Basic Information
Gene ID 7068 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name THRB; ERBA2, NR1A2, THR1
Full Name Thyroid hormone receptor beta
Organism Homo sapiens [9606]

Cross Reference
UniProt P10828 UniGene Hs.187861
PDB 3JZC OMIM 274300
KEGG hsa:7068 UCSC uc003ccx.4

Protein Interactions
DIP DIP-5991N
IntAct P10828
MINT MINT-1508903
STRING 9606.ENSP00000348827

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000280696 Gene3D G3DSA:1.10.565.10 IPR008946 198 475 1.10e-74 Nuclear hormone receptor, ligand-binding
ENSP00000280696 Gene3D G3DSA:3.30.50.10 IPR013088 120 197 2.50e-29 Zinc finger, NHR/GATA-type
ENSP00000280696 Pfam PF00104 IPR000536 283 446 1.20e-21 Nuclear hormone receptor, ligand-binding, core
ENSP00000280696 Pfam PF00105 IPR001628 121 190 3.20e-30 Zinc finger, nuclear hormone receptor-type
ENSP00000280696 PRINTS PR00047 IPR001628 122 138 1.30e-18 Zinc finger, nuclear hormone receptor-type
ENSP00000280696 PRINTS PR00047 IPR001628 138 153 1.30e-18 Zinc finger, nuclear hormone receptor-type
ENSP00000280696 PRINTS PR00047 IPR001628 173 181 1.30e-18 Zinc finger, nuclear hormone receptor-type
ENSP00000280696 PRINTS PR00047 IPR001628 181 189 1.30e-18 Zinc finger, nuclear hormone receptor-type
ENSP00000280696 PRINTS PR00398 IPR001723 185 195 1.10e-29 Steroid hormone receptor
ENSP00000280696 PRINTS PR00398 IPR001723 290 311 1.10e-29 Steroid hormone receptor
ENSP00000280696 PRINTS PR00398 IPR001723 311 327 1.10e-29 Steroid hormone receptor
ENSP00000280696 PRINTS PR00398 IPR001723 378 393 1.10e-29 Steroid hormone receptor
ENSP00000280696 PRINTS PR00398 IPR001723 435 452 1.10e-29 Steroid hormone receptor
ENSP00000280696 PRINTS PR00546 IPR001728 110 124 5.00e-101 Thyroid hormone receptor
ENSP00000280696 PRINTS PR00546 IPR001728 148 159 5.00e-101 Thyroid hormone receptor
ENSP00000280696 PRINTS PR00546 IPR001728 187 203 5.00e-101 Thyroid hormone receptor
ENSP00000280696 PRINTS PR00546 IPR001728 204 222 5.00e-101 Thyroid hormone receptor
ENSP00000280696 PRINTS PR00546 IPR001728 227 244 5.00e-101 Thyroid hormone receptor
ENSP00000280696 PRINTS PR00546 IPR001728 250 269 5.00e-101 Thyroid hormone receptor
ENSP00000280696 PRINTS PR00546 IPR001728 287 308 5.00e-101 Thyroid hormone receptor
ENSP00000280696 PRINTS PR00546 IPR001728 313 332 5.00e-101 Thyroid hormone receptor
ENSP00000280696 PRINTS PR00546 IPR001728 378 400 5.00e-101 Thyroid hormone receptor
ENSP00000280696 ProSitePatterns PS00031 IPR001628 122 148 - Zinc finger, nuclear hormone receptor-type
ENSP00000280696 ProSiteProfiles PS51030 IPR001628 119 196 0.00e-00 Zinc finger, nuclear hormone receptor-type
ENSP00000280696 SMART SM00399 IPR001628 119 192 1.30e-39 Zinc finger, nuclear hormone receptor-type
ENSP00000280696 SMART SM00430 IPR000536 289 447 2.40e-33 Nuclear hormone receptor, ligand-binding, core
ENSP00000280696 SUPERFAMILY SSF48508 IPR008946 230 474 0.00e-00 Nuclear hormone receptor, ligand-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000280696 PF00105 1.7e-30 zf-C4 Zinc finger, C4 type (two domains)
ENSP00000280696 PF00104 5.5e-22 Hormone_recep Ligand-binding domain of nuclear hormone receptor

