Basic Information
Gene ID 100012174
Gene Name LOC100012174
Full Name Signal transducer and activator of transcription
Organism Monodelphis domestica [13616]

Cross Reference
UniProt F7CHH2 UniGene NULL
PDB NULL OMIM NULL
KEGG mdo:100012174 UCSC NULL

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSMODP00000018563 Gene3D G3DSA:1.10.238.10 IPR011992 472 597 4.70e-46 EF-hand domain pair
ENSMODP00000018563 Gene3D G3DSA:1.10.532.10 IPR013799 1 126 8.50e-48 STAT transcription factor, protein interaction
ENSMODP00000018563 Gene3D G3DSA:1.20.1050.20 IPR013800 139 332 2.60e-64 STAT transcription factor, all-alpha
ENSMODP00000018563 Gene3D G3DSA:2.60.40.630 IPR012345 333 471 1.50e-69 STAT transcription factor, DNA-binding, subdomain
ENSMODP00000018563 Gene3D G3DSA:3.30.505.10 IPR000980 598 706 5.40e-40 SH2 domain
ENSMODP00000018563 PANTHER PTHR11801 IPR001217 2 774 0.00e-00 Transcription factor STAT
ENSMODP00000018563 Pfam PF00017 IPR000980 595 668 6.60e-11 SH2 domain
ENSMODP00000018563 Pfam PF01017 IPR013800 138 330 6.70e-55 STAT transcription factor, all-alpha
ENSMODP00000018563 Pfam PF02864 IPR013801 332 583 1.70e-99 STAT transcription factor, DNA-binding
ENSMODP00000018563 Pfam PF02865 IPR013799 2 125 6.70e-47 STAT transcription factor, protein interaction
ENSMODP00000018563 ProSiteProfiles PS50001 IPR000980 589 686 0.00e-00 SH2 domain
ENSMODP00000018563 SMART SM00252 IPR000980 587 688 5.20e-09 SH2 domain
ENSMODP00000018563 SMART SM00964 IPR013799 2 126 2.60e-66 STAT transcription factor, protein interaction
ENSMODP00000018563 SUPERFAMILY SSF47655 IPR015988 137 332 0.00e-00 STAT transcription factor, coiled coil
ENSMODP00000018563 SUPERFAMILY SSF48092 IPR013799 1 125 0.00e-00 STAT transcription factor, protein interaction
ENSMODP00000018563 SUPERFAMILY SSF49417 IPR008967 327 584 0.00e-00 p53-like transcription factor, DNA-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSMODP00000018563 PF01017 0 STAT_alpha STAT protein, all-alpha domain
ENSMODP00000018563 PF02864 0 STAT_bind STAT protein, DNA binding domain
ENSMODP00000018563 PF02865 0 STAT_int STAT protein, protein interaction domain
ENSMODP00000018563 PF00017 7.5e-12 SH2 SH2 domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSMODP00000018563 GO:0001553 biological_process luteinization
ENSMODP00000018563 GO:0001779 biological_process natural killer cell differentiation
ENSMODP00000018563 GO:0006351 biological_process transcription, DNA-templated
ENSMODP00000018563 GO:0007259 biological_process JAK-STAT cascade
ENSMODP00000018563 GO:0007565 biological_process female pregnancy
ENSMODP00000018563 GO:0007595 biological_process lactation
ENSMODP00000018563 GO:0019218 biological_process regulation of steroid metabolic process
ENSMODP00000018563 GO:0019915 biological_process lipid storage
ENSMODP00000018563 GO:0030155 biological_process regulation of cell adhesion
ENSMODP00000018563 GO:0030856 biological_process regulation of epithelial cell differentiation
ENSMODP00000018563 GO:0038161 biological_process prolactin signaling pathway
ENSMODP00000018563 GO:0040018 biological_process positive regulation of multicellular organism growth
ENSMODP00000018563 GO:0042104 biological_process positive regulation of activated T cell proliferation
ENSMODP00000018563 GO:0043029 biological_process T cell homeostasis
ENSMODP00000018563 GO:0043066 biological_process negative regulation of apoptotic process
ENSMODP00000018563 GO:0045086 biological_process positive regulation of interleukin-2 biosynthetic process
ENSMODP00000018563 GO:0045579 biological_process positive regulation of B cell differentiation
ENSMODP00000018563 GO:0045647 biological_process negative regulation of erythrocyte differentiation
ENSMODP00000018563 GO:0045931 biological_process positive regulation of mitotic cell cycle
ENSMODP00000018563 GO:0045944 biological_process positive regulation of transcription from RNA polymerase II promoter
ENSMODP00000018563 GO:0046543 biological_process development of secondary female sexual characteristics
ENSMODP00000018563 GO:0050729 biological_process positive regulation of inflammatory response
ENSMODP00000018563 GO:0005634 cellular_component nucleus
ENSMODP00000018563 GO:0005737 cellular_component cytoplasm
ENSMODP00000018563 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSMODP00000018563 GO:0004871 molecular_function signal transducer activity
ENSMODP00000018563 GO:0005509 molecular_function calcium ion binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
7425 Nasonia vitripennis 100121885 7029 Acyrthosiphon pisum 100161101
6087 Hydra magnipapillata 100206878 9986 Oryctolagus cuniculus 100348267
9601 Pongo abelii 100462537 10029 Cricetulus griseus 100755571
30611 Otolemur garnettii 100958999 9555 Papio anubis 100998364
9669 Mustela putorius furo 101691575 10116 Rattus norvegicus 25126
9031 Gallus gallus 395556 9598 Pan troglodytes 454681
9544 Macaca mulatta 574129 7070 Tribolium castaneum 657965
9646 Ailuropoda melanoleuca ENSAMEG00000006061 9913 Bos taurus ENSBTAG00000009496
9483 Callithrix jacchus ENSCJAG00000000426 10141 Cavia porcellus ENSCPOG00000026466
7955 Danio rerio ENSDARG00000019392 10020 Dipodomys ordii ENSDORG00000000303
9796 Equus caballus ENSECAG00000007847 9365 Erinaceus europaeus ENSEEUG00000003642
9685 Felis catus ENSFCAG00000002153 69293 Gasterosteus aculeatus ENSGACG00000008634
8049 Gadus morhua ENSGMOG00000014154 9785 Loxodonta africana ENSLAFG00000014055
9315 Macropus eugenii ENSMEUG00000006640 9103 Meleagris gallopavo ENSMGAG00000003430
59463 Myotis lucifugus ENSMLUG00000012050 61853 Nomascus leucogenys ENSNLEG00000011444
8128 Oreochromis niloticus ENSONIG00000007261 9978 Ochotona princeps ENSOPRG00000008312
9813 Procavia capensis ENSPCAG00000010107 13735 Pelodiscus sinensis ENSPSIG00000015138
132908 Pteropus vampyrus ENSPVAG00000003876 42254 Sorex araneus ENSSARG00000014229
59729 Taeniopygia guttata ENSTGUG00000002572 99883 Tetraodon nigroviridis ENSTNIG00000011707
31033 Takifugu rubripes ENSTRUG00000015454 9739 Tursiops truncatus ENSTTRG00000007155
8364 Xenopus tropicalis ENSXETG00000000836 8083 Xiphophorus maculatus ENSXMAG00000005165
7897 Latimeria chalumnae ENSLACG00000002646 7757 Petromyzon marinus ENSPMAG00000009008

Paralogs
ENSMODG00000014836