Basic Information
Gene ID 490967
Gene Name STAT3
Full Name Signal transducer and activator of transcription
Organism Canis familiaris [9615]

Cross Reference
UniProt E2RB82 UniGene NULL
PDB NULL OMIM NULL
KEGG NULL UCSC NULL

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSCAFP00000022438 Gene3D G3DSA:1.10.238.10 IPR011992 467 588 4.80e-59 EF-hand domain pair
ENSCAFP00000022438 Gene3D G3DSA:1.10.532.10 IPR013799 1 120 1.10e-45 STAT transcription factor, protein interaction
ENSCAFP00000022438 Gene3D G3DSA:1.20.1050.20 IPR013800 139 321 2.20e-72 STAT transcription factor, all-alpha
ENSCAFP00000022438 Gene3D G3DSA:2.60.40.630 IPR012345 322 466 5.90e-66 STAT transcription factor, DNA-binding, subdomain
ENSCAFP00000022438 Gene3D G3DSA:3.30.505.10 IPR000980 589 718 9.80e-52 SH2 domain
ENSCAFP00000022438 PANTHER PTHR11801 IPR001217 2 770 0.00e-00 Transcription factor STAT
ENSCAFP00000022438 Pfam PF00017 IPR000980 584 674 3.70e-13 SH2 domain
ENSCAFP00000022438 Pfam PF01017 IPR013800 139 319 3.80e-59 STAT transcription factor, all-alpha
ENSCAFP00000022438 Pfam PF02864 IPR013801 321 574 4.60e-127 STAT transcription factor, DNA-binding
ENSCAFP00000022438 Pfam PF02865 IPR013799 2 121 8.40e-42 STAT transcription factor, protein interaction
ENSCAFP00000022438 ProSiteProfiles PS50001 IPR000980 580 670 0.00e-00 SH2 domain
ENSCAFP00000022438 SMART SM00252 IPR000980 582 663 1.50e-03 SH2 domain
ENSCAFP00000022438 SMART SM00964 IPR013799 2 122 1.80e-64 STAT transcription factor, protein interaction
ENSCAFP00000022438 SUPERFAMILY SSF47655 IPR015988 136 321 0.00e-00 STAT transcription factor, coiled coil
ENSCAFP00000022438 SUPERFAMILY SSF48092 IPR013799 1 120 0.00e-00 STAT transcription factor, protein interaction
ENSCAFP00000022438 SUPERFAMILY SSF49417 IPR008967 322 575 0.00e-00 p53-like transcription factor, DNA-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSCAFP00000022438 PF01017 0 STAT_alpha STAT protein, all-alpha domain
ENSCAFP00000022438 PF02864 0 STAT_bind STAT protein, DNA binding domain
ENSCAFP00000022438 PF02865 8.39938e-42 STAT_int STAT protein, protein interaction domain
ENSCAFP00000022438 PF00017 1.4e-13 SH2 SH2 domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSCAFP00000022438 GO:0001659 biological_process temperature homeostasis
ENSCAFP00000022438 GO:0001754 biological_process eye photoreceptor cell differentiation
ENSCAFP00000022438 GO:0006357 biological_process regulation of transcription from RNA polymerase II promoter
ENSCAFP00000022438 GO:0019953 biological_process sexual reproduction
ENSCAFP00000022438 GO:0042593 biological_process glucose homeostasis
ENSCAFP00000022438 GO:0042755 biological_process eating behavior
ENSCAFP00000022438 GO:0045893 biological_process positive regulation of transcription, DNA-templated
ENSCAFP00000022438 GO:0060397 biological_process JAK-STAT cascade involved in growth hormone signaling pathway
ENSCAFP00000022438 GO:0005634 cellular_component nucleus
ENSCAFP00000022438 GO:0005737 cellular_component cytoplasm
ENSCAFP00000022438 GO:0005886 cellular_component plasma membrane
ENSCAFP00000022438 GO:0003677 molecular_function DNA binding
ENSCAFP00000022438 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSCAFP00000022438 GO:0004871 molecular_function signal transducer activity
ENSCAFP00000022438 GO:0005509 molecular_function calcium ion binding
ENSCAFP00000022438 GO:0019901 molecular_function protein kinase binding
ENSCAFP00000022438 GO:0043565 molecular_function sequence-specific DNA binding
ENSCAFP00000022438 GO:0046983 molecular_function protein dimerization activity

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9986 Oryctolagus cuniculus 100348778 10029 Cricetulus griseus 100755865
9597 Pan paniscus 100987766 9555 Papio anubis 100998929
39432 Saimiri boliviensis 101049662 31033 Takifugu rubripes 101070968
9685 Felis catus 101095698 8083 Xiphophorus maculatus 102226045
10090 Mus musculus 20849 10116 Rattus norvegicus 25124
9913 Bos taurus 510814 9606 Homo sapiens 6775
28377 Anolis carolinensis ENSACAG00000017940 9646 Ailuropoda melanoleuca ENSAMEG00000006266
9358 Choloepus hoffmanni ENSCHOG00000009349 10141 Cavia porcellus ENSCPOG00000007939
9361 Dasypus novemcinctus ENSDNOG00000001471 10020 Dipodomys ordii ENSDORG00000000308
9796 Equus caballus ENSECAG00000016439 9365 Erinaceus europaeus ENSEEUG00000002778
9371 Echinops telfairi ENSETEG00000017040 69293 Gasterosteus aculeatus ENSGACG00000008607
9031 Gallus gallus ENSGALG00000007651 9595 Gorilla gorilla ENSGGOG00000017110
8049 Gadus morhua ENSGMOG00000014955 7897 Latimeria chalumnae ENSLACG00000012019
9315 Macropus eugenii ENSMEUG00000006663 9103 Meleagris gallopavo ENSMGAG00000003545
30608 Microcebus murinus ENSMICG00000012015 59463 Myotis lucifugus ENSMLUG00000017449
9544 Macaca mulatta ENSMMUG00000010707 13616 Monodelphis domestica ENSMODG00000028212
9669 Mustela putorius furo ENSMPUG00000010509 61853 Nomascus leucogenys ENSNLEG00000006694
30611 Otolemur garnettii ENSOGAG00000001517 8128 Oreochromis niloticus ENSONIG00000001148
8090 Oryzias latipes ENSORLG00000004061 9813 Procavia capensis ENSPCAG00000010265
9601 Pongo abelii ENSPPYG00000008392 13735 Pelodiscus sinensis ENSPSIG00000015868
9598 Pan troglodytes ENSPTRG00000012749 132908 Pteropus vampyrus ENSPVAG00000003885
42254 Sorex araneus ENSSARG00000014231 9305 Sarcophilus harrisii ENSSHAG00000014833
9823 Sus scrofa ENSSSCG00000016057 43179 Ictidomys tridecemlineatus ENSSTOG00000006741
37347 Tupaia belangeri ENSTBEG00000017412 59729 Taeniopygia guttata ENSTGUG00000002600
99883 Tetraodon nigroviridis ENSTNIG00000017161 9478 Tarsius syrichta ENSTSYG00000012448
9739 Tursiops truncatus ENSTTRG00000007163 30538 Vicugna pacos ENSVPAG00000011545
9483 Callithrix jacchus ENSCJAG00000000409 7955 Danio rerio ENSDARG00000006266
9785 Loxodonta africana ENSLAFG00000014062 9978 Ochotona princeps ENSOPRG00000008362
7757 Petromyzon marinus ENSPMAG00000002770 8364 Xenopus tropicalis ENSXETG00000007642