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    Resources: IPC: Isoelectric Point Calculator
    Submitted by Lukasz Pawel Kozlowski; posted on Sunday, June 12, 2016

    The estimation of the isoelectric point (pI) based on the amino acid sequence is useful for many biochemistry and proteomics techniques such as 2D-PAGE, IEF or mass spectrometry.

    Isoelectric Point Calculator allows for prediction of pI using different algorithms (17 algorithms implemented including two new ones).

    IPC outperform previous algorithms by at least 14.9% for proteins and 0.9% for peptides (on average, 22.1% and 59.6%, respectively), which corresponds to an average error of the pI estimation equal to 0.87 and 0.25 pH units for proteins and peptides, respectively.


    The IPC can be accessed freely at as a web service or standalone program.



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