Basic Information
Gene ID 81812 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name Thra; C-erba-alpha, Nr1a1
Full Name Thyroid hormone receptor alpha
Organism Rattus norvegicus [10116]

Cross Reference
UniProt P63059 UniGene Rn.11307
PDB NULL OMIM NULL
KEGG rno:81812 UCSC NULL

Protein Interactions
DIP NULL
IntAct NULL
MINT MINT-1515753
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSRNOP00000012340 Gene3D G3DSA:1.10.565.10 IPR008946 147 374 3.70e-66 Nuclear hormone receptor, ligand-binding
ENSRNOP00000012340 Gene3D G3DSA:3.30.50.10 IPR013088 51 138 8.70e-28 Zinc finger, NHR/GATA-type
ENSRNOP00000012340 Pfam PF00104 IPR000536 210 358 6.00e-23 Nuclear hormone receptor, ligand-binding, core
ENSRNOP00000012340 Pfam PF00105 IPR001628 52 121 2.00e-29 Zinc finger, nuclear hormone receptor-type
ENSRNOP00000012340 PRINTS PR00047 IPR001628 104 112 7.60e-19 Zinc finger, nuclear hormone receptor-type
ENSRNOP00000012340 PRINTS PR00047 IPR001628 112 120 7.60e-19 Zinc finger, nuclear hormone receptor-type
ENSRNOP00000012340 PRINTS PR00047 IPR001628 53 69 7.60e-19 Zinc finger, nuclear hormone receptor-type
ENSRNOP00000012340 PRINTS PR00047 IPR001628 69 84 7.60e-19 Zinc finger, nuclear hormone receptor-type
ENSRNOP00000012340 PRINTS PR00398 IPR001723 116 126 1.50e-22 Steroid hormone receptor
ENSRNOP00000012340 PRINTS PR00398 IPR001723 221 242 1.50e-22 Steroid hormone receptor
ENSRNOP00000012340 PRINTS PR00398 IPR001723 242 258 1.50e-22 Steroid hormone receptor
ENSRNOP00000012340 PRINTS PR00398 IPR001723 309 324 1.50e-22 Steroid hormone receptor
ENSRNOP00000012340 PRINTS PR00546 IPR001728 118 134 2.20e-99 Thyroid hormone receptor
ENSRNOP00000012340 PRINTS PR00546 IPR001728 135 153 2.20e-99 Thyroid hormone receptor
ENSRNOP00000012340 PRINTS PR00546 IPR001728 158 175 2.20e-99 Thyroid hormone receptor
ENSRNOP00000012340 PRINTS PR00546 IPR001728 181 200 2.20e-99 Thyroid hormone receptor
ENSRNOP00000012340 PRINTS PR00546 IPR001728 218 239 2.20e-99 Thyroid hormone receptor
ENSRNOP00000012340 PRINTS PR00546 IPR001728 244 263 2.20e-99 Thyroid hormone receptor
ENSRNOP00000012340 PRINTS PR00546 IPR001728 309 331 2.20e-99 Thyroid hormone receptor
ENSRNOP00000012340 PRINTS PR00546 IPR001728 41 55 2.20e-99 Thyroid hormone receptor
ENSRNOP00000012340 PRINTS PR00546 IPR001728 79 90 2.20e-99 Thyroid hormone receptor
ENSRNOP00000012340 ProSitePatterns PS00031 IPR001628 53 79 - Zinc finger, nuclear hormone receptor-type
ENSRNOP00000012340 ProSiteProfiles PS51030 IPR001628 50 127 0.00e-00 Zinc finger, nuclear hormone receptor-type
ENSRNOP00000012340 SMART SM00399 IPR001628 50 123 1.00e-38 Zinc finger, nuclear hormone receptor-type
ENSRNOP00000012340 SMART SM00430 IPR000536 220 378 4.70e-34 Nuclear hormone receptor, ligand-binding, core
ENSRNOP00000012340 SUPERFAMILY SSF48508 IPR008946 147 376 0.00e-00 Nuclear hormone receptor, ligand-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSRNOP00000012340 PF00105 9.5e-30 zf-C4 Zinc finger, C4 type (two domains)
ENSRNOP00000012340 PF00104 2.5e-23 Hormone_recep Ligand-binding domain of nuclear hormone receptor

Gene Ontology Annotation
Protein Entry Name Space Description
ENSRNOP00000012340 GO:0006351 biological_process transcription, DNA-templated
ENSRNOP00000012340 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSRNOP00000012340 GO:0030522 biological_process intracellular receptor signaling pathway
ENSRNOP00000012340 GO:0043401 biological_process steroid hormone mediated signaling pathway
ENSRNOP00000012340 GO:0005634 cellular_component nucleus
ENSRNOP00000012340 GO:0003677 molecular_function DNA binding
ENSRNOP00000012340 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSRNOP00000012340 GO:0003707 molecular_function steroid hormone receptor activity
ENSRNOP00000012340 GO:0004887 molecular_function thyroid hormone receptor activity
ENSRNOP00000012340 GO:0008270 molecular_function zinc ion binding
ENSRNOP00000012340 GO:0043565 molecular_function sequence-specific DNA binding
ENSRNOP00000012340 GO:0046872 molecular_function metal ion binding
ENSRNOP00000012340 GO:0070324 molecular_function thyroid hormone binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9597 Pan paniscus 100971326 8083 Xiphophorus maculatus 102237580
7897 Latimeria chalumnae 102345437 8128 Oreochromis niloticus 100702192
10029 Cricetulus griseus 100770653 31033 Takifugu rubripes 101065807
9685 Felis catus 101095056 9595 Gorilla gorilla 101143950
43179 Ictidomys tridecemlineatus 101972353 10090 Mus musculus 21833
9606 Homo sapiens 7067 28377 Anolis carolinensis ENSACAG00000002898
9646 Ailuropoda melanoleuca ENSAMEG00000007644 9615 Canis familiaris ENSCAFG00000016173
9358 Choloepus hoffmanni ENSCHOG00000005495 7719 Ciona intestinalis ENSCING00000021968
10141 Cavia porcellus ENSCPOG00000015132 9361 Dasypus novemcinctus ENSDNOG00000017243
10020 Dipodomys ordii ENSDORG00000015567 9796 Equus caballus ENSECAG00000011120
9365 Erinaceus europaeus ENSEEUG00000009652 9371 Echinops telfairi ENSETEG00000013166
69293 Gasterosteus aculeatus ENSGACG00000003766 8049 Gadus morhua ENSGMOG00000016130
9785 Loxodonta africana ENSLAFG00000026002 13616 Monodelphis domestica ENSMODG00000013018
9978 Ochotona princeps ENSOPRG00000012107 8090 Oryzias latipes ENSORLG00000012005
9813 Procavia capensis ENSPCAG00000001185 9598 Pan troglodytes ENSPTRG00000009112
132908 Pteropus vampyrus ENSPVAG00000008549 37347 Tupaia belangeri ENSTBEG00000017367
9739 Tursiops truncatus ENSTTRG00000016893 8364 Xenopus tropicalis ENSXETG00000024399
9031 Gallus gallus ENSGALG00000000270 9315 Macropus eugenii ENSMEUG00000009980
9544 Macaca mulatta ENSMMUG00000002931 9669 Mustela putorius furo ENSMPUG00000014923
61853 Nomascus leucogenys ENSNLEG00000001519 9823 Sus scrofa ENSSSCG00000017480
99883 Tetraodon nigroviridis ENSTNIG00000003353

Paralogs
ENSRNOG00000006649