Basic Information
Gene ID 64321 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name SOX17
Full Name Transcription factor SOX-17
Organism Homo sapiens [9606]

Cross Reference
UniProt Q9H6I2 UniGene Hs.98367
PDB 4A3N OMIM 613674
KEGG hsa:64321 UCSC uc003xsb.4

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING 9606.ENSP00000297316

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000297316 Gene3D G3DSA:1.10.30.10 IPR009071 67 147 2.70e-34 High mobility group box domain
ENSP00000297316 Pfam PF00505 IPR009071 68 136 2.60e-25 High mobility group box domain
ENSP00000297316 Pfam PF12067 IPR021934 201 323 3.70e-16 Sox C-terminal transactivation domain
ENSP00000297316 Pfam PF12067 IPR021934 316 412 2.20e-29 Sox C-terminal transactivation domain
ENSP00000297316 ProSiteProfiles PS50118 IPR009071 68 136 0.00e-00 High mobility group box domain
ENSP00000297316 ProSiteProfiles PS51516 IPR021934 280 413 0.00e-00 Sox C-terminal transactivation domain
ENSP00000297316 SMART SM00398 IPR009071 67 137 5.00e-31 High mobility group box domain
ENSP00000297316 SUPERFAMILY SSF47095 IPR009071 60 140 0.00e-00 High mobility group box domain

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000297316 PF12067 0 Sox_C_TAD Sox C-terminal transactivation domain
ENSP00000297316 PF00505 1.6e-25 HMG_box HMG (high mobility group) box
ENSP00000297316 PF09011 3.2e-11 HMG_box_2 HMG-box domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000297316 GO:0006351 biological_process transcription, DNA-templated
ENSP00000297316 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSP00000297316 GO:0007275 biological_process multicellular organismal development
ENSP00000297316 GO:0007369 biological_process gastrulation
ENSP00000297316 GO:0016055 biological_process Wnt signaling pathway
ENSP00000297316 GO:0045893 biological_process positive regulation of transcription, DNA-templated
ENSP00000297316 GO:0045944 biological_process positive regulation of transcription from RNA polymerase II promoter
ENSP00000297316 GO:0005634 cellular_component nucleus
ENSP00000297316 GO:0003677 molecular_function DNA binding
ENSP00000297316 GO:0008013 molecular_function beta-catenin binding
ENSP00000297316 GO:0043565 molecular_function sequence-specific DNA binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
13616 Monodelphis domestica 100030119 7425 Nasonia vitripennis 100120206
9483 Callithrix jacchus 100396115 61853 Nomascus leucogenys 100591356
31033 Takifugu rubripes 101080200 7897 Latimeria chalumnae 102363300
59463 Myotis lucifugus 102427708 10116 Rattus norvegicus 312936
7029 Acyrthosiphon pisum 100165234 8090 Oryzias latipes 100304455
143995 Megachile rotundata 100876699 9597 Pan paniscus 100969672
9555 Papio anubis 101022699 39432 Saimiri boliviensis 101053885
9669 Mustela putorius furo 101683331 43179 Ictidomys tridecemlineatus 101966515
8083 Xiphophorus maculatus 102225699 7955 Danio rerio 30544
7227 Drosophila melanogaster 36575 9913 Bos taurus 534010
7668 Strongylocentrotus purpuratus 587141 28377 Anolis carolinensis ENSACAG00000017977
9371 Echinops telfairi ENSETEG00000016915 69293 Gasterosteus aculeatus ENSGACG00000004347
30608 Microcebus murinus ENSMICG00000000709 9978 Ochotona princeps ENSOPRG00000007021
59729 Taeniopygia guttata ENSTGUG00000011034 30538 Vicugna pacos ENSVPAG00000005064
9646 Ailuropoda melanoleuca ENSAMEG00000011673 9615 Canis familiaris ENSCAFG00000025327
10141 Cavia porcellus ENSCPOG00000000892 9796 Equus caballus ENSECAG00000009206
9595 Gorilla gorilla ENSGGOG00000023175 8049 Gadus morhua ENSGMOG00000005913
9785 Loxodonta africana ENSLAFG00000028829 9315 Macropus eugenii ENSMEUG00000011391
9986 Oryctolagus cuniculus ENSOCUG00000012651 30611 Otolemur garnettii ENSOGAG00000034932
9813 Procavia capensis ENSPCAG00000003188 7757 Petromyzon marinus ENSPMAG00000009255
132908 Pteropus vampyrus ENSPVAG00000009339 42254 Sorex araneus ENSSARG00000009573
99883 Tetraodon nigroviridis ENSTNIG00000017129 9739 Tursiops truncatus ENSTTRG00000005687