting in Python/Bash
    • Programming with C/C++
    • Statistical analysis ideally in R
    • Extensive knowledge of the Linux command line
    • Working knowledge and interest in Statistical Genetics

    PREFERENCES

    • Management and Statistical Analysis of Big Data
    • Web development such as PHP, HTML
    • Working and knowledge of R Studio
    • Prior working with human population genetics and ancestry inference

    LOCALE

    Living DNA Ltd, Is located in the historic market town of Frome, Somerset, Located outside of Bath in the UK. You will not only be working in a dynamic and exciting team but have a peaceful environment with a high quality of life. You will be working onsite at the companies head office just outside the town centre.

    COMPENSATION

    A Salary of between £31K – £39K depending on experience plus benefits, pension.

    ABOUT US

    Living DNA (www.livingdna.com) is a company focused on using the power of genomics to help people understand more about themselves in unparalleled detail. Our first initiate uses DNA to show the world how connected we are all and start to dissolve the rise in Racism that is occurring. The company works both commercially and with charity partners.

    HOW TO APPLY

    By email to David Nicholson – david[at]livingdna.com and Dr Martin Blythe – martin[at]livingdna.com

    DEADLINE

    24th March 2017

    POLICY

    Living DNA Ltd welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

    BACKGROUND

    A POSTDOC POSITION is available immediately in the lab of Dr. Jeffrey Chang (changlab.uth.tmc.edu) at the University of Texas Health Science Center at Houston in the field of cancer genomics. This position is part of a program to study triple negative breast cancer (TNBC) in the context of a clinical trial with MD Anderson Cancer Center, and is funded by the Cancer Prevention and Research Institute of Texas. The project will be to develop computational methods and pipelines to perform genomic analysis on TNBC samples, as well as to support experimental researchers as needed. The successful applicant will have experience in performing bioinformatic analysis of a range of data types (genome sequencing, RNA-seq, microarrays) to dissect the molecular determinants of the disease.

    REQUIREMENTS

    To join our group, we are looking for highly motivated individuals that have demonstrated scientific productivity, excellent communication skills, and the capacity to conduct independent research. We are interested in applicants with a Ph.D. in Bioinformatics, Computer Science, Statistics, or comparable experience. Experience with next generation sequencing is highly desired. A background in cancer biology is a plus. Salary will follow NIH and university guidelines.

    HOW TO APPLY

    Please send a CV, a brief statement of research interests, and contact information for three references to Dr. Jeffrey Chang (jeffrey.t.chang[at]uth.tmc.edu). IMPORTANT: please include the words "Cancer Genomics Postdoc" in the subject line of the email.

    POLICY

    UTHealth is an EEO/AA employer. UTHealth does not discriminate on the basis of race, color, religion, gender, sexual orientation, national origin, genetics, disability, age, or any other basis prohibited by law. EOE/M/D/F/V.

    BACKGROUND

    An exciting Software Analysis and Development opportunity has become available within the Cancer, Ageing and Somatic Mutation Group (CASM). The successful candidate will be embedded in a large multidisciplinary team and will be tasked with further developing our cancer analysis algorithms specifically for blood cancers. The role involves working closely with scientific and IT staff within CASM to develop novel analytical strategies as well as actively contributing to the statistical modelling and data analysis of this study. In addition, the role will also involve improving existing algorithms to analyse whole genome sequencing and methylation data as well as developing new software where required. The position would suit a Bioinformatician/Statistician who enjoys developing algorithms and building statistical models to analyse complex NGS biological datasets. We are looking for an individual who enjoys working in a multi-disciplinary team environment to help solve complex IT issues which will ultimately aid our analysis of cancer related datasets.

