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    Submitter

    BACKGROUND

    CSRA is seeking a full time Senior Bioinformatics Engineer to join our program in support of the National Cancer Institute (NCI). NCI runs multiple programs for cancer genomics, including TARGET, CTD2, CGCI, and HCMI. CSRA needs a Senior Bioinformatics Engineer to help as part of the Data Coordinating Center for these cancer research efforts. CSRA has a leading practice in bioinformatics supporting the Federal Government, with projects across the NIH and CDC.

    RESPONSIBILITIES

    • Work involves intake and formatting of genomics data via extensive scripting, transfer of data to NCI's Genomics Data Commons, development and maintenance of web applications, coordination with NIH's Center for Information Technology regarding security, storage space, and web hosting.
    • This is an opportunity to make a difference on the cutting edge of cancer research, using bioinformatics skills that require a knowledge of genomics and molecular biology as well as significant IT skills, working with some of the top cancer researchers in the world.
    • The selected candidate will have had extensive experience with handling, manipulating, and performing QC on genomics data, including WGS, WES, and RNASeq data.

    REQUIREMENTS

    Required skills:
    • Bachelors degree and 5+ years hands on bioinformatics experience is required, or equivalent combination. MS preferred
    • Advanced Linux, Perl, and Apache skills (additional skills in Python are a preferred)
    • Extensive knowledge of genomics metadata and data standards
    • Demonstrated expertise creating and maintaining bioinformatics workflows
    • Web application maintenance
    • Experiencing completing setup, managing, and maintaining servers, storage, application stacks, tools, security, code management beyond basic systems support
    • Experience with biomedical data migration and QC
    • Extensive experience in managing genomics data via hands-on programming experience
    Competencies:
    • Excellent verbal and written communication skills required
    • Ability to multi-task in a fast paced environment

    PREFERENCES

    Desired skills:
    • Java
    • Knowledge of dbGaP, SRA, NCI Genomic Data Commons preferred
    • Experience with components of the NCI multi-tier development and deployment stack (Java, Tomcat, AntHillPro, Maven, GitHub)
    • Cancer-specific genomics/bioinformatics experience preferred

    LOCALE

    Onsite at the NCI in Rockville, MD

    HOW TO APPLY

    Please apply directly online via www.csra.com/careers to job #13045 or via this link: jobs.csra.com/sear[...]983/1

    POLICY

    CSRA is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.

    BACKGROUND

    Zymeworks is a fast-growing, clinical-stage biotechnology company dedicated to the research, development and commercialization of best-in-class therapeutic bispecific antibodies and antibody drug conjugates used in the treatment of cancer and autoimmune diseases. Zymeworks is proud to have active collaborations with Merck & Co., Inc., Eli Lilly and Co., Celgene Corporation and GSK, and is committed to making a meaningful difference in the lives of patients everywhere.

    Zymeworks is seeking a LIMS/ELN Informatics Analyst, who will be responsible for modeling experimental workflows, as well as managing and maintaining quality control of experimental and biological data in a Laboratory Information Management System (LIMS) and Electronic Lab Notebook (ELN). The position reports to the Technology Integration & Bioinformatics Team Lead.

    RESPONSIBILITIES

    • Interfaces with our scientific R&D teams to understand the experimental data being produced, provides proposals to organize and formalize the data from these experiments, and works with the software team to store this data in the LIMS/ELN
    • Manages and organizes the storage of our biological data (protein products, antibodies, small molecules, other molecular entities) in the LIMS/ELN, along with associated metadata
    • Administers the LIMS/ELN by assigning roles and permissions to the various groups and users in the organization
    • Works with our in-house lab scientists, and external Contract Research Organizations to develop, document, and enforce standard operating procedures and protocols for our experiments and the associated data upload and management procedures
    • Acts as a point of contact for LIMS/ELN-associated feature requests and work with the users and various stakeholders on prioritizing and delivering these features
    • Works with the LIMS provider and in-house scientific and software teams to implement and support best practices and optimal utilization of the informatics and data management resources
    • Documents and trains scientific staff/end user on best practices and compliance policies related to the LIMS/ELN system and data handling
    Fosters effective and collaborative working relationships with fellow employees, management and external partners

