Basic Information | |||
Gene ID | 2034 ; Check Expression Profles ; Check TFs & Targets Binding | ||
Gene Name | EPAS1; BHLHE73, HIF2A, MOP2, PASD2 | ||
Full Name | Endothelial PAS domain-containing protein 1 | ||
Organism | Homo sapiens [9606] |
Cross Reference | |||
UniProt | Q99814 | UniGene | Hs.468410 |
PDB | 4GS9 | OMIM | 611783 |
KEGG | hsa:2034 | UCSC | uc002ruv.3 |
Protein Interactions | |
DIP | DIP-32857N |
IntAct | Q99814 |
MINT | MINT-1199606 |
STRING | 9606.ENSP00000263734 |
Ensembl/RefSeq | Transcript ID | Protein ID | Gene ID |
ENSEMBL | |||
REFSEQ |
InterPro Annotation | |||||||
Protein | Program | Term | IPRS | Start | End | Score | Description |
ENSP00000263734 | Pfam | PF00989 | IPR013767 | 93 | 163 | 4.80e-05 | PAS fold |
ENSP00000263734 | Pfam | PF08778 | IPR014887 | 831 | 870 | 3.30e-20 | HIF-1 alpha, transactivation domain, C-terminal |
ENSP00000263734 | Pfam | PF11413 | IPR021537 | 517 | 549 | 9.40e-18 | Hypoxia-inducible factor, alpha subunit |
ENSP00000263734 | PRINTS | PR00785 | IPR001067 | 101 | 120 | 9.20e-07 | Nuclear translocator |
ENSP00000263734 | PRINTS | PR00785 | IPR001067 | 243 | 260 | 9.20e-07 | Nuclear translocator |
ENSP00000263734 | PRINTS | PR00785 | IPR001067 | 49 | 69 | 9.20e-07 | Nuclear translocator |
ENSP00000263734 | ProSiteProfiles | PS50112 | IPR000014 | 249 | 300 | 0.00e-00 | PAS domain |
ENSP00000263734 | ProSiteProfiles | PS50112 | IPR000014 | 92 | 147 | 0.00e-00 | PAS domain |
ENSP00000263734 | ProSiteProfiles | PS50888 | IPR011598 | 14 | 67 | 0.00e-00 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSP00000263734 | SMART | SM00086 | IPR001610 | 304 | 347 | 2.20e-11 | PAC motif |
ENSP00000263734 | SMART | SM00091 | IPR000014 | 232 | 298 | 3.70e-10 | PAS domain |
ENSP00000263734 | SMART | SM00091 | IPR000014 | 86 | 152 | 1.50e-11 | PAS domain |
ENSP00000263734 | SMART | SM00353 | IPR011598 | 20 | 75 | 1.30e-11 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSP00000263734 | SUPERFAMILY | SSF47459 | IPR011598 | 11 | 72 | 0.00e-00 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSP00000263734 | SUPERFAMILY | SSF55785 | IPR000014 | 244 | 346 | 0.00e-00 | PAS domain |
ENSP00000263734 | SUPERFAMILY | SSF55785 | IPR000014 | 95 | 201 | 0.00e-00 | PAS domain |
ENSP00000263734 | TIGRFAM | TIGR00229 | IPR000014 | 252 | 328 | 4.70e-08 | PAS domain |
ENSP00000263734 | TIGRFAM | TIGR00229 | IPR000014 | 98 | 150 | 1.00e-05 | PAS domain |
Pfam Annotation | ||||
Protein | Pfam ID | E.value | Name | Description |
ENSP00000263734 | PF14598 | 2.2e-28 | PAS_11 | PAS domain |
ENSP00000263734 | PF08447 | 4.6e-25 | PAS_3 | PAS fold |
ENSP00000263734 | PF08778 | 1.6e-20 | HIF-1a_CTAD | HIF-1 alpha C terminal transactivation domain |
ENSP00000263734 | PF11413 | 4.4e-18 | HIF-1 | Hypoxia-inducible factor-1 |
ENSP00000263734 | PF00989 | 1.4e-14 | PAS | PAS fold |
ENSP00000263734 | PF13426 | 8.8e-11 | PAS_9 | PAS domain |
ENSP00000263734 | PF08448 | 1.5e-07 | PAS_4 | PAS fold |
Gene Ontology Annotation | |||
Protein | Entry | Name Space | Description |
ENSP00000263734 | GO:0001666 | biological_process | response to hypoxia |
ENSP00000263734 | GO:0045893 | biological_process | positive regulation of transcription, DNA-templated |
ENSP00000263734 | GO:0045944 | biological_process | positive regulation of transcription from RNA polymerase II promoter |
