Basic Information | |||
Gene ID | ENSGALG00000011870 | ||
Gene Name | HIF1A | ||
Full Name | Hypoxia-inducible factor 1-alpha | ||
Organism | Gallus gallus [9031] |
Cross Reference | |||
UniProt | F1NJK2 | UniGene | NULL |
PDB | NULL | OMIM | NULL |
KEGG | NULL | UCSC | NULL |
Protein Interactions | |
DIP | NULL |
IntAct | NULL |
MINT | NULL |
STRING | NULL |
Ensembl/RefSeq | Transcript ID | Protein ID | Gene ID |
ENSEMBL |
InterPro Annotation | |||||||
Protein | Program | Term | IPRS | Start | End | Score | Description |
ENSGALP00000019338 | Pfam | PF00989 | IPR013767 | 94 | 151 | 3.00e-05 | PAS fold |
ENSGALP00000019338 | Pfam | PF08778 | IPR014887 | 772 | 811 | 9.90e-23 | HIF-1 alpha, transactivation domain, C-terminal |
ENSGALP00000019338 | Pfam | PF11413 | IPR021537 | 548 | 580 | 3.00e-16 | Hypoxia-inducible factor, alpha subunit |
ENSGALP00000019338 | PRINTS | PR01080 | IPR001321 | 201 | 224 | 6.10e-34 | Hypoxia-inducible factor-1 alpha |
ENSGALP00000019338 | PRINTS | PR01080 | IPR001321 | 360 | 378 | 6.10e-34 | Hypoxia-inducible factor-1 alpha |
ENSGALP00000019338 | PRINTS | PR01080 | IPR001321 | 415 | 433 | 6.10e-34 | Hypoxia-inducible factor-1 alpha |
ENSGALP00000019338 | PRINTS | PR01080 | IPR001321 | 455 | 475 | 6.10e-34 | Hypoxia-inducible factor-1 alpha |
ENSGALP00000019338 | ProSiteProfiles | PS50112 | IPR000014 | 247 | 298 | 0.00e-00 | PAS domain |
ENSGALP00000019338 | ProSiteProfiles | PS50112 | IPR000014 | 80 | 148 | 0.00e-00 | PAS domain |
ENSGALP00000019338 | ProSiteProfiles | PS50888 | IPR011598 | 17 | 70 | 0.00e-00 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSGALP00000019338 | SMART | SM00086 | IPR001610 | 302 | 345 | 8.50e-11 | PAC motif |
ENSGALP00000019338 | SMART | SM00091 | IPR000014 | 230 | 296 | 1.80e-10 | PAS domain |
ENSGALP00000019338 | SMART | SM00091 | IPR000014 | 87 | 153 | 2.40e-10 | PAS domain |
ENSGALP00000019338 | SMART | SM00353 | IPR011598 | 23 | 78 | 1.30e-11 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSGALP00000019338 | SUPERFAMILY | SSF47459 | IPR011598 | 15 | 71 | 0.00e-00 | Myc-type, basic helix-loop-helix (bHLH) domain |
ENSGALP00000019338 | SUPERFAMILY | SSF55785 | IPR000014 | 242 | 343 | 0.00e-00 | PAS domain |
ENSGALP00000019338 | SUPERFAMILY | SSF55785 | IPR000014 | 96 | 200 | 0.00e-00 | PAS domain |
ENSGALP00000019338 | TIGRFAM | TIGR00229 | IPR000014 | 100 | 155 | 4.10e-06 | PAS domain |
ENSGALP00000019338 | TIGRFAM | TIGR00229 | IPR000014 | 249 | 330 | 1.90e-08 | PAS domain |
Pfam Annotation | ||||
Protein | Pfam ID | E.value | Name | Description |
ENSGALP00000019338 | PF14598 | 3.2e-27 | PAS_11 | PAS domain |
ENSGALP00000019338 | PF08447 | 3e-25 | PAS_3 | PAS fold |
ENSGALP00000019338 | PF08778 | 4.8e-23 | HIF-1a_CTAD | HIF-1 alpha C terminal transactivation domain |
ENSGALP00000019338 | PF11413 | 1.4e-16 | HIF-1 | Hypoxia-inducible factor-1 |
ENSGALP00000019338 | PF00989 | 7.1e-16 | PAS | PAS fold |
ENSGALP00000019338 | PF13426 | 5.8e-12 | PAS_9 | PAS domain |
ENSGALP00000019338 | PF08448 | 3.6e-08 | PAS_4 | PAS fold |
Gene Ontology Annotation | |||
Protein | Entry | Name Space | Description |
ENSGALP00000019338 | GO:0001666 | biological_process | response to hypoxia |
ENSGALP00000019338 | GO:0006351 | biological_process | transcription, DNA-templated |
ENSGALP00000019338 | GO:0006355 | biological_process | regulation of transcription, DNA-templated |
ENSGALP00000019338 | GO:0007165 | biological_process | signal transduction |
