Basic Information
Gene ID ENSBTAG00000007159
Gene Name ESR1
Full Name Estrogen receptor
Organism Bos taurus [9913]

Cross Reference
UniProt F1MX59 UniGene NULL
PDB NULL OMIM NULL
KEGG NULL UCSC NULL

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSBTAP00000009422 Gene3D G3DSA:1.10.565.10 IPR008946 240 270 4.50e-100 Nuclear hormone receptor, ligand-binding
ENSBTAP00000009422 Gene3D G3DSA:1.10.565.10 IPR008946 312 549 4.50e-100 Nuclear hormone receptor, ligand-binding
ENSBTAP00000009422 Gene3D G3DSA:3.30.50.10 IPR013088 186 239 9.70e-28 Zinc finger, NHR/GATA-type
ENSBTAP00000009422 Pfam PF00104 IPR000536 329 525 1.80e-27 Nuclear hormone receptor, ligand-binding, core
ENSBTAP00000009422 Pfam PF00105 IPR001628 185 253 2.20e-31 Zinc finger, nuclear hormone receptor-type
ENSBTAP00000009422 Pfam PF02159 IPR001292 42 182 1.40e-44 Oestrogen receptor
ENSBTAP00000009422 Pfam PF12743 IPR024736 553 596 6.50e-21 Oestrogen-type nuclear receptor final C-terminal domain
ENSBTAP00000009422 PIRSF PIRSF002527 IPR024178 42 591 7.20e-290 Oestrogen receptor/oestrogen-related receptor
ENSBTAP00000009422 PIRSF PIRSF500101 IPR001292 1 596 0.00e-00 Oestrogen receptor
ENSBTAP00000009422 PRINTS PR00047 IPR001628 186 202 8.20e-17 Zinc finger, nuclear hormone receptor-type
ENSBTAP00000009422 PRINTS PR00047 IPR001628 202 217 8.20e-17 Zinc finger, nuclear hormone receptor-type
ENSBTAP00000009422 PRINTS PR00047 IPR001628 235 243 8.20e-17 Zinc finger, nuclear hormone receptor-type
ENSBTAP00000009422 PRINTS PR00047 IPR001628 243 251 8.20e-17 Zinc finger, nuclear hormone receptor-type
ENSBTAP00000009422 PRINTS PR00398 IPR001723 247 257 4.70e-26 Steroid hormone receptor
ENSBTAP00000009422 PRINTS PR00398 IPR001723 350 371 4.70e-26 Steroid hormone receptor
ENSBTAP00000009422 PRINTS PR00398 IPR001723 371 387 4.70e-26 Steroid hormone receptor
ENSBTAP00000009422 PRINTS PR00398 IPR001723 439 454 4.70e-26 Steroid hormone receptor
ENSBTAP00000009422 PRINTS PR00398 IPR001723 507 524 4.70e-26 Steroid hormone receptor
ENSBTAP00000009422 PRINTS PR00543 IPR001292 116 132 7.70e-76 Oestrogen receptor
ENSBTAP00000009422 PRINTS PR00543 IPR001292 133 152 7.70e-76 Oestrogen receptor
ENSBTAP00000009422 PRINTS PR00543 IPR001292 154 173 7.70e-76 Oestrogen receptor
ENSBTAP00000009422 PRINTS PR00543 IPR001292 26 43 7.70e-76 Oestrogen receptor
ENSBTAP00000009422 PRINTS PR00543 IPR001292 45 62 7.70e-76 Oestrogen receptor
ENSBTAP00000009422 PRINTS PR00543 IPR001292 6 24 7.70e-76 Oestrogen receptor
ENSBTAP00000009422 PRINTS PR00543 IPR001292 70 85 7.70e-76 Oestrogen receptor
ENSBTAP00000009422 PRINTS PR00543 IPR001292 97 111 7.70e-76 Oestrogen receptor
ENSBTAP00000009422 ProSitePatterns PS00031 IPR001628 186 212 - Zinc finger, nuclear hormone receptor-type
ENSBTAP00000009422 ProSiteProfiles PS51030 IPR001628 183 258 0.00e-00 Zinc finger, nuclear hormone receptor-type
ENSBTAP00000009422 SMART SM00399 IPR001628 183 254 6.40e-40 Zinc finger, nuclear hormone receptor-type
ENSBTAP00000009422 SMART SM00430 IPR000536 349 519 1.20e-35 Nuclear hormone receptor, ligand-binding, core
ENSBTAP00000009422 SUPERFAMILY SSF48508 IPR008946 236 262 0.00e-00 Nuclear hormone receptor, ligand-binding
ENSBTAP00000009422 SUPERFAMILY SSF48508 IPR008946 303 548 0.00e-00 Nuclear hormone receptor, ligand-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSBTAP00000009422 PF02159 1.4013e-44 Oest_recep Oestrogen receptor
ENSBTAP00000009422 PF00105 1.4e-31 zf-C4 Zinc finger, C4 type (two domains)
ENSBTAP00000009422 PF00104 1.2e-27 Hormone_recep Ligand-binding domain of nuclear hormone receptor
ENSBTAP00000009422 PF12743 3.6e-21 ESR1_C Oestrogen-type nuclear receptor final C-terminal

