Basic Information | |||
Gene ID | 10499 ; Check Expression Profles ; Check TFs & Targets Binding | ||
Gene Name | NCOA2; BHLHE75, TIF2 | ||
Full Name | Nuclear receptor coactivator 2 | ||
Organism | Homo sapiens [9606] |
Cross Reference | |||
UniProt | Q15596 | UniGene | Hs.595378 |
PDB | 4NIE | OMIM | 601993 |
KEGG | hsa:10499 | UCSC | uc003xyn.1 |
Protein Interactions | |
DIP | DIP-5997N |
IntAct | Q15596 |
MINT | MINT-122867 |
STRING | 9606.ENSP00000399968 |
Ensembl/RefSeq | Transcript ID | Protein ID | Gene ID |
ENSEMBL | |||
REFSEQ | |||
REFSEQ | |||
REFSEQ | |||
REFSEQ | |||
REFSEQ | |||
REFSEQ |
InterPro Annotation | |||||||
Protein | Program | Term | IPRS | Start | End | Score | Description |
ENSP00000399968 | Gene3D | G3DSA:4.10.280.10 | IPR011598 | 32 | 100 | 9.40e-06 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSP00000399968 | Gene3D | G3DSA:4.10.630.10 | IPR008955 | 638 | 647 | 5.20e-09 | Nuclear receptor coactivator Src-1 |
ENSP00000399968 | Gene3D | G3DSA:4.10.630.10 | IPR008955 | 684 | 709 | 5.20e-09 | Nuclear receptor coactivator Src-1 |
ENSP00000399968 | PANTHER | PTHR10684 | IPR017426 | 2 | 1464 | 0.00e-00 | Nuclear receptor coactivator |
ENSP00000399968 | PANTHER | PTHR10684:SF2 | IPR028822 | 2 | 1464 | 0.00e-00 | Nuclear receptor coactivator 2 |
ENSP00000399968 | Pfam | PF00989 | IPR013767 | 119 | 175 | 4.50e-07 | PAS fold |
ENSP00000399968 | Pfam | PF07469 | IPR010011 | 1281 | 1338 | 8.10e-27 | Domain of unknown function DUF1518 |
ENSP00000399968 | Pfam | PF08815 | IPR014920 | 1071 | 1117 | 1.50e-22 | Nuclear receptor coactivator, Ncoa-type, interlocking |
ENSP00000399968 | Pfam | PF08832 | IPR014935 | 636 | 709 | 4.70e-26 | Steroid receptor coactivator |
ENSP00000399968 | PIRSF | PIRSF038181 | IPR017426 | 1 | 1464 | 0.00e-00 | Nuclear receptor coactivator |
ENSP00000399968 | ProSiteProfiles | PS50112 | IPR000014 | 119 | 183 | 0.00e-00 | PAS domain |
ENSP00000399968 | ProSiteProfiles | PS50888 | IPR011598 | 26 | 83 | 0.00e-00 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSP00000399968 | SMART | SM00086 | IPR001610 | 334 | 377 | 4.50e-03 | PAC motif |
ENSP00000399968 | SMART | SM00091 | IPR000014 | 114 | 181 | 1.10e-12 | PAS domain |
ENSP00000399968 | SMART | SM00353 | IPR011598 | 32 | 89 | 1.80e-10 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSP00000399968 | SUPERFAMILY | SSF47459 | IPR011598 | 32 | 92 | 0.00e-00 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSP00000399968 | SUPERFAMILY | SSF55785 | IPR000014 | 123 | 189 | 0.00e-00 | PAS domain |
ENSP00000399968 | SUPERFAMILY | SSF55785 | IPR000014 | 268 | 372 | 0.00e-00 | PAS domain |
ENSP00000399968 | SUPERFAMILY | SSF69125 | IPR009110 | 1069 | 1114 | 0.00e-00 | Nuclear receptor coactivator, interlocking |
Pfam Annotation | ||||
Protein | Pfam ID | E.value | Name | Description |
ENSP00000399968 | PF14598 | 2.5e-37 | PAS_11 | PAS domain |
ENSP00000399968 | PF07469 | 8.1e-27 | DUF1518 | Domain of unknown function (DUF1518) |
ENSP00000399968 | PF08832 | 1.3e-26 | SRC-1 | Steroid receptor coactivator |
ENSP00000399968 | PF08815 | 4.6e-23 | Nuc_rec_co-act | Nuclear receptor coactivator |
ENSP00000399968 | PF00989 | 8e-08 | PAS | PAS fold |
ENSP00000399968 | PF13426 | 6.8e-07 | PAS_9 | PAS domain |
ENSP00000399968 | PF08447 | 0.00017 | PAS_3 | PAS fold |
