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    Featured announcements
    Opportunity: Bioinformaticist @ The University of Nevada, Las Vegas
    Submitted by Dory Libres; posted on Wednesday, October 18, 2017
    Opportunity: Researcher 6 @ University of Minnesota -- Minneapolis, MN (US)
    Submitted by Jill Hodsdon; posted on Thursday, September 28, 2017

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    Opportunity: Bioinformaticist @ The University of Nevada, Las Vegas
    Submitted by Dory Libres; posted on Wednesday, October 18, 2017

    BACKGROUND

    The University of Nevada, Las Vegas invites applications for a Bioinformaticist, Nevada Institute of Personalized Medicine (18060).

    Profile of the University:
    UNLV is a comprehensive research university of approximately 28,000 students and 3,300 faculty and staff dedicated to teaching, research, and service. The university has internationally recognized programs in hotel administration and creative writing; professional degrees in law, architecture, and dental medicine; and leading programs in fine arts, sciences and education. UNLV is located on a 332-acre main campus and two satellite campuses in dynamic Southern Nevada. For more information, visit us on-line at: www.unlv.edu.

    RESPONSIBILITIES

    Role of the Position:
    The Nevada Institute of Personalized Medicine (NIPM) at the University of Nevada, Las Vegas (UNLV) invites applications for a Bioinformaticist position. The purpose of this position is to provide bioinformatics support to NIPM next generation sequencing and genotyping service and its users. This position provides technical support for bioinformatics and statistical analyses for NIPM faculty and research projects. The position requires skills in the analysis of NGS data, particularly with respect to pipelines for whole genome and exome analysis, RNA-Seq, Methylation, ChiPSeq and other epigenetic analyses; genotype imputation, GWAS, statistical and population genetics. The position requires a sufficient understanding of biology, genetics, genomics and human diseases, and solid computational and statistical training. Experience in NGS sequencing analyses, statistical genetics, and human genetics and disease studies are preferred.

    This position also provides some support working with other team members on database development, maintenance, administration, and curation for NIPM. The position requires a thorough understanding of relational database administration and the ability to analyze, plan, and manage database projects while meeting established deadlines. Software development using client server tools, relational structured query language, and structured programming design skills are desirable. Experience in a biology or medical field highly preferred. Database administration certification is preferred.

    Major Responsibilities:
    • Provide bioinformatics support of NIPM NGS and genotyping service: provide technical support for bioinformatics and statistical analyses for NIPM faculty, research projects, and NGS and Genotyping service Bioinformatics support. The position requires a sufficient understanding of biology, genetics, genomics and human diseases, and solid computational and statistical training. Experience in NGS sequencing analyses, statistical genetics, and human genetics and disease studies preferred. The person should have first-hand experience in large scale genomics/genetics/bioinformatics analyses in human diseases. The experience and skill to manage and maintain Lunix cluster is desired.
    • Maintain NIPM database: maintain security and integrity, build parsers for external data import, installing and testing new versions of the DBMS, writing database documentation, controlling access permissions and privileges, and generate views and SQL and CQL queries for database users and programmers
    • Maintain NIPM website: help the director update content
    • Provide support for NIPM research projects

    REQUIREMENTS

    Minimum Required Qualifications: This position requires a Ph.D. in computer science/bioinformatics or related field from a regionally accredited college of university and two years related professional experience.

    COMPENSATION

    Salary Range:
    Salary competitive with those at similarly situated institutions. Position is contingent upon funding.

    HOW TO APPLY

    Submit a letter of interest, a detailed resume listing qualifications and experience, and the names, addresses, and telephone numbers of at least three professional references who may be contacted. Applicants should fully describe their qualifications and experience, with specific reference to each of the minimum and preferred qualifications because this is the information on which the initial review of materials will be based. The review of materials will begin November 10, 2017, and will continue until the position is filled. Materials should be addressed to Dr. Martin Schiller, Search Committee Chair, and are to be submitted via on-line application at hrsearch.unlv.edu. For assistance with UNLV's on-line applicant portal, contact UNLV Employment Services at (702) 895-3504 or applicant.inquiry[at]unlv.edu.

    Apply Here: www.Click2Apply.net/58vtjc46ddbzjfsb

    PI99849402

    POLICY

    UNLV is an Equal Opportunity / Affirmative Action educator and employer committed to achieving excellence through diversity. All qualified applicants will receive consideration for employment without regard to, among other things, race, color, religion, sex, age, creed, national origin, veteran status, physical or mental disability, sexual orientation, genetic information, gender identity, gender expression, or any other factor protected by anti-discrimination laws. The University of Nevada, Las Vegas employs only United States citizens and non-citizens lawfully authorized to work in the United States. Women, under-represented groups, individuals with disabilities, and veterans are encouraged to apply.

    DESCRIPTION

    We now have an exciting opportunity for a skilled computational biologist to join a growing team led by Dr Stephen Sansom at the Kennedy Institute of Rheumatology (KIR). In this role, you will work in the computational genomics group to develop and run bioinformatics pipelines for the analysis of next-generation sequencing (NGS) data. Taking advantage of our state-of-the-art high-performance compute (HPC) facility you will collaborate closely with KIR scientists to analyse diverse types of genomic data including those from RNA-seq, ATAC/ChIP-seq, micobiome and CyTOF experiments. At the KIR – which is a world-class academic research Institute – researchers are now using such techniques to advance understanding and treatment of diseases such as Rheumatoid Arthritis and Inflammatory Bowel Disease.

