Basic Information
Gene ID 7468 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name WHSC1; KIAA1090, MMSET, NSD2, TRX5
Full Name Histone-lysine N-methyltransferase NSD2
Organism Homo sapiens [9606]

Cross Reference
UniProt O96028 UniGene Hs.113876
PDB NULL OMIM 602952
KEGG hsa:7468 UCSC uc010icf.3

Protein Interactions
DIP DIP-57224N
IntAct O96028
MINT MINT-7103764
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000372351 Gene3D G3DSA:1.10.30.10 IPR009071 457 506 2.20e-08 High mobility group box domain
ENSP00000372351 Gene3D G3DSA:3.30.40.10 IPR013083 1221 1296 5.40e-11 Zinc finger, RING/FYVE/PHD-type
ENSP00000372351 Gene3D G3DSA:3.30.40.10 IPR013083 654 712 1.10e-11 Zinc finger, RING/FYVE/PHD-type
ENSP00000372351 Gene3D G3DSA:3.30.40.10 IPR013083 816 876 2.70e-14 Zinc finger, RING/FYVE/PHD-type
ENSP00000372351 Pfam PF00505 IPR009071 457 506 5.10e-09 High mobility group box domain
ENSP00000372351 Pfam PF00628 IPR019787 833 874 1.20e-07 Zinc finger, PHD-finger
ENSP00000372351 Pfam PF00855 IPR000313 220 329 1.60e-22 PWWP domain
ENSP00000372351 Pfam PF00855 IPR000313 880 967 4.40e-17 PWWP domain
ENSP00000372351 Pfam PF00856 IPR001214 1074 1180 7.80e-26 SET domain
ENSP00000372351 ProSitePatterns PS01359 IPR019786 670 710 - Zinc finger, PHD-type, conserved site
ENSP00000372351 ProSitePatterns PS01359 IPR019786 834 872 - Zinc finger, PHD-type, conserved site
ENSP00000372351 ProSiteProfiles PS50016 IPR019787 667 713 0.00e-00 Zinc finger, PHD-finger
ENSP00000372351 ProSiteProfiles PS50016 IPR019787 831 875 0.00e-00 Zinc finger, PHD-finger
ENSP00000372351 ProSiteProfiles PS50089 IPR001841 717 763 0.00e-00 Zinc finger, RING-type
ENSP00000372351 ProSiteProfiles PS50118 IPR009071 453 502 0.00e-00 High mobility group box domain
ENSP00000372351 ProSiteProfiles PS50280 IPR001214 1063 1180 0.00e-00 SET domain
ENSP00000372351 ProSiteProfiles PS50812 IPR000313 222 286 0.00e-00 PWWP domain
ENSP00000372351 ProSiteProfiles PS50812 IPR000313 880 942 0.00e-00 PWWP domain
ENSP00000372351 ProSiteProfiles PS50868 IPR003616 1187 1203 0.00e-00 Post-SET domain
ENSP00000372351 ProSiteProfiles PS51215 IPR006560 1011 1061 0.00e-00 AWS
ENSP00000372351 SMART SM00184 IPR001841 670 710 2.70e-02 Zinc finger, RING-type
ENSP00000372351 SMART SM00184 IPR001841 717 762 2.90e-05 Zinc finger, RING-type
ENSP00000372351 SMART SM00249 IPR001965 1241 1284 1.00e-10 Zinc finger, PHD-type
ENSP00000372351 SMART SM00249 IPR001965 669 711 5.80e-09 Zinc finger, PHD-type
ENSP00000372351 SMART SM00249 IPR001965 716 763 7.70e-05 Zinc finger, PHD-type
ENSP00000372351 SMART SM00249 IPR001965 833 873 3.60e-13 Zinc finger, PHD-type
ENSP00000372351 SMART SM00293 IPR000313 220 285 4.20e-17 PWWP domain
ENSP00000372351 SMART SM00293 IPR000313 878 940 1.30e-25 PWWP domain
ENSP00000372351 SMART SM00317 IPR001214 1063 1186 1.80e-45 SET domain
ENSP00000372351 SMART SM00398 IPR009071 452 522 5.30e-14 High mobility group box domain
ENSP00000372351 SMART SM00508 IPR003616 1187 1203 3.00e-06 Post-SET domain
ENSP00000372351 SMART SM00570 IPR006560 1011 1062 4.30e-29 AWS
ENSP00000372351 SUPERFAMILY SSF47095 IPR009071 438 507 0.00e-00 High mobility group box domain
ENSP00000372351 SUPERFAMILY SSF57903 IPR011011 1216 1283 0.00e-00 Zinc finger, FYVE/PHD-type
ENSP00000372351 SUPERFAMILY SSF57903 IPR011011 659 711 0.00e-00 Zinc finger, FYVE/PHD-type
ENSP00000372351 SUPERFAMILY SSF57903 IPR011011 821 887 0.00e-00 Zinc finger, FYVE/PHD-type

