Basic Information | |||
Gene ID | 9575 ; Check Expression Profles ; Check TFs & Targets Binding | ||
Gene Name | CLOCK; BHLHE8, KIAA0334 | ||
Full Name | Circadian locomoter output cycles protein kaput | ||
Organism | Homo sapiens [9606] |
Cross Reference | |||
UniProt | O15516 | UniGene | Hs.689578 |
PDB | 4H10 | OMIM | 601851 |
KEGG | hsa:9575 | UCSC | uc003haz.2 |
Protein Interactions | |
DIP | NULL |
IntAct | O15516 |
MINT | NULL |
STRING | 9606.ENSP00000308741 |
Ensembl/RefSeq | Transcript ID | Protein ID | Gene ID |
ENSEMBL | |||
ENSEMBL | |||
ENSEMBL | |||
REFSEQ | |||
REFSEQ | |||
REFSEQ |
InterPro Annotation | |||||||
Protein | Program | Term | IPRS | Start | End | Score | Description |
ENSP00000370723 | Gene3D | G3DSA:4.10.280.10 | IPR011598 | 35 | 85 | 5.70e-12 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSP00000370723 | Pfam | PF00010 | IPR011598 | 35 | 83 | 4.80e-09 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSP00000370723 | Pfam | PF00989 | IPR013767 | 110 | 176 | 7.60e-08 | PAS fold |
ENSP00000370723 | PRINTS | PR00785 | IPR001067 | 100 | 123 | 2.30e-12 | Nuclear translocator |
ENSP00000370723 | PRINTS | PR00785 | IPR001067 | 275 | 292 | 2.30e-12 | Nuclear translocator |
ENSP00000370723 | PRINTS | PR00785 | IPR001067 | 49 | 64 | 2.30e-12 | Nuclear translocator |
ENSP00000370723 | ProSiteProfiles | PS50112 | IPR000014 | 107 | 177 | 0.00e-00 | PAS domain |
ENSP00000370723 | ProSiteProfiles | PS50112 | IPR000014 | 285 | 332 | 0.00e-00 | PAS domain |
ENSP00000370723 | ProSiteProfiles | PS50888 | IPR011598 | 34 | 84 | 0.00e-00 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSP00000370723 | SMART | SM00086 | IPR001610 | 336 | 379 | 3.00e-09 | PAC motif |
ENSP00000370723 | SMART | SM00091 | IPR000014 | 109 | 175 | 7.50e-09 | PAS domain |
ENSP00000370723 | SMART | SM00091 | IPR000014 | 264 | 330 | 1.40e-06 | PAS domain |
ENSP00000370723 | SMART | SM00353 | IPR011598 | 40 | 90 | 4.10e-14 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSP00000370723 | SUPERFAMILY | SSF47459 | IPR011598 | 31 | 104 | 0.00e-00 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSP00000370723 | SUPERFAMILY | SSF55785 | IPR000014 | 118 | 185 | 0.00e-00 | PAS domain |
ENSP00000370723 | SUPERFAMILY | SSF55785 | IPR000014 | 274 | 376 | 0.00e-00 | PAS domain |
Pfam Annotation | ||||
Protein | Pfam ID | E.value | Name | Description |
ENSP00000370723 | PF14598 | 2.1e-24 | PAS_11 | PAS domain |
ENSP00000370723 | PF08447 | 1.7e-15 | PAS_3 | PAS fold |
ENSP00000370723 | PF00989 | 1.2e-10 | PAS | PAS fold |
ENSP00000370723 | PF00010 | 1.8e-09 | HLH | Helix-loop-helix DNA-binding domain |
Gene Ontology Annotation | |||
Protein | Entry | Name Space | Description |
ENSP00000370723 | GO:0006351 | biological_process | transcription, DNA-templated |
ENSP00000370723 | GO:0006355 | biological_process | regulation of transcription, DNA-templated |
ENSP00000370723 | GO:0006974 | biological_process | cellular response to DNA damage stimulus |
ENSP00000370723 | GO:0007165 | biological_process | signal transduction |
ENSP00000370723 | GO:0032922 | biological_process | circadian regulation of gene expression |
ENSP00000370723 | GO:0048511 | biological_process | rhythmic process |
ENSP00000370723 | GO:0005634 | cellular_component | nucleus |
ENSP00000370723 | GO:0005667 | cellular_component | transcription factor complex |
ENSP00000370723 | GO:0005694 | cellular_component | chromosome |
