Basic Information
Gene ID 6657 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name SOX2
Full Name Transcription factor SOX-2
Organism Homo sapiens [9606]

Cross Reference
UniProt P48431 UniGene Hs.732963
PDB 2LE4 OMIM 206900
KEGG hsa:6657 UCSC uc003fkx.3

Protein Interactions
DIP DIP-59913N
IntAct NULL
MINT NULL
STRING 9606.ENSP00000323588

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000439111 Gene3D G3DSA:1.10.30.10 IPR009071 40 119 1.00e-40 High mobility group box domain
ENSP00000439111 Pfam PF00505 IPR009071 41 109 9.50e-27 High mobility group box domain
ENSP00000439111 Pfam PF12336 IPR022097 110 200 4.30e-30 Transcription factor SOX
ENSP00000439111 ProSiteProfiles PS50118 IPR009071 41 109 0.00e-00 High mobility group box domain
ENSP00000439111 SMART SM00398 IPR009071 40 110 6.10e-31 High mobility group box domain
ENSP00000439111 SUPERFAMILY SSF47095 IPR009071 34 113 0.00e-00 High mobility group box domain

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000439111 PF12336 4.3e-30 SOXp SOX transcription factor
ENSP00000439111 PF00505 6e-27 HMG_box HMG (high mobility group) box
ENSP00000439111 PF09011 1.4e-11 HMG_box_2 HMG-box domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000439111 GO:0006351 biological_process transcription, DNA-templated
ENSP00000439111 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSP00000439111 GO:0007275 biological_process multicellular organismal development
ENSP00000439111 GO:0005634 cellular_component nucleus
ENSP00000439111 GO:0003677 molecular_function DNA binding
ENSP00000439111 GO:0043565 molecular_function sequence-specific DNA binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9601 Pongo abelii 100460719 61853 Nomascus leucogenys 100605885
400682 Amphimedon queenslandica 100632156 30195 Bombus terrestris 100643013
10029 Cricetulus griseus 100759815 34638 Metaseiulus occidentalis 100898556
9597 Pan paniscus 100976706 13735 Pelodiscus sinensis 102443720
7668 Strongylocentrotus purpuratus 373202 9615 Canis familiaris 488092
7070 Tribolium castaneum 663351 7029 Acyrthosiphon pisum 100164548
6087 Hydra magnipapillata 100205840 10224 Saccoglossus kowalevskii 100303496
7425 Nasonia vitripennis 100678051 8128 Oreochromis niloticus 100695175
132113 Bombus impatiens 100742000 7463 Apis florea 100866912
143995 Megachile rotundata 100879499 30611 Otolemur garnettii 100963354
9555 Papio anubis 101022620 39432 Saimiri boliviensis 101037370
31033 Takifugu rubripes 101073272 8090 Oryzias latipes 101162114
9669 Mustela putorius furo 101690298 8083 Xiphophorus maculatus 102226408
7897 Latimeria chalumnae 102366157 6239 Caenorhabditis elegans 185534
10090 Mus musculus 20669 7227 Drosophila melanogaster 39567
9031 Gallus gallus 396105 8364 Xenopus tropicalis 407873
9598 Pan troglodytes 460869 10116 Rattus norvegicus 499593
7460 Apis mellifera 726150 9646 Ailuropoda melanoleuca ENSAMEG00000011029
7719 Ciona intestinalis ENSCING00000006005 10141 Cavia porcellus ENSCPOG00000008309
9361 Dasypus novemcinctus ENSDNOG00000019903 9371 Echinops telfairi ENSETEG00000006366
9595 Gorilla gorilla ENSGGOG00000027572 9315 Macropus eugenii ENSMEUG00000006246
30608 Microcebus murinus ENSMICG00000013774 59463 Myotis lucifugus ENSMLUG00000013015
9258 Ornithorhynchus anatinus ENSOANG00000004458 9986 Oryctolagus cuniculus ENSOCUG00000011135
9813 Procavia capensis ENSPCAG00000003690 132908 Pteropus vampyrus ENSPVAG00000007702
9823 Sus scrofa ENSSSCG00000011771 43179 Ictidomys tridecemlineatus ENSSTOG00000011011
99883 Tetraodon nigroviridis ENSTNIG00000003970 9478 Tarsius syrichta ENSTSYG00000001164
9739 Tursiops truncatus ENSTTRG00000004853 28377 Anolis carolinensis ENSACAG00000002492
9358 Choloepus hoffmanni ENSCHOG00000012015 9483 Callithrix jacchus ENSCJAG00000008401
51511 Ciona savignyi ENSCSAVG00000009067 10020 Dipodomys ordii ENSDORG00000007481
9796 Equus caballus ENSECAG00000010653 9685 Felis catus ENSFCAG00000029205
69293 Gasterosteus aculeatus ENSGACG00000006100 8049 Gadus morhua ENSGMOG00000019777
13616 Monodelphis domestica ENSMODG00000021292 7757 Petromyzon marinus ENSPMAG00000009737
37347 Tupaia belangeri ENSTBEG00000007360 30538 Vicugna pacos ENSVPAG00000010334