    RESPONSIBILITIES

    The role involves working closely with scientific and IT staff within CASM to develop novel analytical strategies as well as actively contributing to the statistical modelling and data analysis of this study. In addition, the role will also involve improving existing algorithms to analyse whole genome sequencing and methylation data as well as developing new software where required. The position would suit a Bioinformatician/Statistician who enjoys developing algorithms and building statistical models to analyse complex NGS biological datasets. We are looking for an individual who enjoys working in a multi-disciplinary team environment to help solve complex IT issues which will ultimately aid our analysis of cancer related datasets.

    REQUIREMENTS

    • Good degree in Bioinformatics, Mathematics, Statistics or Computer Science with a scientific background
    • Software development using a compiled language (C,C++, Java)
    • Software development skills (using Perl and/or Python)
    • Experience of statistical analysis in bioinformatics
    • Experience of analysing biological data
    • Extensive experience of communicating effectively internally at all levels and with select external individuals
    • Able to present data
    • Ability to work independently and organise own workload
    • Previous scientific publications
    • Enjoy working as part of a team

    PREFERENCES

    • PhD in a bioinformatics or mathematics subject
    • ORACLE/MySQL databases
    • LSF or Open Grid scheduling software
    • Experience of workflow management IT systems
    • Experience of VMware, OpenStack or Amazon Web Services (AWS)
    • Experience working, developing and compiling software tools in a UNIX/LINUX environment.
    • Background in cancer genetics
    • Evidence of academic excellence

    TERMS

    Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

    LOCALE

    The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited's 100,000 Genomes Sequencing Centre. The Campus is also home to Wellcome Genome Campus Connecting Science. Connecting Science inspires new thinking, sparks conversation and supports learning by drawing on the ground-breaking research taking place on the Campus. Its mission is to enable everyone to explore genomic science and its impact on research, health and society. To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops.

    COMPENSATION

    £31,498 to £39,729, plus excellent benefits.

    Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

    ABOUT US

    The CASM Group has led the way in the systematic analysis of cancer genomes by using the human genome sequence and high throughput mutation detection techniques to identify somatically acquired sequence variants/mutations and hence identify genes critical in the development of human cancers (www.sanger.ac.uk/genetics/CGP/). The IT group has developed a suite of algorithms to analyse genetic variation in cancer genome data. This includes software to detect tumour genetic variation (e.g. single-base substitutions, structural rearrangements, copy number changes) and the ability to annotate the resulting variants and mine the data for interesting patterns and signatures. Campus Life The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

    HOW TO APPLY

    Click on the following link: jobs.sanger.ac.uk/wd/p[...]04870

    Please include a covering letter and CV with your application.

    DEADLINE

    22nd March 2017

    Submitter

    BACKGROUND

    CSRA is seeking a full time Senior Bioinformatics Engineer to join our program in support of the National Cancer Institute (NCI). NCI runs multiple programs for cancer genomics, including TARGET, CTD2, CGCI, and HCMI. CSRA needs a Senior Bioinformatics Engineer to help as part of the Data Coordinating Center for these cancer research efforts. CSRA has a leading practice in bioinformatics supporting the Federal Government, with projects across the NIH and CDC.

    RESPONSIBILITIES

    • Work involves intake and formatting of genomics data via extensive scripting, transfer of data to NCI's Genomics Data Commons, development and maintenance of web applications, coordination with NIH's Center for Information Technology regarding security, storage space, and web hosting.
    • This is an opportunity to make a difference on the cutting edge of cancer research, using bioinformatics skills that require a knowledge of genomics and molecular biology as well as significant IT skills, working with some of the top cancer researchers in the world.
    • The selected candidate will have had extensive experience with handling, manipulating, and performing QC on genomics data, including WGS, WES, and RNASeq data.