ENSGALP00000019338 | GO:0045893 | biological_process | positive regulation of transcription, DNA-templated |
ENSGALP00000019338 | GO:0005634 | cellular_component | nucleus |
ENSGALP00000019338 | GO:0005737 | cellular_component | cytoplasm |
ENSGALP00000019338 | GO:0003677 | molecular_function | DNA binding |
ENSGALP00000019338 | GO:0003700 | molecular_function | sequence-specific DNA binding transcription factor activity |
ENSGALP00000019338 | GO:0004871 | molecular_function | signal transducer activity |
ENSGALP00000019338 | GO:0035035 | molecular_function | histone acetyltransferase binding |
ENSGALP00000019338 | GO:0046983 | molecular_function | protein dimerization activity |
Orthologs | |||||
TAXID | Organism | Gene ID | TAXID | Organism | Gene ID |
9483 | Callithrix jacchus | 100411678 | 61853 | Nomascus leucogenys | 100582446 |
8128 | Oreochromis niloticus | 100703737 | 9555 | Papio anubis | 100999094 |
8083 | Xiphophorus maculatus | 102217674 | 7897 | Latimeria chalumnae | 102348279 |
7070 | Tribolium castaneum | 655772 | 9361 | Dasypus novemcinctus | ENSDNOG00000017069 |
9796 | Equus caballus | ENSECAG00000015597 | 9365 | Erinaceus europaeus | ENSEEUG00000005910 |
7029 | Acyrthosiphon pisum | 100167974 | 10224 | Saccoglossus kowalevskii | 100329032 |
9597 | Pan paniscus | 100993223 | 39432 | Saimiri boliviensis | 101044689 |
9685 | Felis catus | 101083686 | 9669 | Mustela putorius furo | 101692645 |
13735 | Pelodiscus sinensis | 102457736 | 7955 | Danio rerio | 393202 |
9615 | Canis familiaris | 480348 | 10090 | Mus musculus | 53417 |
7668 | Strongylocentrotus purpuratus | 577801 | 9598 | Pan troglodytes | 746195 |
28377 | Anolis carolinensis | ENSACAG00000016205 | 9646 | Ailuropoda melanoleuca | ENSAMEG00000003105 |
9358 | Choloepus hoffmanni | ENSCHOG00000008208 | 10141 | Cavia porcellus | ENSCPOG00000005317 |
51511 | Ciona savignyi | ENSCSAVG00000005768 | 10020 | Dipodomys ordii | ENSDORG00000004304 |
69293 | Gasterosteus aculeatus | ENSGACG00000008525 | 9595 | Gorilla gorilla | ENSGGOG00000003957 |
9315 | Macropus eugenii | ENSMEUG00000003867 | 59463 | Myotis lucifugus | ENSMLUG00000015244 |
30611 | Otolemur garnettii | ENSOGAG00000016112 | 9978 | Ochotona princeps | ENSOPRG00000007753 |
8090 | Oryzias latipes | ENSORLG00000002004 | 9601 | Pongo abelii | ENSPPYG00000005881 |
132908 | Pteropus vampyrus | ENSPVAG00000014497 | 10116 | Rattus norvegicus | ENSRNOG00000008292 |
9823 | Sus scrofa | ENSSSCG00000005096 | 37347 | Tupaia belangeri | ENSTBEG00000011941 |
59729 | Taeniopygia guttata | ENSTGUG00000012978 | 99883 | Tetraodon nigroviridis | ENSTNIG00000017339 |
9478 | Tarsius syrichta | ENSTSYG00000001081 | 8364 | Xenopus tropicalis | ENSXETG00000014449 |
8049 | Gadus morhua | ENSGMOG00000010900 | 9785 | Loxodonta africana | ENSLAFG00000013410 |
9103 | Meleagris gallopavo | ENSMGAG00000013552 | 30608 | Microcebus murinus | ENSMICG00000002224 |
13616 | Monodelphis domestica | ENSMODG00000008760 | 9258 | Ornithorhynchus anatinus | ENSOANG00000009092 |
9986 | Oryctolagus cuniculus | ENSOCUG00000017741 | 9813 | Procavia capensis | ENSPCAG00000011584 |
42254 | Sorex araneus | ENSSARG00000011198 | 9305 | Sarcophilus harrisii | ENSSHAG00000004128 |
43179 | Ictidomys tridecemlineatus | ENSSTOG00000004833 | 31033 | Takifugu rubripes | ENSTRUG00000012093 |
9739 | Tursiops truncatus | ENSTTRG00000012558 | 30538 | Vicugna pacos | ENSVPAG00000002395 |