Basic Information
Gene ID 6773 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name STAT2
Full Name Signal transducer and activator of transcription 2
Organism Homo sapiens [9606]

Cross Reference
UniProt P52630 UniGene Hs.530595
PDB 2KA4 OMIM 600556
KEGG hsa:6773 UCSC uc001slc.3

Protein Interactions
DIP DIP-38511N
IntAct P52630
MINT MINT-1526706
STRING 9606.ENSP00000315768

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000315768 Gene3D G3DSA:1.10.238.10 IPR011992 459 580 5.00e-44 EF-hand domain pair
ENSP00000315768 Gene3D G3DSA:1.10.532.10 IPR013799 1 124 4.10e-34 STAT transcription factor, protein interaction
ENSP00000315768 Gene3D G3DSA:1.20.1050.20 IPR013800 140 316 6.20e-54 STAT transcription factor, all-alpha
ENSP00000315768 Gene3D G3DSA:2.60.40.630 IPR012345 317 458 9.10e-50 STAT transcription factor, DNA-binding, subdomain
ENSP00000315768 Gene3D G3DSA:3.30.505.10 IPR000980 581 703 5.40e-45 SH2 domain
ENSP00000315768 PANTHER PTHR11801 IPR001217 2 769 0.00e-00 Transcription factor STAT
ENSP00000315768 Pfam PF00017 IPR000980 577 647 7.60e-11 SH2 domain
ENSP00000315768 Pfam PF01017 IPR013800 140 313 3.10e-51 STAT transcription factor, all-alpha
ENSP00000315768 Pfam PF02864 IPR013801 316 566 3.60e-100 STAT transcription factor, DNA-binding
ENSP00000315768 Pfam PF02865 IPR013799 2 124 1.70e-37 STAT transcription factor, protein interaction
ENSP00000315768 Pfam PF12188 IPR022756 783 838 2.00e-33 Signal transducer and activation of transcription 2, C-terminal
ENSP00000315768 ProSiteProfiles PS50001 IPR000980 572 667 0.00e-00 SH2 domain
ENSP00000315768 SMART SM00252 IPR000980 570 654 9.10e-09 SH2 domain
ENSP00000315768 SMART SM00964 IPR013799 2 125 1.80e-64 STAT transcription factor, protein interaction
ENSP00000315768 SUPERFAMILY SSF47655 IPR015988 139 316 0.00e-00 STAT transcription factor, coiled coil
ENSP00000315768 SUPERFAMILY SSF48092 IPR013799 1 124 0.00e-00 STAT transcription factor, protein interaction
ENSP00000315768 SUPERFAMILY SSF49417 IPR008967 317 567 0.00e-00 p53-like transcription factor, DNA-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000315768 PF01017 0 STAT_alpha STAT protein, all-alpha domain
ENSP00000315768 PF02864 0 STAT_bind STAT protein, DNA binding domain
ENSP00000315768 PF02865 1.7e-37 STAT_int STAT protein, protein interaction domain
ENSP00000315768 PF12188 2e-33 STAT2_C Signal transducer and activator of transcription 2 C terminal
ENSP00000315768 PF00017 3.1e-11 SH2 SH2 domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000315768 GO:0006357 biological_process regulation of transcription from RNA polymerase II promoter
ENSP00000315768 GO:0007259 biological_process JAK-STAT cascade
ENSP00000315768 GO:0045893 biological_process positive regulation of transcription, DNA-templated
ENSP00000315768 GO:0045944 biological_process positive regulation of transcription from RNA polymerase II promoter
ENSP00000315768 GO:0005634 cellular_component nucleus
ENSP00000315768 GO:0005737 cellular_component cytoplasm
ENSP00000315768 GO:0003677 molecular_function DNA binding
ENSP00000315768 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSP00000315768 GO:0004871 molecular_function signal transducer activity
ENSP00000315768 GO:0005509 molecular_function calcium ion binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9555 Papio anubis 101011342 9595 Gorilla gorilla 101146695
61853 Nomascus leucogenys 100585171 9597 Pan paniscus 100972085
39432 Saimiri boliviensis 101029836 10090 Mus musculus 20847
9544 Macaca mulatta 712694 9646 Ailuropoda melanoleuca ENSAMEG00000003886
10020 Dipodomys ordii ENSDORG00000012958 9669 Mustela putorius furo ENSMPUG00000001431
9258 Ornithorhynchus anatinus ENSOANG00000012739 9823 Sus scrofa ENSSSCG00000000396
43179 Ictidomys tridecemlineatus ENSSTOG00000015985 28377 Anolis carolinensis ENSACAG00000023449
9913 Bos taurus ENSBTAG00000004380 9615 Canis familiaris ENSCAFG00000000121
9358 Choloepus hoffmanni ENSCHOG00000012984 9483 Callithrix jacchus ENSCJAG00000011101
10141 Cavia porcellus ENSCPOG00000014930 9361 Dasypus novemcinctus ENSDNOG00000011002
9796 Equus caballus ENSECAG00000022326 9365 Erinaceus europaeus ENSEEUG00000010238
9685 Felis catus ENSFCAG00000012023 9785 Loxodonta africana ENSLAFG00000014890
9315 Macropus eugenii ENSMEUG00000010173 30608 Microcebus murinus ENSMICG00000000089
59463 Myotis lucifugus ENSMLUG00000006785 30611 Otolemur garnettii ENSOGAG00000001538
9978 Ochotona princeps ENSOPRG00000001512 9813 Procavia capensis ENSPCAG00000007855
132908 Pteropus vampyrus ENSPVAG00000007596 9305 Sarcophilus harrisii ENSSHAG00000000508
9478 Tarsius syrichta ENSTSYG00000007831 9739 Tursiops truncatus ENSTTRG00000007159