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    BACKGROUND

    Job Summary:
    Staff Scientist with expertise in Machine Learning and Computer Science in the field of Translational Genomics at Brigham and Women's Hospital, Harvard Medical School, and the Broad Institute of MIT and Harvard.

    Job Description:
    The Pochet Laboratory in Translational Learning & Informatics (personal.broadinstitute.org/npochet/) within the Department of Neurology at Brigham and Women's Hospital, Harvard Medical School, and the Broad Institute of MIT and Harvard is currently seeking a Staff Scientist with expertise in machine learning and computer science in the field of translational genomics to join our research efforts in understanding the molecular and mechanistic basis of cancer, infectious, neurological and immune mediated disease. This position will function under the supervision of Dr. Nathalie Pochet.

    RESPONSIBILITIES

    This position offers a stimulating and multidisciplinary environment. The Staff Scientist will work as part of a team of researchers across Brigham and Women's Hospital, Harvard Medical School, and the Broad Institute of MIT and Harvard. He or she will join an ongoing research program that aims at developing machine/transfer learning algorithms and software tools for the integrative analysis of multi-omics data to translate knowledge from model systems to patient studies of human disease. The project will entail developing innovative computational strategies for integrative modeling of genomics data, thus developing powerful toolboxes for applications in studies of human disease. The Staff Scientist will collaborate closely with Dr. Nathalie Pochet's broad network of collaborators at Brigham and Women's Hospital, Harvard Medical School, the Broad Institute of MIT and Harvard, and Stanford University.

    REQUIREMENTS

    Applicants should have a strong computational background and expertise in dealing with very large genomics data sets. Excellent programming, data analysis and machine learning skills are required. Experience with RNA and DNA sequencing data is a major plus. The ideal candidate should be passionate about the translation of genomics into clinical practice, and be highly motivated to work in a fast-paced and highly collaborative environment.

    HOW TO APPLY

    Applications and inquiries should be submitted by e-mail to Dr. Nathalie Pochet (nathalie.pochet[at]gmail.com). Please include your CV, a cover letter describing previous research, research interests, and future goals, as well as 3 references.

    BACKGROUND

    Job Summary:
    Research Scientist with expertise in Machine Learning and Computer Science in the field of Translational Genomics at Brigham and Women's Hospital, Harvard Medical School, and the Broad Institute of MIT and Harvard.

    Job Description:
    The Pochet Laboratory in Translational Learning & Informatics (personal.broadinstitute.org/npochet/) within the Department of Neurology at Brigham and Women's Hospital, Harvard Medical School, and the Broad Institute of MIT and Harvard is currently seeking a Research Fellow with expertise in machine learning and computer science in the field of translational genomics to join our research efforts in understanding the molecular and mechanistic basis of cancer, infectious, neurological and immune mediated disease. This position will function under the supervision of Dr. Nathalie Pochet.

    RESPONSIBILITIES

    This position offers a stimulating and multidisciplinary environment. The fellow will work as part of a team of researchers across Brigham and Women's Hospital, Harvard Medical School, and the Broad Institute of MIT and Harvard. He or she will join an ongoing research program that aims at developing machine/transfer learning algorithms and software tools for the integrative analysis of multi-omics data to translate knowledge from model systems to patient studies of human disease. The project will entail developing innovative computational strategies for integrative modeling of genomics data, thus developing powerful toolboxes for applications in studies of human disease. The fellow will collaborate closely with Dr. Nathalie Pochet's broad network of collaborators at Brigham and Women's Hospital, Harvard Medical School, the Broad Institute of MIT and Harvard, and Stanford University.

    REQUIREMENTS

    Applicants should have a strong computational background and expertise in dealing with very large genomics data sets. Excellent programming, data analysis and machine learning skills are required. Experience with RNA and DNA sequencing data is a major plus. The ideal candidate should be passionate about the translation of genomics into clinical practice, and be highly motivated to work in a fast-paced and highly collaborative environment.

    HOW TO APPLY

    Applications and inquiries should be submitted by e-mail to Dr. Nathalie Pochet (nathalie.pochet[at]gmail.com). Please include your CV, a cover letter describing previous research, research interests, and future goals, as well as 3 references.
    Opportunity: Bioinformatics Engineer @ Synthace Ltd -- London, UK
    Submitted by Michael Sadowski; posted on Tuesday, October 16, 2018

    BACKGROUND

    Bioinformatics is hard – trying to master two disciplines is tough, especially when one of them is biology. And it's even harder to do biology when you can't get in the lab and do your own experiments.

    At Synthace we're changing that with Antha, a language for biological research which lets you do real experiments by writing code. Sounds pretty awesome, right? You know what's more awesome? You can join us in making it even better!

    We are looking for an experienced and highly collaborative bioinformatics engineer to develop bioinformatics capabilities within Antha. This exciting role will bring you right to the heart of our highly dynamic interdisciplinary technical team where you'll be working with expert lab scientists, and software engineers making the dream of fully software-driven experimentation a reality.

    RESPONSIBILITIES

    The core responsibility of the role will be bioinformatics application and platform development, primarily in golang. The successful applicant will be expected to design and implement new bioinformatics capabilities in the Antha language in collaboration with a diverse team of biological scientists and software engineers.

