Basic Information
Gene ID 4790 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name NFKB1
Full Name Nuclear factor NF-kappa-B p105 subunit
Organism Homo sapiens [9606]

Cross Reference
UniProt P19838 UniGene Hs.618430
PDB 3GUT OMIM 164011
KEGG hsa:4790 UCSC uc011cer.2

Protein Interactions
DIP DIP-106N
IntAct P19838
MINT MINT-85658
STRING 9606.ENSP00000226574

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000226574 Gene3D G3DSA:1.10.533.10 IPR011029 805 897 1.00e-22 Death-like domain
ENSP00000226574 Gene3D G3DSA:1.25.40.20 IPR020683 515 789 2.40e-54 Ankyrin repeat-containing domain
ENSP00000226574 Gene3D G3DSA:2.60.40.10 IPR013783 248 366 1.90e-52 Immunoglobulin-like fold
ENSP00000226574 Gene3D G3DSA:2.60.40.340 IPR011539 42 244 3.80e-72 Rel homology domain
ENSP00000226574 Pfam PF00023 IPR002110 719 750 2.60e-05 Ankyrin repeat
ENSP00000226574 Pfam PF00531 IPR000488 819 892 1.30e-09 Death domain
ENSP00000226574 Pfam PF00554 IPR011539 45 243 1.00e-72 Rel homology domain
ENSP00000226574 Pfam PF12796 IPR020683 526 612 1.20e-08 Ankyrin repeat-containing domain
ENSP00000226574 Pfam PF12796 IPR020683 620 710 5.80e-14 Ankyrin repeat-containing domain
ENSP00000226574 PRINTS PR00057 IPR000451 232 246 1.90e-44 NF-kappa-B/Rel/Dorsal
ENSP00000226574 PRINTS PR00057 IPR000451 265 285 1.90e-44 NF-kappa-B/Rel/Dorsal
ENSP00000226574 PRINTS PR00057 IPR000451 301 319 1.90e-44 NF-kappa-B/Rel/Dorsal
ENSP00000226574 PRINTS PR00057 IPR000451 342 356 1.90e-44 NF-kappa-B/Rel/Dorsal
ENSP00000226574 PRINTS PR00057 IPR000451 49 66 1.90e-44 NF-kappa-B/Rel/Dorsal
ENSP00000226574 PRINTS PR01415 IPR002110 616 631 9.00e-05 Ankyrin repeat
ENSP00000226574 PRINTS PR01415 IPR002110 667 681 9.00e-05 Ankyrin repeat
ENSP00000226574 ProSitePatterns PS01204 IPR000451 58 64 - NF-kappa-B/Rel/Dorsal
ENSP00000226574 ProSiteProfiles PS50088 IPR002110 582 614 0.00e-00 Ankyrin repeat
ENSP00000226574 ProSiteProfiles PS50088 IPR002110 615 647 0.00e-00 Ankyrin repeat
ENSP00000226574 ProSiteProfiles PS50088 IPR002110 651 683 0.00e-00 Ankyrin repeat
ENSP00000226574 ProSiteProfiles PS50088 IPR002110 685 718 0.00e-00 Ankyrin repeat
ENSP00000226574 ProSiteProfiles PS50088 IPR002110 719 751 0.00e-00 Ankyrin repeat
ENSP00000226574 ProSiteProfiles PS50254 IPR011539 40 247 0.00e-00 Rel homology domain
ENSP00000226574 ProSiteProfiles PS50297 IPR020683 543 751 0.00e-00 Ankyrin repeat-containing domain
ENSP00000226574 SMART SM00005 IPR000488 806 893 7.50e-19 Death domain
ENSP00000226574 SMART SM00248 IPR002110 543 573 2.10e-01 Ankyrin repeat
ENSP00000226574 SMART SM00248 IPR002110 582 611 1.00e-05 Ankyrin repeat
ENSP00000226574 SMART SM00248 IPR002110 615 644 1.10e-03 Ankyrin repeat
ENSP00000226574 SMART SM00248 IPR002110 651 680 6.90e-06 Ankyrin repeat
ENSP00000226574 SMART SM00248 IPR002110 685 715 5.50e-04 Ankyrin repeat
ENSP00000226574 SMART SM00248 IPR002110 719 748 1.10e-03 Ankyrin repeat
ENSP00000226574 SMART SM00429 IPR002909 250 351 1.10e-25 IPT domain
ENSP00000226574 SUPERFAMILY SSF47986 IPR011029 809 890 0.00e-00 Death-like domain
ENSP00000226574 SUPERFAMILY SSF48403 IPR020683 543 761 0.00e-00 Ankyrin repeat-containing domain
ENSP00000226574 SUPERFAMILY SSF49417 IPR008967 42 253 0.00e-00 p53-like transcription factor, DNA-binding
ENSP00000226574 SUPERFAMILY SSF81296 IPR014756 249 381 0.00e-00 Immunoglobulin E-set