Gene Ontology Annotation | |||
Protein | Entry | Name Space | Description |
ENSP00000399968 | GO:0006351 | biological_process | transcription, DNA-templated |
ENSP00000399968 | GO:0005634 | cellular_component | nucleus |
ENSP00000399968 | GO:0003713 | molecular_function | transcription coactivator activity |
ENSP00000399968 | GO:0004402 | molecular_function | histone acetyltransferase activity |
ENSP00000399968 | GO:0004871 | molecular_function | signal transducer activity |
ENSP00000399968 | GO:0030374 | molecular_function | ligand-dependent nuclear receptor transcription coactivator activity |
ENSP00000399968 | GO:0035257 | molecular_function | nuclear hormone receptor binding |
ENSP00000399968 | GO:0046983 | molecular_function | protein dimerization activity |
Orthologs | |||||
TAXID | Organism | Gene ID | TAXID | Organism | Gene ID |
7029 | Acyrthosiphon pisum | 100161757 | 132113 | Bombus impatiens | 100747735 |
9597 | Pan paniscus | 100976890 | 9555 | Papio anubis | 101011914 |
39432 | Saimiri boliviensis | 101031553 | 13735 | Pelodiscus sinensis | 102456412 |
30195 | Bombus terrestris | 100648067 | 9595 | Gorilla gorilla | 101143868 |
9598 | Pan troglodytes | 464226 | 9315 | Macropus eugenii | ENSMEUG00000002794 |
8090 | Oryzias latipes | ENSORLG00000008098 | 10090 | Mus musculus | 17978 |
9646 | Ailuropoda melanoleuca | ENSAMEG00000006233 | 9358 | Choloepus hoffmanni | ENSCHOG00000000075 |
10141 | Cavia porcellus | ENSCPOG00000000493 | 7955 | Danio rerio | ENSDARG00000017929 |
9361 | Dasypus novemcinctus | ENSDNOG00000014500 | 10020 | Dipodomys ordii | ENSDORG00000010899 |
9796 | Equus caballus | ENSECAG00000008394 | 9365 | Erinaceus europaeus | ENSEEUG00000004088 |
9371 | Echinops telfairi | ENSETEG00000018046 | 9685 | Felis catus | ENSFCAG00000032000 |
69293 | Gasterosteus aculeatus | ENSGACG00000002822 | 8049 | Gadus morhua | ENSGMOG00000016251 |
7897 | Latimeria chalumnae | ENSLACG00000017459 | 9785 | Loxodonta africana | ENSLAFG00000009117 |
9103 | Meleagris gallopavo | ENSMGAG00000011424 | 30608 | Microcebus murinus | ENSMICG00000002452 |
59463 | Myotis lucifugus | ENSMLUG00000012692 | 9544 | Macaca mulatta | ENSMMUG00000015978 |
13616 | Monodelphis domestica | ENSMODG00000007376 | 9669 | Mustela putorius furo | ENSMPUG00000010623 |
9258 | Ornithorhynchus anatinus | ENSOANG00000001949 | 9986 | Oryctolagus cuniculus | ENSOCUG00000005967 |
30611 | Otolemur garnettii | ENSOGAG00000013213 | 8128 | Oreochromis niloticus | ENSONIG00000014253 |
9978 | Ochotona princeps | ENSOPRG00000015038 | 7757 | Petromyzon marinus | ENSPMAG00000002534 |
132908 | Pteropus vampyrus | ENSPVAG00000009208 | 10116 | Rattus norvegicus | ENSRNOG00000007975 |
42254 | Sorex araneus | ENSSARG00000006140 | 9305 | Sarcophilus harrisii | ENSSHAG00000014604 |
9823 | Sus scrofa | ENSSSCG00000006194 | 43179 | Ictidomys tridecemlineatus | ENSSTOG00000012735 |
37347 | Tupaia belangeri | ENSTBEG00000007600 | 59729 | Taeniopygia guttata | ENSTGUG00000011459 |
99883 | Tetraodon nigroviridis | ENSTNIG00000008193 | 31033 | Takifugu rubripes | ENSTRUG00000011789 |
9478 | Tarsius syrichta | ENSTSYG00000000545 | 9739 | Tursiops truncatus | ENSTTRG00000013003 |
30538 | Vicugna pacos | ENSVPAG00000010738 | 8364 | Xenopus tropicalis | ENSXETG00000015926 |
8083 | Xiphophorus maculatus | ENSXMAG00000010250 |