    The successful applicant will have the opportunity to further develop his or her bioinformatics skills and to contribute to peer-reviewed research publications. To be considered you should have a degree and/or PhD in bioinformatics (or a related field), strong programming skills and experience with analysis of NGS data.

    Informal enquires to Dr Stephen Sansom are welcomed (stephen.sansom[at]kennedy.ox.ac.uk).

    TERMS

    This opportunity is funded on a 3-year fixed-term contract.

    LOCALE

    Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, Old Road Campus, Oxford

    COMPENSATION

    Grade 7: £31,604 - £38,833 p.a.

    HOW TO APPLY

    For more information and to apply please visit: www.recruit.ox.ac.uk/pls/[...]31472

    Contact Person: NDORMS Personnel Team
    Vacancy ID: 131472
    Contact Phone: 01865 223989
    Contact Email: personnel[at]ndorms.ox.ac.uk

    DEADLINE

    The closing date for applications is 12.00 noon on Monday 6 November 2017.

    DESCRIPTION

    The South Dakota School of Mines & Technology invites applications for a 9-month tenure-track faculty position in Nanoscience and Nanoengineering at the Assistant or Associate Professor level in the area of computational nanoscience, imaging informatics and bioinformatics. Candidates with expertise in other areas relating to bio-nanoscience will also be considered.

    The position is associated with a statewide research center: BioSystems Networks / Translational Research (BioSNTR). BioSNTR is focused on advanced fluorescence and optical imaging methods to leverage bioinformatics towards the understanding of signaling networks and their regulation in living systems. BioSNTR is a collaboration between research university partners South Dakota State University, the University of South Dakota, and South Dakota Mines, with multiple industrial partners, including Sanford Research.

    The successful candidate will be provided a competitive salary and access to center staff and shared resources, including high performance computing infrastructure. The selected candidate will be expected to contribute to the South Dakota Mines Nanoscience and Nanoengineering PhD program by developing a robust extramurally funded research program, teaching and developing relevant graduate courses, mentoring and advising PhD students, and building strong collaborative research teams.

    Specific interests for this position are candidates who could contribute to multiscale modeling, analyzing high volume microscopy data generated by our newly constructed lattice light sheet microscope, and connecting this data with computational biology and next-generation sequencing. Individuals whose research emphasis can complement on-going efforts in biophotonics, cellular level biophysics, super-resolution imaging methods, mechanobiology, and the combination of AFM and fluorescence microscopy for correlative imaging of bio-systems are particularly encouraged to apply.

    Applicants must possess a PhD in a science or engineering discipline closely aligned with Nanoscience and Nanoengineering and/or one of the above-mentioned research emphases. Candidates from underrepresented groups are encouraged to apply. The successful candidate will become a faculty member in an interdisciplinary doctoral program in Nanoscience and Nanoengineering, with an anticipated start date of August 20, 2018. Email Steve.Smith[at]sdsmt.edu for further information regarding this position.

    ABOUT US

    Established in 1885, the South Dakota School of Mines & Technology is a science and engineering research university located in Rapid City, South Dakota. South Dakota Mines is a public university offering bachelor's, master's, and doctoral degrees in engineering and science. Known for our academic rigor, we maintain a 15:1 student-to-faculty ratio. Our students benefit from immersive learning experiences including undergraduate research, co-ops/internships, and numerous nationally competitive engineering teams. Our graduates have a 96% placement rate and an average starting salary of nearly $63,000. Our Research Programs are concentrated in four areas: energy and environment; materials and manufacturing; STEM education; and underground science and engineering.

    South Dakota Mines is a growing university that enrolls around 2,800 students from 44 states and 30 countries. Rapid City is the state's second largest city (with an urban population of 74,048 and metropolitan population of 199,656) and is nestled at the foot of the beautiful Black Hills. Mount Rushmore, the Badlands National Park and Crazy Horse Memorial are all within an hour of the University. Rapid City enjoys a relatively mild climate and offers year-round recreational opportunities, including, hiking, bicycling, skiing, snowboarding, fishing, and hunting, to name a few. For more information about South Dakota Mines and Rapid City, visit: www.sdsmt.edu and visitrapidcity.com.

    HOW TO APPLY

    South Dakota Mines is committed to recruiting and retaining a diverse workforce and offers an excellent comprehensive benefits package including paid medical and life insurance for our employees, as well as medical, dental and vision coverage for spouses and dependents; retirement plans; paid holidays; and a generous sick day allowance. Individuals interested in this position must apply online at www.sdsmt.edu/employment. Human Resources can provide accommodation to the online application process and may be reached at (605) 394-1203. Review of applications will begin December 1, 2017, and will continue until the position is filled. Employment is contingent upon completion of a satisfactory background investigation.

    POLICY

    South Dakota School of Mines & Technology does not discriminate on the basis of sex, race, color, creed, national origin, ancestry, citizenship, gender, gender identification, transgender, sexual orientation, religion, age, disability, genetic information or veteran status in employment or the provision of service.

    BACKGROUND

    We are looking to expand our team with a Bioinformatics Postdoctoral fellow who is up for the challenge of working at the interface of computational, experimental and clinical science. The Peters lab has a long-standing track record of developing and contributing to computational algorithms for T cell epitope identification that are now in broad use in the cancer community even though they were originally intended to be applied for infectious diseases. The candidate will join our recently started effort to develop cancer specific computational tools to aid in the identification of T cell epitopes specific to tumors, and work with data from our network of clinical and experimental collaborators to develop improved algorithms as well as aid in the design and interpretation of experiments.

