Basic Information
Gene ID 2020 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name EN2
Full Name Homeobox protein engrailed-2
Organism Homo sapiens [9606]

Cross Reference
UniProt P19622 UniGene Hs.134989
PDB NULL OMIM 131310
KEGG hsa:2020 UCSC uc003wmb.3

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING 9606.ENSP00000297375

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000297375 Gene3D G3DSA:1.10.10.60 IPR009057 228 302 2.50e-25 Homeodomain-like
ENSP00000297375 Pfam PF00046 IPR001356 245 301 1.10e-21 Homeobox domain
ENSP00000297375 Pfam PF10525 IPR019549 302 333 2.00e-18 Homeobox engrailed, C-terminal
ENSP00000297375 PRINTS PR00024 IPR020479 266 277 2.30e-06 Homeodomain, metazoa
ENSP00000297375 PRINTS PR00024 IPR020479 281 291 2.30e-06 Homeodomain, metazoa
ENSP00000297375 PRINTS PR00024 IPR020479 291 300 2.30e-06 Homeodomain, metazoa
ENSP00000297375 PRINTS PR00026 IPR000747 243 260 7.30e-18 Homeodomain engrailed
ENSP00000297375 PRINTS PR00026 IPR000747 306 323 7.30e-18 Homeodomain engrailed
ENSP00000297375 ProSitePatterns PS00027 IPR017970 277 300 - Homeobox, conserved site
ENSP00000297375 ProSitePatterns PS00033 IPR019737 313 320 - Homeobox engrailed-type, conserved site
ENSP00000297375 ProSiteProfiles PS50071 IPR001356 242 302 0.00e-00 Homeobox domain
ENSP00000297375 SMART SM00389 IPR001356 244 306 7.10e-28 Homeobox domain
ENSP00000297375 SUPERFAMILY SSF46689 IPR009057 235 301 0.00e-00 Homeodomain-like

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000297375 PF00046 7.8e-22 Homeobox Homeobox domain
ENSP00000297375 PF10525 1e-18 Engrail_1_C_sig Engrailed homeobox C-terminal signature domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000297375 GO:0005634 cellular_component nucleus
ENSP00000297375 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
7425 Nasonia vitripennis 100123905 7029 Acyrthosiphon pisum 100161671
10224 Saccoglossus kowalevskii 100303466 9601 Pongo abelii 100459532
9823 Sus scrofa 100512078 61853 Nomascus leucogenys 100581025
30195 Bombus terrestris 100649797 8128 Oreochromis niloticus 100706716
132113 Bombus impatiens 100743858 7463 Apis florea 100870890
143995 Megachile rotundata 100882481 34638 Metaseiulus occidentalis 100908620
30611 Otolemur garnettii 100946410 9597 Pan paniscus 100996220
9555 Papio anubis 101019723 39432 Saimiri boliviensis 101033660
31033 Takifugu rubripes 101068755 43179 Ictidomys tridecemlineatus 101960578
8083 Xiphophorus maculatus 102234767 7897 Latimeria chalumnae 102360063
8364 Xenopus tropicalis ENSXETG00000014994 7227 Drosophila melanogaster 36240
7719 Ciona intestinalis 445653 7668 Strongylocentrotus purpuratus 590038
7070 Tribolium castaneum 661645 9544 Macaca mulatta 716307
7460 Apis mellifera 725151 28377 Anolis carolinensis ENSACAG00000011018
9646 Ailuropoda melanoleuca ENSAMEG00000001224 9913 Bos taurus ENSBTAG00000018917
9615 Canis familiaris ENSCAFG00000005082 9483 Callithrix jacchus ENSCJAG00000017450
10141 Cavia porcellus ENSCPOG00000024572 51511 Ciona savignyi ENSCSAVG00000008099
7955 Danio rerio ENSDARG00000038868 9796 Equus caballus ENSECAG00000021744
9365 Erinaceus europaeus ENSEEUG00000004213 9371 Echinops telfairi ENSETEG00000004995
9685 Felis catus ENSFCAG00000023560 69293 Gasterosteus aculeatus ENSGACG00000003888
9031 Gallus gallus ENSGALG00000025740 9595 Gorilla gorilla ENSGGOG00000022981
8049 Gadus morhua ENSGMOG00000004983 9785 Loxodonta africana ENSLAFG00000032115
9103 Meleagris gallopavo ENSMGAG00000012331 30608 Microcebus murinus ENSMICG00000017594
59463 Myotis lucifugus ENSMLUG00000004165 13616 Monodelphis domestica ENSMODG00000004978
9669 Mustela putorius furo ENSMPUG00000009596 9258 Ornithorhynchus anatinus ENSOANG00000006149
9986 Oryctolagus cuniculus ENSOCUG00000002453 9978 Ochotona princeps ENSOPRG00000015660
8090 Oryzias latipes ENSORLG00000010437 7757 Petromyzon marinus ENSPMAG00000010362
13735 Pelodiscus sinensis ENSPSIG00000014871 9598 Pan troglodytes ENSPTRG00000016137
132908 Pteropus vampyrus ENSPVAG00000003106 10116 Rattus norvegicus ENSRNOG00000046462
9305 Sarcophilus harrisii ENSSHAG00000017591 59729 Taeniopygia guttata ENSTGUG00000000695
99883 Tetraodon nigroviridis ENSTNIG00000012777 9739 Tursiops truncatus ENSTTRG00000013702