Basic Information | |||
Gene ID | ENSG00000113658 ; ![]() ![]() | ||
Gene Name | SMAD5 | ||
Full Name | Mothers against decapentaplegic homolog 5 | ||
Organism | Homo sapiens [9606] |
Cross Reference | |||
UniProt | D6R9D4 | UniGene | NULL |
PDB | NULL | OMIM | NULL |
KEGG | NULL | UCSC | NULL |
Protein Interactions | |
DIP | NULL |
IntAct | NULL |
MINT | NULL |
STRING | NULL |
Ensembl/RefSeq | Transcript ID | Protein ID | Gene ID |
ENSEMBL | |||
ENSEMBL | |||
ENSEMBL | |||
ENSEMBL | |||
ENSEMBL | |||
ENSEMBL | |||
ENSEMBL | |||
ENSEMBL | |||
ENSEMBL |
InterPro Annotation | |||||||
Protein | Program | Term | IPRS | Start | End | Score | Description |
ENSP00000441954 | Gene3D | G3DSA:2.60.200.10 | IPR017855 | 263 | 464 | 1.00e-93 | SMAD domain-like |
ENSP00000441954 | Gene3D | G3DSA:3.90.520.10 | IPR013019 | 5 | 144 | 8.50e-62 | MAD homology, MH1 |
ENSP00000441954 | PANTHER | PTHR13703 | IPR013790 | 1 | 464 | 0.00e-00 | Dwarfin |
ENSP00000441954 | Pfam | PF03165 | IPR003619 | 32 | 132 | 4.80e-42 | MAD homology 1, Dwarfin-type |
ENSP00000441954 | Pfam | PF03166 | IPR001132 | 266 | 438 | 9.90e-76 | SMAD domain, Dwarfin-type |
ENSP00000441954 | ProSiteProfiles | PS51075 | IPR013019 | 13 | 137 | 0.00e-00 | MAD homology, MH1 |
ENSP00000441954 | ProSiteProfiles | PS51076 | IPR001132 | 271 | 464 | 0.00e-00 | SMAD domain, Dwarfin-type |
ENSP00000441954 | SMART | SM00523 | IPR003619 | 26 | 135 | 4.80e-71 | MAD homology 1, Dwarfin-type |
ENSP00000441954 | SMART | SM00524 | IPR001132 | 269 | 440 | 3.40e-104 | SMAD domain, Dwarfin-type |
ENSP00000441954 | SUPERFAMILY | SSF49879 | IPR008984 | 235 | 455 | 0.00e-00 | SMAD/FHA domain |
ENSP00000441954 | SUPERFAMILY | SSF56366 | IPR013019 | 14 | 132 | 0.00e-00 | MAD homology, MH1 |
Pfam Annotation | ||||
Protein | Pfam ID | E.value | Name | Description |
ENSP00000441954 | PF03166 | 0 | MH2 | MH2 domain |
ENSP00000441954 | PF03165 | 2.29953e-42 | MH1 | MH1 domain |
ENSP00000441954 | PF10401 | 1.1e-06 | IRF-3 | Interferon-regulatory factor 3 |
Gene Ontology Annotation | |||
Protein | Entry | Name Space | Description |
ENSP00000441954 | GO:0001657 | biological_process | ureteric bud development |
ENSP00000441954 | GO:0002051 | biological_process | osteoblast fate commitment |
ENSP00000441954 | GO:0006351 | biological_process | transcription, DNA-templated |
ENSP00000441954 | GO:0006468 | biological_process | protein phosphorylation |
ENSP00000441954 | GO:0007179 | biological_process | transforming growth factor beta receptor signaling pathway |
ENSP00000441954 | GO:0030509 | biological_process | BMP signaling pathway |
ENSP00000441954 | GO:0045669 | biological_process | positive regulation of osteoblast differentiation |
ENSP00000441954 | GO:0051216 | biological_process | cartilage development |
ENSP00000441954 | GO:0060348 | biological_process | bone development |
ENSP00000441954 | GO:0071773 | biological_process | cellular response to BMP stimulus |
ENSP00000441954 | GO:1901522 | biological_process | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus |
ENSP00000441954 | GO:0005634 | cellular_component | nucleus |
ENSP00000441954 | GO:0005667 | cellular_component | transcription factor complex |
