Basic Information
Gene ID 10499 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name NCOA2; BHLHE75, TIF2
Full Name Nuclear receptor coactivator 2
Organism Homo sapiens [9606]

Cross Reference
UniProt Q15596 UniGene Hs.595378
PDB 4NIE OMIM 601993
KEGG hsa:10499 UCSC uc003xyn.1

Protein Interactions
DIP DIP-5997N
IntAct Q15596
MINT MINT-122867
STRING 9606.ENSP00000399968

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000399968 Gene3D G3DSA:4.10.280.10 IPR011598 32 100 9.40e-06 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000399968 Gene3D G3DSA:4.10.630.10 IPR008955 638 647 5.20e-09 Nuclear receptor coactivator Src-1
ENSP00000399968 Gene3D G3DSA:4.10.630.10 IPR008955 684 709 5.20e-09 Nuclear receptor coactivator Src-1
ENSP00000399968 PANTHER PTHR10684 IPR017426 2 1464 0.00e-00 Nuclear receptor coactivator
ENSP00000399968 PANTHER PTHR10684:SF2 IPR028822 2 1464 0.00e-00 Nuclear receptor coactivator 2
ENSP00000399968 Pfam PF00989 IPR013767 119 175 4.50e-07 PAS fold
ENSP00000399968 Pfam PF07469 IPR010011 1281 1338 8.10e-27 Domain of unknown function DUF1518
ENSP00000399968 Pfam PF08815 IPR014920 1071 1117 1.50e-22 Nuclear receptor coactivator, Ncoa-type, interlocking
ENSP00000399968 Pfam PF08832 IPR014935 636 709 4.70e-26 Steroid receptor coactivator
ENSP00000399968 PIRSF PIRSF038181 IPR017426 1 1464 0.00e-00 Nuclear receptor coactivator
ENSP00000399968 ProSiteProfiles PS50112 IPR000014 119 183 0.00e-00 PAS domain
ENSP00000399968 ProSiteProfiles PS50888 IPR011598 26 83 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000399968 SMART SM00086 IPR001610 334 377 4.50e-03 PAC motif
ENSP00000399968 SMART SM00091 IPR000014 114 181 1.10e-12 PAS domain
ENSP00000399968 SMART SM00353 IPR011598 32 89 1.80e-10 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000399968 SUPERFAMILY SSF47459 IPR011598 32 92 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000399968 SUPERFAMILY SSF55785 IPR000014 123 189 0.00e-00 PAS domain
ENSP00000399968 SUPERFAMILY SSF55785 IPR000014 268 372 0.00e-00 PAS domain
ENSP00000399968 SUPERFAMILY SSF69125 IPR009110 1069 1114 0.00e-00 Nuclear receptor coactivator, interlocking

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000399968 PF14598 2.5e-37 PAS_11 PAS domain
ENSP00000399968 PF07469 8.1e-27 DUF1518 Domain of unknown function (DUF1518)
ENSP00000399968 PF08832 1.3e-26 SRC-1 Steroid receptor coactivator
ENSP00000399968 PF08815 4.6e-23 Nuc_rec_co-act Nuclear receptor coactivator
ENSP00000399968 PF00989 8e-08 PAS PAS fold
ENSP00000399968 PF13426 6.8e-07 PAS_9 PAS domain
ENSP00000399968 PF08447 0.00017 PAS_3 PAS fold

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000399968 GO:0006351 biological_process transcription, DNA-templated
ENSP00000399968 GO:0005634 cellular_component nucleus
ENSP00000399968 GO:0003713 molecular_function transcription coactivator activity
ENSP00000399968 GO:0004402 molecular_function histone acetyltransferase activity
ENSP00000399968 GO:0004871 molecular_function signal transducer activity
ENSP00000399968 GO:0030374 molecular_function ligand-dependent nuclear receptor transcription coactivator activity
ENSP00000399968 GO:0035257 molecular_function nuclear hormone receptor binding
ENSP00000399968 GO:0046983 molecular_function protein dimerization activity

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
7029 Acyrthosiphon pisum 100161757 132113 Bombus impatiens 100747735
9597 Pan paniscus 100976890 9555 Papio anubis 101011914
39432 Saimiri boliviensis 101031553 13735 Pelodiscus sinensis 102456412
30195 Bombus terrestris 100648067 9595 Gorilla gorilla 101143868
9598 Pan troglodytes 464226 9315 Macropus eugenii ENSMEUG00000002794
8090 Oryzias latipes ENSORLG00000008098 10090 Mus musculus 17978
9646 Ailuropoda melanoleuca ENSAMEG00000006233 9358 Choloepus hoffmanni ENSCHOG00000000075
10141 Cavia porcellus ENSCPOG00000000493 7955 Danio rerio ENSDARG00000017929
9361 Dasypus novemcinctus ENSDNOG00000014500 10020 Dipodomys ordii ENSDORG00000010899
9796 Equus caballus ENSECAG00000008394 9365 Erinaceus europaeus ENSEEUG00000004088
9371 Echinops telfairi ENSETEG00000018046 9685 Felis catus ENSFCAG00000032000
69293 Gasterosteus aculeatus ENSGACG00000002822 8049 Gadus morhua ENSGMOG00000016251
7897 Latimeria chalumnae ENSLACG00000017459 9785 Loxodonta africana ENSLAFG00000009117
9103 Meleagris gallopavo ENSMGAG00000011424 30608 Microcebus murinus ENSMICG00000002452
59463 Myotis lucifugus ENSMLUG00000012692 9544 Macaca mulatta ENSMMUG00000015978
13616 Monodelphis domestica ENSMODG00000007376 9669 Mustela putorius furo ENSMPUG00000010623
9258 Ornithorhynchus anatinus ENSOANG00000001949 9986 Oryctolagus cuniculus ENSOCUG00000005967
30611 Otolemur garnettii ENSOGAG00000013213 8128 Oreochromis niloticus ENSONIG00000014253
9978 Ochotona princeps ENSOPRG00000015038 7757 Petromyzon marinus ENSPMAG00000002534
132908 Pteropus vampyrus ENSPVAG00000009208 10116 Rattus norvegicus ENSRNOG00000007975
42254 Sorex araneus ENSSARG00000006140 9305 Sarcophilus harrisii ENSSHAG00000014604
9823 Sus scrofa ENSSSCG00000006194 43179 Ictidomys tridecemlineatus ENSSTOG00000012735
37347 Tupaia belangeri ENSTBEG00000007600 59729 Taeniopygia guttata ENSTGUG00000011459
99883 Tetraodon nigroviridis ENSTNIG00000008193 31033 Takifugu rubripes ENSTRUG00000011789
9478 Tarsius syrichta ENSTSYG00000000545 9739 Tursiops truncatus ENSTTRG00000013003
30538 Vicugna pacos ENSVPAG00000010738 8364 Xenopus tropicalis ENSXETG00000015926
8083 Xiphophorus maculatus ENSXMAG00000010250