Basic Information
Gene ID ENSLAFG00000012361
Gene Name EPAS1
Full Name Uncharacterized protein
Organism Loxodonta africana [9785]

Cross Reference
UniProt G3T997 UniGene NULL
PDB NULL OMIM NULL
KEGG NULL UCSC NULL

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSLAFP00000010336 Pfam PF00989 IPR013767 85 155 4.70e-05 PAS fold
ENSLAFP00000010336 Pfam PF08778 IPR014887 822 861 1.10e-20 HIF-1 alpha, transactivation domain, C-terminal
ENSLAFP00000010336 Pfam PF11413 IPR021537 507 540 8.60e-18 Hypoxia-inducible factor, alpha subunit
ENSLAFP00000010336 PRINTS PR00785 IPR001067 235 252 9.00e-07 Nuclear translocator
ENSLAFP00000010336 PRINTS PR00785 IPR001067 41 61 9.00e-07 Nuclear translocator
ENSLAFP00000010336 PRINTS PR00785 IPR001067 93 112 9.00e-07 Nuclear translocator
ENSLAFP00000010336 ProSiteProfiles PS50112 IPR000014 241 292 0.00e-00 PAS domain
ENSLAFP00000010336 ProSiteProfiles PS50112 IPR000014 84 139 0.00e-00 PAS domain
ENSLAFP00000010336 ProSiteProfiles PS50888 IPR011598 6 59 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
ENSLAFP00000010336 SMART SM00086 IPR001610 296 339 1.30e-09 PAC motif
ENSLAFP00000010336 SMART SM00091 IPR000014 224 290 3.70e-10 PAS domain
ENSLAFP00000010336 SMART SM00091 IPR000014 78 144 1.50e-11 PAS domain
ENSLAFP00000010336 SMART SM00353 IPR011598 12 67 1.30e-11 Myc-type, basic helix-loop-helix (bHLH) domain
ENSLAFP00000010336 SUPERFAMILY SSF47459 IPR011598 3 64 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
ENSLAFP00000010336 SUPERFAMILY SSF55785 IPR000014 236 337 0.00e-00 PAS domain
ENSLAFP00000010336 SUPERFAMILY SSF55785 IPR000014 87 191 0.00e-00 PAS domain
ENSLAFP00000010336 TIGRFAM TIGR00229 IPR000014 244 320 5.30e-08 PAS domain
ENSLAFP00000010336 TIGRFAM TIGR00229 IPR000014 90 142 1.10e-05 PAS domain

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSLAFP00000010336 PF14598 9.3e-27 PAS_11 PAS domain
ENSLAFP00000010336 PF08447 3.6e-25 PAS_3 PAS fold
ENSLAFP00000010336 PF08778 5e-21 HIF-1a_CTAD HIF-1 alpha C terminal transactivation domain
ENSLAFP00000010336 PF11413 4.2e-18 HIF-1 Hypoxia-inducible factor-1
ENSLAFP00000010336 PF00989 1.5e-14 PAS PAS fold
ENSLAFP00000010336 PF13426 8.5e-11 PAS_9 PAS domain
ENSLAFP00000010336 PF08448 1.7e-07 PAS_4 PAS fold

Gene Ontology Annotation
Protein Entry Name Space Description
ENSLAFP00000010336 GO:0001666 biological_process response to hypoxia
ENSLAFP00000010336 GO:0045893 biological_process positive regulation of transcription, DNA-templated
ENSLAFP00000010336 GO:0045944 biological_process positive regulation of transcription from RNA polymerase II promoter
ENSLAFP00000010336 GO:0071456 biological_process cellular response to hypoxia
ENSLAFP00000010336 GO:0005634 cellular_component nucleus
ENSLAFP00000010336 GO:0005737 cellular_component cytoplasm
ENSLAFP00000010336 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSLAFP00000010336 GO:0004871 molecular_function signal transducer activity
ENSLAFP00000010336 GO:0035035 molecular_function histone acetyltransferase binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9483 Callithrix jacchus 100396711 7897 Latimeria chalumnae 102357464
13735 Pelodiscus sinensis 102453156 9606 Homo sapiens 2034
9646 Ailuropoda melanoleuca ENSAMEG00000006020 9913 Bos taurus ENSBTAG00000003711
9615 Canis familiaris ENSCAFG00000002627 9358 Choloepus hoffmanni ENSCHOG00000005351
9361 Dasypus novemcinctus ENSDNOG00000005938 9796 Equus caballus ENSECAG00000014594
9365 Erinaceus europaeus ENSEEUG00000012802 9685 Felis catus ENSFCAG00000013629
69293 Gasterosteus aculeatus ENSGACG00000011414 9031 Gallus gallus ENSGALG00000010005
8049 Gadus morhua ENSGMOG00000016337 9597 Pan paniscus 100975248
39432 Saimiri boliviensis 101052563 9669 Mustela putorius furo 101679355
10141 Cavia porcellus ENSCPOG00000014242 7955 Danio rerio ENSDARG00000057671
10020 Dipodomys ordii ENSDORG00000003635 59463 Myotis lucifugus ENSMLUG00000007093
9978 Ochotona princeps ENSOPRG00000010205 7757 Petromyzon marinus ENSPMAG00000009272
132908 Pteropus vampyrus ENSPVAG00000011259 43179 Ictidomys tridecemlineatus ENSSTOG00000012628
37347 Tupaia belangeri ENSTBEG00000004645 9739 Tursiops truncatus ENSTTRG00000011883
8083 Xiphophorus maculatus ENSXMAG00000004970 9315 Macropus eugenii ENSMEUG00000004035
9103 Meleagris gallopavo ENSMGAG00000010293 30608 Microcebus murinus ENSMICG00000002949
9544 Macaca mulatta ENSMMUG00000023326 13616 Monodelphis domestica ENSMODG00000000953
9258 Ornithorhynchus anatinus ENSOANG00000015360 9986 Oryctolagus cuniculus ENSOCUG00000014904
30611 Otolemur garnettii ENSOGAG00000008084 9813 Procavia capensis ENSPCAG00000014714
10116 Rattus norvegicus ENSRNOG00000021318 9823 Sus scrofa ENSSSCG00000008443
59729 Taeniopygia guttata ENSTGUG00000003933 99883 Tetraodon nigroviridis ENSTNIG00000009866
31033 Takifugu rubripes ENSTRUG00000005627 9478 Tarsius syrichta ENSTSYG00000001312
8364 Xenopus tropicalis ENSXETG00000026167