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    BACKGROUND

    We are seeking a highly motivated and experienced scientist to join the research group of Peer Bork within the Structural and Computational Biology Unit to contribute to and coordinate activities both within the research group and in the German National Research Data Infrastructure consortium "NFDI4Microbiota" (nfdi4microbiota.de). This consortium will create a new core national infrastructure for microbial research through training and community building activities, as well as through the development of an online analysis and integration system which will prioritise FAIR, open and reproducible research.

    Our bioinformatics research group works on a wide range of research topics with a current focus on microbiome analysis in ecosystems like the human gut or the ocean. We are involved in various national and international projects and also engage in the development, improvement and implementation of standards for microbiome data and metadata in other consortia, including the German Human Genome-Phenome Archive (GHGA, ghga.dkfz.de) and the International Human Microbiome Coordination and Support Action (IHMCSA).

    RESPONSIBILITIES

    Your role will be to coordinate NFDI4Microbiota activities within the Bork group and coordinate and contribute to the creation of data and metadata standards within the consortium. In collaboration with software engineers, you will also lead the creation of an online resource that will centralise and make accessible existing experimental standards in microbiology, with a focus on microbiome approaches and reproducibility. You will develop and implement strategies to support the long-term stability of NFDI4Microbiota and its connection to other consortia. To this end, you will work with producers of microbiome data to identify obstacles and challenges to data sharing, with consumers of such data to identify their needs and encountered problems, and with existing repositories of microbiome data. You will work with colleagues both from the Bork group and other members of the consortium, and therefore have the opportunity to help shape a new national infrastructure for microbiota analysis and collaborate with microbiologists across Germany.

    REQUIREMENTS

    • A university degree in Biology, Bioinformatics, Medical Informatics or a related field; a doctorate is a plus
    • Experience in wet lab microbiology, preferably including in the microbiome field (16S and metagenomics), and in writing experimental protocols (SOPs)
    • Experience using and/or developing data standards
    • Excellent organizational skills and a high motivation to interact and discuss with stakeholders and key players in the fields of experimental, computational, and clinical microbiological research
    • Familiarity with office suites and online collaboration tools
    • Ability to work both independently and in a team at the interface between life sciences and informatics
    • Willingness to learn new skills as projects require
    • Good communication, interpersonal and English language skills
    You might also have:
    • Experience in project management and coordinating research grants (e.g. tracking and fulfilling milestones and deliverables)
    • Experience in generating or curating microbiological and/or microbiome data and metadata
    • Experience in generating online training materials and/or documentation
    • Experience in community development and organising workshops or conference sessions
    • Experience in working with public ontologies, mapping between resources, and data analysis
    • Familiarity with the concepts of analysis pipeline management (e.g. Common Workflow Language, NextFlow, Snakemake)

    COMPENSATION

    Why join us:
    EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation with a very collegial and family friendly working environment. The remuneration package comprises a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits, and the availability of an excellent child care facility on campus.

    What else you need to know:
    We are Europe's flagship research laboratory for the life sciences – an intergovernmental organisation performing scientific research in disciplines including molecular biology, physics, chemistry and computer science. We are an international, innovative and interdisciplinary laboratory with approximately 2000 employees from many nations, operating across six sites, in Heidelberg (HQ), Barcelona, Hinxton near Cambridge, Hamburg, Grenoble and Rome. Our mission is to offer vital services in training scientists, students and visitors at all levels; to develop new instruments and methods in the life sciences and actively engage in technology transfer activities, and to integrate European life science research. Please note that appointments on fixed term contracts can be renewed, depending on circumstances at the time of the review.

    HOW TO APPLY

    Please follow the link below to apply:
    www.embl.org/jobs[...]02062

    DEADLINE

    19 November 2021

    BACKGROUND

    We are seeking a highly motivated computational biologist to join the research group of Peer Bork within the Structural and Computational Biology Unit as a postdoctoral fellow. This bioinformatics group works on a wide range of topics with a current focus on microbiome analysis in ecosystems like the human gut and the ocean. We are offering this position within the context of the newly established National Research Data Infrastructure consortium "NFDI4Microbiota", which aims to support microbiology researchers across Germany by offering open data analysis and integration services as well as training and data standardisation.