    Other important areas of responsibility will include:
    • Developing bespoke informatics workflows for clients and internal users
    • Advising on experimental design and data analysis
    • Developing device models and new capabilities of the Antha language
    • Collaborating with lab scientists to develop executable lab protocols

    REQUIREMENTS

    Our ideal candidate will have:
    • Industry experience working in bioinformatics or related areas (2+ years)
    • Experience developing bioinformatics applications in at least two programming languages including one compiled, typed language such as Go(Golang), Java, C/C++
    • A good knowledge of standard software development tools and methods e.g. version control, test driven development, CI pipelines etc.
    • Experience collaborating with laboratory scientists in an informatics capacity
    • A broad knowledge of bioinformatics data and software e.g. BLAST, sequence databases, sequencing technologies and analysis methods.
    • Education to postgraduate level (ideally MSc / MRes), including higher education in both biological and computational subjects
    • Expertise in data analysis using an appropriate system such as R, PANDAS/numpy/scipy, SAS/JMP
    We are potentially interested in anyone who meets most of the above requirements, so if you're not sure please get in touch!

    As Synthace we aim to foster a culture of respectful, efficient collaboration and high personal effectiveness and we will be looking for candidates to demonstrate these qualities.

    COMPENSATION

    Competitive salary, comprehensive benefits including share options. For a list please visit careers.synthace.com.

    LOCALE

    London, UK

    HOW TO APPLY

    Please mail us a CV and bio to jobs[at]synthace.com

    Submitter

    BACKGROUND

    I have a great opportunity available to work with one of the leading organisations within bioinformatics in the UK as a Technical Innovator, joining the IT team in a visionary role. This unique, exciting and forward-thinking position will be at the cutting-edge of technology, defining the future of the hardware and software pathways to shape the organisation.

    The organisation has one of the world's largest life science IT facilities, providing research groups with HPC clusters that deliver more than 20,000 compute cores, 15 PB of high performance Lustre file systems and data repositories exceeding 16PB.

    This is an ideal opportunity for an enthusiastic individual to complement the existing IT team. This exciting role is to look 5+ years ahead to what may be possible, rather than technology that is available today. You will evaluate how it aligns with the organisation's developing scientific challenges and how to further engage with their strategic commercial and scientific IT partners to develop the solutions that will be need in the future.

    RESPONSIBILITIES

    The core accountabilities of this role include:
    • Define new and emerging technological requirements and map how they can propel our hardware and software forward
    • Produce a 5 year + roadmap
    • Develop and track metrics for benchmarking the quality of technologies
    • Defining technological requirements and specifications based on perception and user feedback
    • Evaluating how emerging and new initiatives will align with our scientist challenges
    • Communicate findings clearly and effectively in a number of ways to technical and non-technical audiences

    REQUIREMENTS

    For such a blue-sky research position, you should possess a mixture of talents and qualifications, and will be able to demonstrate:
    • A strong and creative problem-solving mentality
    • An open and enquiring approach to IT, its challenges and how to overcome them
    • Highly self-motivated and with a will to share and disseminate information
    • An ability to present new ideas and opportunities to a wider audience of both highly technical and non-technical audiences
    • Provide contributions to wider audiences through peer review papers and conference presentations and posters.
    • The proven ability to rapidly learn and evaluate new methods and tools
    • Excellent written, verbal and numerical skills
    • Forward and independent thinking
    This post would be ideally suited to someone with a high degree in a computation or mathematic or scientific background. Specific knowledge of cloud or HPC technologies is desirable but a deep understanding and the implementation of today's IT technologies, such as machine learning and computation approaches is more important.

    COMPENSATION

    There are some great benefits available with this position including the opportunity to work at the forefront of Genomics research with some of the smartest minds in the world. There's also a competitive salary and package available, private health insurance, on-site gym/tennis courts/ cricket pitches and nursery.

    HOW TO APPLY

    Please do not hesitate to contact Harvey Uppal at huppal[at]pararecruit.com or call (+44) 121 616 3407 to discuss this opportunity further.

    Keywords: Roadmap, Architect, HPC, Innovator, Technical, Lead, Bioinformatics, Genomics, Machine Learning, Hardware, Software, Clusters, Cloud, Computational, Cambridge

    RESPONSIBILITIES

    Job Summary/Basic Function:
    My laboratory is seeking a highly motivated, self-starter, Post-doctoral Fellow with the ability to work with optimal resources and little direct supervision to address important questions in the genetics and genomics of the autoimmune diseases Sjögren's syndrome, systemic lupus erythematosus, and multiple sclerosis. Successful candidates will be proficient in techniques such as transracial mapping, high-throughput sequencing of DNA, RNA, and methylation, flow cytometry, cell culture, electrophoretic mobility shift assays, chromosome conformation capture, ChIP-PCR, and genome CRISPR/Cas9 or similar approaches. Competitive individuals will also have some experience in the analysis of genetic data, high-throughput sequencing data and the use of bioinformatics software.

    REQUIREMENTS

    Minimum Qualifications:
    • Ph.D., M.D., or Ph.D./M.D.
    • Previous experience in basic human genetics and/or genomics is required. Must have at least one first author publication. Good written skills necessary. Ability to communicate and write summaries of results required.
    Minimum Degree Required:
    • Doctorate
    Preferred Qualifications:
    • Ideally would have at least two publications with one or more first author, peer-reviewed, English manuscripts in human genetics or genomics. Experience with molecular techniques and analytical methodologies described above would be ideal.

    TERMS

    Classification: Ongoing
    Status: Full-Time

    COMPENSATION

    We offer attractive salaries & comprehensive benefits package, view our benefits omrf.org/abou[...]fits/.

