Basic Information
Gene ID 9575 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name CLOCK; BHLHE8, KIAA0334
Full Name Circadian locomoter output cycles protein kaput
Organism Homo sapiens [9606]

Cross Reference
UniProt O15516 UniGene Hs.689578
PDB 4H10 OMIM 601851
KEGG hsa:9575 UCSC uc003haz.2

Protein Interactions
DIP NULL
IntAct O15516
MINT NULL
STRING 9606.ENSP00000308741

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000370723 Gene3D G3DSA:4.10.280.10 IPR011598 35 85 5.70e-12 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000370723 Pfam PF00010 IPR011598 35 83 4.80e-09 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000370723 Pfam PF00989 IPR013767 110 176 7.60e-08 PAS fold
ENSP00000370723 PRINTS PR00785 IPR001067 100 123 2.30e-12 Nuclear translocator
ENSP00000370723 PRINTS PR00785 IPR001067 275 292 2.30e-12 Nuclear translocator
ENSP00000370723 PRINTS PR00785 IPR001067 49 64 2.30e-12 Nuclear translocator
ENSP00000370723 ProSiteProfiles PS50112 IPR000014 107 177 0.00e-00 PAS domain
ENSP00000370723 ProSiteProfiles PS50112 IPR000014 285 332 0.00e-00 PAS domain
ENSP00000370723 ProSiteProfiles PS50888 IPR011598 34 84 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000370723 SMART SM00086 IPR001610 336 379 3.00e-09 PAC motif
ENSP00000370723 SMART SM00091 IPR000014 109 175 7.50e-09 PAS domain
ENSP00000370723 SMART SM00091 IPR000014 264 330 1.40e-06 PAS domain
ENSP00000370723 SMART SM00353 IPR011598 40 90 4.10e-14 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000370723 SUPERFAMILY SSF47459 IPR011598 31 104 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000370723 SUPERFAMILY SSF55785 IPR000014 118 185 0.00e-00 PAS domain
ENSP00000370723 SUPERFAMILY SSF55785 IPR000014 274 376 0.00e-00 PAS domain

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000370723 PF14598 2.1e-24 PAS_11 PAS domain
ENSP00000370723 PF08447 1.7e-15 PAS_3 PAS fold
ENSP00000370723 PF00989 1.2e-10 PAS PAS fold
ENSP00000370723 PF00010 1.8e-09 HLH Helix-loop-helix DNA-binding domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000370723 GO:0006351 biological_process transcription, DNA-templated
ENSP00000370723 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSP00000370723 GO:0006974 biological_process cellular response to DNA damage stimulus
ENSP00000370723 GO:0007165 biological_process signal transduction
ENSP00000370723 GO:0032922 biological_process circadian regulation of gene expression
ENSP00000370723 GO:0048511 biological_process rhythmic process
ENSP00000370723 GO:0005634 cellular_component nucleus
ENSP00000370723 GO:0005667 cellular_component transcription factor complex
ENSP00000370723 GO:0005694 cellular_component chromosome
ENSP00000370723 GO:0005737 cellular_component cytoplasm
ENSP00000370723 GO:0001047 molecular_function core promoter binding
ENSP00000370723 GO:0003677 molecular_function DNA binding
ENSP00000370723 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSP00000370723 GO:0004402 molecular_function histone acetyltransferase activity
ENSP00000370723 GO:0004871 molecular_function signal transducer activity
ENSP00000370723 GO:0046983 molecular_function protein dimerization activity

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9986 Oryctolagus cuniculus 100349684 9685 Felis catus 101088483
7029 Acyrthosiphon pisum 100163752 9483 Callithrix jacchus 100407407
61853 Nomascus leucogenys 100606130 30195 Bombus terrestris 100650446
8128 Oreochromis niloticus 100690629 132113 Bombus impatiens 100747861
143995 Megachile rotundata 100878984 9597 Pan paniscus 100986920
9555 Papio anubis 101017477 39432 Saimiri boliviensis 101035173
9669 Mustela putorius furo 101674500 43179 Ictidomys tridecemlineatus 101958731
13735 Pelodiscus sinensis 102444504 7955 Danio rerio 352927
7227 Drosophila melanogaster 38872 7668 Strongylocentrotus purpuratus 576191
10116 Rattus norvegicus 60447 7070 Tribolium castaneum 655469
28377 Anolis carolinensis ENSACAG00000009335 9913 Bos taurus ENSBTAG00000044044
9361 Dasypus novemcinctus ENSDNOG00000018101 10020 Dipodomys ordii ENSDORG00000008014
9796 Equus caballus ENSECAG00000006331 9365 Erinaceus europaeus ENSEEUG00000000876
9371 Echinops telfairi ENSETEG00000015604 69293 Gasterosteus aculeatus ENSGACG00000015939
9031 Gallus gallus ENSGALG00000013793 9595 Gorilla gorilla ENSGGOG00000005753
8049 Gadus morhua ENSGMOG00000004825 7897 Latimeria chalumnae ENSLACG00000013436
9785 Loxodonta africana ENSLAFG00000009558 9315 Macropus eugenii ENSMEUG00000005481
30608 Microcebus murinus ENSMICG00000000320 59463 Myotis lucifugus ENSMLUG00000010007
9258 Ornithorhynchus anatinus ENSOANG00000003801 30611 Otolemur garnettii ENSOGAG00000012464
8090 Oryzias latipes ENSORLG00000004495 7757 Petromyzon marinus ENSPMAG00000002704
9601 Pongo abelii ENSPPYG00000014762 132908 Pteropus vampyrus ENSPVAG00000008960
42254 Sorex araneus ENSSARG00000002584 9305 Sarcophilus harrisii ENSSHAG00000005555
9823 Sus scrofa ENSSSCG00000008909 37347 Tupaia belangeri ENSTBEG00000002540
59729 Taeniopygia guttata ENSTGUG00000007513 31033 Takifugu rubripes ENSTRUG00000015488
9478 Tarsius syrichta ENSTSYG00000003546 9739 Tursiops truncatus ENSTTRG00000000960
30538 Vicugna pacos ENSVPAG00000006438 8364 Xenopus tropicalis ENSXETG00000021064
8083 Xiphophorus maculatus ENSXMAG00000016928 9646 Ailuropoda melanoleuca ENSAMEG00000018420
9615 Canis familiaris ENSCAFG00000002140 9358 Choloepus hoffmanni ENSCHOG00000004103
10141 Cavia porcellus ENSCPOG00000011807 9544 Macaca mulatta ENSMMUG00000001919
9978 Ochotona princeps ENSOPRG00000005292 99883 Tetraodon nigroviridis ENSTNIG00000017652