Basic Information
Gene ID 2034 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name EPAS1; BHLHE73, HIF2A, MOP2, PASD2
Full Name Endothelial PAS domain-containing protein 1
Organism Homo sapiens [9606]

Cross Reference
UniProt Q99814 UniGene Hs.468410
PDB 4GS9 OMIM 611783
KEGG hsa:2034 UCSC uc002ruv.3

Protein Interactions
DIP DIP-32857N
IntAct Q99814
MINT MINT-1199606
STRING 9606.ENSP00000263734

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000263734 Pfam PF00989 IPR013767 93 163 4.80e-05 PAS fold
ENSP00000263734 Pfam PF08778 IPR014887 831 870 3.30e-20 HIF-1 alpha, transactivation domain, C-terminal
ENSP00000263734 Pfam PF11413 IPR021537 517 549 9.40e-18 Hypoxia-inducible factor, alpha subunit
ENSP00000263734 PRINTS PR00785 IPR001067 101 120 9.20e-07 Nuclear translocator
ENSP00000263734 PRINTS PR00785 IPR001067 243 260 9.20e-07 Nuclear translocator
ENSP00000263734 PRINTS PR00785 IPR001067 49 69 9.20e-07 Nuclear translocator
ENSP00000263734 ProSiteProfiles PS50112 IPR000014 249 300 0.00e-00 PAS domain
ENSP00000263734 ProSiteProfiles PS50112 IPR000014 92 147 0.00e-00 PAS domain
ENSP00000263734 ProSiteProfiles PS50888 IPR011598 14 67 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000263734 SMART SM00086 IPR001610 304 347 2.20e-11 PAC motif
ENSP00000263734 SMART SM00091 IPR000014 232 298 3.70e-10 PAS domain
ENSP00000263734 SMART SM00091 IPR000014 86 152 1.50e-11 PAS domain
ENSP00000263734 SMART SM00353 IPR011598 20 75 1.30e-11 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000263734 SUPERFAMILY SSF47459 IPR011598 11 72 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
ENSP00000263734 SUPERFAMILY SSF55785 IPR000014 244 346 0.00e-00 PAS domain
ENSP00000263734 SUPERFAMILY SSF55785 IPR000014 95 201 0.00e-00 PAS domain
ENSP00000263734 TIGRFAM TIGR00229 IPR000014 252 328 4.70e-08 PAS domain
ENSP00000263734 TIGRFAM TIGR00229 IPR000014 98 150 1.00e-05 PAS domain

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000263734 PF14598 2.2e-28 PAS_11 PAS domain
ENSP00000263734 PF08447 4.6e-25 PAS_3 PAS fold
ENSP00000263734 PF08778 1.6e-20 HIF-1a_CTAD HIF-1 alpha C terminal transactivation domain
ENSP00000263734 PF11413 4.4e-18 HIF-1 Hypoxia-inducible factor-1
ENSP00000263734 PF00989 1.4e-14 PAS PAS fold
ENSP00000263734 PF13426 8.8e-11 PAS_9 PAS domain
ENSP00000263734 PF08448 1.5e-07 PAS_4 PAS fold

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000263734 GO:0001666 biological_process response to hypoxia
ENSP00000263734 GO:0045893 biological_process positive regulation of transcription, DNA-templated
ENSP00000263734 GO:0045944 biological_process positive regulation of transcription from RNA polymerase II promoter
ENSP00000263734 GO:0071456 biological_process cellular response to hypoxia
ENSP00000263734 GO:0005634 cellular_component nucleus
ENSP00000263734 GO:0005737 cellular_component cytoplasm
ENSP00000263734 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSP00000263734 GO:0004871 molecular_function signal transducer activity
ENSP00000263734 GO:0035035 molecular_function histone acetyltransferase binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9483 Callithrix jacchus 100396711 7029 Acyrthosiphon pisum 100167974
10224 Saccoglossus kowalevskii 100329032 8128 Oreochromis niloticus 100703737
9597 Pan paniscus 100975248 9555 Papio anubis 100999094
39432 Saimiri boliviensis 101052563 9669 Mustela putorius furo 101679355
7897 Latimeria chalumnae 102357464 13735 Pelodiscus sinensis 102453156
7668 Strongylocentrotus purpuratus 577801 9598 Pan troglodytes 746195
28377 Anolis carolinensis ENSACAG00000016205 9913 Bos taurus ENSBTAG00000003711
9615 Canis familiaris ENSCAFG00000002627 9358 Choloepus hoffmanni ENSCHOG00000005351
10141 Cavia porcellus ENSCPOG00000014242 51511 Ciona savignyi ENSCSAVG00000005768
7955 Danio rerio ENSDARG00000057671 10020 Dipodomys ordii ENSDORG00000003635
9796 Equus caballus ENSECAG00000014594 9031 Gallus gallus ENSGALG00000010005
9595 Gorilla gorilla ENSGGOG00000003957 8049 Gadus morhua ENSGMOG00000016337
9785 Loxodonta africana ENSLAFG00000012361 9315 Macropus eugenii ENSMEUG00000004035
9103 Meleagris gallopavo ENSMGAG00000010293 30608 Microcebus murinus ENSMICG00000002949
59463 Myotis lucifugus ENSMLUG00000007093 9986 Oryctolagus cuniculus ENSOCUG00000014904
30611 Otolemur garnettii ENSOGAG00000008084 9978 Ochotona princeps ENSOPRG00000010205
9813 Procavia capensis ENSPCAG00000014714 7757 Petromyzon marinus ENSPMAG00000009272
9601 Pongo abelii ENSPPYG00000005881 132908 Pteropus vampyrus ENSPVAG00000011259
10116 Rattus norvegicus ENSRNOG00000021318 42254 Sorex araneus ENSSARG00000011198
43179 Ictidomys tridecemlineatus ENSSTOG00000012628 37347 Tupaia belangeri ENSTBEG00000004645
59729 Taeniopygia guttata ENSTGUG00000003933 99883 Tetraodon nigroviridis ENSTNIG00000009866
31033 Takifugu rubripes ENSTRUG00000005627 9478 Tarsius syrichta ENSTSYG00000001312
9739 Tursiops truncatus ENSTTRG00000011883 30538 Vicugna pacos ENSVPAG00000002395
8364 Xenopus tropicalis ENSXETG00000026167 8083 Xiphophorus maculatus ENSXMAG00000004970
7070 Tribolium castaneum 655772 9646 Ailuropoda melanoleuca ENSAMEG00000006020
9361 Dasypus novemcinctus ENSDNOG00000005938 9365 Erinaceus europaeus ENSEEUG00000012802
9685 Felis catus ENSFCAG00000013629 69293 Gasterosteus aculeatus ENSGACG00000011414
9544 Macaca mulatta ENSMMUG00000023326 13616 Monodelphis domestica ENSMODG00000000953
9258 Ornithorhynchus anatinus ENSOANG00000009092 9823 Sus scrofa ENSSSCG00000008443