ENSP00000263734 | GO:0071456 | biological_process | cellular response to hypoxia |
ENSP00000263734 | GO:0005634 | cellular_component | nucleus |
ENSP00000263734 | GO:0005737 | cellular_component | cytoplasm |
ENSP00000263734 | GO:0003700 | molecular_function | sequence-specific DNA binding transcription factor activity |
ENSP00000263734 | GO:0004871 | molecular_function | signal transducer activity |
ENSP00000263734 | GO:0035035 | molecular_function | histone acetyltransferase binding |
Orthologs | |||||
TAXID | Organism | Gene ID | TAXID | Organism | Gene ID |
9483 | Callithrix jacchus | 100396711 | 7029 | Acyrthosiphon pisum | 100167974 |
10224 | Saccoglossus kowalevskii | 100329032 | 8128 | Oreochromis niloticus | 100703737 |
9597 | Pan paniscus | 100975248 | 9555 | Papio anubis | 100999094 |
39432 | Saimiri boliviensis | 101052563 | 9669 | Mustela putorius furo | 101679355 |
7897 | Latimeria chalumnae | 102357464 | 13735 | Pelodiscus sinensis | 102453156 |
7668 | Strongylocentrotus purpuratus | 577801 | 9598 | Pan troglodytes | 746195 |
28377 | Anolis carolinensis | ENSACAG00000016205 | 9913 | Bos taurus | ENSBTAG00000003711 |
9615 | Canis familiaris | ENSCAFG00000002627 | 9358 | Choloepus hoffmanni | ENSCHOG00000005351 |
10141 | Cavia porcellus | ENSCPOG00000014242 | 51511 | Ciona savignyi | ENSCSAVG00000005768 |
7955 | Danio rerio | ENSDARG00000057671 | 10020 | Dipodomys ordii | ENSDORG00000003635 |
9796 | Equus caballus | ENSECAG00000014594 | 9031 | Gallus gallus | ENSGALG00000010005 |
9595 | Gorilla gorilla | ENSGGOG00000003957 | 8049 | Gadus morhua | ENSGMOG00000016337 |
9785 | Loxodonta africana | ENSLAFG00000012361 | 9315 | Macropus eugenii | ENSMEUG00000004035 |
9103 | Meleagris gallopavo | ENSMGAG00000010293 | 30608 | Microcebus murinus | ENSMICG00000002949 |
59463 | Myotis lucifugus | ENSMLUG00000007093 | 9986 | Oryctolagus cuniculus | ENSOCUG00000014904 |
30611 | Otolemur garnettii | ENSOGAG00000008084 | 9978 | Ochotona princeps | ENSOPRG00000010205 |
9813 | Procavia capensis | ENSPCAG00000014714 | 7757 | Petromyzon marinus | ENSPMAG00000009272 |
9601 | Pongo abelii | ENSPPYG00000005881 | 132908 | Pteropus vampyrus | ENSPVAG00000011259 |
10116 | Rattus norvegicus | ENSRNOG00000021318 | 42254 | Sorex araneus | ENSSARG00000011198 |
43179 | Ictidomys tridecemlineatus | ENSSTOG00000012628 | 37347 | Tupaia belangeri | ENSTBEG00000004645 |
59729 | Taeniopygia guttata | ENSTGUG00000003933 | 99883 | Tetraodon nigroviridis | ENSTNIG00000009866 |
31033 | Takifugu rubripes | ENSTRUG00000005627 | 9478 | Tarsius syrichta | ENSTSYG00000001312 |
9739 | Tursiops truncatus | ENSTTRG00000011883 | 30538 | Vicugna pacos | ENSVPAG00000002395 |
8364 | Xenopus tropicalis | ENSXETG00000026167 | 8083 | Xiphophorus maculatus | ENSXMAG00000004970 |
7070 | Tribolium castaneum | 655772 | 9646 | Ailuropoda melanoleuca | ENSAMEG00000006020 |
9361 | Dasypus novemcinctus | ENSDNOG00000005938 | 9365 | Erinaceus europaeus | ENSEEUG00000012802 |
9685 | Felis catus | ENSFCAG00000013629 | 69293 | Gasterosteus aculeatus | ENSGACG00000011414 |
9544 | Macaca mulatta | ENSMMUG00000023326 | 13616 | Monodelphis domestica | ENSMODG00000000953 |
9258 | Ornithorhynchus anatinus | ENSOANG00000009092 | 9823 | Sus scrofa | ENSSSCG00000008443 |