Basic Information
Gene ID ENSBTAG00000003711
Gene Name EPAS1
Full Name Endothelial PAS domain protein 1
Organism Bos taurus [9913]

Cross Reference
UniProt A5PJT1 UniGene Bt.45570
PDB NULL OMIM NULL
KEGG NULL UCSC NULL

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING 9913.ENSBTAP00000004836

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSBTAP00000004836 Pfam PF00989 IPR013767 93 163 4.80e-05 PAS fold
ENSBTAP00000004836 Pfam PF08778 IPR014887 831 870 2.00e-20 HIF-1 alpha, transactivation domain, C-terminal
ENSBTAP00000004836 Pfam PF11413 IPR021537 516 549 8.30e-18 Hypoxia-inducible factor, alpha subunit
ENSBTAP00000004836 PRINTS PR00785 IPR001067 101 120 9.20e-07 Nuclear translocator
ENSBTAP00000004836 PRINTS PR00785 IPR001067 243 260 9.20e-07 Nuclear translocator
ENSBTAP00000004836 PRINTS PR00785 IPR001067 49 69 9.20e-07 Nuclear translocator
ENSBTAP00000004836 ProSiteProfiles PS50112 IPR000014 249 300 0.00e-00 PAS domain
ENSBTAP00000004836 ProSiteProfiles PS50112 IPR000014 92 147 0.00e-00 PAS domain
ENSBTAP00000004836 ProSiteProfiles PS50888 IPR011598 14 67 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
ENSBTAP00000004836 SMART SM00086 IPR001610 304 347 2.20e-11 PAC motif
ENSBTAP00000004836 SMART SM00091 IPR000014 232 298 3.80e-10 PAS domain
ENSBTAP00000004836 SMART SM00091 IPR000014 86 152 1.50e-11 PAS domain
ENSBTAP00000004836 SMART SM00353 IPR011598 20 75 1.30e-11 Myc-type, basic helix-loop-helix (bHLH) domain
ENSBTAP00000004836 SUPERFAMILY SSF47459 IPR011598 11 72 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
ENSBTAP00000004836 SUPERFAMILY SSF55785 IPR000014 244 346 0.00e-00 PAS domain
ENSBTAP00000004836 SUPERFAMILY SSF55785 IPR000014 95 202 0.00e-00 PAS domain
ENSBTAP00000004836 TIGRFAM TIGR00229 IPR000014 252 328 1.60e-07 PAS domain
ENSBTAP00000004836 TIGRFAM TIGR00229 IPR000014 98 150 1.00e-05 PAS domain

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSBTAP00000004836 PF14598 2e-28 PAS_11 PAS domain
ENSBTAP00000004836 PF08447 8.1e-25 PAS_3 PAS fold
ENSBTAP00000004836 PF08778 9e-21 HIF-1a_CTAD HIF-1 alpha C terminal transactivation domain
ENSBTAP00000004836 PF11413 4.1e-18 HIF-1 Hypoxia-inducible factor-1
ENSBTAP00000004836 PF00989 8.5e-15 PAS PAS fold
ENSBTAP00000004836 PF13426 2.1e-10 PAS_9 PAS domain
ENSBTAP00000004836 PF08448 2.3e-07 PAS_4 PAS fold

Gene Ontology Annotation
Protein Entry Name Space Description
ENSBTAP00000004836 GO:0001666 biological_process response to hypoxia
ENSBTAP00000004836 GO:0045893 biological_process positive regulation of transcription, DNA-templated
ENSBTAP00000004836 GO:0045944 biological_process positive regulation of transcription from RNA polymerase II promoter
ENSBTAP00000004836 GO:0071456 biological_process cellular response to hypoxia
ENSBTAP00000004836 GO:0005634 cellular_component nucleus
ENSBTAP00000004836 GO:0005737 cellular_component cytoplasm
ENSBTAP00000004836 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSBTAP00000004836 GO:0004871 molecular_function signal transducer activity
ENSBTAP00000004836 GO:0035035 molecular_function histone acetyltransferase binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9483 Callithrix jacchus 100396711 13735 Pelodiscus sinensis 102453156
9606 Homo sapiens 2034 7070 Tribolium castaneum 655772
9646 Ailuropoda melanoleuca ENSAMEG00000006020 7029 Acyrthosiphon pisum 100167974
10224 Saccoglossus kowalevskii 100329032 61853 Nomascus leucogenys 100582446
30195 Bombus terrestris 100643623 8128 Oreochromis niloticus 100703737
132113 Bombus impatiens 100748667 9597 Pan paniscus 100975248
9555 Papio anubis 100999094 39432 Saimiri boliviensis 101052563
9669 Mustela putorius furo 101679355 7897 Latimeria chalumnae 102357464
10090 Mus musculus 53417 7668 Strongylocentrotus purpuratus 577801
9598 Pan troglodytes 746195 28377 Anolis carolinensis ENSACAG00000016205
9615 Canis familiaris ENSCAFG00000002627 9358 Choloepus hoffmanni ENSCHOG00000005351
7719 Ciona intestinalis ENSCING00000001010 10141 Cavia porcellus ENSCPOG00000014242
51511 Ciona savignyi ENSCSAVG00000005768 7955 Danio rerio ENSDARG00000057671
10020 Dipodomys ordii ENSDORG00000003635 9796 Equus caballus ENSECAG00000014594
9031 Gallus gallus ENSGALG00000010005 9595 Gorilla gorilla ENSGGOG00000003957
8049 Gadus morhua ENSGMOG00000016337 9785 Loxodonta africana ENSLAFG00000012361
9315 Macropus eugenii ENSMEUG00000004035 9103 Meleagris gallopavo ENSMGAG00000010293
30608 Microcebus murinus ENSMICG00000002949 59463 Myotis lucifugus ENSMLUG00000007093
9986 Oryctolagus cuniculus ENSOCUG00000014904 30611 Otolemur garnettii ENSOGAG00000008084
9978 Ochotona princeps ENSOPRG00000010205 8090 Oryzias latipes ENSORLG00000002004
9813 Procavia capensis ENSPCAG00000014714 7757 Petromyzon marinus ENSPMAG00000009272
9601 Pongo abelii ENSPPYG00000005881 132908 Pteropus vampyrus ENSPVAG00000011259
10116 Rattus norvegicus ENSRNOG00000021318 42254 Sorex araneus ENSSARG00000011198
9305 Sarcophilus harrisii ENSSHAG00000004128 43179 Ictidomys tridecemlineatus ENSSTOG00000012628
37347 Tupaia belangeri ENSTBEG00000004645 59729 Taeniopygia guttata ENSTGUG00000003933
99883 Tetraodon nigroviridis ENSTNIG00000009866 31033 Takifugu rubripes ENSTRUG00000005627
9478 Tarsius syrichta ENSTSYG00000001312 9739 Tursiops truncatus ENSTTRG00000011883
30538 Vicugna pacos ENSVPAG00000002395 8364 Xenopus tropicalis ENSXETG00000026167
8083 Xiphophorus maculatus ENSXMAG00000004970 9361 Dasypus novemcinctus ENSDNOG00000005938
9365 Erinaceus europaeus ENSEEUG00000012802 9685 Felis catus ENSFCAG00000013629
69293 Gasterosteus aculeatus ENSGACG00000011414 9544 Macaca mulatta ENSMMUG00000023326
13616 Monodelphis domestica ENSMODG00000000953 9258 Ornithorhynchus anatinus ENSOANG00000009092
9823 Sus scrofa ENSSSCG00000008443