    HOW TO APPLY

    Interested candidates should apply online at apptrkr.com/1302624

    Posting Number: 0001165
    Department: Arthritis & Clinical Immunology – Lessard

    DESCRIPTION

    The University of Texas Southwestern Medical Center (UTSW) has launched a fully philanthropically funded Department of Bioinformatics with the mission of creating computational methods for integrative analysis and modeling of complex biomedical processes in high-dimensional and multi-modal data sets. The development of this research program is driven under the premise that bioinformatics is a pattern recognition problem whose solution builds on the combination of computational theory and algorithms that are sharable across all biomedical data types and research applications. Accordingly, the Department seeks continued growth of its faculty with individuals who will address fundamental questions in computer science while effectively translating the results into high-impact basic and clinical research.

    Openings can be filled at the rank of Assistant, Associate, or Full Professor. Generous startup packages and research space will be available through department resources and/or co-recruitment with other UTSW departments. Candidates applying for a position at the Assistant Professor level may qualify for nomination for the (www.utsouthwestern.edu/educ[...].html). Candidates at the Associate and Full Professor level are expected to have an established grant portfolio that will be transferred to UTSW (multiple R01 equivalents).

    LOCALE

    Lyda Hill Department of Bioinformatics
    The University of Texas Southwestern Medical Center
    Dallas, Texas

    COMPENSATION

    Negotiable

    HOW TO APPLY

    Candidates must have a Ph.D. and should submit before December 31, 2018 a 1-page letter of interest, a NIH-formatted biosketch including the sections Personal Statement and Contributions to Science, followed by a complete list of publications, a 3-page research statement, and three letters of reference. All materials must be submitted electronically to AcademicJobsOnline (academicjobsonline.org/ajo/jobs/12104).

    DEADLINE

    December 31, 2018

    POLICY

    UT Southwestern is an affirmative action/equal opportunity employer. Women and members of minority groups, protected veterans and individuals with disabilities, as well as others who would bring additional dimensions to the center's research, teaching, and clinical mission are encouraged to apply.

    BACKGROUND

    We are looking for a Bioinformatician in Epigenetics.

    The position will be available in the Jenuwein group at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg, Germany (www.ie-freiburg.mpg.de/jenuwein). The Jenuwein group studies molecular mechanisms that establish and maintain heterochromatin in mammalian cells. There is a particular focus on the genome-wide regulation of repetitive element expression during mouse ES cell differentiation and in disease using a variety of experimental and next generation sequencing approaches. For these genomewide analyses, we seek an experienced bioinformatician, with a strong background in data analysis and with previous exposure to chromatin biology and epigenetic control mechanisms. This position is open immediately and initially funded for two years.

    Your Opportunities:
    As an embedded bioinformatician, you will have the opportunity to contribute directly to multiple research projects, from experimental design to data analysis and interpretation. This position also offers additional possibilities for participating in the Collaborative Research Center "Medical Epigenetics" (MEDEP). You will also interact with a strong, interdisciplinary bioinformatics and deep sequencing team that provides access to a large Sequencing Facility (HiSeq3000, HiSeq2500, NextSeq500), as well as a high-performance Data Center with Petabyte-scale storage solutions.

    RESPONSIBILITIES

    Your Tasks:
    Responsibilities include the bioinformatics analysis of genome-wide datasets, such as ChIP-seq and RNA-seq, as well as transcription factor motif analysis and analysis of other next-generation sequencing-based experiments. A strong understanding of epigenetic mechanisms of gene regulation will also be necessary, in order to process, analyze, and interpret a variety of datasets, focusing particularly on repetitive DNA elements and chromatin modifying factors.

    REQUIREMENTS

    Your Qualifications:
    We are looking for a dedicated and motivated team player with strong communication skills and good command of the English language, who has a MSc or PhD degree in bioinformatics or biology with a clear computational component. The successful applicant will have a proven record in the analysis of genome-wide datasets and computational skills (Python, R) in a Linux environment. Knowledge of alignment programs (such as STAR), RepeatMasker, and data analysis and visualization tools in R will be necessary.

    COMPENSATION

    We Offer:
    Based within a region that connects Germany, France and Switzerland, our institute hosts a vibrant community of international researchers, state-of-the-art facilities, and modern office spaces. A childcare facility is directly attached to the institute. At the heart of the Black Forest, Freiburg offers a family-friendly atmosphere and excellent recreational possibilities for cultural and outdoor activities. Salaries will be based on previous experience according to the German pay scale for civil service (TVöD) including health insurance and other social benefits.

    HOW TO APPLY

    Candidates should submit their full applications (including a 1 page motivation summary, CV, contact details of referees) to our home page: www.ie-freiburg.mpg.de/jobs.

    For informal inquiries please contact: jenuwein[at]ie-freiburg.mpg.de.

    DEADLINE

    Application deadline: 31.10.2018

    POLICY

    The Max Planck Society seeks to increase the number of women in areas where they are underrepresented and therefore explicitly encourages women to apply. Handicapped applicants with equal qualifications will be given preferential treatment.

    RESPONSIBILITIES

    The postdoctoral fellow positions in our R&D and Regeneron Genetics Center(RGC) are for early career scientist trainees to receive a rigorous scientific training at Regeneron under the auspices of a scientist mentor for a training period up to 4-years. Fellows will be expected to conduct creative exploratory research that results in publishable data within their fellowship period.

    Essential Functions required for the job. List both technical and managerial requirements if applicable.

