Basic Information
Gene ID ENSACAG00000006213
Gene Name ESR1
Full Name Estrogen receptor
Organism Anolis carolinensis [28377]

Cross Reference
UniProt H9GB48 UniGene NULL
PDB NULL OMIM NULL
KEGG NULL UCSC NULL

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSACAP00000006106 Gene3D G3DSA:1.10.565.10 IPR008946 287 317 5.10e-97 Nuclear hormone receptor, ligand-binding
ENSACAP00000006106 Gene3D G3DSA:1.10.565.10 IPR008946 358 595 5.10e-97 Nuclear hormone receptor, ligand-binding
ENSACAP00000006106 Gene3D G3DSA:3.30.50.10 IPR013088 233 286 1.10e-27 Zinc finger, NHR/GATA-type
ENSACAP00000006106 Pfam PF00104 IPR000536 375 571 2.40e-28 Nuclear hormone receptor, ligand-binding, core
ENSACAP00000006106 Pfam PF00105 IPR001628 232 300 2.50e-31 Zinc finger, nuclear hormone receptor-type
ENSACAP00000006106 Pfam PF02159 IPR001292 96 229 2.10e-53 Oestrogen receptor
ENSACAP00000006106 Pfam PF12743 IPR024736 599 641 1.80e-17 Oestrogen-type nuclear receptor final C-terminal domain
ENSACAP00000006106 PIRSF PIRSF002527 IPR024178 96 641 4.10e-284 Oestrogen receptor/oestrogen-related receptor
ENSACAP00000006106 PIRSF PIRSF500101 IPR001292 51 642 0.00e-00 Oestrogen receptor
ENSACAP00000006106 PRINTS PR00047 IPR001628 233 249 1.10e-16 Zinc finger, nuclear hormone receptor-type
ENSACAP00000006106 PRINTS PR00047 IPR001628 249 264 1.10e-16 Zinc finger, nuclear hormone receptor-type
ENSACAP00000006106 PRINTS PR00047 IPR001628 282 290 1.10e-16 Zinc finger, nuclear hormone receptor-type
ENSACAP00000006106 PRINTS PR00047 IPR001628 290 298 1.10e-16 Zinc finger, nuclear hormone receptor-type
ENSACAP00000006106 PRINTS PR00398 IPR001723 294 304 9.70e-26 Steroid hormone receptor
ENSACAP00000006106 PRINTS PR00398 IPR001723 396 417 9.70e-26 Steroid hormone receptor
ENSACAP00000006106 PRINTS PR00398 IPR001723 417 433 9.70e-26 Steroid hormone receptor
ENSACAP00000006106 PRINTS PR00398 IPR001723 485 500 9.70e-26 Steroid hormone receptor
ENSACAP00000006106 PRINTS PR00398 IPR001723 553 570 9.70e-26 Steroid hormone receptor
ENSACAP00000006106 PRINTS PR00543 IPR001292 120 135 1.20e-73 Oestrogen receptor
ENSACAP00000006106 PRINTS PR00543 IPR001292 145 159 1.20e-73 Oestrogen receptor
ENSACAP00000006106 PRINTS PR00543 IPR001292 163 179 1.20e-73 Oestrogen receptor
ENSACAP00000006106 PRINTS PR00543 IPR001292 180 199 1.20e-73 Oestrogen receptor
ENSACAP00000006106 PRINTS PR00543 IPR001292 201 220 1.20e-73 Oestrogen receptor
ENSACAP00000006106 PRINTS PR00543 IPR001292 60 78 1.20e-73 Oestrogen receptor
ENSACAP00000006106 PRINTS PR00543 IPR001292 80 97 1.20e-73 Oestrogen receptor
ENSACAP00000006106 PRINTS PR00543 IPR001292 99 116 1.20e-73 Oestrogen receptor
ENSACAP00000006106 ProSitePatterns PS00031 IPR001628 233 259 - Zinc finger, nuclear hormone receptor-type
ENSACAP00000006106 ProSiteProfiles PS51030 IPR001628 230 305 0.00e-00 Zinc finger, nuclear hormone receptor-type
ENSACAP00000006106 SMART SM00399 IPR001628 230 301 6.40e-40 Zinc finger, nuclear hormone receptor-type
ENSACAP00000006106 SMART SM00430 IPR000536 395 565 2.10e-35 Nuclear hormone receptor, ligand-binding, core
ENSACAP00000006106 SUPERFAMILY SSF48508 IPR008946 353 594 0.00e-00 Nuclear hormone receptor, ligand-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSACAP00000006106 PF02159 0 Oest_recep Oestrogen receptor
ENSACAP00000006106 PF00105 1.4e-31 zf-C4 Zinc finger, C4 type (two domains)
ENSACAP00000006106 PF00104 1.5e-28 Hormone_recep Ligand-binding domain of nuclear hormone receptor
ENSACAP00000006106 PF12743 7e-18 ESR1_C Oestrogen-type nuclear receptor final C-terminal