    RESPONSIBILITIES

    Your role would be to develop and run approaches for multi-omic data integration and the analysis of large-scale microbiomics data (metagenomes, metatranscriptomes, metabolomes etc.) for biological discoveries. For the development of these approaches, data will mostly come from various internal and external human microbiome projects, but also from ocean and soil. Within the NFDI4Microbiota consortium, you will develop data integration services that will put researchers' data in context using relevant public data sets and databases, and expand the biological questions they can answer through multi-omic integration. Throughout the project, workflows you set up with the help of software engineers will be made available to outside scientists through a web-portal. The work will comprise both methodological development and applied aspects, and also aims at biological discoveries. You will work with colleagues both from the Bork group and other members of the consortium, and therefore have the opportunity to help shape a new national infrastructure for microbiota analysis and collaborate with microbiologists across Germany.

    REQUIREMENTS

    • A PhD degree in Biology, Bioinformatics, Computer Science, or a related field
    • Proven biological background knowledge and bioinformatics skills related to the group's research
    • Experience in data integration, statistical analysis and visualisation, e.g. in Python or R
    • Experience developing new strategies, workflows or tools for data analysis
    • Competence in processing large microbiomics and/or multi-omics datasets
    • Ability to work both independently and in a team
    • Willingness to learn new skills as projects require
    • Good communication, interpersonal and English language skills
    You might also have:
    • Familiarity with processing next-generation sequencing data and performing metagenomic analysis
    • Experience working with the Linux command line and compute clusters
    • Experimental experience in microbiology
    • Experience working in large consortiums

    COMPENSATION

    Why join us:
    EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation with a very collegial and family friendly working environment. The remuneration package comprises a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits, and the availability of an excellent child care facility on campus.

    What else you need to know:
    We are Europe's flagship research laboratory for the life sciences – an intergovernmental organisation performing scientific research in disciplines including molecular biology, physics, chemistry and computer science. We are an international, innovative and interdisciplinary laboratory with approximately 2000 employees from many nations, operating across six sites, in Heidelberg (HQ), Barcelona, Hinxton near Cambridge, Hamburg, Grenoble and Rome. Our mission is to offer vital services in training scientists, students and visitors at all levels; to develop new instruments and methods in the life sciences and actively engage in technology transfer activities, and to integrate European life science research. Please note that appointments on fixed term contracts can be renewed, depending on circumstances at the time of the review.

    HOW TO APPLY

    Please follow the link below to apply:
    www.embl.org/jobs[...]02064

    DEADLINE

    19 November 2021

    One postdoctoral research associate position is available for motivated candidates in the Department of Bioinformatics and Genomics at the University of North Carolina at Charlotte. The successful applicant will work on an NSF funded project to investigate protein-DNA interactions and to develop novel algorithms for protein-DNA complex model assessments.

    REQUIREMENTS

    An ideal candidate shall have a Ph.D. degree in bioinformatics, computational biology, computational chemistry, biophysics, computer science or a related field. The candidates should have good communication skills and can work independently and as a team member.

    PREFERENCES

    Good programming skills. Experience in structural bioinformatics and machine learning.

    TERMS

    Up to three years.

    LOCALE

    Charlotte, NC, USA

    COMPENSATION

    Competitive salary based on experience.

    HOW TO APPLY

    Send a copy of recent CV, three references, and a brief research statement to Dr. Jun-tao Guo (jguo4[at]uncc.edu)

    DEADLINE

    Until the position is filled.

    DESCRIPTION

    At Regeneron, we are known for our scientific excellence, our biomedical innovations, and our commitment to publishing important basic science findings – often leading the way in discovering and communicating important mechanistic insights. We are a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. We have a long-standing postdoctoral fellow program and are committed to training the next generation of leading scientists.

    The postdoctoral fellow position is for early career scientist trainees who have finished graduate school, and received their PhDs (or MDs, DVMs, etc), to receive a rigorous scientific postdoctoral training at Regeneron under the auspices of a scientist mentor. The program spans up to four years. Fellows will be expected to conduct creative mechanistic exploratory research that results in publication. The program is academic in nature - the goal is to ask fundamental questions - not to work on Regeneron therapeutic agents.