    REQUIREMENTS

    • BSc in Biochemistry, Molecular Biology, Chemistry or a related field and a minimum of 2 years' experience working with LIMS/ELN software in the biopharmaceutical industry
    • Proven interpersonal skills with the ability to work collaboratively as a member of cross-functional team. Ability to establish and maintain effective working relationships
    • Familiarity with proteins, protein expression and purification methods is required, as well as basic knowledge of experiments like mass spectroscopy, DSC, SPR, FACS or other cell-based assays is required.
    • Should be IT savvy, experience and strong drive to work in data management including capturing, refining, annotating, characterizing, and storing data is a must.
    • Experience in the capture and management of high throughput experimental data will be an asset.
    • Experience in negotiating software requirements within and across research departments and translate those requirements to software solutions
    • Basic experience with any programming languages (Python, C/C++, Fortran, Java), or experience with scripting languages like Bash/Perl is an asset. Basic knowledge of databases like SQL, PostgreSQL will be highly favored.
    • Fluent in written and spoken English

    ABOUT US

    Why Work for Us?

    Zymeworks' employees are passionate, engaged and extremely motivated to succeed. We are excited by the cutting-edge science and technology, the endless possibilities this union holds and the sheer opportunity to be a part of something big. To learn more about Zymeworks Inc. and our current openings, please visit our website at www.zymeworks.com.

    We offer challenging career opportunities, competitive benefits and an environment that recognizes and rewards performance.

    HOW TO APPLY

    If you are interested in applying for this position, please email your curriculum vitae and cover letter including available start date in PDF format with "1401 – LIMS/ELN Informatics Analyst" in the subject line to zymeworks-job80[at]mytribehr.com. Due to the high volume of applicants, only those selected for interviews will be contacted.

    RESPONSIBILITIES

    We seek a talented computational scientist to specialize in analysis and interpretation of high-throughput epigenomic data to elucidate key aspects of therapeutic action. The insight gained will contribute directly to identification and development of novel therapies for complex diseases of unmet medical need.

    The successful candidate will work closely with Celgene's global research analytics and epigenetic biology teams to advance our research and development of novel therapeutic agents related to epigenetic mechanisms. The role will involve participation in the analysis and interpretation of experiments that capitalize on cancer therapeutic opportunities in epigenetics.

    A key area of research focus will be the integration of multiple genomic data types to produce a robust understanding of disease state or phenotype. In the context of therapeutic discovery, these efforts will yield novel high-confidence drug targets, and in the context of translational research, objectives include understanding mechanisms of response to our emerging therapeutics.

    Research Analytics activities at CITRE focus on application of contemporary computational analysis methods to improve therapeutic outcomes for Celgene patient populations across a range of diseases. This position would involve considerable inter-disciplinary collaboration with colleagues across Celgene Research and academic collaborators.

    The successful candidate for this role will work closely with Research Analytics team members to define and execute projects, and to communicate discoveries to biology and clinical research teams.

    Responsibilities include, but are not limited to:
    • Perform computational biology analysis for exploration and interpretation of high-throughput data including NGS and MS proteomics assays
    • Develop and implement state-of-the-art approaches for biological pathway and network analysis to elucidate the perturbation of cellular mechanisms
    • Engage in development of methods and platforms for integration of heterogeneous biological data towards answering broader scientific questions
    • Participate in the presentation and reporting of methods, results and conclusions to a publishable standard
    • Participate in wider group endeavors concerning the elucidation of compound mechanisms of action, drug resistance and prediction of target indications

    REQUIREMENTS

    • PhD in computational biology / bioinformatics, statistics, computer science or related fields, with a firm grasp of genomics and/or genetics, from a recognized higher-education establishment
    • Post-doctoral research experience (2+ years) preferred in analysis, integration and interpretation of epigenomic and other high-throughput data (e.g. Histone & TF ChIP, DNA methylation, chromatin accessibility, proteomics and expression data)
    • Publication record in analysis of next-generation sequencing data: familiarity with publicly-available sequence alignment pipelines, SNV calling algorithms, common NGS manipulation tools and standardized NGS data formats (e.g. SAM/BAM, VCF)
    • Demonstrable competence in statistical programming and data manipulation, using e.g. Unix/Linux, Perl, Python, and R/Matlab/SAS, plus good knowledge of contemporary database structures
    • Familiarity with protein interaction/regulatory network collections and network/pathway based analysis methods to distil rational biological interpretation and functional insight from biological data
    • Ability to collaborate well and communicate the output of computational research in the context of multi-disciplinary scientific teams
    • Excellent oral and written communication skills in English. Proficiency in Spanish language would be advantageous