    RESPONSIBILITIES

    • High-Throughput Sequencing data analysis (exome and transcriptome from bulk and single-cell sequencing)
    • TCR sequence analysis
    • Application and development of state-of-the-art analysis tools
    • Communicate with clinical collaborators and aid in translational study design

    REQUIREMENTS

    • PhD degree, ideally in Computational Biology or Bioinformatics (candidates with equivalent skills and interests in computer science, statistics, and biomedicine will be considered)
    • Experience with at least one programming language is required (e.g. Python, R, or Perl)
    • Experience with High-Throughput Sequencing data
    • Experience with TCR sequence analysis is a strong plus
    • Knowledge of or strong interest in cancer biology and immunology is a strong plus

    COMPENSATION

    Salary will be commensurate with experience.

    Full-time employment at LJI includes a competitive salary, medical/dental/vision benefits and contributions to a retirement plan (403B).

    ABOUT US

    In 2017, LJI was ranked as one of the best places to work in San Diego by the San Diego Business Journal. The Institute hosts 24 world-renowned faculty and over 100 postdoctoral researchers hailing from 21 different countries. LJI is located in the Science Research Park on the campus of UC San Diego, with easy access to the San Diego life sciences community and all that the area has to offer.

    HOW TO APPLY

    Interested applicants should submit their resume and cover letter (single attachment) through our online portal here to be considered: www.lji.org/careers/

    POLICY

    LJI provides Equal Employment Opportunity (EEO) to all employees and applicants regardless of race, national origin, religion, sex, marital status, age, mental or physical disability, medical condition, veteran status, sexual orientation, or pregnancy. This applies to all personnel practices, including recruitment, hiring, training, promotion, compensation, benefits, transfers, educational assistance, and social and recreational programs.

    BACKGROUND

    A bioinformatic position focused on the analysis of complex datasets including: DNA-sequencing, RNA-sequencing, metabolomics and drug sensitivity data. Specific emphasis will be placed on delineating the impact of specific pathways on disease progression and therapeutic response using data from clinically annotated tissue specimens and patient-derived models.

    Ideal candidates will have experience with bioinformatics, have a track record of leading projects to publication, and be creative in using computational methods to interrogate complex biological problems.

    Postdoctoral fellows will be expected to direct independent projects in a multi-disciplinary setting, assist in mentoring junior lab members, and apply for independent fellowship funding.

    A long-term goal of the project is to bring the research to clinical application and fellows will have the opportunity to directly contribute to clinical trial development and interactions with the multi-disciplinary teams in molecular oncology.

    REQUIREMENTS

    • MS or PhD with relevant experience in bio-informatics or computational biology
    • Record of research accomplishment
    • Self motivated with a positive attitude
    • Strong interpersonal skills

    HOW TO APPLY

    Interested individuals should send a CV, statement of interests, with a list of three references to:
    Erik Knudsen, PhD
    Professor of Cancer Biology
    eknudsen[at]email.arizona.edu
    Opportunity: Support Bioinformatician @ Genomics England -- London, UK
    Submitted by Eugene Mc Daid; posted on Tuesday, October 17, 2017

    BACKGROUND

    Paramount are working in partnership with Genomics England to expand their team in order to deliver success Paramount are working in partnership with Genomics England to expand their team in order to with the 100,000 Genomes Project. This is a challenging and fast moving project with the aim to carry out whole genome sequencing on 100,000 participants. Genomics England works with key partners to collect, transport, store, quality check and sequence the samples from participants. The aim for this project is to create a new genomic medicine service for the NHS – transforming the way people are cared for. Patients may be offered a diagnosis where there wasn't one before. In time, there is the potential of new and more effective treatments.

    The post holder provides high calibre bioinformatics research support to external researchers and industrial partners by enabling analysis, facilitating access to datasets and ensuring optimal use of the Genomics England Research Data Centre. The post holder will act as a second line of support for users of the Research Environment. They will be intimately familiar with the data and applications.

    The support team is also tasked with quality assuring the data and applications released into the research environment. The role includes elements of a bioinformatician and data analyst, ensuring that our users have an excellent customer experience.

    RESPONSIBILITIES

    • Understanding our research environment and being both a super user and advocate internally and externally
    • Understanding the needs of customers (academic, NHS and industry); working with customers to ensure that their scientific projects are successful and that they gain value from their interactions with our Research Environment. This includes face to face engagement to assess needs and execution
    • Supporting users with how to use our software and data
    • Carrying out custom analyses on demand
    • Managing data, QA releases, supporting data intake and extraction through airlocks and adding external data to our environment, helping with data extraction and generation of data extracts
    • Providing high calibre troubleshooting of problems for customers, appraise customers and Genomics England options and execute solutions, co-ordinating with internal teams when necessary
    • Keeping track of customer relationships and being the internal authority on specific customer issues, needs, and future plans
    • Sharing knowledge within Genomics England about customer needs and experiences and contributing to the development of the Research Environment
    • Collaborating internally, particularly with others in the Chief Scientist's team, our Commercial team, Bioinformatics team and software and infrastructure engineers, to develop and deploy suitable solutions for customers
    • Working from time to time on the NHS Clinical Interpretation pipeline (creating a seamless bioinformatics team who understand the NHS and research pipelines)