    The program will consist of:
    • Four years of formal postdoctoral training in a program directed by an award-winning educator
    • Exposure to the biotechnology industry's most successful and innovative scientists
    • Opportunities to pursue cutting-edge, creative biomedical research in a prestigious, well-resourced, and highly driven industry environment
    • Weekly postdoctoral scientist meetings to foster scientific rigor, creative thinking, critical reasoning, and career advancement
    • Encouragement of scholarly productivity such as publications and conference presentations
    As part of your Postdoctoral Training Program, you will:
    • Conduct forward-looking, innovative, and creative research to address a novel scientific question of your choice under the auspices of a scientist mentor
    • Publish and disseminate data via external conferences and peer-reviewed publications
    • Assist with mentoring and teaching intern and other more junior trainees
    • Participate in postdoctoral program activities such as weekly meetings and the annual research conference
    • Present data internally, including at lab meetings, trainee meetings, and company wide seminars
    • Provide ongoing reports of research progress to supervisors and program staff

    REQUIREMENTS

    Experience and Required Skills:
    • Doctoral degree in a relevant discipline
    • Scientists looking for their first or second postdoctoral training
    • Superior scientific skills including critical and analytical thinking
    • Demonstrated publication success as evidenced by peer-reviewed publications
    • Good written and oral communication skills
    • Ability to interact dynamically and constructively with scientific peers
    • Note: occasional travel

    HOW TO APPLY

    Log in to www.regeneron.com, Select – Careers, and Enter – the Job # for the position(s) of interest.

    Job #'s:
    Postdoctoral Fellow, R&D – 14207BR
    Postdoctoral Fellow, RGC – 14212BR

    Application Details:
    Applications Accepted: October 1, 2018 - December 1, 2018
    Letter of recommendation are required. (Please find additional details in online application)

    Applications received after December 1, 2018 may not be considered.
    Following the close date, please allow 3-4 months for review and interviews.

    Targeted Start Date: July 2019
    If you have an issue submitting or any questions, please email:
    postdoctoral[at]regeneron.com.

    BACKGROUND

    Job Summary/Basic Function:
    The Functional and Chemical Genomics Program at the Oklahoma Medical Research Foundation (OMRF, omrf.org) is inviting applications for Staff Scientist positions. The selected candidates will help lead collaborative projects. OMRF is a non-profit private foundation dedicated to fundamental, interdisciplinary research and to the translation of knowledge to medicine. Research interests within FCG include fundamental questions emerging from ongoing high-throughput genetic and epigenetic studies of disease using the latest technologies in genomics, functional genomics, model system biology, and chemical biology. The Program occupies newly renovated space designed to foster highly collaborative and innovative research using genetic model systems including C. elegans, Drosophila, planaria, zebrafish, mice, and stem cells. Our strategy aims to embrace the post-genomic era in scaling the functional analysis of genetic and epigenetic alterations underlying human disease. OMRF researchers have access to state-of-the-art facilities and outstanding core technology laboratories including Imaging, Next-generation Sequencing, Clinical Genomics, and more.

    Three specific interdisciplinary project opportunities include:
    • Dr. Wan Hee Yoon and Dr. Gaurav Varshney are collaborating on a project to model human diseases carrying OGDH family genes. Fellows undertaking this project will emerge with expertise in Drosophila genetics and CRISPR/Cas-9 targeting in zebrafish.
    • Dr. David Jones, Dr. Jian Li, and Dr. Magdalena Bieniasz are collaborating on a project examining a novel role of HSF1 and its aberrant activation in cancer. Fellows will have the opportunity to develop expertise in utilization of patient-derived xenograft (PDX) tumor models, to determine programmatic transcriptional targets of HSF1 and its connection to known oncogenes and tumor suppressor genes.
    • Dr. David Forsthoefel, Dr. Wan Hee Yoon, and Dr. David Jones are collaborating on a project examining the roles of Xbp1 in stem cells, regeneration, innate immunity, and cancer. Fellows involved in this project will help define the mechanistic roles of Xbp1 and novel proteostasis regulators in planaria, Drosophila, and zebrafish.

    REQUIREMENTS

    Minimum Qualifications:
    • Ph.D. in a biological science, chemistry, physics or other relevant area, M.D., or equivalent.
    Minimum Degree Required:
    • Doctorate

    TERMS

    Classification: Ongoing
    Status: Full-Time

    COMPENSATION

    We offer attractive salaries & comprehensive benefits package, view our benefits here: omrf.org/abou[...]fits/

    HOW TO APPLY

    Interested candidates should apply online at apptrkr.com/1305739

    Posting Number: 0001185
    Department: Functional and Chemical Genomics
    Opportunity: Rare Disease Analyst @ Genomics England -- London, UK
    Submitted by Eugene Mc Daid; posted on Wednesday, October 03, 2018

    Submitter

    BACKGROUND

    Paramount are working in partnership with Genomics England to expand their team in order to deliver success with the 100,000 Genomes Project. This is a challenging and fast moving project with the aim to carry out whole genome sequencing on 100,000 participants.
    We are excited to advertise this position for a Senior Rare Disease Analyst as a 12-month fixed contract with the likelihood of extension.

    RESPONSIBILITIES

    This senior role is part of a talented and motivated Bioinformatics team and it will be responsible for applying computational and statistical methods to analyse large datasets using:
    • Whole exome/genome sequencing
    • Association testing
    • Rare variant association analysis
    • Burden testing
    • Benchmarking genome analysis pipelines

    REQUIREMENTS

    • Post doctorate with at least 2-3 years' experience of working in this field
    • Deep knowledge of association testing
    • Good knowledge of genomics and rare diseases
    • A demonstrable ability to cope under pressure and deliver to deadlines
    • Ability to communicate effectively within a multidisciplinary team
    • Flexible and co-operative approach to colleagues
    • Ability to work independently and to show initiative within a team
    • Ability to prioritise and balance competing demands
    • Excellent technical writing skills

    ABOUT US

    Genomics England works at the cutting edge of science, technology and healthcare. Our mission is to deliver the ground-breaking 100,000 Genomes Project – the biggest national genome sequencing project of its kind anywhere in the world. As it moves beyond the 100,000 Genomes Project, Genomics England will work with NHSE to launch the world's first Genomic Medicine Service within a national healthcare system. In partnership with government, the NHS, academia, industry and the public, Genomics England aims to realise the potential of genomic medicine: to embed state-of-the-art care in the NHS; bring health benefits to UK citizens; and consolidate the UK's position as the 'go to' destination for international genomic research and investment.