    REQUIREMENTS

    Required skills:
    • Bachelors degree and 5+ years hands on bioinformatics experience is required, or equivalent combination. MS preferred
    • Advanced Linux, Perl, and Apache skills (additional skills in Python are a preferred)
    • Extensive knowledge of genomics metadata and data standards
    • Demonstrated expertise creating and maintaining bioinformatics workflows
    • Web application maintenance
    • Experiencing completing setup, managing, and maintaining servers, storage, application stacks, tools, security, code management beyond basic systems support
    • Experience with biomedical data migration and QC
    • Extensive experience in managing genomics data via hands-on programming experience
    Competencies:
    • Excellent verbal and written communication skills required
    • Ability to multi-task in a fast paced environment

    PREFERENCES

    Desired skills:
    • Java
    • Knowledge of dbGaP, SRA, NCI Genomic Data Commons preferred
    • Experience with components of the NCI multi-tier development and deployment stack (Java, Tomcat, AntHillPro, Maven, GitHub)
    • Cancer-specific genomics/bioinformatics experience preferred

    LOCALE

    Onsite at the NCI in Rockville, MD

    HOW TO APPLY

    Please apply directly online via www.csra.com/careers to job #13045 or via this link: jobs.csra.com/sear[...]983/1

    POLICY

    CSRA is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.

    BACKGROUND

    Zymeworks is a fast-growing, clinical-stage biotechnology company dedicated to the research, development and commercialization of best-in-class therapeutic bispecific antibodies and antibody drug conjugates used in the treatment of cancer and autoimmune diseases. Zymeworks is proud to have active collaborations with Merck & Co., Inc., Eli Lilly and Co., Celgene Corporation and GSK, and is committed to making a meaningful difference in the lives of patients everywhere.

    Zymeworks is seeking a LIMS/ELN Informatics Analyst, who will be responsible for modeling experimental workflows, as well as managing and maintaining quality control of experimental and biological data in a Laboratory Information Management System (LIMS) and Electronic Lab Notebook (ELN). The position reports to the Technology Integration & Bioinformatics Team Lead.

    RESPONSIBILITIES

    • Interfaces with our scientific R&D teams to understand the experimental data being produced, provides proposals to organize and formalize the data from these experiments, and works with the software team to store this data in the LIMS/ELN
    • Manages and organizes the storage of our biological data (protein products, antibodies, small molecules, other molecular entities) in the LIMS/ELN, along with associated metadata
    • Administers the LIMS/ELN by assigning roles and permissions to the various groups and users in the organization
    • Works with our in-house lab scientists, and external Contract Research Organizations to develop, document, and enforce standard operating procedures and protocols for our experiments and the associated data upload and management procedures
    • Acts as a point of contact for LIMS/ELN-associated feature requests and work with the users and various stakeholders on prioritizing and delivering these features
    • Works with the LIMS provider and in-house scientific and software teams to implement and support best practices and optimal utilization of the informatics and data management resources
    • Documents and trains scientific staff/end user on best practices and compliance policies related to the LIMS/ELN system and data handling
    Fosters effective and collaborative working relationships with fellow employees, management and external partners

    REQUIREMENTS

    • BSc in Biochemistry, Molecular Biology, Chemistry or a related field and a minimum of 2 years' experience working with LIMS/ELN software in the biopharmaceutical industry
    • Proven interpersonal skills with the ability to work collaboratively as a member of cross-functional team. Ability to establish and maintain effective working relationships
    • Familiarity with proteins, protein expression and purification methods is required, as well as basic knowledge of experiments like mass spectroscopy, DSC, SPR, FACS or other cell-based assays is required.
    • Should be IT savvy, experience and strong drive to work in data management including capturing, refining, annotating, characterizing, and storing data is a must.
    • Experience in the capture and management of high throughput experimental data will be an asset.
    • Experience in negotiating software requirements within and across research departments and translate those requirements to software solutions
    • Basic experience with any programming languages (Python, C/C++, Fortran, Java), or experience with scripting languages like Bash/Perl is an asset. Basic knowledge of databases like SQL, PostgreSQL will be highly favored.
    • Fluent in written and spoken English

    ABOUT US

    Why Work for Us?