    REQUIREMENTS

    • Evidence of experience of bioinformatics research and analytics using large genomic datasets of next generation sequencing data alongside clinical data in a field relevant to Genomics England
    • Good customer-service orientation, disposition to help, and proven expertise in partnership working with customers, preferably in the scientific/pharma industry
    • Strong communication skills, both written and verbal and excellent facilitation, influencing and presentation skills
    • Proven ability to communicate with key customer and internal stakeholders from diverse backgrounds (e.g. management, IT, R and D, biology, bioinformatics)
    • Excellent team working skills and comfortable working as part of matrix teams and as part of external teams to ensure delivery
    • Experience of working in a knowledge sharing environment
    • Willingness to travel occasionally (< 15%) to meet customers or to attend events to gain market insight
    • Experience with cloud-scale data processing and high-performance computing
    • Educated to MSc level (or higher), in a relevant scientific discipline
    • Demonstrated knowledge and competence in relevant programming languages and applications (e.g. R, Python, Perl, SQL) and experience of using a suite of bioinformatics tools to problem solve and answer research questions
    • Adaptable to an ever-evolving working environment
    • Experience of technical writing
    • Experience of database development and design, ideally including both SQL and NoSQL (eg Hadoop)
    • Experience in "data wrangling" large and or complex data sets using tools such as those from R/tidyverse
    • Proven understanding of clinical and phenotypic data management and the sensitivities surrounding patient cohort data

    COMPENSATION

    There are some great benefits on offer with this role including a competitive salary, pension, generous holidays and more.

    HOW TO APPLY

    Please do not hesitate to contact Harvey Uppal at huppal[at]pararecruit.com or call (+44) 121 616 3407 to discuss this opportunity further.

    Keywords: Support, Bioinformatician, London, Genomics England, Customer, QA/ QC, Clinical, Perl, Python, NGS, SQL, Clinical, Pipeline, HPC, Cloud.

    BACKGROUND

    Paramount are working in partnership with Genomics England to expand their team in order to deliver success Paramount are working in partnership with Genomics England to expand their team in order to with the 100,000 Genomes Project. This is a challenging and fast moving project with the aim to carry out whole genome sequencing on 100,000 participants. Genomics England works with key partners to collect, transport, store, quality check and sequence the samples from participants. The aim for this project is to create a new genomic medicine service for the NHS – transforming the way people are cared for. Patients may be offered a diagnosis where there wasn't one before. In time, there is the potential of new and more effective treatments.

    The post holder provides high calibre bioinformatics research support to external researchers and industrial partners by delivering custom analyses, facilitating access to datasets and ensuring optimal use of the Genomics England Research Data Centre. The post holder will ensure the scientific quality and integrity of the analyses that the team produces.

    The post holder leads a skilled team that supports our academic and industrial partners by analysing the program's data to answer our partner's questions. The post holder ensures the delivery of the team's objectives, staff management and development and provides hand on support as a senior genomics data analyst. There is cross-working with other bioinformatics team members running our interpretation pipeline for the National Health Service.

    RESPONSIBILITIES

    • Developing and executing the operational strategy, objectives and metrics and delivery plans for supporting users, knowledge sharing and continuous improvement.
    • Developing and managing a high performance team (around 5 people)
    • Sharing knowledge within Genomics England about customer needs and experiences and contributing to the development of the Research Environment.
    • Collaborating internally, particularly with others in the Chief Scientist's team, our Commercial team, Bioinformatics team and software and infrastructure engineers, to develop and deploy suitable solutions for customers.
    • Understanding the needs of customers (academic, NHS and industry); working with customers to ensure that their scientific projects are successful and that they gain value from their interactions with our Research Environment.
    • Understanding our research environment and being both a super user and advocate internally and externally.
    • Providing high calibre troubleshooting of problems for customers, appraise customers and Genomics England options and execute solutions, co-ordinating with internal teams when necessary.
    • Carrying out complex custom analyses
    • Keeping track of customer relationships and being the internal authority on specific customer issues, needs, and future plans.
    • Being the key point of contact with customers collecting and updating requirements, communicating progress and feedback
    • Working from time to time on the NHS Clinical Interpretation pipeline (creating a seamless bioinformatics team who understand the NHS and research pipelines).

    REQUIREMENTS

    • A background in a strongly quantitative discipline such as Mathematics, Physics, or Computer Science with at least 3 years of postdoctoral work in fields related to statistical genetics or genomics, or a demonstrable equivalent background
    • Strong evidence of experience in genomics research and data analysis using large genomic datasets of next generation sequencing data alongside clinical data in a field relevant to Genomics England.
    • Team leadership expertise, with a focus on developing self-driven individuals
    • Excellent communication skills, both written and verbal and excellent facilitation, influencing and presentation skills.
    • Proven ability to communicate with key customer and internal stakeholders from diverse backgrounds (e.g. management, IT, R and D, biology, bioinformatics)
    • Strong customer-service orientation and proven experience in partnership working with customers, preferably in the scientific/pharma industry.
    • Excellent team working skills and comfortable working as part of matrix teams and as part of external teams to ensure delivery.
    • Willingness to travel occasionally (< 15%) to meet customers or to attend events to gain market insight.
    • Experience with cloud-scale data processing and high-performance computing.
    • Demonstrated knowledge and competence in relevant programming languages and applications (e.g. R, Python, Scala) and experience of using a suite of bioinformatics tools to problem solve and answer research questions.
    • Ability to work independently with a high degree of motivation and focus, and to complete tasks according to company priorities with minimal supervision.
    • Adaptable to an ever-evolving working environment
    • Experience of technical writing.
    • Experience using of databases, including both SQL and NoSQL solutions
    • Strong publication record in a relevant field, and a proven ability to stay abreast of developments in that field.
    • Previous experience of delivering training resources and events.
    • Proven understanding of clinical and phenotypic data management and the sensitivities surrounding patient cohort data.