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000280696 GO:0006351 biological_process transcription, DNA-templated
ENSP00000280696 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSP00000280696 GO:0030522 biological_process intracellular receptor signaling pathway
ENSP00000280696 GO:0043401 biological_process steroid hormone mediated signaling pathway
ENSP00000280696 GO:0005634 cellular_component nucleus
ENSP00000280696 GO:0003677 molecular_function DNA binding
ENSP00000280696 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSP00000280696 GO:0003707 molecular_function steroid hormone receptor activity
ENSP00000280696 GO:0004887 molecular_function thyroid hormone receptor activity
ENSP00000280696 GO:0008270 molecular_function zinc ion binding
ENSP00000280696 GO:0043565 molecular_function sequence-specific DNA binding
ENSP00000280696 GO:0046872 molecular_function metal ion binding
ENSP00000280696 GO:0070324 molecular_function thyroid hormone binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
10224 Saccoglossus kowalevskii 100313752 13735 Pelodiscus sinensis 102448851
9796 Equus caballus 100051615 9483 Callithrix jacchus 100394325
9103 Meleagris gallopavo 100545018 8128 Oreochromis niloticus 100702392
9597 Pan paniscus 100993061 9555 Papio anubis 101007506
39432 Saimiri boliviensis 101050682 9669 Mustela putorius furo 101673177
43179 Ictidomys tridecemlineatus 101973293 10090 Mus musculus 21834
7668 Strongylocentrotus purpuratus 584535 9544 Macaca mulatta 699969
9913 Bos taurus ENSBTAG00000017802 9358 Choloepus hoffmanni ENSCHOG00000000987
7719 Ciona intestinalis ENSCING00000021968 10141 Cavia porcellus ENSCPOG00000010519
51511 Ciona savignyi ENSCSAVG00000006056 9365 Erinaceus europaeus ENSEEUG00000005916
9371 Echinops telfairi ENSETEG00000016652 9685 Felis catus ENSFCAG00000022754
9595 Gorilla gorilla ENSGGOG00000007268 8049 Gadus morhua ENSGMOG00000008051
9785 Loxodonta africana ENSLAFG00000013921 9315 Macropus eugenii ENSMEUG00000010735
30608 Microcebus murinus ENSMICG00000011433 13616 Monodelphis domestica ENSMODG00000014903
9258 Ornithorhynchus anatinus ENSOANG00000012237 30611 Otolemur garnettii ENSOGAG00000002010
9813 Procavia capensis ENSPCAG00000012625 9601 Pongo abelii ENSPPYG00000014063
132908 Pteropus vampyrus ENSPVAG00000001768 10116 Rattus norvegicus ENSRNOG00000006649
42254 Sorex araneus ENSSARG00000013590 9305 Sarcophilus harrisii ENSSHAG00000004159
9823 Sus scrofa ENSSSCG00000011211 37347 Tupaia belangeri ENSTBEG00000004123
59729 Taeniopygia guttata ENSTGUG00000003349 99883 Tetraodon nigroviridis ENSTNIG00000009795
31033 Takifugu rubripes ENSTRUG00000008015 9478 Tarsius syrichta ENSTSYG00000008478
9739 Tursiops truncatus ENSTTRG00000001859 30538 Vicugna pacos ENSVPAG00000005832
9646 Ailuropoda melanoleuca ENSAMEG00000017962 10020 Dipodomys ordii ENSDORG00000004966
69293 Gasterosteus aculeatus ENSGACG00000007996 59463 Myotis lucifugus ENSMLUG00000009632
7757 Petromyzon marinus ENSPMAG00000005715 8364 Xenopus tropicalis ENSXETG00000003871

Paralogs
7067