Gene Ontology Annotation
Protein Entry Name Space Description
ENSBTAP00000009422 GO:0006351 biological_process transcription, DNA-templated
ENSBTAP00000009422 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSBTAP00000009422 GO:0007200 biological_process phospholipase C-activating G-protein coupled receptor signaling pathway
ENSBTAP00000009422 GO:0007204 biological_process positive regulation of cytosolic calcium ion concentration
ENSBTAP00000009422 GO:0010863 biological_process positive regulation of phospholipase C activity
ENSBTAP00000009422 GO:0030518 biological_process intracellular steroid hormone receptor signaling pathway
ENSBTAP00000009422 GO:0043124 biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling
ENSBTAP00000009422 GO:0043433 biological_process negative regulation of sequence-specific DNA binding transcription factor activity
ENSBTAP00000009422 GO:0045429 biological_process positive regulation of nitric oxide biosynthetic process
ENSBTAP00000009422 GO:0051000 biological_process positive regulation of nitric-oxide synthase activity
ENSBTAP00000009422 GO:0051091 biological_process positive regulation of sequence-specific DNA binding transcription factor activity
ENSBTAP00000009422 GO:0071392 biological_process cellular response to estradiol stimulus
ENSBTAP00000009422 GO:0005634 cellular_component nucleus
ENSBTAP00000009422 GO:0005794 cellular_component Golgi apparatus
ENSBTAP00000009422 GO:0005886 cellular_component plasma membrane
ENSBTAP00000009422 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSBTAP00000009422 GO:0003707 molecular_function steroid hormone receptor activity
ENSBTAP00000009422 GO:0005496 molecular_function steroid binding
ENSBTAP00000009422 GO:0008270 molecular_function zinc ion binding
ENSBTAP00000009422 GO:0030284 molecular_function estrogen receptor activity
ENSBTAP00000009422 GO:0043565 molecular_function sequence-specific DNA binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9615 Canis familiaris 403640 9598 Pan troglodytes 452964
13616 Monodelphis domestica 100027187 9555 Papio anubis 100303417
9986 Oryctolagus cuniculus 100351261 9483 Callithrix jacchus 100385918
9601 Pongo abelii 100459579 9103 Meleagris gallopavo 100542782
61853 Nomascus leucogenys 100580202 10141 Cavia porcellus 100713276
10029 Cricetulus griseus 100768474 9597 Pan paniscus 100980011
39432 Saimiri boliviensis 101034130 9669 Mustela putorius furo 101690352
8083 Xiphophorus maculatus 102235986 7897 Latimeria chalumnae 102366308
13735 Pelodiscus sinensis 102456765 10090 Mus musculus 13982
9606 Homo sapiens 2099 9544 Macaca mulatta 574110
28377 Anolis carolinensis ENSACAG00000006213 9646 Ailuropoda melanoleuca ENSAMEG00000011072
9358 Choloepus hoffmanni ENSCHOG00000012987 7955 Danio rerio ENSDARG00000004111
9365 Erinaceus europaeus ENSEEUG00000000828 9371 Echinops telfairi ENSETEG00000006131
9685 Felis catus ENSFCAG00000031492 69293 Gasterosteus aculeatus ENSGACG00000008711
9031 Gallus gallus ENSGALG00000012973 9785 Loxodonta africana ENSLAFG00000017799
30608 Microcebus murinus ENSMICG00000007592 59463 Myotis lucifugus ENSMLUG00000014181
9258 Ornithorhynchus anatinus ENSOANG00000015561 30611 Otolemur garnettii ENSOGAG00000012580
8128 Oreochromis niloticus ENSONIG00000013354 8090 Oryzias latipes ENSORLG00000014514
10116 Rattus norvegicus ENSRNOG00000019358 42254 Sorex araneus ENSSARG00000004419
9305 Sarcophilus harrisii ENSSHAG00000008174 99883 Tetraodon nigroviridis ENSTNIG00000012264
31033 Takifugu rubripes ENSTRUG00000018219 9478 Tarsius syrichta ENSTSYG00000006280
9739 Tursiops truncatus ENSTTRG00000002996 8364 Xenopus tropicalis ENSXETG00000012364
9361 Dasypus novemcinctus ENSDNOG00000013868 10020 Dipodomys ordii ENSDORG00000010443
9796 Equus caballus ENSECAG00000022441 9595 Gorilla gorilla ENSGGOG00000009678
8049 Gadus morhua ENSGMOG00000014898 9315 Macropus eugenii ENSMEUG00000003564
9978 Ochotona princeps ENSOPRG00000012663 9813 Procavia capensis ENSPCAG00000011157
7757 Petromyzon marinus ENSPMAG00000008530 132908 Pteropus vampyrus ENSPVAG00000001923
9823 Sus scrofa ENSSSCG00000005109 43179 Ictidomys tridecemlineatus ENSSTOG00000006748
37347 Tupaia belangeri ENSTBEG00000005946 59729 Taeniopygia guttata ENSTGUG00000011249
30538 Vicugna pacos ENSVPAG00000001185