    COMPENSATION

    There are some great benefits on offer with this role including a competitive salary, pension, generous holidays and more.

    HOW TO APPLY

    Please do not hesitate to contact Harvey Uppal at huppal[at]pararecruit.com or call (+44) 121 616 3407 to discuss this opportunity further.

    Keywords: Head, Bioinformatics, Genomics, London, Genomics England, Leadership, Management, NGS, Pipeline, Delivery, Commercial, Customer, Big Data, Hadoop, Python, SQL, Scala.

    BACKGROUND

    Moderna is seeking a talented and motivated bioinformatician/computational biologist to work as part of a highly collaborative, multi-disciplinary team. The primary focus for this position will be the analysis, visualization, and interpretation of complex datasets, primarily NGS. The successful applicant will collaborate with individuals and groups across Research and the therapeutic areas to support the advancement of Moderna's mRNA technology platform and pipeline.

    RESPONSIBILITIES

    • Analyze high throughput datasets, primarily Next Generation Sequencing (NGS)
    • Apply biological and statistical knowledge to draw rigorous, actionable conclusions form complex data sets
    • Leverage relevant public data resources to enable and enhance data analysis
    • Develop and apply bioinformatics tools to process, analyze, and interpret data relevant to developing mRNA therapeutics
    • Communicate findings internally and externally
    • Collaborate with groups across the company to support research projects

    REQUIREMENTS

    • B.S. with 6+ years of experience or M.S. with 1+ years of experience in Bioinformatics, Computational Biology, or related field
    • Experience with analysis of next generation sequencing (NGS) data using state of the art bioinformatics tools
    • Experience using publically-available biological databases of sequences and functional data, such as EMBL, GenBank, Entrez, UniProt, RefSeq, miRBase, ENCODE, TCCA, or Roadmap
    • Proficient in at least one programming or scripting language, such as Python, Perl, and/or R
    • Comfort working in a Linux-based High Performance Computing environment
    • Creative problem solver able to draw conclusions from complex datasets, and present them in a clear and understandable way
    • Strong written and oral communication skill

    HOW TO APPLY

    Please apply here: modernatx.wd1.myworkdayjobs.com/en-U[...]_R562

    POLICY

    Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

    BACKGROUND

    The Sanger Mouse Pipelines Genome Engineering group(GE) generates custom mutations in mice by gene targeting in embryonic stem (ES) cells and directly in the mouse zygote by applying cutting edge gene targeting technology.GE creates mutant alleles of interest to Sanger Institute Faculty, many of which are used as models for human disease. Our efforts benefit from extensive targeting vector/ES cell modular resources generated previously as part of the KOMP, EUCOMM, and EUCOMMTOOLs high throughput gene targeting programs and associated expertise as well as the successful implementation of CRISPR/Cas9 methods.

    RESPONSIBILITIES

    We are seeking a highly motivated and flexible individual to join the GE team as an Research Assistant or Advanced Research Assistant. The post holder's main responsibilities will be execution of day-to-day workflows of projects for the generation of targeting vectors, CRISPR/Cas9 reagents and the generation and validation of quality assured targeted mouse ES cells. Key responsibilities include execution and timely delivery of these resources, accurate record keeping, project troubleshooting and an ability to work across multiple projects. In addition, the group also has a research and development (R&D) commitment to implement new approaches that facilitate the insertion of complex alleles directly into the mouse zygote.

    Previous experience of mammalian cell culture, especially mouse ES cell (mESC) culture is a prerequisite for this role. The candidate would also be expected to be able to genotype the mESC clones generated in order to provide quality assured reagents for microinjection. The candidate should have a broad knowledge of molecular biology techniques such as nucleic acid extraction, construct generation (via conventional cloning, Gibson assembly and/or recombineering), PCR, restriction enzyme analysis and sequencing. An understanding of conventional gene targeting and the more recent CRISPR/Cas9 genome engineering techniques would be advantageous. The successful candidate must be able to work as part of a team and also have the ability to independently handle complex workflows from project start to delivery. Good communication/record keeping skills are a key part of the role.

    Some weekend cell culture is anticipated in this role.

    REQUIREMENTS

    Research Assistant Essential Skills:
    • Practical experience in cell culture
    • An understanding and practical experience in molecular biology strategies and techniques, including molecular cloning, nucleic acid isolation and purification, and PCR.
    • Ability to test and implement new approaches and techniques including troubleshooting
    • Capable of performing/tracking a variety of challenging projects simultaneously
    • Ability to work as part of a team and also independently once appropriate training and guidance have been provided.
    • Good communication skills to allow accurate information to be exchanged
    • Science degree in biological sciences
    • Practical laboratory experience
    • Ability to schedule and deliver simultaneous projects within agreed deadlines
    Advanced Research Assistant Essential Skills:
    • Experienced in mammalian cell culture, especially routine mouse ES cells culturing.
    • An understanding and practical experience in molecular biology strategies and techniques, including some of the following: molecular cloning, construct generation (via conventional cloning, Gibson assembly and recombineering), PCR, restriction enzyme analysis and sequencing.
    • Isolation and purification of nucleic acid, particularly RNA based methodologies for the generation of CRISPR reagents.
    • Practical experience and theoretical understanding of genotyping techniques, including qPCR, long range PCR and sequencing and data interpretation there of.
    • Capable of performing/tracking a variety of challenging projects simultaneously
    • Ability to work as part of a team and also independently once appropriate training and guidance has been provided.
    • Good communication skills to allow accurate information to be exchanged
    • Science degree in biological sciences or extensive, proven practical experience
    • Ability to schedule and deliver simultaneous projects within agreed deadlines
    • Good computer skills

    PREFERENCES

    • Experience of transfection, nucleofection and electroporation technologies would be advantageous
    • Practical experience in understanding gene structures on standard genome browsers
    • Practical experience and theoretical understanding of gene targeting strategies
    • Ability to test, implement and troubleshoot new approaches and techniques

    TERMS

    Permanent

    LOCALE

    The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus.