    COMPENSATION

    There are some great benefits on offer with this role including a competitive salary, pension, generous holidays and more.

    HOW TO APPLY

    Please do not hesitate to contact Harvey Uppal at huppal[at]pararecruit.com or call (+44) 121 616 3407 to discuss this opportunity further.

    Keywords: Rare, Disease, Analyst, WGS, WES, Genomics, Bioinformatics, Pipelines, Statistics, Testing, Writing, Variants, NGS, London, Fixed-Term.

    Submitter

    BACKGROUND

    A very interesting opportunity has just become available for a Principal Scientist within Computational Biology to join a world leading Pharma company in Germany. You will be joining the research department as a Principal Scientist, working with dedicated partners in specific Therapeutic Area (TA) departments. These include, CNS/Neuroscience, Cancer Immunology, Cardiometabolic Disease and Research Beyond Borders. An ideal candidate will have a strong background in biomarker discovery and strong connections/collaborations with various Pharma, Biotech or Academic Institutions within this field that they can utilise.

    RESPONSIBILITIES

    Your Tasks:
    • You work as an Expert in Bioinformatics and Data Science within the Computational Biology Group together with members of the Partner function and the Computational Biology Core function.
    • You will establish and develop new analysis strategies for RNA-Seq, single cell RNA-Seq and other NGS approaches and have strong experience with GWAS studies.
    • You oversee and contribute to the development of automated standard analysis pipelines, automation of interactions between infrastructure components, or requirements analyses for such systems. You will also contribute to the company's global computational biology infrastructure in collaborations with bioinformaticians and members of IT and external partners in international teams.
    • You are the key interface to the NGS lab within the Computational Biology group and play a driving role in the definition of experimental design strategies and coordinate the implementation and development of the LIMS. Together with the NGS lab you develop outsourcing strategies.
    • You carry out data analyses to generate and test hypotheses in the context of new therapeutic concepts in collaboration with other members of the Computational Biology group or scientists from BI's Therapeutic Areas for Drug Discovery (Cardiometabolic Research, Central Nervous System Research, Inflammation & Respiratory Research, Immune Modulation & Research Beyond Borders). You support others and drive projects as the responsible computational biologist.
    • You contribute to projects during all phases from experimental design to downstream analysis as the computational biology specialist in interdisciplinary teams.

    REQUIREMENTS

    Your Qualifications:
    • You hold a PhD degree or equivalent qualification in Computational Biology or related fields several years of post-PhD experience.
    • You will have strong experience in data science, Machine Learning and statistical approaches in order to analyse large multi-omics data sets.
    • You have excellent knowledge and a broad spectrum in bioinformatics and computational biology with a focus on topics related to RNA-Seq, single cell RNA-Seq and other NGS applications as well as GWAS experience. You have analyzed from initial QC to downstream a large number of different RNA-Seq projects, and you have hands-on experience with scRNA-Seq data from multiple platforms. In addition you have a good overview of recent developments in terms of NGS instruments and protocols. Ideally you have collaborated closely with genomics teams and dealt with LIMS as well.
    • Your solid background in statistics and experimental design allows you to define the way forward also for complex questions.
    • You have several years of experience in R/Bioconductor or Python and at least one additional programming language. You have robust coding skills, experience with version control systems (e.g. git) and constantly strive for well documented and reproducible analyses. In addition you are familiar with Linux, local and cloud-based HPC environments and have experience with queuing systems and modern pipelining systems (e.g. CWL, bpipe etc).
    • Experience with other type of omics data, network biology or machine learning is an additional asset.
    • You have previously demonstrated that you can apply your skills to turn large datasets into relevant insight in concrete biological and disease related topics in interdisciplinary collaborations.
    • Your fluency in English both in writing and in speaking will enable you to act in an international working environment.
    • You are characterized by a focused working style, flexibility as well as innovative thinking, and problem solving and analytical skills.
    • You are a reliable team player with excellent organization and communication skills, and with a high degree of motivation.

    COMPENSATION

    There are some great benefits on offer with this position including a competitive salary, bonus scheme, relocation package and more.

    HOW TO APPLY

    Please do not hesitate to contact Harvey Uppal on +44 121 616 3407 or huppal[at]pararecruit.com to discuss this opportunity further.

    Keywords: Principal, Scientist, Computational, Biology, Data Science, Biostatistics, Stats, Machine Learning, AI, Human, Genetics, GWAS, RNA, Python, Bioinformatics, Genomics, NGS, Drug Discovery, Biomarker, Germany, Europe

    BACKGROUND

    We are looking for two new senior systems administrators to join our new operations unit at the National Genome Center.

    If you are interested in a unique opportunity to be involved and put your mark on the development on the new infrastructure for personalized medicine in Denmark you should consider applying for this position.

    About us / National Genome Center:
    In December 2016, the Danish Government and Danish Regions launched the national strategy for Personalised Medicine. The strategy lays the foundation for a balanced development of Personalised Medicine in Denmark for the benefit of patients – now and in the future.