    LOCALE

    CITRE, Seville, Spain

    TERMS

    Manager: Principal Scientist, Research Analytics (RIKU)
    Contract: Fixed-term, 2 year duration, full-time

    ABOUT US

    CITRE Background:
    Multinational biopharmaceutical company Celgene, world leader in developing new treatments for cancer and inflammatory diseases, has established the Celgene Institute for Translational Research Europe (CITRE®) in Seville, Spain. CITRE is the company's first dedicated R&D site outside the USA and provides a bridge between Celgene R&D and the European research community.

    CITRE was founded in 2010, and laboratory research activities began in June 2011. The Institute now houses a team of highly qualified scientific research and administrative staff drawn from Spain and other European member states. The Institute is located in the Cartuja `93 Science and Technology Park and its activities focus on Translational Research into new treatments for cancer and other rare and complex diseases.

    Scientific activities at CITRE comprise three main departments: The Human Diseased Tissue Laboratory (HDTL), the Computational Biology research group, and the Clinical Trials Unit. Onsite facilities include extensive cell culture, flow cytometry, microscopy, genomics, immunohistochemistry, and state-of-the-art computational analysis infrastructure for biomarker discovery and patient stratification.

    The three groups are inter-linked by the CITRE tissue Biobank, which receives patient tissue samples, obtained from multi-centre Celgene trials managed by the CITRE Clinical Trials Unit in Spain and across Europe, to provide the basis for inter-disciplinary research into biomarker detection, patient selection criteria, and compound mechanisms of action.

    Together, these components form a Translational Research centre which coordinates and conducts Celgene medical research in Europe, and enables rapid and effective transfer of new developments and discoveries at Celgene to EU patients. Furthermore, CITRE provides a focal point in Europe for collaborative translational research into cancer and inflammatory diseases, with a mission to rapidly deliver new Celgene compounds to the clinic.

    HOW TO APPLY

    Contact:
    Those interested in the position described should submit full CV and cover letter addressed to:
    Silvia Banus (sbanus[at]celgene.com)
    CELGENE S.L.
    Paseo de Recoletos 39, 4º
    28004 MADRID

    By sending your application you acknowledge that the information you provide to Celgene will be stored in a database which is the property of Celgene, for the purposes of processing this information. This information may be shared with Celgene affiliates and agents, including Celgene's parent company based in the USA (Celgene Corporation). You understand that you have the right of access to and the right to rectify the data concerning me, according to applicable privacy laws. You understand that these rights can be exercised by sending an email to the following address: privacy[at]celgene.com, and that more information can be found on the privacy policy located on Celgene's web site, www.celgene.com/util[...].aspx.

    Submitter

    EXCERPT

    Maverick geneticist George Church, at Harvard University, has announced that he believes he is just two years away from creating a hybrid woolly mammoth embryo. The end goal is to develop a mammoth embryo into a fetus, and to take it to full term, he told New Scientist.

    However, resurrecting a pure woolly mammoth this way is still many years away. First, Church's team is adding key genetic traits – such as shaggy long hair, thick layers of fat and cold-adapted blood – to the genome of the Asian elephant.
    Source: www.newscientist.com/arti[...]s-so/

    Submitter

    EXCERPT

    On Wednesday, the three-judge panel from the Patent Trial and Appeal Board (PTAB) hearing the interference case issued a judgement of no interference-in-fact, stopping UC's bid for intellectual property underpinning the most lucrative applications of genome editing.

    "Broad has persuaded us that the parties claim patentably distinct subject matter," the panel wrote in its decision. "[Broad's] claims, which are all limited to CRISPR/Cas9 systems in a eukaryotic environment, are not drawn to the same invention as UC's claims, which are all directed to CRISPR/Cas9 systems not restricted to any environment."
    Source: www.genomeweb.com/gene[...]-over

     

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