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Genomic Study
 Sequence Source Links

Database Satistics
Drugs Targets : 13
Drugs : 4
Genes : 80
Attenuated Vaccine : 4

Structural Protein
C Protein (Capsid Protein)
Description The core protein representing the least conserved structural protein among different flaviviruses (less than 40%) is located at the very amino-terminal end of the polyprotein. Its carboxy-terminal region, serving as a signal sequence, anchors the capsid protein into the ER membrane and thus translocates prM into the lumen of the endoplasmatic reticulum. Subsequently, this signal sequence is cleaved off by the action of host cell signalases liberating the N-terminus of prM whereas C remains closely associated with the ER membrane promoting viral assembly. This association is mediated by the non absolute required internal hydrophobic region present in all flaviviruses (aa 45-65).

It was shown that the capsid protein is also found in the nucleus and can possibly interact with hnRNP K, suggesting a role in regulation of the dengue lifecycle probably by controlling apoptosis.

The membrane-associated capsid protein mediates viral assembly by a highly coordinated interaction with the E-prM heterodimer in the ER. Several copies of the capsid protein and one copy of the genomic RNA form the nucleocapsid (NC) finally budding into the lumen of the ER and producing immature viral particles.
packaging of viral RNA
forming the nucleocapsid
binding of viral RNA
mediating viral assembly
regulation of the viral lifecycle
Cellular Location Cytoplasm, Nucleus, anchored into the ER membrane (early stage of infection) & associated with ER membrane (late stage of infection before vial assembly)
Structure Solution Structure of Dengue Virus Capsid Protein Reveals a New Fold (Ma et al 2004)
PDB : 1R6R
Download PBD File:
Synonyms C protein, nucleocapside, core protein

References (Pubmed)

15608696, 9621059, 15254179, 12768036 , 9201220 , 14993605 , 15269372 , 11747608 , 11884577 , 12466486