    The program consists of:
    • Up to four years of formal postdoctoral training in a program co-Directed by award-winning and published Regeneron scientists, committed to training postdoctoral fellows
    • Exposure to the biotechnology industry's most successful and innovative scientists
    • Opportunities to pursue ground breaking, creative biomedical research in a prestigious, well- resourced, and dynamic industry environment
    • Weekly postdoctoral scientist meetings to cultivate scientific rigor, creative thinking, critical reasoning, and career advancement
    • Support of scholarly productivity such as publications and conference presentations
    As part of your Postdoctoral Training Program, you will:
    • Conduct forward-looking and innovative research to address a novel scientific question of your choice with the guidance of a mentor
    • Publish and disseminate data via external conferences and peer-reviewed publications
    • Have the opportunity to assist with mentoring and guiding interns and other more junior trainees
    • Participate in postdoctoral program activities such as weekly meetings and the annual research conference
    • Present data internally, including at lab meetings, trainee meetings, and company-wide seminars
    • Provide reports of research progress to supervisors and program staff

    REQUIREMENTS

    Experience and Required Skills:
    • Doctoral degree in a relevant subject area
    • Scientists looking for their first postdoctoral training (or those with less than one year of postdoctoral training)
    • Outstanding scientific skills including critical and analytical thinking
    • Demonstrated publication success as evidenced by peer-reviewed publications
    • Good written and oral communication skills
    • Ability to interact dynamically and constructively with peers, and cross-functionally when applicable
    Note: Occasional travel

    HOW TO APPLY

    Apply online: careers.regeneron.com/job/[...]nings

    Applications Accepted: October 1, 2021 – December 1, 2021

    Required Documents:
    • A full academic CV
    • At least two letters of recommendation
    • Responses to two essay questions
    Within one business day of applying you will receive an email with instructions on how to complete your essay questions and upload documents.

    DEADLINE

    All documents are required to be submitted no later than December 1, 2021.

    Applications received after December 1, 2021 may not be considered.

    Following the close date, please allow 3-4 months for review and interviews.

    Targeted Start Date: Summer 2022, but the start date is flexible – depending on when you finish defending your graduate thesis or finish up prior manuscripts.

    If you have an issue submitting or any questions, please email: postdoctoral[at]regeneron.com.

    Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels!

    POLICY

    Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or maternity status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.

    Submitter

    DESCRIPTION

    Genomics Data Scientists investigate and develop solutions to extract more information from the genome (alignment and variant calling) and to interpret the genome in the context of a persons clinical features.

    They work as part of squads building and translating state of the art analytics into clinically-fit production quality solutions.

    Key Accountabilities Include:
    • Benchmarking and fine-tuning tools for quality control, processing and analysis of whole genome sequence data, e.g., alignment, variant callers for types of variants
    • Develop algorithms for variant prioritisation / classification to improve their diagnostic potential or actionability
    • Performing custom computational analysis for a range of projects in rare disease/germline or cancer/somatic samples and carefully document results using reproducible computing principles
    • Developing, prototyping, and validating new features for genome analysis in collaboration with internal and external stakeholders
    • Work with other squad members to ensure that solutions are implemented in a robust, scalable, fit for clinic, accredited, production ready for converting prototypes to production pipelines
    • Continuously scan the scientific literature to identify new approaches to genome analysis that can be implemented to improve our capabilities
    • Contribute to the publication and dissemination of our learnings in the form of scientific papers, white papers, conferences, etc.
    • Establishing general bioinformatics resources for day-to-day use by colleagues
    • Know and understand the meaning behind our virtues of Empathy, Integrity, Focus, Connection, Speed, Curiosity, Impact and embody them in all aspects of your role

    REQUIREMENTS

    Key Skills Include:
    • Excellent knowledge in cancer genomics, approaches to call somatic variation and interpret cancer genomes
    • Strong knowledge of statistics and/or machine learning
    • Strong knowledge of high throughput sequencing algorithms and available resources. Experience with full cycle of analysing NGS data from sequencing QC to annotation and prioritization of variants.
    • Strong programming skills (Python, R)
    • Excellent technical writing skills
    • A decent publication record demonstrating their ability to conceive and carry to conclusion scientific investigations
    • Excellent ability to represent and visualise data to derive insights
    • A demonstrable ability to cope under pressure and deliver to deadlines
    • Experience in handling large data sets
    • Ability to communicate effectively within a multidisciplinary team
    • Flexible and co-operative approach to colleagues
    • Experience and flexibility to collaborate on code with others including good working knowledge of Git
    • Ability to work independently and to show initiative within a team
    • Ability to prioritise and balance competing demands

    COMPENSATION

    There are some great benefits on offer with this role including a competitive salary, pension, generous holidays and more.

    HOW TO APPLY

    Please do not hesitate to contact Harvey Uppal at huppal[at]pararecruit.com or call (+44) 121 616 3407 to discuss this opportunity further.

    Keywords: Rare, Disease, Analyst, Cancer, WGS, WES, Genomics, Bioinformatics, Germline, Somatic, Mutations, Clinical, Python, Pipelines, Statistics, Testing, Writing, Variants, Alignment, Statistical, Genetics, NGS, London

     

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