    COMPENSATION

    Salary in the region of £19,000 to £30,000 per annum depending on role and experience

    HOW TO APPLY

    For further information, job description and to apply; jobs.sanger.ac.uk/wd/p[...]28434

    DEADLINE

    31st October 2017

    POLICY

    Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

    BACKGROUND

    Position Summary:
    The Regeneron Genetics Center (RGC) is a wholly-owned subsidiary of the Company, whose goals are to apply large scale human genetics to identify new drug targets and to guide the development of therapeutics programs and precision medicine. Building upon Regeneron's strengths in mouse genetics and genetics-driven drug discovery and development, the RGC specializes in ultra-high-throughput exome sequencing, large scale informatics and data analysis encompassing genomics and electronic health records, and translating genetic discoveries into new biology and drug discovery opportunities. The RGC leverages multiple approaches including large population based studies, Mendelian genetics and family based studies, founder population genetics, and large-scale disease focused projects and has developed a network of over 50 collaborations with research organizations around the world. Including some of the largest sequencing studies in the world, such as the DiscovEHR study in collaboration with Geisinger Health System, and an initiative to sequence 500,000 participants with the UK Biobank, the RGC has built one of the largest human genetics databases, including sequence data from over several hundred thousand participants and rapidly growing. Our interests encompass a breadth of different areas across all therapeutic areas and the RGC is highly integrated into all facets of research and development at Regeneron. Program goals include target discovery, indication discovery, and patient-disease stratification. Objectives include advancing basic science around the world through public sharing of discoveries, providing clinically-valuable insights to physicians and providers of collaborating health-care systems, improving patient outcomes, and identifying novel targets for drug development.

    Summary:
    The postdoctoral fellow position is for early career scientist trainees to receive a rigorous scientific training at the Regeneron Genetics Center under the auspices of a scientist mentor during a 4-year training period. Fellows will be expected to conduct creative exploratory research that results in publishable data within their fellowship period.

    The program will consist of:
    • Four years of formal postdoctoral training in a program directed by an award-winning educator
    • Exposure to the biotechnology industry's most successful and innovative scientists
    • Opportunities to pursue cutting-edge, creative biomedical research in a prestigious, well- resourced, and highly driven industry environment
    • Weekly postdoctoral scientist meetings to foster scientific rigor, creative thinking, critical reasoning, and career advancement
    • Encouragement of scholarly productivity such as publications and conference presentations

    RESPONSIBILITIES

    As part of your Postdoctoral Training Program, you will:
    • Conduct forward-looking, innovative, and creative research to address a novel scientific question of your choice under the auspices of a scientist mentor
    • Publish and disseminate data via external conferences and peer-reviewed publications
    • Assist with mentoring and teaching intern and other more junior trainees
    • Participate in postdoctoral program activities such as weekly meetings and the annual research conference
    • Present data internally, including at lab meetings, trainee meetings, and company wide seminars
    • Provide ongoing reports of research progress to supervisors and program staff

    REQUIREMENTS

    • Doctoral degree in a relevant discipline
    • Scientists looking for their first or second postdoctoral training
    • Superior scientific skills including critical and analytical thinking
    • Demonstrated publication success as evidenced by peer-reviewed publications
    • Good written and oral communication skills
    • Ability to interact dynamically and constructively with scientific peers
    • Note: occasional travel

    HOW TO APPLY

    Applications Accepted: October 1, 2017 - December 1, 2017

    Letters of recommendation are required.

    Please find additional details in online application: careers.regeneron.com/job/[...]nings

    Applications received after December 1, 2017 may not be considered.

    Following the close date, please allow 3-4 months for review and interviews.

    Targeted Start Date: July 2018

    If you have an issue submitting or any questions, please email: postdoctoral[at]regeneron.com.

    BACKGROUND

    Position Summary:
    Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

    Summary:
    The postdoctoral fellow position is for early career scientist trainees to receive a rigorous scientific training at Regeneron under the auspices of a scientist mentor during a 4-year training period. Fellows will be expected to conduct creative exploratory research that results in publishable data within their fellowship period.