    Zymeworks' employees are passionate, engaged and extremely motivated to succeed. We are excited by the cutting-edge science and technology, the endless possibilities this union holds and the sheer opportunity to be a part of something big. To learn more about Zymeworks Inc. and our current openings, please visit our website at www.zymeworks.com.

    We offer challenging career opportunities, competitive benefits and an environment that recognizes and rewards performance.

    HOW TO APPLY

    If you are interested in applying for this position, please visit our website at www.zymeworks.com and include your curriculum vitae and cover letter in PDF format. Due to the high volume of applicants, only those selected for interviews will be contacted.

    RESPONSIBILITIES

    We seek a talented computational scientist to specialize in analysis and interpretation of high-throughput epigenomic data to elucidate key aspects of therapeutic action. The insight gained will contribute directly to identification and development of novel therapies for complex diseases of unmet medical need.

    The successful candidate will work closely with Celgene's global research analytics and epigenetic biology teams to advance our research and development of novel therapeutic agents related to epigenetic mechanisms. The role will involve participation in the analysis and interpretation of experiments that capitalize on cancer therapeutic opportunities in epigenetics.

    A key area of research focus will be the integration of multiple genomic data types to produce a robust understanding of disease state or phenotype. In the context of therapeutic discovery, these efforts will yield novel high-confidence drug targets, and in the context of translational research, objectives include understanding mechanisms of response to our emerging therapeutics.

    Research Analytics activities at CITRE focus on application of contemporary computational analysis methods to improve therapeutic outcomes for Celgene patient populations across a range of diseases. This position would involve considerable inter-disciplinary collaboration with colleagues across Celgene Research and academic collaborators.

    The successful candidate for this role will work closely with Research Analytics team members to define and execute projects, and to communicate discoveries to biology and clinical research teams.

    Responsibilities include, but are not limited to:
    • Perform computational biology analysis for exploration and interpretation of high-throughput data including NGS and MS proteomics assays
    • Develop and implement state-of-the-art approaches for biological pathway and network analysis to elucidate the perturbation of cellular mechanisms
    • Engage in development of methods and platforms for integration of heterogeneous biological data towards answering broader scientific questions
    • Participate in the presentation and reporting of methods, results and conclusions to a publishable standard
    • Participate in wider group endeavors concerning the elucidation of compound mechanisms of action, drug resistance and prediction of target indications

    REQUIREMENTS

    • PhD in computational biology / bioinformatics, statistics, computer science or related fields, with a firm grasp of genomics and/or genetics, from a recognized higher-education establishment
    • Post-doctoral research experience (2+ years) preferred in analysis, integration and interpretation of epigenomic and other high-throughput data (e.g. Histone & TF ChIP, DNA methylation, chromatin accessibility, proteomics and expression data)
    • Publication record in analysis of next-generation sequencing data: familiarity with publicly-available sequence alignment pipelines, SNV calling algorithms, common NGS manipulation tools and standardized NGS data formats (e.g. SAM/BAM, VCF)
    • Demonstrable competence in statistical programming and data manipulation, using e.g. Unix/Linux, Perl, Python, and R/Matlab/SAS, plus good knowledge of contemporary database structures
    • Familiarity with protein interaction/regulatory network collections and network/pathway based analysis methods to distil rational biological interpretation and functional insight from biological data
    • Ability to collaborate well and communicate the output of computational research in the context of multi-disciplinary scientific teams
    • Excellent oral and written communication skills in English. Proficiency in Spanish language would be advantageous

    LOCALE

    CITRE, Seville, Spain

    TERMS

    Manager: Principal Scientist, Research Analytics (RIKU)
    Contract: Fixed-term, 2 year duration, full-time

    ABOUT US

    CITRE Background:
    Multinational biopharmaceutical company Celgene, world leader in developing new treatments for cancer and inflammatory diseases, has established the Celgene Institute for Translational Research Europe (CITRE®) in Seville, Spain. CITRE is the company's first dedicated R&D site outside the USA and provides a bridge between Celgene R&D and the European research community.

