Basic Information
Gene ID ENSOGAG00000012580
Gene Name ESR1
Full Name Estrogen receptor
Organism Otolemur garnettii [30611]

Cross Reference
UniProt H0X794 UniGene NULL
PDB NULL OMIM NULL
KEGG NULL UCSC NULL

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSOGAP00000011271 Gene3D G3DSA:1.10.565.10 IPR008946 239 269 2.20e-99 Nuclear hormone receptor, ligand-binding
ENSOGAP00000011271 Gene3D G3DSA:1.10.565.10 IPR008946 311 551 2.20e-99 Nuclear hormone receptor, ligand-binding
ENSOGAP00000011271 Gene3D G3DSA:3.30.50.10 IPR013088 185 238 9.70e-28 Zinc finger, NHR/GATA-type
ENSOGAP00000011271 Pfam PF00104 IPR000536 330 527 2.00e-27 Nuclear hormone receptor, ligand-binding, core
ENSOGAP00000011271 Pfam PF00105 IPR001628 184 252 2.20e-31 Zinc finger, nuclear hormone receptor-type
ENSOGAP00000011271 Pfam PF02159 IPR001292 42 181 3.10e-52 Oestrogen receptor
ENSOGAP00000011271 Pfam PF12743 IPR024736 555 598 1.10e-19 Oestrogen-type nuclear receptor final C-terminal domain
ENSOGAP00000011271 PIRSF PIRSF002527 IPR024178 42 593 7.00e-292 Oestrogen receptor/oestrogen-related receptor
ENSOGAP00000011271 PIRSF PIRSF500101 IPR001292 1 598 0.00e-00 Oestrogen receptor
ENSOGAP00000011271 PRINTS PR00047 IPR001628 185 201 8.30e-17 Zinc finger, nuclear hormone receptor-type
ENSOGAP00000011271 PRINTS PR00047 IPR001628 201 216 8.30e-17 Zinc finger, nuclear hormone receptor-type
ENSOGAP00000011271 PRINTS PR00047 IPR001628 234 242 8.30e-17 Zinc finger, nuclear hormone receptor-type
ENSOGAP00000011271 PRINTS PR00047 IPR001628 242 250 8.30e-17 Zinc finger, nuclear hormone receptor-type
ENSOGAP00000011271 PRINTS PR00398 IPR001723 246 256 5.90e-27 Steroid hormone receptor
ENSOGAP00000011271 PRINTS PR00398 IPR001723 349 370 5.90e-27 Steroid hormone receptor
ENSOGAP00000011271 PRINTS PR00398 IPR001723 370 386 5.90e-27 Steroid hormone receptor
ENSOGAP00000011271 PRINTS PR00398 IPR001723 438 453 5.90e-27 Steroid hormone receptor
ENSOGAP00000011271 PRINTS PR00398 IPR001723 509 526 5.90e-27 Steroid hormone receptor
ENSOGAP00000011271 PRINTS PR00543 IPR001292 115 131 2.20e-83 Oestrogen receptor
ENSOGAP00000011271 PRINTS PR00543 IPR001292 132 151 2.20e-83 Oestrogen receptor
ENSOGAP00000011271 PRINTS PR00543 IPR001292 153 172 2.20e-83 Oestrogen receptor
ENSOGAP00000011271 PRINTS PR00543 IPR001292 26 43 2.20e-83 Oestrogen receptor
ENSOGAP00000011271 PRINTS PR00543 IPR001292 45 62 2.20e-83 Oestrogen receptor
ENSOGAP00000011271 PRINTS PR00543 IPR001292 6 24 2.20e-83 Oestrogen receptor
ENSOGAP00000011271 PRINTS PR00543 IPR001292 70 85 2.20e-83 Oestrogen receptor
ENSOGAP00000011271 PRINTS PR00543 IPR001292 97 111 2.20e-83 Oestrogen receptor
ENSOGAP00000011271 ProSitePatterns PS00031 IPR001628 185 211 - Zinc finger, nuclear hormone receptor-type
ENSOGAP00000011271 ProSiteProfiles PS51030 IPR001628 182 257 0.00e-00 Zinc finger, nuclear hormone receptor-type
ENSOGAP00000011271 SMART SM00399 IPR001628 182 253 6.40e-40 Zinc finger, nuclear hormone receptor-type
ENSOGAP00000011271 SMART SM00430 IPR000536 348 521 3.20e-37 Nuclear hormone receptor, ligand-binding, core
ENSOGAP00000011271 SUPERFAMILY SSF48508 IPR008946 235 261 0.00e-00 Nuclear hormone receptor, ligand-binding
ENSOGAP00000011271 SUPERFAMILY SSF48508 IPR008946 302 550 0.00e-00 Nuclear hormone receptor, ligand-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSOGAP00000011271 PF02159 0 Oest_recep Oestrogen receptor
ENSOGAP00000011271 PF00105 1.4e-31 zf-C4 Zinc finger, C4 type (two domains)
ENSOGAP00000011271 PF00104 1.2e-27 Hormone_recep Ligand-binding domain of nuclear hormone receptor
ENSOGAP00000011271 PF12743 1.1e-19 ESR1_C Oestrogen-type nuclear receptor final C-terminal

