Researchers have discovered a unique intracellular region of the voltage-gated sodium channel isoform 1.7 (NaV1.7), which has been widely linked to chronic pain. This region allows NaV1.7 to be regulated by intracellular auxiliary proteins and can be targeted to alleviate chronic pain. The team's findings show that focusing on this sequence can greatly reverse mechanical allodynia in preclinical models of nerve injury and a model of chemotherapy-induced peripheral neuropathy.

https://www.pnas.org/eprint/VFPZQAPKSCFKBB2GMADF/full