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000372351 PF00855 1.8e-40 PWWP PWWP domain
ENSP00000372351 PF00856 7.8e-26 SET SET domain
ENSP00000372351 PF00628 5.8e-16 PHD PHD-finger
ENSP00000372351 PF00505 1.9e-09 HMG_box HMG (high mobility group) box
ENSP00000372351 PF09011 0.00018 HMG_box_2 HMG-box domain

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
30195 Bombus terrestris 100649537 9597 Pan paniscus 100993332
39432 Saimiri boliviensis 101052056 9595 Gorilla gorilla 101140725
9669 Mustela putorius furo 101690532 10090 Mus musculus 107823
7668 Strongylocentrotus purpuratus 580047 7425 Nasonia vitripennis 100116149
132113 Bombus impatiens 100743680 28377 Anolis carolinensis ENSACAG00000007905
9646 Ailuropoda melanoleuca ENSAMEG00000014221 9913 Bos taurus ENSBTAG00000007986
9365 Erinaceus europaeus ENSEEUG00000014911 9685 Felis catus ENSFCAG00000010620
9785 Loxodonta africana ENSLAFG00000008162 9544 Macaca mulatta ENSMMUG00000009943
13616 Monodelphis domestica ENSMODG00000004162 61853 Nomascus leucogenys ENSNLEG00000000081
30611 Otolemur garnettii ENSOGAG00000014890 7757 Petromyzon marinus ENSPMAG00000003901
9601 Pongo abelii ENSPPYG00000014534 9823 Sus scrofa ENSSSCG00000008682
9739 Tursiops truncatus ENSTTRG00000013701 9615 Canis familiaris ENSCAFG00000014951
9358 Choloepus hoffmanni ENSCHOG00000005628 9483 Callithrix jacchus ENSCJAG00000001876
10141 Cavia porcellus ENSCPOG00000007513 9361 Dasypus novemcinctus ENSDNOG00000010075
10020 Dipodomys ordii ENSDORG00000013095 9371 Echinops telfairi ENSETEG00000003950
7897 Latimeria chalumnae ENSLACG00000010693 9315 Macropus eugenii ENSMEUG00000009817
9103 Meleagris gallopavo ENSMGAG00000013051 9258 Ornithorhynchus anatinus ENSOANG00000014321
9986 Oryctolagus cuniculus ENSOCUG00000005245 9978 Ochotona princeps ENSOPRG00000002707
9813 Procavia capensis ENSPCAG00000006545 13735 Pelodiscus sinensis ENSPSIG00000006591
132908 Pteropus vampyrus ENSPVAG00000000845 42254 Sorex araneus ENSSARG00000001096
9305 Sarcophilus harrisii ENSSHAG00000006750 43179 Ictidomys tridecemlineatus ENSSTOG00000003369
37347 Tupaia belangeri ENSTBEG00000013959 59729 Taeniopygia guttata ENSTGUG00000010558
8364 Xenopus tropicalis ENSXETG00000026376