Basic Information
Gene ID 38872
Gene Name Clk; CLOCK, jrk, PAS1; CG7391
Full Name Circadian locomoter output cycles protein kaput
Organism Drosophila melanogaster [7227]

Cross Reference
UniProt O61735 UniGene Dm.7596
PDB NULL OMIM NULL
KEGG dme:Dmel_CG7391 UCSC CG7391-RA

Protein Interactions
DIP DIP-46595N
IntAct O61735
MINT MINT-7025605
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
FBpp0099478 Gene3D G3DSA:4.10.280.10 IPR011598 17 64 3.50e-09 Myc-type, basic helix-loop-helix (bHLH) domain
FBpp0099478 Pfam PF00010 IPR011598 17 64 4.90e-06 Myc-type, basic helix-loop-helix (bHLH) domain
FBpp0099478 PRINTS PR00785 IPR001067 266 283 2.50e-12 Nuclear translocator
FBpp0099478 PRINTS PR00785 IPR001067 30 45 2.50e-12 Nuclear translocator
FBpp0099478 PRINTS PR00785 IPR001067 81 104 2.50e-12 Nuclear translocator
FBpp0099478 ProSiteProfiles PS50112 IPR000014 88 147 0.00e-00 PAS domain
FBpp0099478 ProSiteProfiles PS50888 IPR011598 15 65 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
FBpp0099478 SMART SM00086 IPR001610 327 370 1.60e-06 PAC motif
FBpp0099478 SMART SM00091 IPR000014 255 321 4.20e-06 PAS domain
FBpp0099478 SMART SM00091 IPR000014 90 156 3.40e-06 PAS domain
FBpp0099478 SMART SM00353 IPR011598 21 71 1.00e-09 Myc-type, basic helix-loop-helix (bHLH) domain
FBpp0099478 SUPERFAMILY SSF47459 IPR011598 17 85 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
FBpp0099478 SUPERFAMILY SSF55785 IPR000014 265 367 0.00e-00 PAS domain
FBpp0099478 SUPERFAMILY SSF55785 IPR000014 99 152 0.00e-00 PAS domain

Pfam Annotation
Protein Pfam ID E.value Name Description
FBpp0099478 PF14598 8.5e-21 PAS_11 PAS domain
FBpp0099478 PF08447 2.6e-13 PAS_3 PAS fold
FBpp0099478 PF00010 4.9e-06 HLH Helix-loop-helix DNA-binding domain
FBpp0099478 PF00989 0.00019 PAS PAS fold

Gene Ontology Annotation
Protein Entry Name Space Description
FBpp0099478 GO:0006351 biological_process transcription, DNA-templated
FBpp0099478 GO:0005634 cellular_component nucleus
FBpp0099478 GO:0005667 cellular_component transcription factor complex
FBpp0099478 GO:0003677 molecular_function DNA binding
FBpp0099478 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
FBpp0099478 GO:0004871 molecular_function signal transducer activity
FBpp0099478 GO:0046983 molecular_function protein dimerization activity

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
7029 Acyrthosiphon pisum 100163752 9986 Oryctolagus cuniculus 100349684
61853 Nomascus leucogenys 100606130 30195 Bombus terrestris 100650446
10029 Cricetulus griseus 100756929 7463 Apis florea 100869092
143995 Megachile rotundata 100878984 9597 Pan paniscus 100971685
39432 Saimiri boliviensis 101052614 9685 Felis catus 101088483
9669 Mustela putorius furo 101674500 7955 Danio rerio 352927
7425 Nasonia vitripennis 100114103 9483 Callithrix jacchus 100407407
132113 Bombus impatiens 100747861 34638 Metaseiulus occidentalis 100900259
9555 Papio anubis 101017477 43179 Ictidomys tridecemlineatus 101958731
13735 Pelodiscus sinensis 102444504 9358 Choloepus hoffmanni ENSCHOG00000008122
10141 Cavia porcellus ENSCPOG00000002470 9361 Dasypus novemcinctus ENSDNOG00000018101
9595 Gorilla gorilla ENSGGOG00000005753 8049 Gadus morhua ENSGMOG00000012332
9103 Meleagris gallopavo ENSMGAG00000014799 59463 Myotis lucifugus ENSMLUG00000010007
9258 Ornithorhynchus anatinus ENSOANG00000003801 30611 Otolemur garnettii ENSOGAG00000012464
9813 Procavia capensis ENSPCAG00000004689 7757 Petromyzon marinus ENSPMAG00000002704
9305 Sarcophilus harrisii ENSSHAG00000010526 9823 Sus scrofa ENSSSCG00000008909
59729 Taeniopygia guttata ENSTGUG00000010003 9739 Tursiops truncatus ENSTTRG00000000960
8083 Xiphophorus maculatus ENSXMAG00000016928 7668 Strongylocentrotus purpuratus 576191
10116 Rattus norvegicus 60447 7070 Tribolium castaneum 655469
9606 Homo sapiens 9575 28377 Anolis carolinensis ENSACAG00000007946
9646 Ailuropoda melanoleuca ENSAMEG00000018420 9913 Bos taurus ENSBTAG00000044044
9615 Canis familiaris ENSCAFG00000002140 10020 Dipodomys ordii ENSDORG00000015727
9796 Equus caballus ENSECAG00000006331 9365 Erinaceus europaeus ENSEEUG00000000876
9371 Echinops telfairi ENSETEG00000015604 69293 Gasterosteus aculeatus ENSGACG00000020338
9031 Gallus gallus ENSGALG00000016774 7897 Latimeria chalumnae ENSLACG00000016260
9785 Loxodonta africana ENSLAFG00000016336 9315 Macropus eugenii ENSMEUG00000005481
30608 Microcebus murinus ENSMICG00000016027 9544 Macaca mulatta ENSMMUG00000001919
13616 Monodelphis domestica ENSMODG00000001691 9978 Ochotona princeps ENSOPRG00000001179
8090 Oryzias latipes ENSORLG00000004495 9601 Pongo abelii ENSPPYG00000014762
132908 Pteropus vampyrus ENSPVAG00000008960 37347 Tupaia belangeri ENSTBEG00000012008
99883 Tetraodon nigroviridis ENSTNIG00000004102 31033 Takifugu rubripes ENSTRUG00000015488
9478 Tarsius syrichta ENSTSYG00000003546 30538 Vicugna pacos ENSVPAG00000006438
8364 Xenopus tropicalis ENSXETG00000021769