Basic Information
Gene ID 20851 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name Stat5b
Full Name Signal transducer and activator of transcription 5B
Organism Mus musculus [10090]

Cross Reference
UniProt P42232 UniGene Mm.34064
PDB NULL OMIM NULL
KEGG mmu:20851 UCSC uc007lmi.2

Protein Interactions
DIP DIP-898N
IntAct P42232
MINT NULL
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSMUSP00000004143 Gene3D G3DSA:1.10.238.10 IPR011992 472 597 4.20e-47 EF-hand domain pair
ENSMUSP00000004143 Gene3D G3DSA:1.10.532.10 IPR013799 1 125 1.00e-47 STAT transcription factor, protein interaction
ENSMUSP00000004143 Gene3D G3DSA:1.20.1050.20 IPR013800 139 332 3.30e-65 STAT transcription factor, all-alpha
ENSMUSP00000004143 Gene3D G3DSA:2.60.40.630 IPR012345 333 471 1.30e-68 STAT transcription factor, DNA-binding, subdomain
ENSMUSP00000004143 Gene3D G3DSA:3.30.505.10 IPR000980 598 711 7.80e-41 SH2 domain
ENSMUSP00000004143 PANTHER PTHR11801 IPR001217 2 778 0.00e-00 Transcription factor STAT
ENSMUSP00000004143 Pfam PF00017 IPR000980 595 667 1.80e-10 SH2 domain
ENSMUSP00000004143 Pfam PF01017 IPR013800 138 330 4.60e-55 STAT transcription factor, all-alpha
ENSMUSP00000004143 Pfam PF02864 IPR013801 332 583 6.90e-98 STAT transcription factor, DNA-binding
ENSMUSP00000004143 Pfam PF02865 IPR013799 2 125 7.90e-47 STAT transcription factor, protein interaction
ENSMUSP00000004143 ProSiteProfiles PS50001 IPR000980 589 686 0.00e-00 SH2 domain
ENSMUSP00000004143 SMART SM00252 IPR000980 587 676 1.70e-06 SH2 domain
ENSMUSP00000004143 SMART SM00964 IPR013799 2 126 1.40e-64 STAT transcription factor, protein interaction
ENSMUSP00000004143 SUPERFAMILY SSF47655 IPR015988 136 332 0.00e-00 STAT transcription factor, coiled coil
ENSMUSP00000004143 SUPERFAMILY SSF48092 IPR013799 1 124 0.00e-00 STAT transcription factor, protein interaction
ENSMUSP00000004143 SUPERFAMILY SSF49417 IPR008967 327 584 0.00e-00 p53-like transcription factor, DNA-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSMUSP00000004143 PF01017 0 STAT_alpha STAT protein, all-alpha domain
ENSMUSP00000004143 PF02864 0 STAT_bind STAT protein, DNA binding domain
ENSMUSP00000004143 PF02865 0 STAT_int STAT protein, protein interaction domain
ENSMUSP00000004143 PF00017 5.6e-12 SH2 SH2 domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSMUSP00000004143 GO:0001553 biological_process luteinization
ENSMUSP00000004143 GO:0001779 biological_process natural killer cell differentiation
ENSMUSP00000004143 GO:0006351 biological_process transcription, DNA-templated
ENSMUSP00000004143 GO:0007259 biological_process JAK-STAT cascade
ENSMUSP00000004143 GO:0007565 biological_process female pregnancy
ENSMUSP00000004143 GO:0007595 biological_process lactation
ENSMUSP00000004143 GO:0019218 biological_process regulation of steroid metabolic process
ENSMUSP00000004143 GO:0019915 biological_process lipid storage
ENSMUSP00000004143 GO:0030155 biological_process regulation of cell adhesion
ENSMUSP00000004143 GO:0030856 biological_process regulation of epithelial cell differentiation
ENSMUSP00000004143 GO:0038161 biological_process prolactin signaling pathway
ENSMUSP00000004143 GO:0040018 biological_process positive regulation of multicellular organism growth
ENSMUSP00000004143 GO:0042104 biological_process positive regulation of activated T cell proliferation
ENSMUSP00000004143 GO:0043029 biological_process T cell homeostasis
ENSMUSP00000004143 GO:0043066 biological_process negative regulation of apoptotic process
ENSMUSP00000004143 GO:0045086 biological_process positive regulation of interleukin-2 biosynthetic process
