Basic Information
Gene ID ENSLAFG00000014062
Gene Name STAT3
Full Name Signal transducer and activator of transcription
Organism Loxodonta africana [9785]

Cross Reference
UniProt G3TCI8 UniGene NULL
PDB NULL OMIM NULL
KEGG NULL UCSC NULL

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSLAFP00000025834 Gene3D G3DSA:1.10.238.10 IPR011992 468 589 3.80e-59 EF-hand domain pair
ENSLAFP00000025834 Gene3D G3DSA:1.10.532.10 IPR013799 1 120 1.10e-45 STAT transcription factor, protein interaction
ENSLAFP00000025834 Gene3D G3DSA:1.20.1050.20 IPR013800 139 321 1.40e-72 STAT transcription factor, all-alpha
ENSLAFP00000025834 Gene3D G3DSA:2.60.40.630 IPR012345 322 467 1.10e-63 STAT transcription factor, DNA-binding, subdomain
ENSLAFP00000025834 Gene3D G3DSA:3.30.505.10 IPR000980 590 720 9.60e-52 SH2 domain
ENSLAFP00000025834 PANTHER PTHR11801 IPR001217 2 772 0.00e-00 Transcription factor STAT
ENSLAFP00000025834 Pfam PF00017 IPR000980 585 675 2.40e-13 SH2 domain
ENSLAFP00000025834 Pfam PF01017 IPR013800 139 319 3.70e-59 STAT transcription factor, all-alpha
ENSLAFP00000025834 Pfam PF02864 IPR013801 321 575 3.20e-125 STAT transcription factor, DNA-binding
ENSLAFP00000025834 Pfam PF02865 IPR013799 2 121 8.50e-42 STAT transcription factor, protein interaction
ENSLAFP00000025834 ProSiteProfiles PS50001 IPR000980 581 671 0.00e-00 SH2 domain
ENSLAFP00000025834 SMART SM00252 IPR000980 583 664 1.00e-03 SH2 domain
ENSLAFP00000025834 SMART SM00964 IPR013799 2 122 1.80e-64 STAT transcription factor, protein interaction
ENSLAFP00000025834 SUPERFAMILY SSF47655 IPR015988 136 321 0.00e-00 STAT transcription factor, coiled coil
ENSLAFP00000025834 SUPERFAMILY SSF48092 IPR013799 1 120 0.00e-00 STAT transcription factor, protein interaction
ENSLAFP00000025834 SUPERFAMILY SSF49417 IPR008967 322 576 0.00e-00 p53-like transcription factor, DNA-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSLAFP00000025834 PF01017 0 STAT_alpha STAT protein, all-alpha domain
ENSLAFP00000025834 PF02864 0 STAT_bind STAT protein, DNA binding domain
ENSLAFP00000025834 PF02865 8.50028e-42 STAT_int STAT protein, protein interaction domain
ENSLAFP00000025834 PF00017 9e-14 SH2 SH2 domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSLAFP00000025834 GO:0001659 biological_process temperature homeostasis
ENSLAFP00000025834 GO:0001754 biological_process eye photoreceptor cell differentiation
ENSLAFP00000025834 GO:0006357 biological_process regulation of transcription from RNA polymerase II promoter
ENSLAFP00000025834 GO:0019953 biological_process sexual reproduction
ENSLAFP00000025834 GO:0042593 biological_process glucose homeostasis
ENSLAFP00000025834 GO:0042755 biological_process eating behavior
ENSLAFP00000025834 GO:0045893 biological_process positive regulation of transcription, DNA-templated
ENSLAFP00000025834 GO:0060397 biological_process JAK-STAT cascade involved in growth hormone signaling pathway
ENSLAFP00000025834 GO:0005634 cellular_component nucleus
ENSLAFP00000025834 GO:0005737 cellular_component cytoplasm
ENSLAFP00000025834 GO:0005886 cellular_component plasma membrane
ENSLAFP00000025834 GO:0003677 molecular_function DNA binding
ENSLAFP00000025834 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSLAFP00000025834 GO:0004871 molecular_function signal transducer activity
ENSLAFP00000025834 GO:0005509 molecular_function calcium ion binding
ENSLAFP00000025834 GO:0019901 molecular_function protein kinase binding
ENSLAFP00000025834 GO:0043565 molecular_function sequence-specific DNA binding
ENSLAFP00000025834 GO:0046983 molecular_function protein dimerization activity

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9483 Callithrix jacchus ENSCJAG00000000409 9986 Oryctolagus cuniculus 100348778
10029 Cricetulus griseus 100755865 9597 Pan paniscus 100987766
9555 Papio anubis 100998929 39432 Saimiri boliviensis 101049662
31033 Takifugu rubripes 101070968 9685 Felis catus 101095698
8083 Xiphophorus maculatus 102226045 9615 Canis familiaris 490967
28377 Anolis carolinensis ENSACAG00000017940 9646 Ailuropoda melanoleuca ENSAMEG00000006266
9358 Choloepus hoffmanni ENSCHOG00000009349 10141 Cavia porcellus ENSCPOG00000007939
9361 Dasypus novemcinctus ENSDNOG00000001471 10020 Dipodomys ordii ENSDORG00000000308
9796 Equus caballus ENSECAG00000016439 69293 Gasterosteus aculeatus ENSGACG00000008607
9595 Gorilla gorilla ENSGGOG00000017110 8049 Gadus morhua ENSGMOG00000014955
7897 Latimeria chalumnae ENSLACG00000012019 9315 Macropus eugenii ENSMEUG00000006663
9103 Meleagris gallopavo ENSMGAG00000003545 30608 Microcebus murinus ENSMICG00000012015
59463 Myotis lucifugus ENSMLUG00000017449 9544 Macaca mulatta ENSMMUG00000010707
13616 Monodelphis domestica ENSMODG00000028212 9669 Mustela putorius furo ENSMPUG00000010509
9258 Ornithorhynchus anatinus ENSOANG00000031491 30611 Otolemur garnettii ENSOGAG00000001517
8128 Oreochromis niloticus ENSONIG00000001148 8090 Oryzias latipes ENSORLG00000004061
9813 Procavia capensis ENSPCAG00000010265 9601 Pongo abelii ENSPPYG00000008392
13735 Pelodiscus sinensis ENSPSIG00000015868 132908 Pteropus vampyrus ENSPVAG00000003885
42254 Sorex araneus ENSSARG00000014231 9305 Sarcophilus harrisii ENSSHAG00000014833
43179 Ictidomys tridecemlineatus ENSSTOG00000006741 59729 Taeniopygia guttata ENSTGUG00000002600
9478 Tarsius syrichta ENSTSYG00000012448 9739 Tursiops truncatus ENSTTRG00000007163
8364 Xenopus tropicalis ENSXETG00000007642 9978 Ochotona princeps ENSOPRG00000008362