Basic Information
Gene ID 22259 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name Nr1h3; Lxra
Full Name Oxysterols receptor LXR-alpha
Organism Mus musculus [10090]

Cross Reference
UniProt Q9Z0Y9 UniGene Mm.22690
PDB 3FC6 OMIM NULL
KEGG mmu:22259 UCSC uc008kvc.2

Protein Interactions
DIP NULL
IntAct Q9Z0Y9
MINT NULL
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSMUSP00000002177 Gene3D G3DSA:1.10.565.10 IPR008946 150 191 1.10e-87 Nuclear hormone receptor, ligand-binding
ENSMUSP00000002177 Gene3D G3DSA:1.10.565.10 IPR008946 231 444 1.10e-87 Nuclear hormone receptor, ligand-binding
ENSMUSP00000002177 Gene3D G3DSA:3.30.50.10 IPR013088 96 149 1.10e-24 Zinc finger, NHR/GATA-type
ENSMUSP00000002177 Pfam PF00104 IPR000536 241 425 2.50e-36 Nuclear hormone receptor, ligand-binding, core
ENSMUSP00000002177 Pfam PF00105 IPR001628 95 162 8.40e-27 Zinc finger, nuclear hormone receptor-type
ENSMUSP00000002177 PRINTS PR00047 IPR001628 112 127 5.00e-17 Zinc finger, nuclear hormone receptor-type
ENSMUSP00000002177 PRINTS PR00047 IPR001628 145 153 5.00e-17 Zinc finger, nuclear hormone receptor-type
ENSMUSP00000002177 PRINTS PR00047 IPR001628 153 161 5.00e-17 Zinc finger, nuclear hormone receptor-type
ENSMUSP00000002177 PRINTS PR00047 IPR001628 96 112 5.00e-17 Zinc finger, nuclear hormone receptor-type
ENSMUSP00000002177 PRINTS PR00398 IPR001723 157 167 2.80e-24 Steroid hormone receptor
ENSMUSP00000002177 PRINTS PR00398 IPR001723 258 279 2.80e-24 Steroid hormone receptor
ENSMUSP00000002177 PRINTS PR00398 IPR001723 279 295 2.80e-24 Steroid hormone receptor
ENSMUSP00000002177 PRINTS PR00398 IPR001723 347 362 2.80e-24 Steroid hormone receptor
ENSMUSP00000002177 PRINTS PR00398 IPR001723 404 421 2.80e-24 Steroid hormone receptor
ENSMUSP00000002177 PRINTS PR02034 IPR023257 131 145 1.10e-40 Liver X receptor
ENSMUSP00000002177 PRINTS PR02034 IPR023257 312 327 1.10e-40 Liver X receptor
ENSMUSP00000002177 PRINTS PR02034 IPR023257 339 352 1.10e-40 Liver X receptor
ENSMUSP00000002177 PRINTS PR02034 IPR023257 414 431 1.10e-40 Liver X receptor
ENSMUSP00000002177 PRINTS PR02034 IPR023257 83 93 1.10e-40 Liver X receptor
ENSMUSP00000002177 ProSitePatterns PS00031 IPR001628 96 122 - Zinc finger, nuclear hormone receptor-type
ENSMUSP00000002177 ProSiteProfiles PS51030 IPR001628 93 168 0.00e-00 Zinc finger, nuclear hormone receptor-type
ENSMUSP00000002177 SMART SM00399 IPR001628 93 164 3.20e-38 Zinc finger, nuclear hormone receptor-type
ENSMUSP00000002177 SMART SM00430 IPR000536 257 416 5.80e-46 Nuclear hormone receptor, ligand-binding, core
ENSMUSP00000002177 SUPERFAMILY SSF48508 IPR008946 204 443 0.00e-00 Nuclear hormone receptor, ligand-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSMUSP00000002177 PF00104 1.7e-36 Hormone_recep Ligand-binding domain of nuclear hormone receptor
ENSMUSP00000002177 PF00105 4.8e-27 zf-C4 Zinc finger, C4 type (two domains)