Gene Ontology Annotation
Protein Entry Name Space Description
ENSOGAP00000011271 GO:0006351 biological_process transcription, DNA-templated
ENSOGAP00000011271 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSOGAP00000011271 GO:0007200 biological_process phospholipase C-activating G-protein coupled receptor signaling pathway
ENSOGAP00000011271 GO:0007204 biological_process positive regulation of cytosolic calcium ion concentration
ENSOGAP00000011271 GO:0010863 biological_process positive regulation of phospholipase C activity
ENSOGAP00000011271 GO:0030518 biological_process intracellular steroid hormone receptor signaling pathway
ENSOGAP00000011271 GO:0043124 biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling
ENSOGAP00000011271 GO:0043433 biological_process negative regulation of sequence-specific DNA binding transcription factor activity
ENSOGAP00000011271 GO:0045429 biological_process positive regulation of nitric oxide biosynthetic process
ENSOGAP00000011271 GO:0051000 biological_process positive regulation of nitric-oxide synthase activity
ENSOGAP00000011271 GO:0051091 biological_process positive regulation of sequence-specific DNA binding transcription factor activity
ENSOGAP00000011271 GO:0071392 biological_process cellular response to estradiol stimulus
ENSOGAP00000011271 GO:0005634 cellular_component nucleus
ENSOGAP00000011271 GO:0005794 cellular_component Golgi apparatus
ENSOGAP00000011271 GO:0005886 cellular_component plasma membrane
ENSOGAP00000011271 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSOGAP00000011271 GO:0003707 molecular_function steroid hormone receptor activity
ENSOGAP00000011271 GO:0005496 molecular_function steroid binding
ENSOGAP00000011271 GO:0008270 molecular_function zinc ion binding
ENSOGAP00000011271 GO:0030284 molecular_function estrogen receptor activity
ENSOGAP00000011271 GO:0043565 molecular_function sequence-specific DNA binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
13616 Monodelphis domestica 100027187 9555 Papio anubis 100303417
9986 Oryctolagus cuniculus 100351261 61853 Nomascus leucogenys 100580202
9597 Pan paniscus 100980011 10090 Mus musculus 13982
9615 Canis familiaris 403640 28377 Anolis carolinensis ENSACAG00000006213
9913 Bos taurus ENSBTAG00000007159 10020 Dipodomys ordii ENSDORG00000010443
9796 Equus caballus ENSECAG00000022441 9365 Erinaceus europaeus ENSEEUG00000000828
9595 Gorilla gorilla ENSGGOG00000009678 8049 Gadus morhua ENSGMOG00000014898
9315 Macropus eugenii ENSMEUG00000003564 9258 Ornithorhynchus anatinus ENSOANG00000015561
9483 Callithrix jacchus 100385918 9103 Meleagris gallopavo 100542782
10141 Cavia porcellus 100713276 10029 Cricetulus griseus 100768474
39432 Saimiri boliviensis 101034130 9669 Mustela putorius furo 101690352
8083 Xiphophorus maculatus 102235986 13735 Pelodiscus sinensis 102456765
9606 Homo sapiens 2099 9646 Ailuropoda melanoleuca ENSAMEG00000011072
7955 Danio rerio ENSDARG00000004111 9371 Echinops telfairi ENSETEG00000006131
9685 Felis catus ENSFCAG00000031492 69293 Gasterosteus aculeatus ENSGACG00000008711
9031 Gallus gallus ENSGALG00000012973 30608 Microcebus murinus ENSMICG00000007592
59463 Myotis lucifugus ENSMLUG00000014181 8090 Oryzias latipes ENSORLG00000014514
42254 Sorex araneus ENSSARG00000004419 31033 Takifugu rubripes ENSTRUG00000018219
9478 Tarsius syrichta ENSTSYG00000006280 9739 Tursiops truncatus ENSTTRG00000002996
8364 Xenopus tropicalis ENSXETG00000012364 8128 Oreochromis niloticus ENSONIG00000013354
9978 Ochotona princeps ENSOPRG00000012663 132908 Pteropus vampyrus ENSPVAG00000001923
10116 Rattus norvegicus ENSRNOG00000019358 43179 Ictidomys tridecemlineatus ENSSTOG00000006748
37347 Tupaia belangeri ENSTBEG00000005946 59729 Taeniopygia guttata ENSTGUG00000011249
99883 Tetraodon nigroviridis ENSTNIG00000012264 30538 Vicugna pacos ENSVPAG00000001185