Basic Information | |||
Gene ID | 393202 | ||
Gene Name | hif1ab; hif1a | ||
Full Name | Hypoxia inducible factor 1 alpha | ||
Organism | Danio rerio [7955] |
Cross Reference | |||
UniProt | Q6EHI4 | UniGene | Dr.75612 |
PDB | NULL | OMIM | NULL |
KEGG | dre:393202 | UCSC | NULL |
Protein Interactions | |
DIP | NULL |
IntAct | NULL |
MINT | NULL |
STRING | 7955.ENSDARP00000004329 |
Ensembl/RefSeq | Transcript ID | Protein ID | Gene ID |
ENSEMBL | |||
REFSEQ | |||
REFSEQ |
InterPro Annotation | |||||||
Protein | Program | Term | IPRS | Start | End | Score | Description |
ENSDARP00000004329 | Pfam | PF08778 | IPR014887 | 740 | 777 | 2.20e-23 | HIF-1 alpha, transactivation domain, C-terminal |
ENSDARP00000004329 | Pfam | PF11413 | IPR021537 | 543 | 574 | 2.40e-16 | Hypoxia-inducible factor, alpha subunit |
ENSDARP00000004329 | PRINTS | PR01080 | IPR001321 | 201 | 224 | 2.50e-06 | Hypoxia-inducible factor-1 alpha |
ENSDARP00000004329 | PRINTS | PR01080 | IPR001321 | 427 | 445 | 2.50e-06 | Hypoxia-inducible factor-1 alpha |
ENSDARP00000004329 | ProSiteProfiles | PS50112 | IPR000014 | 249 | 298 | 0.00e-00 | PAS domain |
ENSDARP00000004329 | ProSiteProfiles | PS50112 | IPR000014 | 81 | 157 | 0.00e-00 | PAS domain |
ENSDARP00000004329 | ProSiteProfiles | PS50888 | IPR011598 | 16 | 69 | 0.00e-00 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSDARP00000004329 | SMART | SM00086 | IPR001610 | 302 | 345 | 2.80e-10 | PAC motif |
ENSDARP00000004329 | SMART | SM00091 | IPR000014 | 230 | 296 | 2.20e-09 | PAS domain |
ENSDARP00000004329 | SMART | SM00091 | IPR000014 | 88 | 154 | 2.90e-10 | PAS domain |
ENSDARP00000004329 | SMART | SM00353 | IPR011598 | 22 | 77 | 1.50e-11 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSDARP00000004329 | SUPERFAMILY | SSF47459 | IPR011598 | 14 | 87 | 0.00e-00 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSDARP00000004329 | SUPERFAMILY | SSF55785 | IPR000014 | 242 | 343 | 0.00e-00 | PAS domain |
ENSDARP00000004329 | SUPERFAMILY | SSF55785 | IPR000014 | 97 | 197 | 0.00e-00 | PAS domain |
ENSDARP00000004329 | TIGRFAM | TIGR00229 | IPR000014 | 101 | 167 | 1.60e-05 | PAS domain |
ENSDARP00000004329 | TIGRFAM | TIGR00229 | IPR000014 | 249 | 331 | 3.30e-06 | PAS domain |
Pfam Annotation | ||||
Protein | Pfam ID | E.value | Name | Description |
ENSDARP00000004329 | PF14598 | 4.7e-26 | PAS_11 | PAS domain |
ENSDARP00000004329 | PF08778 | 8.3e-24 | HIF-1a_CTAD | HIF-1 alpha C terminal transactivation domain |
ENSDARP00000004329 | PF08447 | 3e-22 | PAS_3 | PAS fold |
ENSDARP00000004329 | PF11413 | 9.7e-17 | HIF-1 | Hypoxia-inducible factor-1 |
ENSDARP00000004329 | PF00989 | 3.7e-14 | PAS | PAS fold |
ENSDARP00000004329 | PF13426 | 2.6e-09 | PAS_9 | PAS domain |
ENSDARP00000004329 | PF08448 | 5.2e-06 | PAS_4 | PAS fold |
Gene Ontology Annotation | |||
Protein | Entry | Name Space | Description |
ENSDARP00000004329 | GO:0001666 | biological_process | response to hypoxia |
ENSDARP00000004329 | GO:0006351 | biological_process | transcription, DNA-templated |
ENSDARP00000004329 | GO:0006355 | biological_process | regulation of transcription, DNA-templated |
ENSDARP00000004329 | GO:0007165 | biological_process | signal transduction |
ENSDARP00000004329 | GO:0045893 | biological_process | positive regulation of transcription, DNA-templated |