    CITRE was founded in 2010, and laboratory research activities began in June 2011. The Institute now houses a team of highly qualified scientific research and administrative staff drawn from Spain and other European member states. The Institute is located in the Cartuja `93 Science and Technology Park and its activities focus on Translational Research into new treatments for cancer and other rare and complex diseases.

    Scientific activities at CITRE comprise three main departments: The Human Diseased Tissue Laboratory (HDTL), the Computational Biology research group, and the Clinical Trials Unit. Onsite facilities include extensive cell culture, flow cytometry, microscopy, genomics, immunohistochemistry, and state-of-the-art computational analysis infrastructure for biomarker discovery and patient stratification.

    The three groups are inter-linked by the CITRE tissue Biobank, which receives patient tissue samples, obtained from multi-centre Celgene trials managed by the CITRE Clinical Trials Unit in Spain and across Europe, to provide the basis for inter-disciplinary research into biomarker detection, patient selection criteria, and compound mechanisms of action.

    Together, these components form a Translational Research centre which coordinates and conducts Celgene medical research in Europe, and enables rapid and effective transfer of new developments and discoveries at Celgene to EU patients. Furthermore, CITRE provides a focal point in Europe for collaborative translational research into cancer and inflammatory diseases, with a mission to rapidly deliver new Celgene compounds to the clinic.

    HOW TO APPLY

    Contact:
    Those interested in the position described should submit full CV and cover letter addressed to:
    Silvia Banus (sbanus[at]celgene.com)
    CELGENE S.L.
    Paseo de Recoletos 39, 4º
    28004 MADRID

    By sending your application you acknowledge that the information you provide to Celgene will be stored in a database which is the property of Celgene, for the purposes of processing this information. This information may be shared with Celgene affiliates and agents, including Celgene's parent company based in the USA (Celgene Corporation). You understand that you have the right of access to and the right to rectify the data concerning me, according to applicable privacy laws. You understand that these rights can be exercised by sending an email to the following address: privacy[at]celgene.com, and that more information can be found on the privacy policy located on Celgene's web site, www.celgene.com/util[...].aspx.

    BACKGROUND

    Applications are sought for a Software Developer to maintain and enhance SNPnexus (www.snp-nexus.org) a hugely popular analytical tool that allows researchers to assess the potential significance of sequence variations that could lead to diseases. The successful candidate will be responsible for SNPnexus enhancement to ensure that it remains a cutting-edge tool and continues to contribute to maximising the knowledge extracted from sequencing data. The aim is to introduce new modules for multi-sample analyses, noncoding annotation and the discovery of novel/rare disease-causing variants, and improve its speed/efficacy. The post will be based in the Bioinformatics Unit, Centre of Molecular Oncology, Barts Cancer Institute, within the Barts and The London School of Medicine and Dentistry, Queen Mary University of London.

    REQUIREMENTS

    Essential requirements for this post include an MSc in Bioinformatics/Computer Science or a related discipline, significant experience in software development ideally in a life science environment. Experience in biological science research and familiarity with functional annotation of genome sequence variations are very desirable, and will be an advantage. A demonstrated ability to communicate well, work within a team are essential. The technical requirements for this post include expertise in CGI scripting language (e.g., Perl or Python), relational database management systems (e.g., MySQL), and web application development technologies. Experience of additional languages, such as C/C++ or Java, is also important. Experience with Linux network/server administration would be essential. Experience in R statistical environment and Bioconductor is desirable.

    TERMS

    The post is full time for 35 months, in the first instance.

    LOCALE

    Department: Centre for Molecular Oncology, Barts Cancer Institute
    Poplar, Greater London
    UK

    COMPENSATION

    Starting salary will be in the range £32,405 - £38,062 (Grade 4) per annum inclusive of London Allowance. Benefits include 30 days' annual leave, defined benefit pension scheme and interest-free season ticket loan.