ENSP00000370723 | GO:0005737 | cellular_component | cytoplasm |
ENSP00000370723 | GO:0001047 | molecular_function | core promoter binding |
ENSP00000370723 | GO:0003677 | molecular_function | DNA binding |
ENSP00000370723 | GO:0003700 | molecular_function | sequence-specific DNA binding transcription factor activity |
ENSP00000370723 | GO:0004402 | molecular_function | histone acetyltransferase activity |
ENSP00000370723 | GO:0004871 | molecular_function | signal transducer activity |
ENSP00000370723 | GO:0046983 | molecular_function | protein dimerization activity |
Orthologs | |||||
TAXID | Organism | Gene ID | TAXID | Organism | Gene ID |
9986 | Oryctolagus cuniculus | 100349684 | 9685 | Felis catus | 101088483 |
7029 | Acyrthosiphon pisum | 100163752 | 9483 | Callithrix jacchus | 100407407 |
61853 | Nomascus leucogenys | 100606130 | 30195 | Bombus terrestris | 100650446 |
8128 | Oreochromis niloticus | 100690629 | 132113 | Bombus impatiens | 100747861 |
143995 | Megachile rotundata | 100878984 | 9597 | Pan paniscus | 100986920 |
9555 | Papio anubis | 101017477 | 39432 | Saimiri boliviensis | 101035173 |
9669 | Mustela putorius furo | 101674500 | 43179 | Ictidomys tridecemlineatus | 101958731 |
13735 | Pelodiscus sinensis | 102444504 | 7955 | Danio rerio | 352927 |
7227 | Drosophila melanogaster | 38872 | 7668 | Strongylocentrotus purpuratus | 576191 |
10116 | Rattus norvegicus | 60447 | 7070 | Tribolium castaneum | 655469 |
28377 | Anolis carolinensis | ENSACAG00000009335 | 9913 | Bos taurus | ENSBTAG00000044044 |
9361 | Dasypus novemcinctus | ENSDNOG00000018101 | 10020 | Dipodomys ordii | ENSDORG00000008014 |
9796 | Equus caballus | ENSECAG00000006331 | 9365 | Erinaceus europaeus | ENSEEUG00000000876 |
9371 | Echinops telfairi | ENSETEG00000015604 | 69293 | Gasterosteus aculeatus | ENSGACG00000015939 |
9031 | Gallus gallus | ENSGALG00000013793 | 9595 | Gorilla gorilla | ENSGGOG00000005753 |
8049 | Gadus morhua | ENSGMOG00000004825 | 7897 | Latimeria chalumnae | ENSLACG00000013436 |
9785 | Loxodonta africana | ENSLAFG00000009558 | 9315 | Macropus eugenii | ENSMEUG00000005481 |
30608 | Microcebus murinus | ENSMICG00000000320 | 59463 | Myotis lucifugus | ENSMLUG00000010007 |
9258 | Ornithorhynchus anatinus | ENSOANG00000003801 | 30611 | Otolemur garnettii | ENSOGAG00000012464 |
8090 | Oryzias latipes | ENSORLG00000004495 | 7757 | Petromyzon marinus | ENSPMAG00000002704 |
9601 | Pongo abelii | ENSPPYG00000014762 | 132908 | Pteropus vampyrus | ENSPVAG00000008960 |
42254 | Sorex araneus | ENSSARG00000002584 | 9305 | Sarcophilus harrisii | ENSSHAG00000005555 |
9823 | Sus scrofa | ENSSSCG00000008909 | 37347 | Tupaia belangeri | ENSTBEG00000002540 |
59729 | Taeniopygia guttata | ENSTGUG00000007513 | 31033 | Takifugu rubripes | ENSTRUG00000015488 |
9478 | Tarsius syrichta | ENSTSYG00000003546 | 9739 | Tursiops truncatus | ENSTTRG00000000960 |
30538 | Vicugna pacos | ENSVPAG00000006438 | 8364 | Xenopus tropicalis | ENSXETG00000021064 |
8083 | Xiphophorus maculatus | ENSXMAG00000016928 | 9646 | Ailuropoda melanoleuca | ENSAMEG00000018420 |
9615 | Canis familiaris | ENSCAFG00000002140 | 9358 | Choloepus hoffmanni | ENSCHOG00000004103 |
10141 | Cavia porcellus | ENSCPOG00000011807 | 9544 | Macaca mulatta | ENSMMUG00000001919 |
9978 | Ochotona princeps | ENSOPRG00000005292 | 99883 | Tetraodon nigroviridis | ENSTNIG00000017652 |