ENSDARP00000004329 | GO:0045944 | biological_process | positive regulation of transcription from RNA polymerase II promoter |
ENSDARP00000004329 | GO:0071456 | biological_process | cellular response to hypoxia |
ENSDARP00000004329 | GO:0005634 | cellular_component | nucleus |
ENSDARP00000004329 | GO:0005737 | cellular_component | cytoplasm |
ENSDARP00000004329 | GO:0003677 | molecular_function | DNA binding |
ENSDARP00000004329 | GO:0003700 | molecular_function | sequence-specific DNA binding transcription factor activity |
ENSDARP00000004329 | GO:0004871 | molecular_function | signal transducer activity |
ENSDARP00000004329 | GO:0035035 | molecular_function | histone acetyltransferase binding |
ENSDARP00000004329 | GO:0046983 | molecular_function | protein dimerization activity |
Orthologs | |||||
TAXID | Organism | Gene ID | TAXID | Organism | Gene ID |
9483 | Callithrix jacchus | 100411678 | 61853 | Nomascus leucogenys | 100582446 |
8128 | Oreochromis niloticus | 100703737 | 9597 | Pan paniscus | 100993223 |
9555 | Papio anubis | 100999094 | 39432 | Saimiri boliviensis | 101044689 |
9685 | Felis catus | 101083686 | 8083 | Xiphophorus maculatus | 102217674 |
7897 | Latimeria chalumnae | 102348279 | 7029 | Acyrthosiphon pisum | 100167974 |
10224 | Saccoglossus kowalevskii | 100329032 | 9669 | Mustela putorius furo | 101692645 |
13735 | Pelodiscus sinensis | 102457736 | 9615 | Canis familiaris | 480348 |
10090 | Mus musculus | 53417 | 9598 | Pan troglodytes | 746195 |
28377 | Anolis carolinensis | ENSACAG00000016205 | 9646 | Ailuropoda melanoleuca | ENSAMEG00000003105 |
9358 | Choloepus hoffmanni | ENSCHOG00000008208 | 10141 | Cavia porcellus | ENSCPOG00000005317 |
10020 | Dipodomys ordii | ENSDORG00000004304 | 69293 | Gasterosteus aculeatus | ENSGACG00000008525 |
9595 | Gorilla gorilla | ENSGGOG00000003957 | 59463 | Myotis lucifugus | ENSMLUG00000015244 |
9978 | Ochotona princeps | ENSOPRG00000007753 | 9601 | Pongo abelii | ENSPPYG00000005881 |
132908 | Pteropus vampyrus | ENSPVAG00000014497 | 10116 | Rattus norvegicus | ENSRNOG00000008292 |
9823 | Sus scrofa | ENSSSCG00000005096 | 99883 | Tetraodon nigroviridis | ENSTNIG00000017339 |
9478 | Tarsius syrichta | ENSTSYG00000001081 | 8364 | Xenopus tropicalis | ENSXETG00000014449 |
7668 | Strongylocentrotus purpuratus | 577801 | 7070 | Tribolium castaneum | 655772 |
9361 | Dasypus novemcinctus | ENSDNOG00000017069 | 9796 | Equus caballus | ENSECAG00000015597 |
9365 | Erinaceus europaeus | ENSEEUG00000005910 | 9031 | Gallus gallus | ENSGALG00000011870 |
8049 | Gadus morhua | ENSGMOG00000010900 | 9785 | Loxodonta africana | ENSLAFG00000013410 |
9103 | Meleagris gallopavo | ENSMGAG00000013552 | 30608 | Microcebus murinus | ENSMICG00000002224 |
13616 | Monodelphis domestica | ENSMODG00000008760 | 9258 | Ornithorhynchus anatinus | ENSOANG00000009092 |
9986 | Oryctolagus cuniculus | ENSOCUG00000017741 | 30611 | Otolemur garnettii | ENSOGAG00000016112 |
8090 | Oryzias latipes | ENSORLG00000002004 | 7757 | Petromyzon marinus | ENSPMAG00000000126 |
42254 | Sorex araneus | ENSSARG00000011198 | 9305 | Sarcophilus harrisii | ENSSHAG00000004128 |
43179 | Ictidomys tridecemlineatus | ENSSTOG00000004833 | 37347 | Tupaia belangeri | ENSTBEG00000011941 |
59729 | Taeniopygia guttata | ENSTGUG00000012978 | 31033 | Takifugu rubripes | ENSTRUG00000012093 |
9739 | Tursiops truncatus | ENSTTRG00000012558 | 30538 | Vicugna pacos | ENSVPAG00000002395 |