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000226574 PF00554 0 RHD Rel homology domain (RHD)
ENSP00000226574 PF12796 2e-34 Ank_2 Ankyrin repeats (3 copies)
ENSP00000226574 PF00023 5.1e-33 Ank Ankyrin repeat
ENSP00000226574 PF13637 1.2e-26 Ank_4 Ankyrin repeats (many copies)
ENSP00000226574 PF13857 1.9e-21 Ank_5 Ankyrin repeats (many copies)
ENSP00000226574 PF13606 2.6e-21 Ank_3 Ankyrin repeat
ENSP00000226574 PF00531 4.1e-10 Death Death domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000226574 GO:0006351 biological_process transcription, DNA-templated
ENSP00000226574 GO:0005634 cellular_component nucleus
ENSP00000226574 GO:0005737 cellular_component cytoplasm
ENSP00000226574 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
10224 Saccoglossus kowalevskii 100303565 61853 Nomascus leucogenys 100581655
400682 Amphimedon queenslandica 100616089 9597 Pan paniscus 100979341
9555 Papio anubis 101026781 39432 Saimiri boliviensis 101035787
43179 Ictidomys tridecemlineatus 101972573 59463 Myotis lucifugus 102435748
10090 Mus musculus 18034 7668 Strongylocentrotus purpuratus 373533
7955 Danio rerio 415100 9544 Macaca mulatta 710324
10116 Rattus norvegicus 81736 28377 Anolis carolinensis ENSACAG00000014215
9646 Ailuropoda melanoleuca ENSAMEG00000008882 9913 Bos taurus ENSBTAG00000020270
9615 Canis familiaris ENSCAFG00000010730 9358 Choloepus hoffmanni ENSCHOG00000010814
7719 Ciona intestinalis ENSCING00000006933 9483 Callithrix jacchus ENSCJAG00000017928
10141 Cavia porcellus ENSCPOG00000007789 51511 Ciona savignyi ENSCSAVG00000003063
9361 Dasypus novemcinctus ENSDNOG00000006855 10020 Dipodomys ordii ENSDORG00000007447
9796 Equus caballus ENSECAG00000015042 9371 Echinops telfairi ENSETEG00000007738
9685 Felis catus ENSFCAG00000007557 69293 Gasterosteus aculeatus ENSGACG00000016876
9031 Gallus gallus ENSGALG00000005653 9595 Gorilla gorilla ENSGGOG00000009071
8049 Gadus morhua ENSGMOG00000007506 7897 Latimeria chalumnae ENSLACG00000002751
9785 Loxodonta africana ENSLAFG00000009344 9315 Macropus eugenii ENSMEUG00000001334
9103 Meleagris gallopavo ENSMGAG00000011299 30608 Microcebus murinus ENSMICG00000014491
13616 Monodelphis domestica ENSMODG00000020672 9669 Mustela putorius furo ENSMPUG00000009413
9258 Ornithorhynchus anatinus ENSOANG00000022123 9986 Oryctolagus cuniculus ENSOCUG00000021712
30611 Otolemur garnettii ENSOGAG00000016379 8128 Oreochromis niloticus ENSONIG00000004349
9978 Ochotona princeps ENSOPRG00000005212 8090 Oryzias latipes ENSORLG00000002942
9813 Procavia capensis ENSPCAG00000008172 7757 Petromyzon marinus ENSPMAG00000006461
9601 Pongo abelii ENSPPYG00000014965 13735 Pelodiscus sinensis ENSPSIG00000008515
132908 Pteropus vampyrus ENSPVAG00000002722 9305 Sarcophilus harrisii ENSSHAG00000007374
9823 Sus scrofa ENSSSCG00000010580 37347 Tupaia belangeri ENSTBEG00000003520
59729 Taeniopygia guttata ENSTGUG00000003595 99883 Tetraodon nigroviridis ENSTNIG00000002693
31033 Takifugu rubripes ENSTRUG00000004360 9478 Tarsius syrichta ENSTSYG00000004853
9739 Tursiops truncatus ENSTTRG00000010852 30538 Vicugna pacos ENSVPAG00000000280
8364 Xenopus tropicalis ENSXETG00000021325 8083 Xiphophorus maculatus ENSXMAG00000015369