    The Barts Cancer Institute requires that applicants invited for interview will need to provide all certificates to confirm their qualifications (specified in the Job Description).

    Candidates must be able to demonstrate their eligibility to work in the UK in accordance with the Immigration, Asylum and Nationality Act 2006. Where required this may include entry clearance or continued leave to remain under the Points Based Immigration Scheme.

    HOW TO APPLY

    Informal enquiries about this post, including arrangements to visit the Institute/Centre, can be made to Professor Claude Chelala (c.chelala[at]qmul.ac.uk).

    Application enquiries can be directed to recruitment[at]qmul.ac.uk

    Details about Barts Cancer Institute can be found at www.bci.qmul.ac.uk

    To apply, please visit webapps2.is.qmul.ac.uk/jobs[...]10633

    Reference: QMUL10633

    Date posted: 23-Jan-2017

    DEADLINE

    The closing date is 26th February and interviews are likely to be held shortly thereafter.

    POLICY

    Valuing Diversity & Committed to Equality

    BACKGROUND

    Postdoctoral positions(both computational and wet lab) are available in the department of Bioinformatics and Computational Biology at the University of Texas MD Anderson Cancer Center (MDACC). We study resistance to targeted therapies and aim to discover combination therapies to overcome or forestall the resistance in cancer. Our laboratory combines advanced network inference and machine learning algorithms with drug perturbation and profiling experiments.

    Apply for a postdoc position If you are interested in
    • Working in a highly collaborative, experimental, computational and translational cancer biology program
    • Working at MDACC (ranked number one in the nation for cancer care by U.S. News & World Report and number one in the number of awarded grants from the NCI)
    • Having excellent benefits & salary

    REQUIREMENTS

    Computational: Candidates must have a PhD in a relevant field (e.g., bioinformatics, biophysics, genomics, computer science, statistics) and a strong track record. A good understanding of statistics, experience in algorithm development and programming skills (e.g., R, Matlab, C++, Fortran, Python) are required. Knowledge of cancer biology, signaling pathways and drug response mechanisms is highly preferred.

    Experimental: Candidates must have a PhD in a relevant field (e.g., cell biology, pharmacology, systems biology, biochemistry) and a strong track record. Experience in mammalian cell culture and drug perturbation experiments is required. Candidates must have the desire to gain experience in bioinformatics, very good quantitative skills, and statistics knowledge. For all candidates, a good understanding of cancer biology, signaling pathways and drug response mechanisms is highly preferred.

    LOCALE

    UT MD Anderson Cancer Center, Houston TX

    COMPENSATION

    $65K/yr for computational biology postdocs and NIH scale for experimentalist postdocs.

    ABOUT US

    MDACC is one of the world's foremost institutions for cancer research. It offers salaries and benefits that are highly competitive, especially given the relatively low cost of living in Houston. Houston is one of the world's most interesting and diverse cities, featuring great neighborhoods, excellent private and public schools, superb museums, highly acclaimed opera, symphony, ballet, and theater, first-rate international cuisine, and year-round recreational and entertainment opportunities.

    HOW TO APPLY

    Email letter of interest, CV, a list of 2-3 references to akorkut/at/mdanderson(dot)org. In your email, please make sure that subject line is "postdoc application/korkut lab".

    Contact:
    Anil Korkut
    Bioinformatics and Computational Biology
    The University of Texas M. D. Anderson Cancer Center
    1515 Holcombe Blvd.
    Houston, TX 77030
    United States
    Email: akorkut/at/mdanderson(dot)org

    POLICY

    M. D. Anderson Cancer Center is an equal opportunity employer and does not discriminate on basis of race, color, national origin, gender, sexual orientation, age, religion, disability or veteran status except where such distinction is required by law. All positions at The University of Texas M. D. Anderson Cancer Center are security sensitive and subject to examination of criminal history record information. Smoke-free and drug-free environment.
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