ENSMUSP00000004143 GO:0045579 biological_process positive regulation of B cell differentiation
ENSMUSP00000004143 GO:0045647 biological_process negative regulation of erythrocyte differentiation
ENSMUSP00000004143 GO:0045931 biological_process positive regulation of mitotic cell cycle
ENSMUSP00000004143 GO:0045944 biological_process positive regulation of transcription from RNA polymerase II promoter
ENSMUSP00000004143 GO:0046543 biological_process development of secondary female sexual characteristics
ENSMUSP00000004143 GO:0050729 biological_process positive regulation of inflammatory response
ENSMUSP00000004143 GO:0005634 cellular_component nucleus
ENSMUSP00000004143 GO:0005737 cellular_component cytoplasm
ENSMUSP00000004143 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSMUSP00000004143 GO:0004871 molecular_function signal transducer activity
ENSMUSP00000004143 GO:0005509 molecular_function calcium ion binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
7425 Nasonia vitripennis 100121885 7029 Acyrthosiphon pisum 100161101
6087 Hydra magnipapillata 100206878 9986 Oryctolagus cuniculus 100348267
9601 Pongo abelii 100462537 400682 Amphimedon queenslandica 100641588
30195 Bombus terrestris 100647789 132113 Bombus impatiens 100743540
10029 Cricetulus griseus 100755571 7463 Apis florea 100864112
143995 Megachile rotundata 100880948 34638 Metaseiulus occidentalis 100904925
30611 Otolemur garnettii 100958999 9597 Pan paniscus 100989105
9555 Papio anubis 101000002 39432 Saimiri boliviensis 101043203
9669 Mustela putorius furo 101691575 10116 Rattus norvegicus 25126
9823 Sus scrofa 397340 9358 Choloepus hoffmanni ENSCHOG00000005387
9315 Macropus eugenii ENSMEUG00000006640 8083 Xiphophorus maculatus ENSXMAG00000005165
9031 Gallus gallus 395556 7460 Apis mellifera 413742
7227 Drosophila melanogaster 42428 9598 Pan troglodytes 454681
9544 Macaca mulatta 574129 7668 Strongylocentrotus purpuratus 576433
7070 Tribolium castaneum 657965 7719 Ciona intestinalis 778770
9646 Ailuropoda melanoleuca ENSAMEG00000006061 9913 Bos taurus ENSBTAG00000009496
9615 Canis familiaris ENSCAFG00000015509 9483 Callithrix jacchus ENSCJAG00000000426
10141 Cavia porcellus ENSCPOG00000026466 51511 Ciona savignyi ENSCSAVG00000011110
7955 Danio rerio ENSDARG00000019392 9361 Dasypus novemcinctus ENSDNOG00000007398
9796 Equus caballus ENSECAG00000007847 9365 Erinaceus europaeus ENSEEUG00000003642
9685 Felis catus ENSFCAG00000028112 69293 Gasterosteus aculeatus ENSGACG00000008634
9595 Gorilla gorilla ENSGGOG00000008216 8049 Gadus morhua ENSGMOG00000014154
7897 Latimeria chalumnae ENSLACG00000002646 9785 Loxodonta africana ENSLAFG00000014055
9103 Meleagris gallopavo ENSMGAG00000003430 30608 Microcebus murinus ENSMICG00000011988
59463 Myotis lucifugus ENSMLUG00000012050 13616 Monodelphis domestica ENSMODG00000014836
61853 Nomascus leucogenys ENSNLEG00000011444 9258 Ornithorhynchus anatinus ENSOANG00000006496
8128 Oreochromis niloticus ENSONIG00000007261 9978 Ochotona princeps ENSOPRG00000008312
8090 Oryzias latipes ENSORLG00000003961 9813 Procavia capensis ENSPCAG00000010107
7757 Petromyzon marinus ENSPMAG00000009008 13735 Pelodiscus sinensis ENSPSIG00000015138
132908 Pteropus vampyrus ENSPVAG00000003876 43179 Ictidomys tridecemlineatus ENSSTOG00000006691
37347 Tupaia belangeri ENSTBEG00000009608 59729 Taeniopygia guttata ENSTGUG00000002572
99883 Tetraodon nigroviridis ENSTNIG00000011707 31033 Takifugu rubripes ENSTRUG00000015454
9478 Tarsius syrichta ENSTSYG00000000267 9739 Tursiops truncatus ENSTTRG00000006684
30538 Vicugna pacos ENSVPAG00000005450 8364 Xenopus tropicalis ENSXETG00000000836

Paralogs
20850