Basic Information | |||
Gene ID | 3280 ; ![]() ![]() | ||
Gene Name | HES1; BHLHB39, HL, HRY | ||
Full Name | Transcription factor HES-1 | ||
Organism | Homo sapiens [9606] |
Cross Reference | |||
UniProt | Q14469 | UniGene | Hs.250666 |
PDB | NULL | OMIM | 139605 |
KEGG | hsa:3280 | UCSC | uc003ftq.2 |
Protein Interactions | |
DIP | NULL |
IntAct | Q14469 |
MINT | MINT-6774152 |
STRING | 9606.ENSP00000232424 |
Ensembl/RefSeq | Transcript ID | Protein ID | Gene ID |
ENSEMBL | |||
REFSEQ |
InterPro Annotation | |||||||
Protein | Program | Term | IPRS | Start | End | Score | Description |
ENSP00000232424 | Gene3D | G3DSA:4.10.280.10 | IPR011598 | 33 | 94 | 1.30e-14 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSP00000232424 | Pfam | PF00010 | IPR011598 | 35 | 92 | 2.10e-14 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSP00000232424 | Pfam | PF07527 | IPR003650 | 109 | 150 | 3.20e-20 | Orange |
ENSP00000232424 | ProSiteProfiles | PS50888 | IPR011598 | 34 | 91 | 0.00e-00 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSP00000232424 | ProSiteProfiles | PS51054 | IPR003650 | 110 | 143 | 0.00e-00 | Orange |
ENSP00000232424 | SMART | SM00353 | IPR011598 | 40 | 97 | 2.10e-16 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSP00000232424 | SMART | SM00511 | IPR018352 | 108 | 152 | 6.70e-21 | Orange subgroup |
ENSP00000232424 | SUPERFAMILY | SSF47459 | IPR011598 | 25 | 94 | 0.00e-00 | Myc-type, basic helix-loop-helix (bHLH) domain |
Pfam Annotation | ||||
Protein | Pfam ID | E.value | Name | Description |
ENSP00000232424 | PF07527 | 1.8e-20 | Hairy_orange | Hairy Orange |
ENSP00000232424 | PF00010 | 1.2e-14 | HLH | Helix-loop-helix DNA-binding domain |
Gene Ontology Annotation | |||
Protein | Entry | Name Space | Description |
ENSP00000232424 | GO:0000122 | biological_process | negative regulation of transcription from RNA polymerase II promoter |
ENSP00000232424 | GO:0006351 | biological_process | transcription, DNA-templated |
ENSP00000232424 | GO:0006355 | biological_process | regulation of transcription, DNA-templated |
ENSP00000232424 | GO:0007219 | biological_process | Notch signaling pathway |
ENSP00000232424 | GO:0007275 | biological_process | multicellular organismal development |
ENSP00000232424 | GO:0045892 | biological_process | negative regulation of transcription, DNA-templated |
ENSP00000232424 | GO:0005634 | cellular_component | nucleus |
ENSP00000232424 | GO:0003677 | molecular_function | DNA binding |
ENSP00000232424 | GO:0043565 | molecular_function | sequence-specific DNA binding |
ENSP00000232424 | GO:0046982 | molecular_function | protein heterodimerization activity |
ENSP00000232424 | GO:0046983 | molecular_function | protein dimerization activity |
Orthologs | |||||
TAXID | Organism | Gene ID | TAXID | Organism | Gene ID |
9669 | Mustela putorius furo | 101691000 | 7897 | Latimeria chalumnae | 102355895 |
8364 | Xenopus tropicalis | 100038090 | 7425 | Nasonia vitripennis | 100117641 |
7029 | Acyrthosiphon pisum | 100163408 | 59729 | Taeniopygia guttata | 100225879 |
10224 | Saccoglossus kowalevskii | 100303558 | 28377 | Anolis carolinensis | 100558625 |
30195 | Bombus terrestris | 100643707 | 132113 | Bombus impatiens | 100742057 |
10029 | Cricetulus griseus | 100756407 | 7463 | Apis florea | 100865915 |
143995 | Megachile rotundata | 100876689 | 34638 | Metaseiulus occidentalis | 100897626 |
9597 | Pan paniscus | 100975593 | 9555 | Papio anubis | 101006374 |
39432 | Saimiri boliviensis | 101047984 | 9595 | Gorilla gorilla | 101137927 |
43179 | Ictidomys tridecemlineatus | 101960521 | 13735 | Pelodiscus sinensis | 102463824 |
7227 | Drosophila melanogaster | 35800 | 9031 | Gallus gallus | 395128 |
7668 | Strongylocentrotus purpuratus | 414294 | 9598 | Pan troglodytes | 460942 |
9913 | Bos taurus | 539547 | 7070 | Tribolium castaneum | 660626 |
7460 | Apis mellifera | 724914 | 9615 | Canis familiaris | ENSCAFG00000019577 |
9358 | Choloepus hoffmanni | ENSCHOG00000005633 | 7719 | Ciona intestinalis | ENSCING00000003929 |
9483 | Callithrix jacchus | ENSCJAG00000000166 | 51511 | Ciona savignyi | ENSCSAVG00000004162 |
10020 | Dipodomys ordii | ENSDORG00000014783 | 9796 | Equus caballus | ENSECAG00000026945 |
9365 | Erinaceus europaeus | ENSEEUG00000007286 | 9685 | Felis catus | ENSFCAG00000029144 |
8049 | Gadus morhua | ENSGMOG00000015708 | 9315 | Macropus eugenii | ENSMEUG00000013941 |
9103 | Meleagris gallopavo | ENSMGAG00000007566 | 30608 | Microcebus murinus | ENSMICG00000012430 |
59463 | Myotis lucifugus | ENSMLUG00000008549 | 13616 | Monodelphis domestica | ENSMODG00000019833 |
61853 | Nomascus leucogenys | ENSNLEG00000006836 | 9258 | Ornithorhynchus anatinus | ENSOANG00000015683 |
30611 | Otolemur garnettii | ENSOGAG00000024214 | 8128 | Oreochromis niloticus | ENSONIG00000002619 |
9978 | Ochotona princeps | ENSOPRG00000006690 | 8090 | Oryzias latipes | ENSORLG00000007556 |
9813 | Procavia capensis | ENSPCAG00000007135 | 7757 | Petromyzon marinus | ENSPMAG00000001409 |
9601 | Pongo abelii | ENSPPYG00000014419 | 132908 | Pteropus vampyrus | ENSPVAG00000015487 |
10116 | Rattus norvegicus | ENSRNOG00000001720 | 42254 | Sorex araneus | ENSSARG00000014246 |
9823 | Sus scrofa | ENSSSCG00000026362 | 37347 | Tupaia belangeri | ENSTBEG00000017537 |
99883 | Tetraodon nigroviridis | ENSTNIG00000015567 | 31033 | Takifugu rubripes | ENSTRUG00000017395 |
9739 | Tursiops truncatus | ENSTTRG00000001687 | 30538 | Vicugna pacos | ENSVPAG00000000708 |
8083 | Xiphophorus maculatus | ENSXMAG00000003794 | 9646 | Ailuropoda melanoleuca | ENSAMEG00000015855 |
10141 | Cavia porcellus | ENSCPOG00000021042 | 69293 | Gasterosteus aculeatus | ENSGACG00000009264 |