    The National Genome Center is established as part of the realisation of the national strategy for Personalised Medicine 2017-2020 and is intended to ensure governance and coordination of the strategy's initiatives at the national level. The center's primary task is to lay the foundation for the development of better diagnostics and more targeted treatments using whole genome sequencing.

    In order to achieve this goal, the National Genome Center's core mission is, in cooperation with the Danish Regions and universities, to establish and operate a national technological infrastructure with sufficient capacity to handle a significant increase in the use of whole genome sequencing in the Danish healthcare system and associated needs for data analysis, interpretation, storage, knowledge sharing, and research.

    The National Genome Center is located at Ørestads Boulevard 5, 2300 København S, together with Statens Serum Institute and the Danish Health Data Authority. The center is expected to become an organization with a core of approx. 40 employees including a separate organization in relation to IT infrastructure (HPC systems, etc.). Broad cooperation across the country with regions, universities, organizations, etc. is essential for Center's work.

    More information about the national strategy for Personalised Medicine and the National Genome Center is to be found at www.sum.dk under "Tema".

    RESPONSIBILITIES

    About the positions:
    The two HDPA System Administrators share responsibility for Linux high performance cluster and hardware and software systems including but not limited to: stand-alone servers and private cloud infrastructure, back-up systems and on demand high-performance computing environments.

    The computer installation comprises of a multi-processor high performance cluster, and a large number of Linux servers dedicated to specific services.

    The work will focus on assuring the stable operation of the center's scientific supercomputing facility. It will include maintenance of the hardware and software installation and monitoring of the system software backup, documentation and user support.

    REQUIREMENTS

    Education and experience:
    If you have a degree in Computer Science or a related field it is an advantage but not a requirement for this position. Relevant it work experience is required.

    Required qualifications include:
    • Experience with Linux server and network administration
    • Experience with server and network security
    • Experience with system and network log analysis
    • Extensive experience with network and security solutions
    • Experience with Linux virtualization
    • Experience with queuing systems
    • Experience with Open stack is a plus
    • Experience with Backup and Tiered storage
    • Experience with Linux modules and software installation
    • Experience with Linux, Mac OS end user support
    • Fluency in English, spoken and written

    TERMS

    The position is a full time position and is available from December 1st 2018.

    COMPENSATION

    We offer:
    We offer an interesting and challenging job in an international atmosphere with the focus on innovation, in an ambitious environment. We place emphasis on a high level of professionalism among our staff, so skills development is an integral part of our organization. We offer a great flexibility in the position.

    Salary and appointment terms:
    Depending on your educational background salary and appointment terms will be bases on either...

    1. The collective agreement between the Danish Ministry of Finance and the Danish Federation of Professional Associations (AC) (overenskomst for akademikere i staten) Depending on your academic qualifications and experience there is a possibility of being classified as a special or senior consultant according to appendix 4 (protocol concerning special- and senior consultants).

    or

    2. The organizational agreement between The Danish Finance Ministry and the Organisation for Salaried Employees HK/Stat (Organisationsaftale for kontorfunktionærer, laboranter og it-medarbejdere (HK)), according to chapter 5 in the agreement and the collective agreement between The Danish Finance Ministry and the Organisation of Public Employees (OAO-S-Fællesoverenskomsten).

    HOW TO APPLY

    Please visit candidate.hr-manager.net/Appl[...]aId=5

    Click "apply" to send your job application with curriculum vitae and diploma / exam certificates before October 14th 2018. The first round of interviews is expected to be held from October 15th till October 19th 2018 (week 42) and second round of interviews is expected to be held from October 22nd till October 26th 2018 (week 43).

    Further information:
    For further information about the job you are welcome to contact head of the infrastructure of the National Genome Center, Peter Løngreen, (phone 29 44 14 99).

    DEADLINE

    Application due: 14-10-2018
    Start date: 01-12-2018

    POLICY

    The Ministry of Health have non-smoking working hours.

    We encourage everyone who are interested to apply to the position – regardless of age, gender, religion, disabilities or ethnicity.

    BACKGROUND

    We are looking for a Database administrator with a strong focus on performance and scalability to join our new operations unit at the National Genome Center.

    If you are interested in a unique opportunity to be involved and put your mark on the development on the new infrastructure for personalized medicine in Denmark you should consider applying for this position.

    About us / National Genome Center:
    In December 2016, the Danish Government and Danish Regions launched the national strategy for Personalised Medicine. The strategy lays the foundation for a balanced development of Personalised Medicine in Denmark for the benefit of patients – now and in the future.

    The National Genome Center is established as part of the realisation of the national strategy for Personalised Medicine 2017-2020 and is intended to ensure governance and coordination of the strategy's initiatives at the national level. The center's primary task is to lay the foundation for the development of better diagnostics and more targeted treatments using whole genome sequencing.

    In order to achieve this goal, the National Genome Center's core mission is, in cooperation with the Danish Regions and universities, to establish and operate a national technological infrastructure with sufficient capacity to handle a significant increase in the use of whole genome sequencing in the Danish healthcare system and associated needs for data analysis, interpretation, storage, knowledge sharing, and research.

    The National Genome Center is located at Ørestads Boulevard 5, 2300 København S, together with Statens Serum Institute and the Danish Health Data Authority. The center is expected to become an organization with a core of approx. 40 employees including a separate organization in relation to IT infrastructure (HPC systems, etc.). Broad cooperation across the country with regions, universities, organizations, etc. is essential for Center's work.

    More information about the national strategy for Personalised Medicine and the National Genome Center is to be found at www.sum.dk under "Tema".