    The program will consist of:
    • Four years of formal postdoctoral training in a program directed by an award-winning educator
    • Exposure to the biotechnology industry's most successful and innovative scientists
    • Opportunities to pursue cutting-edge, creative biomedical research in a prestigious, well- resourced, and highly driven industry environment
    • Weekly postdoctoral scientist meetings to foster scientific rigor, creative thinking, critical reasoning, and career advancement
    • Encouragement of scholarly productivity such as publications and conference presentations

    RESPONSIBILITIES

    As part of your Postdoctoral Training Program, you will:
    • Conduct forward-looking, innovative, and creative research to address a novel scientific question of your choice under the auspices of a scientist mentor
    • Publish and disseminate data via external conferences and peer-reviewed publications
    • Assist with mentoring and teaching intern and other more junior trainees
    • Participate in postdoctoral program activities such as weekly meetings and the annual research conference
    • Present data internally, including at lab meetings, trainee meetings, and company wide seminars
    • Provide ongoing reports of research progress to supervisors and program staff

    REQUIREMENTS

    • Doctoral degree in a relevant discipline
    • Scientists looking for their first or second postdoctoral training
    • Superior scientific skills including critical and analytical thinking
    • Demonstrated publication success as evidenced by peer-reviewed publications
    • Good written and oral communication skills
    • Ability to interact dynamically and constructively with scientific peers
    • Note: occasional travel

    HOW TO APPLY

    Applications accepted: October 1, 2017 - December 1, 2017

    Letters of recommendation are required. Please find additional details in online application: careers.regeneron.com/job/[...]nings

    Applications received after December 1, 2017 may not be considered.

    Following the close date, please allow 3-4 months for review and interviews.

    Targeted Start Date: July 2018

    If you have an issue submitting or any questions, please email: postdoctoral[at]regeneron.com.

    RESPONSIBILITIES

    The Bioinformatics Scientist III will develop and maintain bioinformatics pipelines for novel qPCR and NGS applications, perform NGS data analysis and provide computational support for research and product development. This individual will work closely with other scientists and be a key contributor to the product development team.

    Duties:
    • Develops and maintains pipelines for NGS and qPCR applications
    • Provides data analysis support for product development and external collaborations
    • Works closely with R&D scientists to support their daily research activities
    • Participates in brainstorming sessions and contributes ideas in technology, algorithms and products
    • Works independently and also collaborates with other team members to meet project deadlines
    • Prepares and delivers presentations based on scientific and technical progress and achievements
    • Demonstrates and upholds behavior consistent with the Integrated DNA Technologies Core Values and delivers the Integrated DNA Technologies experience to customers and other business associates.
    • Performs other duties as assigned

    REQUIREMENTS

    Education:
    • Bachelor's degree (in Biology, Computer Science, Mathematics, Statistics or a related field) with six or more years relevant work experience required
    • Master's degree (in Bioinformatics, Biostatistics, Computer Science, Applied Mathematics or a related field) with four or more years relevant work experience preferred
    • PhD degree (in Bioinformatics, Biostatistics, Computer Science, Applied Mathematics or a related field) preferred
    Professional Experience:
    • Previous experience in NGS required
    • Knowledge and understanding of computational and biological issues required
    • Previous experience working in a multidisciplinary, fast-paced and results-oriented environment preferred
    • Publications in peer-reviewed journals preferred
    Other Job Qualifications:
    • Familiarity with Python or other scripting languages
    • Programming and data analysis experience in a distributed Unix environment
    • Familiarity with public bioinformatics resources and tools
    • Knowledge of best-practice data presentation methods for internal and external audiences
    • Ability to easily integrate into and collaborate with a multidisciplinary team
    • Excellent oral and written communication skills
    • Adaptability to performing a variety of duties, often changing from one task to another without loss of efficiency or composure.
    • Ability to maintain both a high standard of courtesy and cooperation in dealing with co-workers.
    • Adaptability to accepting responsibility for the direction, control or planning of an activity.
    Physical Requirements:
    • Exert up to 10 lbs. of force occasionally and/or up to a minimal amount frequently

    TERMS

    Shift/Schedule: M-F 40 Hour Week (United States of America)

    LOCALE

    Job Locations: US-IA-Coralville

    HOW TO APPLY

    Apply Here: www.Click2apply.net/h22d9ptvkk2fgdcp

    ID: 2017-3518
    Category: Research & Development
    # of Openings: 1
    Posted Date: 8 hours ago

    PI99779690

    DEADLINE

    11/11/2017

    POLICY

    Integrated DNA Technologies is an equal employment and affirmative action employer. Minorities, women, veterans and individuals with disabilities are encouraged to apply.

    BACKGROUND

    We are seeking a motivated and enthusiastic computational biologist to join the research group of Dr Adam Mead. Funded by the Medical Research Council (MRC) and John Fell Fund, the position is initially available fixed-term for 2 years. You will be involved with developing new and innovative strategies for the analysis of cutting-edge single cell transcriptomic datasets and will lead a project focused on single-cell analysis of haematopoietic stem and progenitor cells. Working within the MRC WIMM Centre for Computational Biology you will interact closely with Dr David Sims who leads CGAT. The Mead laboratory is located in the excellent environment of the MRC Weatherall Institute of Molecular Medicine, which has a world-renowned scientific environment and outstanding core facilities and equipment, including a dedicated single-cell genomics facility. Our research programme is focused on using single-cell approaches to understand how the normal cellular and molecular pathways in haematopoiesis are perturbed in myeloid leukaemias and in pre-leukaemic conditions e.g. Giustacchini et al Nature Medicine, 2017. For further information on Dr Mead's research group and the Institute please see: www.imm.ox.ac.uk/home.

    REQUIREMENTS

    You will hold a PhD or MSc in statistics, computational biology or a similar scientific subject, with post-qualification research experience. Experience in the analysis of high dimensional datasets and demonstrable skills/track record in statistics are essential. You will also have experience of working in a UNIX/LINUX environment and programming in Perl or Python.

