Basic Information
Gene ID 17129 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name Smad5; Madh5, Msmad5
Full Name Mothers against decapentaplegic homolog 5
Organism Mus musculus [10090]

Cross Reference
UniProt P97454 UniGene Mm.272920
PDB NULL OMIM NULL
KEGG mmu:17129 UCSC uc007qsw.2

Protein Interactions
DIP NULL
IntAct P97454
MINT MINT-99279
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSMUSP00000065798 Gene3D G3DSA:2.60.200.10 IPR017855 263 465 6.50e-97 SMAD domain-like
ENSMUSP00000065798 Gene3D G3DSA:3.90.520.10 IPR013019 5 144 8.60e-62 MAD homology, MH1
ENSMUSP00000065798 PANTHER PTHR13703 IPR013790 1 465 0.00e-00 Dwarfin
ENSMUSP00000065798 Pfam PF03165 IPR003619 32 132 4.80e-42 MAD homology 1, Dwarfin-type
ENSMUSP00000065798 Pfam PF03166 IPR001132 266 442 7.40e-78 SMAD domain, Dwarfin-type
ENSMUSP00000065798 ProSiteProfiles PS51075 IPR013019 13 137 0.00e-00 MAD homology, MH1
ENSMUSP00000065798 ProSiteProfiles PS51076 IPR001132 271 465 0.00e-00 SMAD domain, Dwarfin-type
ENSMUSP00000065798 SMART SM00523 IPR003619 26 135 4.80e-71 MAD homology 1, Dwarfin-type
ENSMUSP00000065798 SMART SM00524 IPR001132 269 441 2.50e-108 SMAD domain, Dwarfin-type
ENSMUSP00000065798 SUPERFAMILY SSF49879 IPR008984 231 456 0.00e-00 SMAD/FHA domain
ENSMUSP00000065798 SUPERFAMILY SSF56366 IPR013019 14 132 0.00e-00 MAD homology, MH1

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSMUSP00000065798 PF03166 0 MH2 MH2 domain
ENSMUSP00000065798 PF03165 2.29953e-42 MH1 MH1 domain
ENSMUSP00000065798 PF10401 1.1e-06 IRF-3 Interferon-regulatory factor 3

Gene Ontology Annotation
Protein Entry Name Space Description
ENSMUSP00000065798 GO:0001657 biological_process ureteric bud development
ENSMUSP00000065798 GO:0002051 biological_process osteoblast fate commitment
ENSMUSP00000065798 GO:0006351 biological_process transcription, DNA-templated
ENSMUSP00000065798 GO:0006468 biological_process protein phosphorylation
ENSMUSP00000065798 GO:0007179 biological_process transforming growth factor beta receptor signaling pathway
ENSMUSP00000065798 GO:0030509 biological_process BMP signaling pathway
ENSMUSP00000065798 GO:0045669 biological_process positive regulation of osteoblast differentiation
ENSMUSP00000065798 GO:0051216 biological_process cartilage development
ENSMUSP00000065798 GO:0060348 biological_process bone development
ENSMUSP00000065798 GO:0071773 biological_process cellular response to BMP stimulus
ENSMUSP00000065798 GO:1901522 biological_process positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
ENSMUSP00000065798 GO:0005634 cellular_component nucleus
ENSMUSP00000065798 GO:0005667 cellular_component transcription factor complex
ENSMUSP00000065798 GO:0005737 cellular_component cytoplasm
ENSMUSP00000065798 GO:0000979 molecular_function RNA polymerase II core promoter sequence-specific DNA binding
ENSMUSP00000065798 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSMUSP00000065798 GO:0046872 molecular_function metal ion binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9601 Pongo abelii 100448249 400682 Amphimedon queenslandica 100639179
10029 Cricetulus griseus 100754116 31033 Takifugu rubripes 101064562
13616 Monodelphis domestica 100011974 9258 Ornithorhynchus anatinus 100089852
7425 Nasonia vitripennis 100116381 7029 Acyrthosiphon pisum 100167170
6087 Hydra magnipapillata 100211577 10224 Saccoglossus kowalevskii 100303484
9986 Oryctolagus cuniculus 100342616 9646 Ailuropoda melanoleuca 100467794
9103 Meleagris gallopavo 100542490 28377 Anolis carolinensis 100564659
61853 Nomascus leucogenys 100580616 30195 Bombus terrestris 100648431
8128 Oreochromis niloticus 100706145 10141 Cavia porcellus 100717571
132113 Bombus impatiens 100742193 7463 Apis florea 100865795
143995 Megachile rotundata 100875661 34638 Metaseiulus occidentalis 100907251
9597 Pan paniscus 100969842 9555 Papio anubis 101017482
39432 Saimiri boliviensis 101050360 9685 Felis catus 101081602
9595 Gorilla gorilla 101137217 9669 Mustela putorius furo 101687381
43179 Ictidomys tridecemlineatus 101974404 7897 Latimeria chalumnae 102346718
7227 Drosophila melanogaster 33529 7460 Apis mellifera 412601
9598 Pan troglodytes 450142 9615 Canis familiaris 475456
7668 Strongylocentrotus purpuratus 582943 7070 Tribolium castaneum 659927
9544 Macaca mulatta 712645 9913 Bos taurus 768050
7719 Ciona intestinalis 778756 9358 Choloepus hoffmanni ENSCHOG00000009259
9483 Callithrix jacchus ENSCJAG00000005968 51511 Ciona savignyi ENSCSAVG00000004749
9361 Dasypus novemcinctus ENSDNOG00000006004 10020 Dipodomys ordii ENSDORG00000004533
9796 Equus caballus ENSECAG00000022649 9365 Erinaceus europaeus ENSEEUG00000001684
9371 Echinops telfairi ENSETEG00000019912 9606 Homo sapiens ENSG00000113658
69293 Gasterosteus aculeatus ENSGACG00000018718 8049 Gadus morhua ENSGMOG00000005788
9315 Macropus eugenii ENSMEUG00000005813 59463 Myotis lucifugus ENSMLUG00000002321
9978 Ochotona princeps ENSOPRG00000010102 8090 Oryzias latipes ENSORLG00000007377
9813 Procavia capensis ENSPCAG00000006817 7757 Petromyzon marinus ENSPMAG00000009833
13735 Pelodiscus sinensis ENSPSIG00000003731 132908 Pteropus vampyrus ENSPVAG00000016214
10116 Rattus norvegicus ENSRNOG00000018483 42254 Sorex araneus ENSSARG00000009234
9823 Sus scrofa ENSSSCG00000025920 59729 Taeniopygia guttata ENSTGUG00000001214
99883 Tetraodon nigroviridis ENSTNIG00000003701 9739 Tursiops truncatus ENSTTRG00000016274
30538 Vicugna pacos ENSVPAG00000007328 8364 Xenopus tropicalis ENSXETG00000020292
8083 Xiphophorus maculatus ENSXMAG00000016280 9305 Sarcophilus harrisii ENSSHAG00000006806
9478 Tarsius syrichta ENSTSYG00000005318

Paralogs
55994