    RESPONSIBILITIES

    About the position:
    You will as our new Database Administrator be managing high performance databases at the national platform as well as participate in designing and implementing new databases.

    Our technology stack:
    • Mongo
    • HIVE
    • Oracle/MS-SQL
    • Open stack & Spark
    • PostgreSQL/MySQL, Elastic, Neo4j
    You will be managing systems for exploring, interacting with the data coming from various sources such as our internal systems and external providers. Your responsibilities will relate mostly to the backend systems.

    Your main tasks would include:
    • Developing new architectures and systems while maintaining clean and coherent infrastructure
    • Performance and maintaining systems
    • Optimising queries and fine-tuning
    • Collaborating with the project partners outside of the team if needed
    • Participate and manage design and deployment of the new systems
    • Maintaining user-facing documentation and description of the system
    • Ensuring compliance of the system and liaise in with the data protection team
    • Participating in regular meetings where the team members altogether discuss the progress and the next steps
    Your education and experience:
    • A degree in Computer Science, Bioinformatics, Data Science or a related field, or equivalent work experience.
    Required qualifications include:
    • Experience with using REST APIs
    • Proven track record
    • Relevant experience
    • Invest time in new upcoming technologies

    PREFERENCES

    It would be a plus to have experience with:
    • Open stack
    • Compliance
    • Managing Linux servers
    • Data lake architecture
    • Agile development (Scrum etc.)

    TERMS

    The position is a full time position and is available from December 1st 2018.

    COMPENSATION

    We offer:
    We offer an interesting and challenging job in an international atmosphere with the focus on innovation, in an ambitious environment. We place emphasis on a high level of professionalism among our staff, so skills development is an integral part of our organization. We offer a great flexibility in the position.

    Salary and appointment terms:
    Depending on your educational background salary and appointment terms will be bases on either...

    1. The collective agreement between the Danish Ministry of Finance and the Danish Federation of Professional Associations (AC) (overenskomst for akademikere i staten). Depending on your academic qualifications and experience there is a possibility of being classified as a special or senior consultant according to appendix 4 (protocol concerning special- and senior consultants).

    or

    2. The organizational agreement between The Danish Finance Ministry and the Organisation for Salaried Employees HK/Stat (Organisationsaftale for kontorfunktionærer, laboranter og it-medarbejdere (HK)), according to chapter 5 in the agreement and the collective agreement between The Danish Finance Ministry and the Organisation of Public Employees (OAO-S-Fællesoverenskomsten).

    HOW TO APPLY

    Please visit candidate.hr-manager.net/Appl[...]aId=5

    Click "apply" to send your job application with curriculum vitae and diploma / exam certificates before October 14th 2018. The first round of interviews is expected to be held from October 15th till October 19th 2018 (week 42) and second round of interviews is expected to be held from October 22nd till October 26th 2018 (week 43).

    Further information:
    For further information about the job you are welcome to contact head of the infrastructure of the National Genome Center, Peter Løngreen, (phone 29 44 14 99).

    DEADLINE

    Application due: 14-10-2018
    Start date: 01-12-2018

    POLICY

    The Ministry of Health have non-smoking working hours.

    We encourage everyone who are interested to apply to the position – regardless of age, gender, religion, disabilities or ethnicity.

    BACKGROUND

    We are looking for a Backend developer with experience in designing secure scalable systems to join our new operations unit at the National Genome Center.

    If you are interested in a unique opportunity to be involved and put your mark on the development on the new infrastructure for personalized medicine in Denmark you should consider applying for this position.

    About us / National Genome Center:
    In December 2016, the Danish Government and Danish Regions launched the national strategy for Personalised Medicine. The strategy lays the foundation for a balanced development of Personalised Medicine in Denmark for the benefit of patients – now and in the future.

    The National Genome Center is established as part of the realisation of the national strategy for Personalised Medicine 2017-2020 and is intended to ensure governance and coordination of the strategy's initiatives at the national level. The center's primary task is to lay the foundation for the development of better diagnostics and more targeted treatments using whole genome sequencing.

    In order to achieve this goal, the National Genome Center's core mission is, in cooperation with the Danish Regions and universities, to establish and operate a national technological infrastructure with sufficient capacity to handle a significant increase in the use of whole genome sequencing in the Danish healthcare system and associated needs for data analysis, interpretation, storage, knowledge sharing, and research.

    The National Genome Center is located at Ørestads Boulevard 5, 2300 København S, together with Statens Serum Institute and the Danish Health Data Authority. The center is expected to become an organization with a core of approx. 40 employees including a separate organization in relation to IT infrastructure (HPC systems, etc.). Broad cooperation across the country with regions, universities, organizations, etc. is essential for Center's work.

    More information about the national strategy for Personalised Medicine and the National Genome Center is to be found at www.sum.dk under "Tema".

    RESPONSIBILITIES

    About the position:
    You will be a member of a team that will designing and building maintainable system aimed at providing easy access to advanced functionalities in very complex backends.

    As a Backend developer/Software architect, you will play a key role in designing new high performing systems for our users and customers. Each new system has to take into consideration the individual domain of the users, while still being secure and scalable and easy to use. While your main responsibilities are within a backend domain, you might be required to take on overall tasks as well.

    Your main tasks would include:
    • Designing new secure scalable systems
    • Building these systems
    • Building a back catalogue of Customizable Software Components for the technology stack used at the center
    You will have the opportunity to influence the choice of languages, frameworks and tools.

    You will have a unique opportunity to involved and put your mark on the development on the new infrastructure for personalized medicine in Denmark.