    LOCALE

    Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford

    COMPENSATION

    Grade 8: £39,992 - £47,722 p.a. Consideration will be given to applicants who do not fulfill all of the criteria for a Grade 8 appointment. A reduction in duties and criteria for a Grade 7 appointment (£31,604 - £38,833 p.a.) are detailed in the job description.

    HOW TO APPLY

    Applications for this vacancy are to be made online at www.recruit.ox.ac.uk (Vacancy ID 131303). You will be required to upload a CV and supporting statement as part of your online application.

    DEADLINE

    The closing date for this position is 12.00 noon on 27 October 2017.
    Opportunity: Senior Cancer Analyst @ Genomics England -- London, UK
    Submitted by Eugene Mc Daid; posted on Tuesday, October 10, 2017

    BACKGROUND

    Paramount are working in partnership with Genomics England to expand their team in order to deliver success with the 100,000 Genomes Project. This is a challenging and fast moving project with the aim to carry out whole genome sequencing on 100,000 participants. Genomics England works with key partners to collect, transport, store, quality check and sequence the samples from participants. The aim for this project is to create a new genomic medicine service for the NHS – transforming the way people are cared for. Patients may be offered a diagnosis where there wasn't one before. In time, there is the potential of new and more effective treatments.

    Genomics England applies state of the art approaches to whole genome sequences for processing, analysis, quality assurance and annotation. This includes integrating phenotypic and other clinical data with whole genome sequencing to create a world-leading, high fidelity data repository for the NHS and third party users.

    The Bioinformatics team develops and applies state of the art approaches to 100,000 whole genome sequences (WGS) in the areas of:
    • Analysis of WGS in cancer and rare diseases 

    • Sequence alignment and variant calling of up to 100 genomes per day
    • Quality assurance and sample provenance monitoring

    RESPONSIBILITIES

    This senior level analyst role is part of a highly motivated Bioinformatics team, working as part of a small team responsible for cancer analysis.
    Accountabilities:
    • Monitoring quality of WGS data
    • Benchmarking tools for cancer WGS analysis
    • Performing computational analyses for a range of projects
    • Developing and implementing new features for cancer sequencing data analysis
    • Establishing general bioinformatics resources for day-to-day use by colleagues

    REQUIREMENTS

    • MSc or PhD (or equivalent experience) in Bioinformatics or Cancer Molecular Biology or equivalent work experience
    • Good knowledge of cancer genomics
    • Solid skillset in Bioinformatics and experience of working as a computational biologist
    • Practical knowledge of NGS algorithms and available resources for cancer bioinformatics
    • Experience with full cycle of analysing NGS data from sequencing QC to annotation and prioritization of variants
    • Experience with handling large data sets and setting pipelines
    • Strong programming skills (Python, R); ability to develop codes as a part of team
    • Practical knowledge and understanding of statistics
    • Excellent technical writing skills
    • A demonstrable ability to cope under pressure and deliver to deadlines
    • Ability to communicate effectively within a multidisciplinary team
    • Flexible and co-operative approach to colleagues
    • Ability to work independently and to show initiative within a team
    • Ability to prioritise and balance competing demands

    COMPENSATION

    There are some great benefits on offer with this role including a competitive salary, pension, generous holidays and more.

    HOW TO APPLY

    Please do not hesitate to contact Harvey Uppal at huppal[at]pararecruit.com or call (+44) 121 616 3407 to discuss this opportunity further.

    Keywords: Bioinformatics, Genomics, London, WGS, WES, Cancer, NGS, Molecular, Biology, Computational, QA, QC, Analyst, Python, R, Statistics, Pipeline

    BACKGROUND

    A highly motivated Senior Staff Scientist is needed to work within a world leading Malaria genomics team that uses cutting edge technology to study the comparative and functional genomics of malaria parasites. Our group studies the genome biology and function genomics of parasites.

    RESPONSIBILITIES

    We seek an enthusiastic and innovative individual primarily to provide wide-ranging support and strategic direction to the bioinformatics needs of the Malaria projects with our team. The candidate will get the opportunity to develop projects and collaborations that use comparative genomics, RNA-seq and single cell transcriptomic approaches to explore the evolution and function of genes in malaria parasites. The successful candidate will work closely with other computational and wet lab scientists within the team, as well as the extended Malaria Programme.

    The post holder will be able to advise and instruct others in bioinformatics analyses and may supervise students, junior staff and visiting workers.

    REQUIREMENTS

    • Ph.D. in a relevant subject (e.g biological science, computational biology)
    • Extensive experience in bioinformatics
    • Extensive programming experience
    • Good understanding of sequencing, assembly and analysis technologies
    • Good understanding of sequencing-based functional genomics approaches
    • Demonstrable leadership within an analysis group
    • Ability to communicate work effectively to diverse audiences and to represent group at Scientific meetings
    • Ability to work on large number of projects simultaneously
    • Ability to interact productively with other members of a team
    • Supervision experience

    PREFERENCES

    • Broad and relevant parasitology knowledge
    • Good understanding of Malaria biology

    COMPENSATION

    Salary range £43,000 to £49,000 pa plus excellent benefits.

    Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

    ABOUT US

    The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited's 100,000 Genomes Sequencing Centre. The Campus is also home to Wellcome Genome Campus Connecting Science. Connecting Science inspires new thinking, sparks conversation and supports learning by drawing on the ground-breaking research taking place on the Campus. Its mission is to enable everyone to explore genomic science and its impact on research, health and society.

    HOW TO APPLY

    Click on the following link: jobs.sanger.ac.uk/wd/p[...]28081

    DEADLINE

    9th November 2017

    POLICY

    Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.
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