Gene Ontology Annotation
Protein Entry Name Space Description
ENSMUSP00000002177 GO:0005634 cellular_component nucleus
ENSMUSP00000002177 GO:0003677 molecular_function DNA binding
ENSMUSP00000002177 GO:0003707 molecular_function steroid hormone receptor activity
ENSMUSP00000002177 GO:0008270 molecular_function zinc ion binding
ENSMUSP00000002177 GO:0043565 molecular_function sequence-specific DNA binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9258 Ornithorhynchus anatinus 100074592 7029 Acyrthosiphon pisum 100160393
10224 Saccoglossus kowalevskii 100313647 9601 Pongo abelii 100453246
9646 Ailuropoda melanoleuca 100474551 28377 Anolis carolinensis 100567692
61853 Nomascus leucogenys 100605954 30195 Bombus terrestris 100646757
9785 Loxodonta africana 100673961 132113 Bombus impatiens 100749603
10029 Cricetulus griseus 100756988 7463 Apis florea 100872217
143995 Megachile rotundata 100883359 34638 Metaseiulus occidentalis 100908536
9597 Pan paniscus 100971327 9555 Papio anubis 100997292
39432 Saimiri boliviensis 101027381 9595 Gorilla gorilla 101126697
9669 Mustela putorius furo 101692562 8083 Xiphophorus maculatus 102221658
7897 Latimeria chalumnae 102366585 13735 Pelodiscus sinensis 102462146
7425 Nasonia vitripennis 100119033 8128 Oreochromis niloticus 100702741
43179 Ictidomys tridecemlineatus 101976065 7668 Strongylocentrotus purpuratus 574588
9615 Canis familiaris ENSCAFG00000008824 10141 Cavia porcellus ENSCPOG00000013362
59463 Myotis lucifugus ENSMLUG00000017646 9813 Procavia capensis ENSPCAG00000016194
9598 Pan troglodytes ENSPTRG00000003560 42254 Sorex araneus ENSSARG00000002403
9305 Sarcophilus harrisii ENSSHAG00000017152 7227 Drosophila melanogaster 35540
9031 Gallus gallus 395221 9823 Sus scrofa 397553
7460 Apis mellifera 406084 10116 Rattus norvegicus 58852
7070 Tribolium castaneum 657515 9544 Macaca mulatta 695618
9606 Homo sapiens 9971 9358 Choloepus hoffmanni ENSCHOG00000001621
7719 Ciona intestinalis ENSCING00000007203 7955 Danio rerio ENSDARG00000057741
9361 Dasypus novemcinctus ENSDNOG00000011206 10020 Dipodomys ordii ENSDORG00000007747
9365 Erinaceus europaeus ENSEEUG00000003283 9371 Echinops telfairi ENSETEG00000000415
9685 Felis catus ENSFCAG00000002528 69293 Gasterosteus aculeatus ENSGACG00000017167
8049 Gadus morhua ENSGMOG00000005399 30608 Microcebus murinus ENSMICG00000007066
13616 Monodelphis domestica ENSMODG00000019906 9986 Oryctolagus cuniculus ENSOCUG00000002095
9978 Ochotona princeps ENSOPRG00000009497 8090 Oryzias latipes ENSORLG00000001286
132908 Pteropus vampyrus ENSPVAG00000007321 37347 Tupaia belangeri ENSTBEG00000000492
59729 Taeniopygia guttata ENSTGUG00000016341 99883 Tetraodon nigroviridis ENSTNIG00000009590
31033 Takifugu rubripes ENSTRUG00000016403 9478 Tarsius syrichta ENSTSYG00000001532
9739 Tursiops truncatus ENSTTRG00000014149 30538 Vicugna pacos ENSVPAG00000011840
8364 Xenopus tropicalis ENSXETG00000030372