ENSP00000441954 | GO:0005737 | cellular_component | cytoplasm |
ENSP00000441954 | GO:0000979 | molecular_function | RNA polymerase II core promoter sequence-specific DNA binding |
ENSP00000441954 | GO:0003700 | molecular_function | sequence-specific DNA binding transcription factor activity |
ENSP00000441954 | GO:0046872 | molecular_function | metal ion binding |
Orthologs | |||||
TAXID | Organism | Gene ID | TAXID | Organism | Gene ID |
13616 | Monodelphis domestica | 100011974 | 9258 | Ornithorhynchus anatinus | 100089852 |
7029 | Acyrthosiphon pisum | 100167170 | 6087 | Hydra magnipapillata | 100211577 |
10224 | Saccoglossus kowalevskii | 100303484 | 9646 | Ailuropoda melanoleuca | 100467794 |
9103 | Meleagris gallopavo | 100542490 | 28377 | Anolis carolinensis | 100564659 |
61853 | Nomascus leucogenys | 100580616 | 30195 | Bombus terrestris | 100648431 |
8128 | Oreochromis niloticus | 100706145 | 10029 | Cricetulus griseus | 100754116 |
143995 | Megachile rotundata | 100875661 | 34638 | Metaseiulus occidentalis | 100907251 |
9597 | Pan paniscus | 100969842 | 9555 | Papio anubis | 101017482 |
39432 | Saimiri boliviensis | 101050360 | 31033 | Takifugu rubripes | 101064562 |
9669 | Mustela putorius furo | 101687381 | 43179 | Ictidomys tridecemlineatus | 101974404 |
7897 | Latimeria chalumnae | 102346718 | 10090 | Mus musculus | 17129 |
7227 | Drosophila melanogaster | 33529 | 9598 | Pan troglodytes | 450142 |
7668 | Strongylocentrotus purpuratus | 582943 | 7070 | Tribolium castaneum | 659927 |
9544 | Macaca mulatta | 712645 | 9796 | Equus caballus | ENSECAG00000022649 |
9365 | Erinaceus europaeus | ENSEEUG00000001684 | 7425 | Nasonia vitripennis | 100116381 |
9986 | Oryctolagus cuniculus | 100342616 | 10141 | Cavia porcellus | 100717571 |
132113 | Bombus impatiens | 100742193 | 7463 | Apis florea | 100865795 |
9685 | Felis catus | 101081602 | 9595 | Gorilla gorilla | 101137217 |
9615 | Canis familiaris | 475456 | 9913 | Bos taurus | 768050 |
9358 | Choloepus hoffmanni | ENSCHOG00000009259 | 9483 | Callithrix jacchus | ENSCJAG00000005968 |
9361 | Dasypus novemcinctus | ENSDNOG00000006004 | 10020 | Dipodomys ordii | ENSDORG00000004533 |
9371 | Echinops telfairi | ENSETEG00000019912 | 9978 | Ochotona princeps | ENSOPRG00000010102 |
8090 | Oryzias latipes | ENSORLG00000007377 | 132908 | Pteropus vampyrus | ENSPVAG00000016214 |
42254 | Sorex araneus | ENSSARG00000009234 | 59729 | Taeniopygia guttata | ENSTGUG00000001214 |
9739 | Tursiops truncatus | ENSTTRG00000016274 | 30538 | Vicugna pacos | ENSVPAG00000007328 |
69293 | Gasterosteus aculeatus | ENSGACG00000018718 | 8049 | Gadus morhua | ENSGMOG00000005788 |
9315 | Macropus eugenii | ENSMEUG00000005813 | 59463 | Myotis lucifugus | ENSMLUG00000002321 |
9813 | Procavia capensis | ENSPCAG00000006817 | 7757 | Petromyzon marinus | ENSPMAG00000009833 |
13735 | Pelodiscus sinensis | ENSPSIG00000003731 | 10116 | Rattus norvegicus | ENSRNOG00000018483 |
9305 | Sarcophilus harrisii | ENSSHAG00000006806 | 9823 | Sus scrofa | ENSSSCG00000025920 |
99883 | Tetraodon nigroviridis | ENSTNIG00000003701 | 9478 | Tarsius syrichta | ENSTSYG00000005318 |
8083 | Xiphophorus maculatus | ENSXMAG00000016280 |
Paralogs | |||
4093 |