Basic Information
Gene ID 4609 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name MYC; BHLHE39
Full Name Myc proto-oncogene protein
Organism Homo sapiens [9606]

Cross Reference
UniProt P01106 UniGene Hs.202453
PDB 2OR9 OMIM 190080
KEGG hsa:4609 UCSC uc022bbe.1

Protein Interactions
DIP DIP-28143N
IntAct P01106
MINT MINT-257327
STRING 9606.ENSP00000367207

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000367207 Gene3D G3DSA:4.10.280.10 IPR011598 370 443 6.30e-18 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000367207 Pfam PF00010 IPR011598 370 422 4.10e-15 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000367207 Pfam PF01056 IPR012682 16 360 3.30e-141 Transcription regulator Myc, N-terminal
ENSP00000367207 Pfam PF02344 IPR003327 423 454 8.20e-19 Leucine zipper, Myc
ENSP00000367207 PIRSF PIRSF001705 IPR002418 11 452 0.00e-00 Transcription regulator Myc
ENSP00000367207 PRINTS PR00044 IPR002418 143 158 4.00e-50 Transcription regulator Myc
ENSP00000367207 PRINTS PR00044 IPR002418 319 328 4.00e-50 Transcription regulator Myc
ENSP00000367207 PRINTS PR00044 IPR002418 362 378 4.00e-50 Transcription regulator Myc
ENSP00000367207 PRINTS PR00044 IPR002418 379 394 4.00e-50 Transcription regulator Myc
ENSP00000367207 PRINTS PR00044 IPR002418 404 417 4.00e-50 Transcription regulator Myc
ENSP00000367207 PRINTS PR00044 IPR002418 60 78 4.00e-50 Transcription regulator Myc
ENSP00000367207 ProSiteProfiles PS50888 IPR011598 369 421 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000367207 SMART SM00353 IPR011598 375 427 3.60e-17 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000367207 SUPERFAMILY SSF47459 IPR011598 368 450 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000367207 PF01056 0 Myc_N Myc amino-terminal region
ENSP00000367207 PF02344 8.2e-19 Myc-LZ Myc leucine zipper domain
ENSP00000367207 PF00010 2.2e-16 HLH Helix-loop-helix DNA-binding domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000367207 GO:0000165 biological_process MAPK cascade
ENSP00000367207 GO:0006338 biological_process chromatin remodeling
ENSP00000367207 GO:0006351 biological_process transcription, DNA-templated
ENSP00000367207 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSP00000367207 GO:0006879 biological_process cellular iron ion homeostasis
ENSP00000367207 GO:0006974 biological_process cellular response to DNA damage stimulus
ENSP00000367207 GO:0010332 biological_process response to gamma radiation
ENSP00000367207 GO:0032204 biological_process regulation of telomere maintenance
ENSP00000367207 GO:0032873 biological_process negative regulation of stress-activated MAPK cascade
ENSP00000367207 GO:0042493 biological_process response to drug
ENSP00000367207 GO:0043066 biological_process negative regulation of apoptotic process
ENSP00000367207 GO:0043280 biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
ENSP00000367207 GO:0045656 biological_process negative regulation of monocyte differentiation
ENSP00000367207 GO:0045893 biological_process positive regulation of transcription, DNA-templated
ENSP00000367207 GO:0045944 biological_process positive regulation of transcription from RNA polymerase II promoter
ENSP00000367207 GO:0048146 biological_process positive regulation of fibroblast proliferation
ENSP00000367207 GO:0050679 biological_process positive regulation of epithelial cell proliferation
ENSP00000367207 GO:0051276 biological_process chromosome organization
ENSP00000367207 GO:0051782 biological_process negative regulation of cell division
ENSP00000367207 GO:0060070 biological_process canonical Wnt signaling pathway
ENSP00000367207 GO:2000573 biological_process positive regulation of DNA biosynthetic process
ENSP00000367207 GO:2001022 biological_process positive regulation of response to DNA damage stimulus
ENSP00000367207 GO:0005634 cellular_component nucleus
ENSP00000367207 GO:0005654 cellular_component nucleoplasm
ENSP00000367207 GO:0005730 cellular_component nucleolus
ENSP00000367207 GO:0003677 molecular_function DNA binding
ENSP00000367207 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSP00000367207 GO:0032403 molecular_function protein complex binding
ENSP00000367207 GO:0046983 molecular_function protein dimerization activity
ENSP00000367207 GO:0070888 molecular_function E-box binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
10224 Saccoglossus kowalevskii 100303478 10029 Cricetulus griseus 100758352
9597 Pan paniscus 100972175 9555 Papio anubis 101000645
43179 Ictidomys tridecemlineatus 101957086 8083 Xiphophorus maculatus 102224917
7897 Latimeria chalumnae 102357079 7955 Danio rerio 393141
9031 Gallus gallus 420332 39432 Saimiri boliviensis 101047066
10090 Mus musculus 18109 9544 Macaca mulatta 694626
9615 Canis familiaris ENSCAFG00000001086 9258 Ornithorhynchus anatinus ENSOANG00000008107
8128 Oreochromis niloticus ENSONIG00000013987 30538 Vicugna pacos ENSVPAG00000005895
8364 Xenopus tropicalis ENSXETG00000015485 28377 Anolis carolinensis ENSACAG00000010372
9646 Ailuropoda melanoleuca ENSAMEG00000014717 9913 Bos taurus ENSBTAG00000023372
9483 Callithrix jacchus ENSCJAG00000012620 10141 Cavia porcellus ENSCPOG00000003326
10020 Dipodomys ordii ENSDORG00000010277 9796 Equus caballus ENSECAG00000002896
9365 Erinaceus europaeus ENSEEUG00000001458 9371 Echinops telfairi ENSETEG00000007657
9685 Felis catus ENSFCAG00000025438 69293 Gasterosteus aculeatus ENSGACG00000004456
9595 Gorilla gorilla ENSGGOG00000012135 8049 Gadus morhua ENSGMOG00000006081
9785 Loxodonta africana ENSLAFG00000001410 9315 Macropus eugenii ENSMEUG00000006124
9103 Meleagris gallopavo ENSMGAG00000015875 30608 Microcebus murinus ENSMICG00000014990
59463 Myotis lucifugus ENSMLUG00000026933 13616 Monodelphis domestica ENSMODG00000001735
9669 Mustela putorius furo ENSMPUG00000001327 9986 Oryctolagus cuniculus ENSOCUG00000014289
30611 Otolemur garnettii ENSOGAG00000005372 9978 Ochotona princeps ENSOPRG00000011259
8090 Oryzias latipes ENSORLG00000007021 9813 Procavia capensis ENSPCAG00000008554
9601 Pongo abelii ENSPPYG00000018878 13735 Pelodiscus sinensis ENSPSIG00000008301
9598 Pan troglodytes ENSPTRG00000020581 132908 Pteropus vampyrus ENSPVAG00000010355
10116 Rattus norvegicus ENSRNOG00000004500 42254 Sorex araneus ENSSARG00000010372
9823 Sus scrofa ENSSSCG00000005965 37347 Tupaia belangeri ENSTBEG00000005715
59729 Taeniopygia guttata ENSTGUG00000012513 99883 Tetraodon nigroviridis ENSTNIG00000017136
31033 Takifugu rubripes ENSTRUG00000008797 9739 Tursiops truncatus ENSTTRG00000016278