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    Resources: CAR-T core functional component sequence retrieval strategy with the Patsnap Bio Sequence Database
    Submitted by Chilly Cui; posted on Wednesday, October 04, 2023

    Submitter

    Chimeric antigen receptor (CAR) T cell therapy, in which a patient's own T lymphocytes are engineered to recognize and kill cancer cells, has achieved remarkable success in some hematological malignancies in preclinical and clinical trials, resulting in six FDA-approved CAR-T products currently available in the market. Once equipped with a CAR construct, T cells act as living drugs and recognize and eliminate the target tumor cells in an MHC-independent manner.

    CARs are synthetic immune receptors that connect a single-chain variable fragment (scFv), derived from a monoclonal antibody to T cell signaling domains to eradicate tumor cells independent of the major histocompatibility complex (MHC).

    Once equipped with a CAR, T cells, known as CAR-T cells, act as living drugs and recognize and eliminate the target tumor cells. The conventional CAR structure consists of three modular components: the ectodomain, the transmembrane domain, and the endodomain, each of which has specific components and functions and thus the potential to be optimized.

    An exemplification using Tisagenlecleucel demonstrates the approach of performing sequence retrieval for each individual region, as well as searching for the overall relevant sequence through a combination of different fragments.

    Continue reading: https://synapse.patsnap.com/blog/car-t-core-functional-component-sequence-retrieval-strategy

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