Gene Ontology Annotation
Protein Entry Name Space Description
ENSACAP00000006106 GO:0006351 biological_process transcription, DNA-templated
ENSACAP00000006106 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSACAP00000006106 GO:0007200 biological_process phospholipase C-activating G-protein coupled receptor signaling pathway
ENSACAP00000006106 GO:0007204 biological_process positive regulation of cytosolic calcium ion concentration
ENSACAP00000006106 GO:0010863 biological_process positive regulation of phospholipase C activity
ENSACAP00000006106 GO:0030518 biological_process intracellular steroid hormone receptor signaling pathway
ENSACAP00000006106 GO:0043124 biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling
ENSACAP00000006106 GO:0043433 biological_process negative regulation of sequence-specific DNA binding transcription factor activity
ENSACAP00000006106 GO:0045429 biological_process positive regulation of nitric oxide biosynthetic process
ENSACAP00000006106 GO:0051000 biological_process positive regulation of nitric-oxide synthase activity
ENSACAP00000006106 GO:0051091 biological_process positive regulation of sequence-specific DNA binding transcription factor activity
ENSACAP00000006106 GO:0071392 biological_process cellular response to estradiol stimulus
ENSACAP00000006106 GO:0005634 cellular_component nucleus
ENSACAP00000006106 GO:0005794 cellular_component Golgi apparatus
ENSACAP00000006106 GO:0005886 cellular_component plasma membrane
ENSACAP00000006106 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSACAP00000006106 GO:0003707 molecular_function steroid hormone receptor activity
ENSACAP00000006106 GO:0005496 molecular_function steroid binding
ENSACAP00000006106 GO:0008270 molecular_function zinc ion binding
ENSACAP00000006106 GO:0030284 molecular_function estrogen receptor activity
ENSACAP00000006106 GO:0043565 molecular_function sequence-specific DNA binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9555 Papio anubis 100303417 9986 Oryctolagus cuniculus 100351261
7897 Latimeria chalumnae 102366308 9615 Canis familiaris 403640
9598 Pan troglodytes 452964 13616 Monodelphis domestica 100027187
9483 Callithrix jacchus 100385918 9601 Pongo abelii 100459579
9103 Meleagris gallopavo 100542782 61853 Nomascus leucogenys 100580202
10141 Cavia porcellus 100713276 10029 Cricetulus griseus 100768474
9597 Pan paniscus 100980011 39432 Saimiri boliviensis 101034130
9669 Mustela putorius furo 101690352 8083 Xiphophorus maculatus 102235986
13735 Pelodiscus sinensis 102456765 10090 Mus musculus 13982
9606 Homo sapiens 2099 9544 Macaca mulatta 574110
9646 Ailuropoda melanoleuca ENSAMEG00000011072 7955 Danio rerio ENSDARG00000004111
9371 Echinops telfairi ENSETEG00000006131 9685 Felis catus ENSFCAG00000031492
69293 Gasterosteus aculeatus ENSGACG00000008711 9031 Gallus gallus ENSGALG00000012973
30608 Microcebus murinus ENSMICG00000007592 59463 Myotis lucifugus ENSMLUG00000014181
30611 Otolemur garnettii ENSOGAG00000012580 8090 Oryzias latipes ENSORLG00000014514
10116 Rattus norvegicus ENSRNOG00000019358 42254 Sorex araneus ENSSARG00000004419
9305 Sarcophilus harrisii ENSSHAG00000008174 99883 Tetraodon nigroviridis ENSTNIG00000012264
31033 Takifugu rubripes ENSTRUG00000018219 9478 Tarsius syrichta ENSTSYG00000006280
9739 Tursiops truncatus ENSTTRG00000002996 8364 Xenopus tropicalis ENSXETG00000012364
9913 Bos taurus ENSBTAG00000007159 9358 Choloepus hoffmanni ENSCHOG00000012987
9361 Dasypus novemcinctus ENSDNOG00000013868 10020 Dipodomys ordii ENSDORG00000010443
9796 Equus caballus ENSECAG00000022441 9365 Erinaceus europaeus ENSEEUG00000000828
9595 Gorilla gorilla ENSGGOG00000009678 8049 Gadus morhua ENSGMOG00000014898
9785 Loxodonta africana ENSLAFG00000017799 9315 Macropus eugenii ENSMEUG00000003564
9258 Ornithorhynchus anatinus ENSOANG00000015561 8128 Oreochromis niloticus ENSONIG00000013354
9978 Ochotona princeps ENSOPRG00000012663 9813 Procavia capensis ENSPCAG00000011157
7757 Petromyzon marinus ENSPMAG00000008530 132908 Pteropus vampyrus ENSPVAG00000001923
9823 Sus scrofa ENSSSCG00000005109 43179 Ictidomys tridecemlineatus ENSSTOG00000006748
37347 Tupaia belangeri ENSTBEG00000005946 59729 Taeniopygia guttata ENSTGUG00000011249
30538 Vicugna pacos ENSVPAG00000001185