Basic Information | |||
Gene ID | 79733 ; Check Expression Profles ; Check TFs & Targets Binding | ||
Gene Name | E2F8 | ||
Full Name | Transcription factor E2F8 | ||
Organism | Homo sapiens [9606] |
Cross Reference | |||
UniProt | A0AVK6 | UniGene | Hs.523526 |
PDB | NULL | OMIM | 612047 |
KEGG | hsa:79733 | UCSC | uc001mpm.3 |
Protein Interactions | |
DIP | NULL |
IntAct | A0AVK6 |
MINT | MINT-6541611 |
STRING | 9606.ENSP00000250024 |
Ensembl/RefSeq | Transcript ID | Protein ID | Gene ID |
ENSEMBL | |||
ENSEMBL | |||
REFSEQ | |||
REFSEQ | |||
REFSEQ |
InterPro Annotation | |||||||
Protein | Program | Term | IPRS | Start | End | Score | Description |
ENSP00000250024 | Gene3D | G3DSA:1.10.10.10 | IPR011991 | 108 | 184 | 1.30e-24 | Winged helix-turn-helix DNA-binding domain |
ENSP00000250024 | Gene3D | G3DSA:1.10.10.10 | IPR011991 | 259 | 349 | 4.80e-23 | Winged helix-turn-helix DNA-binding domain |
ENSP00000250024 | PANTHER | PTHR12081 | IPR015633 | 1 | 762 | 0.00e-00 | E2F Family |
ENSP00000250024 | Pfam | PF02319 | IPR003316 | 113 | 182 | 6.80e-21 | Transcription factor E2F/dimerisation partner (TDP) |
ENSP00000250024 | Pfam | PF02319 | IPR003316 | 261 | 347 | 3.20e-19 | Transcription factor E2F/dimerisation partner (TDP) |
Pfam Annotation | ||||
Protein | Pfam ID | E.value | Name | Description |
ENSP00000250024 | PF02319 | 8.00141e-43 | E2F_TDP | E2F/DP family winged-helix DNA-binding domain |
ENSP00000250024 | PF01978 | 0.00021 | TrmB | Sugar-specific transcriptional regulator TrmB |
Gene Ontology Annotation | |||
Protein | Entry | Name Space | Description |
ENSP00000250024 | GO:0000122 | biological_process | negative regulation of transcription from RNA polymerase II promoter |
ENSP00000250024 | GO:0001890 | biological_process | placenta development |
ENSP00000250024 | GO:0002040 | biological_process | sprouting angiogenesis |
ENSP00000250024 | GO:0006351 | biological_process | transcription, DNA-templated |
ENSP00000250024 | GO:0032466 | biological_process | negative regulation of cytokinesis |
ENSP00000250024 | GO:0032877 | biological_process | positive regulation of DNA endoreduplication |
ENSP00000250024 | GO:0060707 | biological_process | trophoblast giant cell differentiation |
ENSP00000250024 | GO:0060718 | biological_process | chorionic trophoblast cell differentiation |
ENSP00000250024 | GO:0070365 | biological_process | hepatocyte differentiation |
ENSP00000250024 | GO:0005634 | cellular_component | nucleus |
ENSP00000250024 | GO:0005667 | cellular_component | transcription factor complex |
ENSP00000250024 | GO:0003700 | molecular_function | sequence-specific DNA binding transcription factor activity |
ENSP00000250024 | GO:0003714 | molecular_function | transcription corepressor activity |
Orthologs | |||||
TAXID | Organism | Gene ID | TAXID | Organism | Gene ID |
9796 | Equus caballus | 100071962 | 9597 | Pan paniscus | 100970405 |
9595 | Gorilla gorilla | 101153297 | 9986 | Oryctolagus cuniculus | 100350717 |
9483 | Callithrix jacchus | 100408568 | 10029 | Cricetulus griseus | 100760871 |
7668 | Strongylocentrotus purpuratus | 100891325 | 9555 | Papio anubis | 101024508 |
39432 | Saimiri boliviensis | 101053563 | 9685 | Felis catus | 101082690 |
9669 | Mustela putorius furo | 101693740 | 59463 | Myotis lucifugus | 102437294 |
10090 | Mus musculus | 108961 | 9358 | Choloepus hoffmanni | ENSCHOG00000006322 |
7719 | Ciona intestinalis | ENSCING00000014484 | 10141 | Cavia porcellus | ENSCPOG00000013766 |
10020 | Dipodomys ordii | ENSDORG00000000040 | 9371 | Echinops telfairi | ENSETEG00000004363 |
8049 | Gadus morhua | ENSGMOG00000019253 | 9315 | Macropus eugenii | ENSMEUG00000013506 |
30608 | Microcebus murinus | ENSMICG00000017089 | 9544 | Macaca mulatta | ENSMMUG00000010853 |
9258 | Ornithorhynchus anatinus | ENSOANG00000011290 | 30611 | Otolemur garnettii | ENSOGAG00000005774 |
8128 | Oreochromis niloticus | ENSONIG00000007135 | 9978 | Ochotona princeps | ENSOPRG00000012881 |
9813 | Procavia capensis | ENSPCAG00000003996 | 13735 | Pelodiscus sinensis | ENSPSIG00000008707 |
10116 | Rattus norvegicus | ENSRNOG00000022537 | 37347 | Tupaia belangeri | ENSTBEG00000005521 |
99883 | Tetraodon nigroviridis | ENSTNIG00000009615 | 31033 | Takifugu rubripes | ENSTRUG00000015792 |
9478 | Tarsius syrichta | ENSTSYG00000007279 | 9739 | Tursiops truncatus | ENSTTRG00000005707 |
30538 | Vicugna pacos | ENSVPAG00000012423 | 8364 | Xenopus tropicalis | ENSXETG00000004436 |
28377 | Anolis carolinensis | ENSACAG00000015743 | 51511 | Ciona savignyi | ENSCSAVG00000010123 |
9361 | Dasypus novemcinctus | ENSDNOG00000003349 | 9365 | Erinaceus europaeus | ENSEEUG00000011472 |
69293 | Gasterosteus aculeatus | ENSGACG00000017086 | 9031 | Gallus gallus | ENSGALG00000004023 |
7897 | Latimeria chalumnae | ENSLACG00000016113 | 9785 | Loxodonta africana | ENSLAFG00000022713 |
9103 | Meleagris gallopavo | ENSMGAG00000002303 | 8090 | Oryzias latipes | ENSORLG00000000786 |
132908 | Pteropus vampyrus | ENSPVAG00000012522 | 9305 | Sarcophilus harrisii | ENSSHAG00000018372 |
43179 | Ictidomys tridecemlineatus | ENSSTOG00000008838 | 59729 | Taeniopygia guttata | ENSTGUG00000015857 |
8083 | Xiphophorus maculatus | ENSXMAG00000010237 |