Basic Information
Gene ID ENSDARG00000057671
Gene Name epas1b; epas1
Full Name Epas1 protein
Organism Danio rerio [7955]

Cross Reference
UniProt B3DJD1 UniGene Dr.83091
PDB NULL OMIM NULL
KEGG NULL UCSC NULL

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING 7955.ENSDARP00000074832

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSDARP00000074832 Pfam PF00989 IPR013767 93 148 4.50e-05 PAS fold
ENSDARP00000074832 Pfam PF08778 IPR014887 795 834 1.60e-21 HIF-1 alpha, transactivation domain, C-terminal
ENSDARP00000074832 Pfam PF11413 IPR021537 511 544 3.40e-17 Hypoxia-inducible factor, alpha subunit
ENSDARP00000074832 ProSiteProfiles PS50112 IPR000014 246 297 0.00e-00 PAS domain
ENSDARP00000074832 ProSiteProfiles PS50112 IPR000014 92 156 0.00e-00 PAS domain
ENSDARP00000074832 ProSiteProfiles PS50888 IPR011598 14 67 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
ENSDARP00000074832 SMART SM00086 IPR001610 301 344 1.60e-12 PAC motif
ENSDARP00000074832 SMART SM00091 IPR000014 229 295 1.30e-08 PAS domain
ENSDARP00000074832 SMART SM00091 IPR000014 86 152 7.20e-09 PAS domain
ENSDARP00000074832 SMART SM00353 IPR011598 20 75 1.70e-11 Myc-type, basic helix-loop-helix (bHLH) domain
ENSDARP00000074832 SUPERFAMILY SSF47459 IPR011598 12 76 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
ENSDARP00000074832 SUPERFAMILY SSF55785 IPR000014 241 343 0.00e-00 PAS domain
ENSDARP00000074832 SUPERFAMILY SSF55785 IPR000014 96 209 0.00e-00 PAS domain
ENSDARP00000074832 TIGRFAM TIGR00229 IPR000014 251 327 5.10e-08 PAS domain
ENSDARP00000074832 TIGRFAM TIGR00229 IPR000014 98 154 7.70e-06 PAS domain

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSDARP00000074832 PF14598 6e-29 PAS_11 PAS domain
ENSDARP00000074832 PF08447 4.7e-28 PAS_3 PAS fold
ENSDARP00000074832 PF08778 8.4e-22 HIF-1a_CTAD HIF-1 alpha C terminal transactivation domain
ENSDARP00000074832 PF11413 1.6e-17 HIF-1 Hypoxia-inducible factor-1
ENSDARP00000074832 PF00989 1.9e-14 PAS PAS fold
ENSDARP00000074832 PF13426 6.6e-14 PAS_9 PAS domain
ENSDARP00000074832 PF08448 3.9e-10 PAS_4 PAS fold

Gene Ontology Annotation
Protein Entry Name Space Description
ENSDARP00000074832 GO:0001666 biological_process response to hypoxia
ENSDARP00000074832 GO:0045893 biological_process positive regulation of transcription, DNA-templated
ENSDARP00000074832 GO:0045944 biological_process positive regulation of transcription from RNA polymerase II promoter
ENSDARP00000074832 GO:0071456 biological_process cellular response to hypoxia
ENSDARP00000074832 GO:0005634 cellular_component nucleus
ENSDARP00000074832 GO:0005737 cellular_component cytoplasm
ENSDARP00000074832 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSDARP00000074832 GO:0004871 molecular_function signal transducer activity
ENSDARP00000074832 GO:0035035 molecular_function histone acetyltransferase binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9483 Callithrix jacchus 100396711 39432 Saimiri boliviensis 101052563
9669 Mustela putorius furo 101679355 7897 Latimeria chalumnae 102357464
13735 Pelodiscus sinensis 102453156 9606 Homo sapiens 2034
9646 Ailuropoda melanoleuca ENSAMEG00000006020 9913 Bos taurus ENSBTAG00000003711
9615 Canis familiaris ENSCAFG00000002627 9358 Choloepus hoffmanni ENSCHOG00000005351
10141 Cavia porcellus ENSCPOG00000014242 9597 Pan paniscus 100975248
59463 Myotis lucifugus ENSMLUG00000007093 132908 Pteropus vampyrus ENSPVAG00000011259
43179 Ictidomys tridecemlineatus ENSSTOG00000012628 8083 Xiphophorus maculatus ENSXMAG00000004970
9361 Dasypus novemcinctus ENSDNOG00000005938 9796 Equus caballus ENSECAG00000014594
9365 Erinaceus europaeus ENSEEUG00000012802 9685 Felis catus ENSFCAG00000013629
69293 Gasterosteus aculeatus ENSGACG00000011414 9031 Gallus gallus ENSGALG00000010005
8049 Gadus morhua ENSGMOG00000016337 9785 Loxodonta africana ENSLAFG00000012361
9315 Macropus eugenii ENSMEUG00000004035 9103 Meleagris gallopavo ENSMGAG00000010293
30608 Microcebus murinus ENSMICG00000002949 9544 Macaca mulatta ENSMMUG00000023326
13616 Monodelphis domestica ENSMODG00000000953 30611 Otolemur garnettii ENSOGAG00000008084
9978 Ochotona princeps ENSOPRG00000010205 9813 Procavia capensis ENSPCAG00000014714
7757 Petromyzon marinus ENSPMAG00000009272 10116 Rattus norvegicus ENSRNOG00000021318
9823 Sus scrofa ENSSSCG00000008443 59729 Taeniopygia guttata ENSTGUG00000003933
99883 Tetraodon nigroviridis ENSTNIG00000009866 31033 Takifugu rubripes ENSTRUG00000005627
9739 Tursiops truncatus ENSTTRG00000011883 8364 Xenopus tropicalis ENSXETG00000026167