    REQUIREMENTS

    Your education and experience:
    • A degree in Computer Science, Bioinformatics, Data Science or a related field, or equivalent work experience is required.
    Required qualifications include:
    • Solid Experience with building applications on the NGS data
    • Documented experience with Python & R
    • Experience with building and using REST APIs
    • Experience with Object Oriented and MVC approaches to programming
    • Experience with databases
    • Experience with CI/CD (continuous integration and continuous delivery)
    • Git version control
    • Experience with architectures using security by design

    PREFERENCES

    It would be a plus to have experience with:
    • Agile development (Scrum etc)
    • Designing domain specific solutions
    • Test drive design
    • Frontend framework such as Angular
    • NodeJS
    • Frameworks for rapid development
    • Provisioning and configuration management tools

    TERMS

    The position is a full time position and is available from December 1st 2018.

    COMPENSATION

    We offer:
    We offer an interesting and challenging job in an international atmosphere with the focus on innovation, in an ambitious environment. We place emphasis on a high level of professionalism among our staff, so skills development is an integral part of our organization. We offer a great flexibility in the position.

    Salary and appointment terms:
    Depending on your educational background salary and appointment terms will be bases on either...

    1. The collective agreement between the Danish Ministry of Finance and the Danish Federation of Professional Associations (AC) (overenskomst for akademikere i staten) Depending on your academic qualifications and experience there is a possibility of being classified as a special or senior consultant according to appendix 4 (protocol concerning special- and senior consultants).

    or

    2. The organizational agreement between The Danish Finance Ministry and the Organisation for Salaried Employees HK/Stat (Organisationsaftale for kontorfunktionærer, laboranter og it-medarbejdere (HK)), according to chapter 5 in the agreement and the collective agreement between The Danish Finance Ministry and the Organisation of Public Employees (OAO-S-Fællesoverenskomsten).

    HOW TO APPLY

    Please visit candidate.hr-manager.net/Appl[...]aId=5

    Click "apply" to send your job application with curriculum vitae and diploma / exam certificates before October 14th 2018. The first round of interviews is expected to be held from October 15th till October 19th 2018 (week 42) and second round of interviews is expected to be held from October 22nd till October 26th 2018 (week 43).

    Further information:
    For further information about the job you are welcome to contact head of the infrastructure of the National Genome Center, Peter Løngreen (phone 29 44 14 99).

    DEADLINE

    Application due: 14-10-2018
    Start date: 01-12-2018

    POLICY

    The Ministry of Health have non-smoking working hours.

    We encourage everyone who are interested to apply to the position – regardless of age, gender, religion, disabilities or ethnicity.

    BACKGROUND

    Computercraft is seeking a forward thinker to work on site at the National Center for Biotechnology Information (NCBI) to drive the advancement of existing and new sequence display and analysis tools. This individual will develop and actualize a user-focused vision for NCBI's displays and tools that are part of many well-known sequence resources (e.g., BLAST, RefSeq, Gene, Genome Data Viewer) relied upon daily for sequence alignment and analysis. This work will involve identifying and prioritizing customer needs, conceiving a vision for the advancement of these displays and tools, developing a plan to guide implementation, and working in a cross-functional capacity, communicating with both scientists and programmers as well as NCBI leadership.

    To see the "big picture," the right candidate will have training in molecular biology, bioinformatics, or related field and bench research to understand the science; familiarity with graphical displays (genome browsers), aligners, and sequence analysis tools to understand currently available resources; knowledge of how these tools are used by those engaged in basic research, clinical work, and educational efforts to understand the needs of NCBI's users; and experience in the area of software development to understand the process for transforming ideas into public-facing online products.

    RESPONSIBILITIES

    • Determine community needs with respect to different areas of sequence analysis through attendance at research conferences, analysis of the literature, and the establishment of relationships with biologists and bioinformaticians.
    • Evaluate competitor tools.
    • Identify existing and new research areas that would benefit from tools and displays offering access to NCBI sequence data.
    • Support program leadership in defining a product vision, a road map, and growth opportunities for sequence data analysis tools.
    • Provide direction to Agile development teams to transform NCBI's value-added sequence data into resources serving researchers, educators and clinicians world wide.
    • Define, evaluate, and apply key performance indicators in development of NCBI resources.

    REQUIREMENTS

    • Ph.D. in molecular biology, bioinformatics, or related field
    • Extensive experience with a wide range of locally developed, public and/or commercial tools for sequence analysis and visualization of biological data (e.g., graphical displays/genome browsers, BLAST, alignment tools)
    • Experience with software development, including writing scripts
    • Ability to develop a creative, user-focused vision and communicate vision to developers
    • Proficiency in problem solving, planning, and time management
    • Excellent verbal and written communication, consensus-building, and interpersonal skills
    • Ability to guide and motivate a product team and collaborate with cross-functional groups of scientists and software developers

    PREFERENCES

    • Demonstrated engagement with communities developing or using sequence analysis tools
    • Postdoctoral training
    • Familiarity with Agile development methods
    • Certified Scrum Product Owner (CSPO)

    LOCALE

    Computercraft, NIH Main Campus in Bethesda, MD

    COMPENSATION

    Computercraft offers a competitive salary, an excellent benefits package, the opportunity for a positive work-life balance with a standard 40-hour work week, and the chance to work alongside a team of highly accomplished professionals.

    HOW TO APPLY

    To apply for this position or learn about other Computercraft job opportunities, please visit the Careers section of our website: computercraft-usa.com.

    POLICY

    Computercraft is an equal opportunity employer.
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